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The map label for this gene is algC [H]

Identifier: 86748648

GI number: 86748648

Start: 1714870

End: 1716366

Strand: Reverse

Name: algC [H]

Synonym: RPB_1523

Alternate gene names: 86748648

Gene position: 1716366-1714870 (Counterclockwise)

Preceding gene: 86748649

Following gene: 86748646

Centisome position: 32.19

GC content: 64.13

Gene sequence:

>1497_bases
ATGTTTCCTCCGCCGAAGCCACTACTCCTTCCCAATACCTACGCCTACGAATCCGAGCCGATGGTGAAGCCGACCGGATT
CCGCGAATACGACGCGCGCTGGCTGTTCGGCAAGGAGATCAACCTGATGGGCGTGCAGGCGCTGGGCATGGGGCTCGGCA
CGCTGATCGCCGAACTCGGCCAGCCCAAGGAAATCGTCACCGGACACGATTTCCGCGGCTACTCCGCCTCGATCAAATAC
GCACTGATCGCGGGCTTGATGTCGTCGGGTTGCAAGGTCCACGACATCGGGCTGGCGGTGACGCCGATGGCCTATTTCGC
TCAGTTCGATCTGGACGTGCCCTGCGTCGCCATGGTGACGGCTTCGCACAACGACAATGGCTGGACCGGCGTCAAGATGG
GCGCCAACCGCCCCCTGACCTTCGGGCCGGACGAGATGGGCCGGCTCAAGGAGATCGTGCTGAACGCGCAGTTCGCCAGC
GGCGCCGGCTCCTATGTGTTTCACGAGAACTATCCGGCGCGCTATATCGCCGACCTCACCAAGCACGCCAAACTCGCGCG
CAAGCTCAAGGTCGTGGTCGCCTGCGGCAACGGTACCGCAGGCGCGTTCGCGCCCCAGGTGATGGAGGCGATCGGTTGCG
AGGTGATCCCACTCGATACCGAACTCGATCACACCTTTCCGAAGTACAATCCCAATCCGGAAGACATGGAGATGCTGCAC
GCGATCCGCGACGCGGTGCTGCAGCACAAGGCCGATCTCGGCCTCGGCTTCGACGGCGACGGCGATCGCTGCGGTGTGGT
CGACGACACCGGTGAGGAGATCTTCGCCGACAAGGTCGGGGTGATGCTGGCGCGCGACATGTCGGCGATCACGCCCGACG
CGCAGTTCGTGGTCGACGTGAAGTCCACCGGGCTGTTCCACACCGATCCGGTGCTGCAGGCGCAGGGCGCGCGCACGGAA
TATTGGAAGACCGGCCATTCTTACATGAAGCGCCGCACCAACGAATTGAAGGCGCTGGCCGGTTTCGAGAAGTCCGGCCA
CTTTTTCTTCAACGTCCCGCCCGGCCGGGGCTATGACGACGGCCTGGTGTCGGCGATCGCGATCTGCGAGATGCTCGATC
GCGCGCCCGGCAAGTCGATGTCGGACCTCAAGAACGCGCTGCCGAAGACCTGGTCGTCGCCGACGATGTCGCCGCATTGC
GACGACGAGACCAAATACGGCGTGATCGACGCGGTGGTGAAGCATTTCGAAGCCGCGCAGGCGAATGGCGACAAGGTCGC
CGCACAGCCGATCCGCGACCTCGTCACCGTCAACGGCGTCCGGGTCACCTGCGAGGACGGCAGCTGGGGGCTGGTCCGCG
CCTCCTCGAACAAGCCCGAACTCGTCGTCGTCGTCGAAAGCCCGGTGTCGGAAGCGCGGATGCACGAGATGTTCGAGGCG
GTGAACGTCGTGCTGCGCCGGCATCCGGAAGTCGGCGCCTACAACCAGACGATCTGA

Upstream 100 bases:

>100_bases
GCCTGATCCGAGAGCACCGGACGGGCGCAGGCGCCGACGATGGCGCCTCGCCGCGCTATCGCAGCCGGCGAGCCAAATCC
GCGAAGCTCAGAGATCTTTC

Downstream 100 bases:

>100_bases
ACGGCCGCGGCGCCGTGCGGCCCGACGGACCGCGCCGAGCGGCGGACTTCCAGAACCTCCCGCAACACGCGCGCGATTGC
GCTCGACCTGAAGCAGGCGG

Product: phosphomannomutase C

Products: NA

Alternate protein names: PMM / PGM [H]

Number of amino acids: Translated: 498; Mature: 498

Protein sequence:

>498_residues
MFPPPKPLLLPNTYAYESEPMVKPTGFREYDARWLFGKEINLMGVQALGMGLGTLIAELGQPKEIVTGHDFRGYSASIKY
ALIAGLMSSGCKVHDIGLAVTPMAYFAQFDLDVPCVAMVTASHNDNGWTGVKMGANRPLTFGPDEMGRLKEIVLNAQFAS
GAGSYVFHENYPARYIADLTKHAKLARKLKVVVACGNGTAGAFAPQVMEAIGCEVIPLDTELDHTFPKYNPNPEDMEMLH
AIRDAVLQHKADLGLGFDGDGDRCGVVDDTGEEIFADKVGVMLARDMSAITPDAQFVVDVKSTGLFHTDPVLQAQGARTE
YWKTGHSYMKRRTNELKALAGFEKSGHFFFNVPPGRGYDDGLVSAIAICEMLDRAPGKSMSDLKNALPKTWSSPTMSPHC
DDETKYGVIDAVVKHFEAAQANGDKVAAQPIRDLVTVNGVRVTCEDGSWGLVRASSNKPELVVVVESPVSEARMHEMFEA
VNVVLRRHPEVGAYNQTI

Sequences:

>Translated_498_residues
MFPPPKPLLLPNTYAYESEPMVKPTGFREYDARWLFGKEINLMGVQALGMGLGTLIAELGQPKEIVTGHDFRGYSASIKY
ALIAGLMSSGCKVHDIGLAVTPMAYFAQFDLDVPCVAMVTASHNDNGWTGVKMGANRPLTFGPDEMGRLKEIVLNAQFAS
GAGSYVFHENYPARYIADLTKHAKLARKLKVVVACGNGTAGAFAPQVMEAIGCEVIPLDTELDHTFPKYNPNPEDMEMLH
AIRDAVLQHKADLGLGFDGDGDRCGVVDDTGEEIFADKVGVMLARDMSAITPDAQFVVDVKSTGLFHTDPVLQAQGARTE
YWKTGHSYMKRRTNELKALAGFEKSGHFFFNVPPGRGYDDGLVSAIAICEMLDRAPGKSMSDLKNALPKTWSSPTMSPHC
DDETKYGVIDAVVKHFEAAQANGDKVAAQPIRDLVTVNGVRVTCEDGSWGLVRASSNKPELVVVVESPVSEARMHEMFEA
VNVVLRRHPEVGAYNQTI
>Mature_498_residues
MFPPPKPLLLPNTYAYESEPMVKPTGFREYDARWLFGKEINLMGVQALGMGLGTLIAELGQPKEIVTGHDFRGYSASIKY
ALIAGLMSSGCKVHDIGLAVTPMAYFAQFDLDVPCVAMVTASHNDNGWTGVKMGANRPLTFGPDEMGRLKEIVLNAQFAS
GAGSYVFHENYPARYIADLTKHAKLARKLKVVVACGNGTAGAFAPQVMEAIGCEVIPLDTELDHTFPKYNPNPEDMEMLH
AIRDAVLQHKADLGLGFDGDGDRCGVVDDTGEEIFADKVGVMLARDMSAITPDAQFVVDVKSTGLFHTDPVLQAQGARTE
YWKTGHSYMKRRTNELKALAGFEKSGHFFFNVPPGRGYDDGLVSAIAICEMLDRAPGKSMSDLKNALPKTWSSPTMSPHC
DDETKYGVIDAVVKHFEAAQANGDKVAAQPIRDLVTVNGVRVTCEDGSWGLVRASSNKPELVVVVESPVSEARMHEMFEA
VNVVLRRHPEVGAYNQTI

Specific function: The phosphomannomutase activity produces a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. Also involved in core-LPS biosynthesis due to it

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Escherichia coli, GI1788361, Length=501, Percent_Identity=29.5409181636727, Blast_Score=151, Evalue=8e-38,
Organism=Escherichia coli, GI1789566, Length=244, Percent_Identity=27.4590163934426, Blast_Score=74, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2; =5.4.2.8 [H]

Molecular weight: Translated: 54232; Mature: 54232

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFPPPKPLLLPNTYAYESEPMVKPTGFREYDARWLFGKEINLMGVQALGMGLGTLIAELG
CCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCEEEHHHHHHHHHHHHHHHC
QPKEIVTGHDFRGYSASIKYALIAGLMSSGCKVHDIGLAVTPMAYFAQFDLDVPCVAMVT
CCCEEECCCCCCCCCCHHHHHHHHHHHHCCCEEEECCEEHHHHHHHHHCCCCCCEEEEEE
ASHNDNGWTGVKMGANRPLTFGPDEMGRLKEIVLNAQFASGAGSYVFHENYPARYIADLT
ECCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCEECCCCCCEEEECCCCHHHHHHHH
KHAKLARKLKVVVACGNGTAGAFAPQVMEAIGCEVIPLDTELDHTFPKYNPNPEDMEMLH
HHHHHHHEEEEEEEECCCCCCHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCHHHHHHHH
AIRDAVLQHKADLGLGFDGDGDRCGVVDDTGEEIFADKVGVMLARDMSAITPDAQFVVDV
HHHHHHHHHHHHCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
KSTGLFHTDPVLQAQGARTEYWKTGHSYMKRRTNELKALAGFEKSGHFFFNVPPGRGYDD
CCCCCEECCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCH
GLVSAIAICEMLDRAPGKSMSDLKNALPKTWSSPTMSPHCDDETKYGVIDAVVKHFEAAQ
HHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHC
ANGDKVAAQPIRDLVTVNGVRVTCEDGSWGLVRASSNKPELVVVVESPVSEARMHEMFEA
CCCCCCHHHHHHHHHEECCEEEEEECCCEEEEEECCCCCCEEEEECCCHHHHHHHHHHHH
VNVVLRRHPEVGAYNQTI
HHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MFPPPKPLLLPNTYAYESEPMVKPTGFREYDARWLFGKEINLMGVQALGMGLGTLIAELG
CCCCCCCEECCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCEEEHHHHHHHHHHHHHHHC
QPKEIVTGHDFRGYSASIKYALIAGLMSSGCKVHDIGLAVTPMAYFAQFDLDVPCVAMVT
CCCEEECCCCCCCCCCHHHHHHHHHHHHCCCEEEECCEEHHHHHHHHHCCCCCCEEEEEE
ASHNDNGWTGVKMGANRPLTFGPDEMGRLKEIVLNAQFASGAGSYVFHENYPARYIADLT
ECCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHCCEECCCCCCEEEECCCCHHHHHHHH
KHAKLARKLKVVVACGNGTAGAFAPQVMEAIGCEVIPLDTELDHTFPKYNPNPEDMEMLH
HHHHHHHEEEEEEEECCCCCCHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCHHHHHHHH
AIRDAVLQHKADLGLGFDGDGDRCGVVDDTGEEIFADKVGVMLARDMSAITPDAQFVVDV
HHHHHHHHHHHHCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
KSTGLFHTDPVLQAQGARTEYWKTGHSYMKRRTNELKALAGFEKSGHFFFNVPPGRGYDD
CCCCCEECCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCH
GLVSAIAICEMLDRAPGKSMSDLKNALPKTWSSPTMSPHCDDETKYGVIDAVVKHFEAAQ
HHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHC
ANGDKVAAQPIRDLVTVNGVRVTCEDGSWGLVRASSNKPELVVVVESPVSEARMHEMFEA
CCCCCCHHHHHHHHHEECCEEEEEECCCEEEEEECCCCCCEEEEECCCHHHHHHHHHHHH
VNVVLRRHPEVGAYNQTI
HHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12534463 [H]