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The map label for this gene is pntAA [H]

Identifier: 86748560

GI number: 86748560

Start: 1623949

End: 1625073

Strand: Direct

Name: pntAA [H]

Synonym: RPB_1435

Alternate gene names: 86748560

Gene position: 1623949-1625073 (Clockwise)

Preceding gene: 86748559

Following gene: 86748561

Centisome position: 30.46

GC content: 66.58

Gene sequence:

>1125_bases
ATGAAAATTGCTGTTGCCAAAGAACTCGATGCTTCTGAACCGCGTGTCGCGGCGACGCCCGACACGGTGAAGAAGCTGAA
GGCGCTGGGTGCCGACATCGTCGTCGAGCCGGGTGCCGGCATCAAGTCGGGTCTGCCGGATTCCGATTTCACCGCCGCCG
GCGCCACCGTCAGCGCCGACGCGCTGAAGGACGCCGACATCATCCTCAAGGTGAAGCGTCCGGAAGCCTCCGAACTCGCC
GCCTACAAGCGCGGCGCGCTGGTGATGGCGATCATGGACCCCTACGGCAACGACGCCGCGCTGAAGGCGATGGCCGACGC
CGGCGTCACCGCCTTCGCGATGGAGCTGATGCCGCGCATCACCCGCGCGCAGGTGATGGACGTGCTGTCGAGCCAGGCCA
ATCTCGCCGGCTATCGCGCGGTGATCGACGCCGCCGAGCAGTTCGGCCGGGTGTTTCCGATGATGATGACCGCGGCCGGC
ACCGTGCCCGCCGCCAAGGTGTTCATCATGGGCGTCGGCGTCGCCGGCCTGCAGGCGATCGCCACCGCGCGCCGGCTCGG
CGCCATCGTCACCGCGACCGACGTCCGCCCCGCCACCAAGGAGCAGGTCGAATCGTTGGGCGCCAAGTTCCTCGCGGTCG
AGGACGAAGAGTTCAAGAACGCCCAGACCGCCGGCGGCTACGCCAAGGAAATGTCGAAAGAGTATCAGGCCAAGCAGGCC
GCTCTGACCGCCGAACACATCAAGAAGCAGGACATCGTCATCACCACCGCGCTGATCCCGGGCCGGCCCGCGCCGCGCCT
CGTCACCGCCGAGATGGTGCGCTCGATGAAACCGGGTTCGGTGCTGGTCGATCTGGCGGTCGAGCGCGGCGGCAACGTCG
AAGGTGCAAAGCCCGGCGAAGTCGTCGAGACCGACGGCGTCAGGATCGTCGGTTACACCAATGTCGCCGGCCGCGTCGCG
GCGTCGGCGTCCGCCCTGTATGCGCGCAATCTGTTCAGCTTCATCGAGACGCTGATCAACAAGGACAGCAAGGCGCTGGC
GGTGAATTGGGACGACGATCTGGTCAAGGCCACCGCGCTGACGCGCGACGGCGCCGTCGTTCACCCGAACTTCCAGCCGA
AATAA

Upstream 100 bases:

>100_bases
ATGGCGATCTTCCTGACCTGACTTCGACCCTGAGTGCATCGCCGGAAAGCGGTGTCGAGACTGCCAGCTCACGCGCGCGC
CAGGCGCCGCAGGAGGCTCC

Downstream 100 bases:

>100_bases
AGGAAAGCCGCCATGGAGCATGTCGTGCAGGCCGTCGATCCGTTCGTGTTTCGGCTGTCGATTTTCGTTCTGGCCGTGTT
CGTCGGCTATTTCGTGGTGT

Product: NAD(P)(+) transhydrogenase (AB-specific)

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit alpha 1; Proton-translocating transhydrogenase component 1; Pyridine nucleotide transhydrogenase subunit alpha 1; dI [H]

Number of amino acids: Translated: 374; Mature: 374

Protein sequence:

>374_residues
MKIAVAKELDASEPRVAATPDTVKKLKALGADIVVEPGAGIKSGLPDSDFTAAGATVSADALKDADIILKVKRPEASELA
AYKRGALVMAIMDPYGNDAALKAMADAGVTAFAMELMPRITRAQVMDVLSSQANLAGYRAVIDAAEQFGRVFPMMMTAAG
TVPAAKVFIMGVGVAGLQAIATARRLGAIVTATDVRPATKEQVESLGAKFLAVEDEEFKNAQTAGGYAKEMSKEYQAKQA
ALTAEHIKKQDIVITTALIPGRPAPRLVTAEMVRSMKPGSVLVDLAVERGGNVEGAKPGEVVETDGVRIVGYTNVAGRVA
ASASALYARNLFSFIETLINKDSKALAVNWDDDLVKATALTRDGAVVHPNFQPK

Sequences:

>Translated_374_residues
MKIAVAKELDASEPRVAATPDTVKKLKALGADIVVEPGAGIKSGLPDSDFTAAGATVSADALKDADIILKVKRPEASELA
AYKRGALVMAIMDPYGNDAALKAMADAGVTAFAMELMPRITRAQVMDVLSSQANLAGYRAVIDAAEQFGRVFPMMMTAAG
TVPAAKVFIMGVGVAGLQAIATARRLGAIVTATDVRPATKEQVESLGAKFLAVEDEEFKNAQTAGGYAKEMSKEYQAKQA
ALTAEHIKKQDIVITTALIPGRPAPRLVTAEMVRSMKPGSVLVDLAVERGGNVEGAKPGEVVETDGVRIVGYTNVAGRVA
ASASALYARNLFSFIETLINKDSKALAVNWDDDLVKATALTRDGAVVHPNFQPK
>Mature_374_residues
MKIAVAKELDASEPRVAATPDTVKKLKALGADIVVEPGAGIKSGLPDSDFTAAGATVSADALKDADIILKVKRPEASELA
AYKRGALVMAIMDPYGNDAALKAMADAGVTAFAMELMPRITRAQVMDVLSSQANLAGYRAVIDAAEQFGRVFPMMMTAAG
TVPAAKVFIMGVGVAGLQAIATARRLGAIVTATDVRPATKEQVESLGAKFLAVEDEEFKNAQTAGGYAKEMSKEYQAKQA
ALTAEHIKKQDIVITTALIPGRPAPRLVTAEMVRSMKPGSVLVDLAVERGGNVEGAKPGEVVETDGVRIVGYTNVAGRVA
ASASALYARNLFSFIETLINKDSKALAVNWDDDLVKATALTRDGAVVHPNFQPK

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG3288

COG function: function code C; NAD/NADP transhydrogenase alpha subunit

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=388, Percent_Identity=40.979381443299, Blast_Score=261, Evalue=9e-70,
Organism=Homo sapiens, GI122939153, Length=388, Percent_Identity=40.979381443299, Blast_Score=261, Evalue=9e-70,
Organism=Escherichia coli, GI1787887, Length=371, Percent_Identity=44.743935309973, Blast_Score=310, Evalue=1e-85,
Organism=Caenorhabditis elegans, GI17550456, Length=365, Percent_Identity=46.027397260274, Blast_Score=315, Evalue=3e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 39212; Mature: 39212

Theoretical pI: Translated: 7.65; Mature: 7.65

Prosite motif: PS00837 ALADH_PNT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIAVAKELDASEPRVAATPDTVKKLKALGADIVVEPGAGIKSGLPDSDFTAAGATVSAD
CCEEEECCCCCCCCCEECCHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCCCEEEHH
ALKDADIILKVKRPEASELAAYKRGALVMAIMDPYGNDAALKAMADAGVTAFAMELMPRI
HCCCCEEEEEECCCCHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCHHHHHHHHHHHH
TRAQVMDVLSSQANLAGYRAVIDAAEQFGRVFPMMMTAAGTVPAAKVFIMGVGVAGLQAI
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEEEEEECCHHHHHHH
ATARRLGAIVTATDVRPATKEQVESLGAKFLAVEDEEFKNAQTAGGYAKEMSKEYQAKQA
HHHHHHCEEEEECCCCCCHHHHHHHCCCEEEEECCHHHCCCCCCCHHHHHHHHHHHHHHH
ALTAEHIKKQDIVITTALIPGRPAPRLVTAEMVRSMKPGSVLVDLAVERGGNVEGAKPGE
HHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCC
VVETDGVRIVGYTNVAGRVAASASALYARNLFSFIETLINKDSKALAVNWDDDLVKATAL
EEECCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHEE
TRDGAVVHPNFQPK
ECCCCEECCCCCCC
>Mature Secondary Structure
MKIAVAKELDASEPRVAATPDTVKKLKALGADIVVEPGAGIKSGLPDSDFTAAGATVSAD
CCEEEECCCCCCCCCEECCHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCCCEEEHH
ALKDADIILKVKRPEASELAAYKRGALVMAIMDPYGNDAALKAMADAGVTAFAMELMPRI
HCCCCEEEEEECCCCHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCHHHHHHHHHHHH
TRAQVMDVLSSQANLAGYRAVIDAAEQFGRVFPMMMTAAGTVPAAKVFIMGVGVAGLQAI
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEEEEEECCHHHHHHH
ATARRLGAIVTATDVRPATKEQVESLGAKFLAVEDEEFKNAQTAGGYAKEMSKEYQAKQA
HHHHHHCEEEEECCCCCCHHHHHHHCCCEEEEECCHHHCCCCCCCHHHHHHHHHHHHHHH
ALTAEHIKKQDIVITTALIPGRPAPRLVTAEMVRSMKPGSVLVDLAVERGGNVEGAKPGE
HHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCC
VVETDGVRIVGYTNVAGRVAASASALYARNLFSFIETLINKDSKALAVNWDDDLVKATAL
EEECCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHEE
TRDGAVVHPNFQPK
ECCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8075801 [H]