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The map label for this gene is nuoC

Identifier: 86748474

GI number: 86748474

Start: 1536880

End: 1538625

Strand: Direct

Name: nuoC

Synonym: RPB_1349

Alternate gene names: 86748474

Gene position: 1536880-1538625 (Clockwise)

Preceding gene: 86748473

Following gene: 86748475

Centisome position: 28.83

GC content: 65.92

Gene sequence:

>1746_bases
GTGAGCGCAACCGACCTCGTCAGCGAACTCGGCGCGCGATTCGGAGACGCGGTGCTGGGCGAGCAGACCACGCGTGAGCG
GTTTCCGACGGTGTGGATCCGTCCGGAGGCGTCGGCTGCCGTGCATCGCTATCTGAAGCACGAGGTCGAGCGCCCGTTCA
GGATGCTGGTCGATCTGTGGGCGATCGACGAGACCGCGCGCAAACATCGCGAGGGGCAGCCGCCGTCCGGCATCACCATC
GCCAGCCATCTGATGTCGCACGAGCGCAACGCCGACATCCGGCTGAAGGTCGGGCTCGACGCCGAGTATCCGAGCGCGAA
GTCGATCGCGGGCGTGTACCCCAACGCGGCGTGGTACGAGCGCGAAGCCTATGACATGTTCGGCGTCGAATTCGAAGCCC
AGCCGCATTCGCTGCGCATTCTGCTGCCGCCCGGATGGGAAGGCCATCCGATGCGCAAGACCCAGCCCGGCCGCGCCACC
GAGCGGCCGCTGTTCAACATGACCGCGGCGCTGTTCGACGCCAAGGAGCACGCGCTCGCCGCCGATCCGGAGAAATTCGG
CCTGCCGACGCATCGCGACGGCGTCGAACTGATGATCCTGAACTACGGGCCGCACAGCATGGCGACCCATGGCGTGTTTC
GCATCGTGCTGGCGCTCGATGGCGAGGAGATCGTCGCGGCGCGGCCGGACATCGGTTTCCATCATCGCGGCGCCGAGAAA
ATGGCGGAGCGCCAGACCTGGCACAATTTCCTGCCCTACACCGACCGCGTCGACTATCTCGGCGGCGTGATGGGCGAGAT
GCCGTATCTGCAGGCGGTCGAGAAAGCCTGCGGCATCACCGTACCGGATCGCGCGCTGACGGTGCGGGTGATGCTGTCGG
AAATGTTCCGCATCATGAATCACCTGCTGTTCTACGGCACCATGGCGCAGGACACCGGCGCGATGTCGCCGGTGTTCTAC
ATGTTCGTCGATCGCGAGCGCGGCTACCGGGTGATCGAGGCGATCACCGGCGCGCGGATGCATCCCGGCTATTTCCGCAT
CGGCGGGCTGTCGATGGACCTGCCGCAGGGCTGGGACAGGCTGGTGCGCGAATTCCTCGACTGGATGCCGGCGCGGCTTG
CCGACTACGAAGGCATGGTGTTGCGCAATGAGATCTTCCAGGCGCGGACCAAGGGAGTTGCTGCCTACGACACCGCGATG
GCGCTGGACTGGGGCGTCACCGGGCCCGGGCTGCGCGCGACCGGCTCCGCATGGGACGTCCGCAAGGCGCGGCCCTATTC
GGGCTTCGAGAATTTCGAGTTCGAAATTCCGGTCGGCCATAACGGCGATTGCTACGACCGCACCGTGGTGCGGGTCGAGG
AGATCCGCCAATCGCTGAAAATCATCCGGCAGTGCGTCGACAACATGCCGTCCGGCCCGATCAAGGCCGACCATCCGCTG
ACCACGCCGCCGCCGCGCGAGCGGATGCTGCACGACATCGAGACCATGATCCATCATTTCGTCGGCGCCAGCTGGGGGCC
GGTGCTGCCGCCGGGTGAGACCACCGGGCAGGTCGAGACCGTGCGCGGGCTCACGCAATTCGCGCTGATTTCCGACGGCG
AACCGTCGAGCTATCGCACGCGGATTCGCACGCCGTCGTTCCCGCATCTGCAGATGATTTCGGCGGTGGCGCCCGGCATG
ATGGTGGCCGATCTCGTCGCCTATCTGGGCAGTATCGACTACGTGATGTCGGACGTCGACCGATGA

Upstream 100 bases:

>100_bases
TCGGCAACAGTGCGGGCCTCGGCTTCGATGCGCCGCGCCGGCGCGACGAGCGTCACGACCAACGTATGGCGCAGACCCTT
CTCGATCCGCCGGAGACATT

Downstream 100 bases:

>100_bases
GCCTCAGCCCCGCCATCAGGACCGCGATCGCGCAGGCCGCCGCCCATCACGGCGGGCCGAAGGCCGCGATGCTGGAAGCG
CTGAAGTTGGTGCAGGAGGC

Product: bifunctional NADH:ubiquinone oxidoreductase subunit C/D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit C/D; NDH-1 subunit C/D

Number of amino acids: Translated: 581; Mature: 580

Protein sequence:

>581_residues
MSATDLVSELGARFGDAVLGEQTTRERFPTVWIRPEASAAVHRYLKHEVERPFRMLVDLWAIDETARKHREGQPPSGITI
ASHLMSHERNADIRLKVGLDAEYPSAKSIAGVYPNAAWYEREAYDMFGVEFEAQPHSLRILLPPGWEGHPMRKTQPGRAT
ERPLFNMTAALFDAKEHALAADPEKFGLPTHRDGVELMILNYGPHSMATHGVFRIVLALDGEEIVAARPDIGFHHRGAEK
MAERQTWHNFLPYTDRVDYLGGVMGEMPYLQAVEKACGITVPDRALTVRVMLSEMFRIMNHLLFYGTMAQDTGAMSPVFY
MFVDRERGYRVIEAITGARMHPGYFRIGGLSMDLPQGWDRLVREFLDWMPARLADYEGMVLRNEIFQARTKGVAAYDTAM
ALDWGVTGPGLRATGSAWDVRKARPYSGFENFEFEIPVGHNGDCYDRTVVRVEEIRQSLKIIRQCVDNMPSGPIKADHPL
TTPPPRERMLHDIETMIHHFVGASWGPVLPPGETTGQVETVRGLTQFALISDGEPSSYRTRIRTPSFPHLQMISAVAPGM
MVADLVAYLGSIDYVMSDVDR

Sequences:

>Translated_581_residues
MSATDLVSELGARFGDAVLGEQTTRERFPTVWIRPEASAAVHRYLKHEVERPFRMLVDLWAIDETARKHREGQPPSGITI
ASHLMSHERNADIRLKVGLDAEYPSAKSIAGVYPNAAWYEREAYDMFGVEFEAQPHSLRILLPPGWEGHPMRKTQPGRAT
ERPLFNMTAALFDAKEHALAADPEKFGLPTHRDGVELMILNYGPHSMATHGVFRIVLALDGEEIVAARPDIGFHHRGAEK
MAERQTWHNFLPYTDRVDYLGGVMGEMPYLQAVEKACGITVPDRALTVRVMLSEMFRIMNHLLFYGTMAQDTGAMSPVFY
MFVDRERGYRVIEAITGARMHPGYFRIGGLSMDLPQGWDRLVREFLDWMPARLADYEGMVLRNEIFQARTKGVAAYDTAM
ALDWGVTGPGLRATGSAWDVRKARPYSGFENFEFEIPVGHNGDCYDRTVVRVEEIRQSLKIIRQCVDNMPSGPIKADHPL
TTPPPRERMLHDIETMIHHFVGASWGPVLPPGETTGQVETVRGLTQFALISDGEPSSYRTRIRTPSFPHLQMISAVAPGM
MVADLVAYLGSIDYVMSDVDR
>Mature_580_residues
SATDLVSELGARFGDAVLGEQTTRERFPTVWIRPEASAAVHRYLKHEVERPFRMLVDLWAIDETARKHREGQPPSGITIA
SHLMSHERNADIRLKVGLDAEYPSAKSIAGVYPNAAWYEREAYDMFGVEFEAQPHSLRILLPPGWEGHPMRKTQPGRATE
RPLFNMTAALFDAKEHALAADPEKFGLPTHRDGVELMILNYGPHSMATHGVFRIVLALDGEEIVAARPDIGFHHRGAEKM
AERQTWHNFLPYTDRVDYLGGVMGEMPYLQAVEKACGITVPDRALTVRVMLSEMFRIMNHLLFYGTMAQDTGAMSPVFYM
FVDRERGYRVIEAITGARMHPGYFRIGGLSMDLPQGWDRLVREFLDWMPARLADYEGMVLRNEIFQARTKGVAAYDTAMA
LDWGVTGPGLRATGSAWDVRKARPYSGFENFEFEIPVGHNGDCYDRTVVRVEEIRQSLKIIRQCVDNMPSGPIKADHPLT
TPPPRERMLHDIETMIHHFVGASWGPVLPPGETTGQVETVRGLTQFALISDGEPSSYRTRIRTPSFPHLQMISAVAPGMM
VADLVAYLGSIDYVMSDVDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the complex I 49 kDa subunit family

Homologues:

Organism=Homo sapiens, GI4758786, Length=414, Percent_Identity=40.3381642512077, Blast_Score=313, Evalue=2e-85,
Organism=Homo sapiens, GI260898743, Length=404, Percent_Identity=40.0990099009901, Blast_Score=305, Evalue=1e-82,
Organism=Homo sapiens, GI4758788, Length=126, Percent_Identity=38.8888888888889, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI145693162, Length=577, Percent_Identity=55.4592720970537, Blast_Score=675, Evalue=0.0,
Organism=Escherichia coli, GI1789076, Length=510, Percent_Identity=27.843137254902, Blast_Score=167, Evalue=2e-42,
Organism=Escherichia coli, GI1788832, Length=498, Percent_Identity=26.7068273092369, Blast_Score=139, Evalue=7e-34,
Organism=Caenorhabditis elegans, GI17555284, Length=416, Percent_Identity=41.5865384615385, Blast_Score=338, Evalue=4e-93,
Organism=Caenorhabditis elegans, GI17568379, Length=416, Percent_Identity=41.3461538461538, Blast_Score=336, Evalue=2e-92,
Organism=Drosophila melanogaster, GI221459469, Length=383, Percent_Identity=42.5587467362924, Blast_Score=343, Evalue=2e-94,
Organism=Drosophila melanogaster, GI24638644, Length=388, Percent_Identity=42.0103092783505, Blast_Score=333, Evalue=2e-91,
Organism=Drosophila melanogaster, GI24656494, Length=126, Percent_Identity=37.3015873015873, Blast_Score=73, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOCD_RHOP2 (Q2J0F1)

Other databases:

- EMBL:   CP000250
- RefSeq:   YP_484970.1
- HSSP:   Q56220
- STRING:   Q2J0F1
- GeneID:   3908454
- GenomeReviews:   CP000250_GR
- KEGG:   rpb:RPB_1349
- eggNOG:   COG0649
- HOGENOM:   HBG459705
- OMA:   PHLQQIP
- ProtClustDB:   PRK11742
- BioCyc:   RPAL316058:RPB_1349-MONOMER
- GO:   GO:0006810
- HAMAP:   MF_01359
- InterPro:   IPR010219
- InterPro:   IPR023062
- InterPro:   IPR001135
- InterPro:   IPR001268
- InterPro:   IPR014029
- InterPro:   IPR022885
- ProDom:   PD001581
- TIGRFAMs:   TIGR01962

Pfam domain/function: PF00329 Complex1_30kDa; PF00346 Complex1_49kDa

EC number: =1.6.99.5

Molecular weight: Translated: 65355; Mature: 65223

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: PS00542 COMPLEX1_30K; PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSATDLVSELGARFGDAVLGEQTTRERFPTVWIRPEASAAVHRYLKHEVERPFRMLVDLW
CCHHHHHHHHHHHHCCHHHCCCHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
AIDETARKHREGQPPSGITIASHLMSHERNADIRLKVGLDAEYPSAKSIAGVYPNAAWYE
HHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHC
REAYDMFGVEFEAQPHSLRILLPPGWEGHPMRKTQPGRATERPLFNMTAALFDAKEHALA
CHHHHHHCEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCC
ADPEKFGLPTHRDGVELMILNYGPHSMATHGVFRIVLALDGEEIVAARPDIGFHHRGAEK
CCHHHHCCCCCCCCCEEEEEECCCCHHHHHHHEEEEEEECCCEEEEECCCCCCCCCCHHH
MAERQTWHNFLPYTDRVDYLGGVMGEMPYLQAVEKACGITVPDRALTVRVMLSEMFRIMN
HHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
HLLFYGTMAQDTGAMSPVFYMFVDRERGYRVIEAITGARMHPGYFRIGGLSMDLPQGWDR
HHHHHCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHCCCCCCCEEEECCEECCCCHHHHH
LVREFLDWMPARLADYEGMVLRNEIFQARTKGVAAYDTAMALDWGVTGPGLRATGSAWDV
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHEEEECCCCCCCCCCCCCCCCC
RKARPYSGFENFEFEIPVGHNGDCYDRTVVRVEEIRQSLKIIRQCVDNMPSGPIKADHPL
CCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
TTPPPRERMLHDIETMIHHFVGASWGPVLPPGETTGQVETVRGLTQFALISDGEPSSYRT
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHEEECCCCCCHHHE
RIRTPSFPHLQMISAVAPGMMVADLVAYLGSIDYVMSDVDR
ECCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SATDLVSELGARFGDAVLGEQTTRERFPTVWIRPEASAAVHRYLKHEVERPFRMLVDLW
CHHHHHHHHHHHHCCHHHCCCHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
AIDETARKHREGQPPSGITIASHLMSHERNADIRLKVGLDAEYPSAKSIAGVYPNAAWYE
HHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHC
REAYDMFGVEFEAQPHSLRILLPPGWEGHPMRKTQPGRATERPLFNMTAALFDAKEHALA
CHHHHHHCEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCC
ADPEKFGLPTHRDGVELMILNYGPHSMATHGVFRIVLALDGEEIVAARPDIGFHHRGAEK
CCHHHHCCCCCCCCCEEEEEECCCCHHHHHHHEEEEEEECCCEEEEECCCCCCCCCCHHH
MAERQTWHNFLPYTDRVDYLGGVMGEMPYLQAVEKACGITVPDRALTVRVMLSEMFRIMN
HHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHH
HLLFYGTMAQDTGAMSPVFYMFVDRERGYRVIEAITGARMHPGYFRIGGLSMDLPQGWDR
HHHHHCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHCCCCCCCEEEECCEECCCCHHHHH
LVREFLDWMPARLADYEGMVLRNEIFQARTKGVAAYDTAMALDWGVTGPGLRATGSAWDV
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHEEEECCCCCCCCCCCCCCCCC
RKARPYSGFENFEFEIPVGHNGDCYDRTVVRVEEIRQSLKIIRQCVDNMPSGPIKADHPL
CCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
TTPPPRERMLHDIETMIHHFVGASWGPVLPPGETTGQVETVRGLTQFALISDGEPSSYRT
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHEEECCCCCCHHHE
RIRTPSFPHLQMISAVAPGMMVADLVAYLGSIDYVMSDVDR
ECCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA