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The map label for this gene is serA [H]

Identifier: 86748440

GI number: 86748440

Start: 1497847

End: 1499436

Strand: Direct

Name: serA [H]

Synonym: RPB_1315

Alternate gene names: 86748440

Gene position: 1497847-1499436 (Clockwise)

Preceding gene: 86748439

Following gene: 86748441

Centisome position: 28.09

GC content: 64.97

Gene sequence:

>1590_bases
ATGACCGCACCCAAAGTCCTCATTTCCGACGCCCTGTCGGAAGCCGCCGTGCAGATCTTCAAGGATCGCGGCATCGACGT
CGATTTCCAGCCGGCGCTCGGTAAAGACAAAGAGAAGCTCGCCGAGATCATCGGCAATTACGACGGCCTGGCGATTCGCT
CGGCCACCAAGGCGACCGCGAAGATTCTCGAAAAGGCCACCCGGCTGAAGGTGATCGGCCGCGCCGGCATCGGCGTCGAC
AACGTCGAAATCCCCGCCGCGACCGCCAAGGGCGTGATCGTGATGAACACGCCGTTCGGCAATTCGATCACCACCGCCGA
GCACGCCATCACCATGATGCTGGCGCTGGCCCGCGAGATCCCGGCGGCCGACGCCTCGACCCAGGCCGGCAAGTGGGAGA
AGAACCGCTTCATGGGCGTCGAGATCACCGCCAAGACGCTCGGCGTGATCGGCTGCGGCAATATCGGCTCGATCGCCGCC
GACCGCGCGCTCGGCCTGAAGATGAAGGTGATCGCGTTCGATCCGTTCCTGTCGCCGGAGCGCGCGCGCGATCTCGGCGT
CGAGAAGGTCGAGCTCGAAGACCTGTTCAAGCGCGCCGATTTCATCACGCTGCACACCCCGCTCACCGACAAGACCAAGA
ACATCATCGACGCCGCCGCCATCGCCAAGATGAAGAAGGGCGTCCGCATCATCAATTGTGCCCGCGGCGGTCTGGTCGAC
GAGCAGGCGCTCGCCGAGGCGCTGAAGTCCGGCCAGGTCGCCGGCGCGGCGTTCGACGTGTTCTCCGAAGAGCCGGCGAC
CAGCAACGTGCTGTTCGGCCTGCCCAACGTGATCTGCACCCCGCATCTCGGCGCCTCGACCACCGAAGCGCAGGAGAACG
TCGCGCTGCAGGTCGCCGAACAGATGAGCGACTATCTGCTCAACGGCGCCATCACCAACGCCGTCAACTTCCCGTCGATC
ACCGCCGAAGAAGCGCCGAAGCTGAAGCCGTTCATCGAGCTGGCCGAAAAGCTCGGCTCGTTCGCCGGCCAATTGACCGA
AACGGGCATCACCAAGGTCACCATCACCTACGAGGGTGAAGTCGCCGAGATGAAGATCAAGGCGCTGACCTCCGCGGTGC
TGTCGGGTCTGCTGCGGCCGATGCTGGGCGACATCAACGTCGTCTCCGCGCCGGTGATCGCCAAGGAGCGCGGCATGGTG
GTGGACGAGATCGTCCGCGCCGCCGAGAGCGACTACGAGAGCCTGATCACCCTGACGGTCGCCACCGAGAAGCAGGAACG
CTCGGTGTCCGGCACCGTCTATGCCGACGGCAAGCCGCGCCTGGTCGACATCAAGGGCATTCGCGTCGACGCCGAATTCG
GCCAATCGATGATCTACGTCACCAACGAGGACAAGCCGGGCTTCATCGGCAAGTTCGCGAGCCTGCTGGGTGACGCCAAG
GTCAACATCGCCACCTTCAATCTCGGCCGCCACAGCCAGGGCGGCGACGCCATCGCGCTGGTCGAGATCGACGGCCCGGC
GCCCGCCGACGTCATCGCCAAGGTGCAGGCGCTGCCGCAGGTGAAGCAGGCCAAAGCGCTGGCGTTCTGA

Upstream 100 bases:

>100_bases
CGCCACCCCTCACCCGTCGCGGACTGCGTCCGCGCCACCCTCTCCCACAAGGGGAGAGGGGAAGAGCGCCTCCCAATTCA
TTTCAGCAGGATCACATCCC

Downstream 100 bases:

>100_bases
GACTTTCGCCTTAGCAAATCGGCGACAGACGATGAAATCCCTCCCTCGCGGGAGGGATTTTGCGTTCCGCTGTGCGGCAA
AAGACACAAGCTGTGCAAAG

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 529; Mature: 528

Protein sequence:

>529_residues
MTAPKVLISDALSEAAVQIFKDRGIDVDFQPALGKDKEKLAEIIGNYDGLAIRSATKATAKILEKATRLKVIGRAGIGVD
NVEIPAATAKGVIVMNTPFGNSITTAEHAITMMLALAREIPAADASTQAGKWEKNRFMGVEITAKTLGVIGCGNIGSIAA
DRALGLKMKVIAFDPFLSPERARDLGVEKVELEDLFKRADFITLHTPLTDKTKNIIDAAAIAKMKKGVRIINCARGGLVD
EQALAEALKSGQVAGAAFDVFSEEPATSNVLFGLPNVICTPHLGASTTEAQENVALQVAEQMSDYLLNGAITNAVNFPSI
TAEEAPKLKPFIELAEKLGSFAGQLTETGITKVTITYEGEVAEMKIKALTSAVLSGLLRPMLGDINVVSAPVIAKERGMV
VDEIVRAAESDYESLITLTVATEKQERSVSGTVYADGKPRLVDIKGIRVDAEFGQSMIYVTNEDKPGFIGKFASLLGDAK
VNIATFNLGRHSQGGDAIALVEIDGPAPADVIAKVQALPQVKQAKALAF

Sequences:

>Translated_529_residues
MTAPKVLISDALSEAAVQIFKDRGIDVDFQPALGKDKEKLAEIIGNYDGLAIRSATKATAKILEKATRLKVIGRAGIGVD
NVEIPAATAKGVIVMNTPFGNSITTAEHAITMMLALAREIPAADASTQAGKWEKNRFMGVEITAKTLGVIGCGNIGSIAA
DRALGLKMKVIAFDPFLSPERARDLGVEKVELEDLFKRADFITLHTPLTDKTKNIIDAAAIAKMKKGVRIINCARGGLVD
EQALAEALKSGQVAGAAFDVFSEEPATSNVLFGLPNVICTPHLGASTTEAQENVALQVAEQMSDYLLNGAITNAVNFPSI
TAEEAPKLKPFIELAEKLGSFAGQLTETGITKVTITYEGEVAEMKIKALTSAVLSGLLRPMLGDINVVSAPVIAKERGMV
VDEIVRAAESDYESLITLTVATEKQERSVSGTVYADGKPRLVDIKGIRVDAEFGQSMIYVTNEDKPGFIGKFASLLGDAK
VNIATFNLGRHSQGGDAIALVEIDGPAPADVIAKVQALPQVKQAKALAF
>Mature_528_residues
TAPKVLISDALSEAAVQIFKDRGIDVDFQPALGKDKEKLAEIIGNYDGLAIRSATKATAKILEKATRLKVIGRAGIGVDN
VEIPAATAKGVIVMNTPFGNSITTAEHAITMMLALAREIPAADASTQAGKWEKNRFMGVEITAKTLGVIGCGNIGSIAAD
RALGLKMKVIAFDPFLSPERARDLGVEKVELEDLFKRADFITLHTPLTDKTKNIIDAAAIAKMKKGVRIINCARGGLVDE
QALAEALKSGQVAGAAFDVFSEEPATSNVLFGLPNVICTPHLGASTTEAQENVALQVAEQMSDYLLNGAITNAVNFPSIT
AEEAPKLKPFIELAEKLGSFAGQLTETGITKVTITYEGEVAEMKIKALTSAVLSGLLRPMLGDINVVSAPVIAKERGMVV
DEIVRAAESDYESLITLTVATEKQERSVSGTVYADGKPRLVDIKGIRVDAEFGQSMIYVTNEDKPGFIGKFASLLGDAKV
NIATFNLGRHSQGGDAIALVEIDGPAPADVIAKVQALPQVKQAKALAF

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=399, Percent_Identity=44.1102756892231, Blast_Score=332, Evalue=4e-91,
Organism=Homo sapiens, GI61743967, Length=282, Percent_Identity=35.1063829787234, Blast_Score=149, Evalue=7e-36,
Organism=Homo sapiens, GI4557497, Length=282, Percent_Identity=35.1063829787234, Blast_Score=149, Evalue=9e-36,
Organism=Homo sapiens, GI145580578, Length=242, Percent_Identity=38.8429752066116, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI4557499, Length=242, Percent_Identity=38.8429752066116, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI145580575, Length=262, Percent_Identity=37.4045801526718, Blast_Score=146, Evalue=6e-35,
Organism=Homo sapiens, GI6912396, Length=265, Percent_Identity=30.5660377358491, Blast_Score=117, Evalue=3e-26,
Organism=Escherichia coli, GI1789279, Length=325, Percent_Identity=37.2307692307692, Blast_Score=186, Evalue=2e-48,
Organism=Escherichia coli, GI87082289, Length=318, Percent_Identity=29.874213836478, Blast_Score=149, Evalue=5e-37,
Organism=Escherichia coli, GI1787645, Length=304, Percent_Identity=32.5657894736842, Blast_Score=135, Evalue=6e-33,
Organism=Escherichia coli, GI1788660, Length=267, Percent_Identity=28.8389513108614, Blast_Score=76, Evalue=6e-15,
Organism=Escherichia coli, GI87081824, Length=245, Percent_Identity=26.1224489795918, Blast_Score=66, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=308, Percent_Identity=47.4025974025974, Blast_Score=278, Evalue=5e-75,
Organism=Caenorhabditis elegans, GI25147481, Length=251, Percent_Identity=33.8645418326693, Blast_Score=142, Evalue=6e-34,
Organism=Saccharomyces cerevisiae, GI6322116, Length=332, Percent_Identity=35.2409638554217, Blast_Score=207, Evalue=3e-54,
Organism=Saccharomyces cerevisiae, GI6320925, Length=331, Percent_Identity=34.7432024169184, Blast_Score=207, Evalue=5e-54,
Organism=Saccharomyces cerevisiae, GI6324055, Length=272, Percent_Identity=29.4117647058824, Blast_Score=135, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6324964, Length=310, Percent_Identity=27.0967741935484, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6325144, Length=115, Percent_Identity=37.3913043478261, Blast_Score=76, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6324980, Length=197, Percent_Identity=26.3959390862944, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI19921140, Length=325, Percent_Identity=44, Blast_Score=276, Evalue=3e-74,
Organism=Drosophila melanogaster, GI24646446, Length=260, Percent_Identity=35.7692307692308, Blast_Score=138, Evalue=8e-33,
Organism=Drosophila melanogaster, GI24646448, Length=260, Percent_Identity=35.7692307692308, Blast_Score=138, Evalue=8e-33,
Organism=Drosophila melanogaster, GI24646452, Length=260, Percent_Identity=35.7692307692308, Blast_Score=138, Evalue=8e-33,
Organism=Drosophila melanogaster, GI24646450, Length=260, Percent_Identity=35.7692307692308, Blast_Score=138, Evalue=8e-33,
Organism=Drosophila melanogaster, GI62472511, Length=260, Percent_Identity=35.7692307692308, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24585516, Length=304, Percent_Identity=27.3026315789474, Blast_Score=125, Evalue=1e-28,
Organism=Drosophila melanogaster, GI28574286, Length=244, Percent_Identity=30.7377049180328, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24585514, Length=267, Percent_Identity=27.7153558052434, Blast_Score=115, Evalue=8e-26,
Organism=Drosophila melanogaster, GI28574282, Length=267, Percent_Identity=27.7153558052434, Blast_Score=115, Evalue=8e-26,
Organism=Drosophila melanogaster, GI45551003, Length=267, Percent_Identity=27.7153558052434, Blast_Score=115, Evalue=9e-26,
Organism=Drosophila melanogaster, GI28574284, Length=267, Percent_Identity=27.7153558052434, Blast_Score=115, Evalue=1e-25,
Organism=Drosophila melanogaster, GI45552429, Length=267, Percent_Identity=27.7153558052434, Blast_Score=115, Evalue=1e-25,
Organism=Drosophila melanogaster, GI28571528, Length=265, Percent_Identity=29.0566037735849, Blast_Score=104, Evalue=2e-22,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 55984; Mature: 55853

Theoretical pI: Translated: 5.19; Mature: 5.19

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAPKVLISDALSEAAVQIFKDRGIDVDFQPALGKDKEKLAEIIGNYDGLAIRSATKATA
CCCCHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHCCCCCEEEEHHHHHHH
KILEKATRLKVIGRAGIGVDNVEIPAATAKGVIVMNTPFGNSITTAEHAITMMLALAREI
HHHHHHHHEEEEECCCCCCCCEECCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHC
PAADASTQAGKWEKNRFMGVEITAKTLGVIGCGNIGSIAADRALGLKMKVIAFDPFLSPE
CCCCCCCCCCCCCCCCEEEEEEEHHHEEEEECCCCCCHHHHHHCCCEEEEEEECCCCCCH
RARDLGVEKVELEDLFKRADFITLHTPLTDKTKNIIDAAAIAKMKKGVRIINCARGGLVD
HHHHCCCCEECHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCC
EQALAEALKSGQVAGAAFDVFSEEPATSNVLFGLPNVICTPHLGASTTEAQENVALQVAE
HHHHHHHHHCCCCCCEEEEHHCCCCCCCCEEECCCCCEECCCCCCCCCHHHHHHHHHHHH
QMSDYLLNGAITNAVNFPSITAEEAPKLKPFIELAEKLGSFAGQLTETGITKVTITYEGE
HHHHHHHHCHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEECCC
VAEMKIKALTSAVLSGLLRPMLGDINVVSAPVIAKERGMVVDEIVRAAESDYESLITLTV
HHHHHHHHHHHHHHHHHHHHHHCCCEEECCCEEECCCCCHHHHHHHHHHCCCCEEEEEEE
ATEKQERSVSGTVYADGKPRLVDIKGIRVDAEFGQSMIYVTNEDKPGFIGKFASLLGDAK
ECCHHHCCCCCEEEECCCCEEEEEEEEEEEHHHCCEEEEEECCCCCCHHHHHHHHHCCCE
VNIATFNLGRHSQGGDAIALVEIDGPAPADVIAKVQALPQVKQAKALAF
EEEEEEECCCCCCCCCEEEEEEECCCCCHHHHHHHHHCCHHHHHHHCCC
>Mature Secondary Structure 
TAPKVLISDALSEAAVQIFKDRGIDVDFQPALGKDKEKLAEIIGNYDGLAIRSATKATA
CCCHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHCCCCCEEEEHHHHHHH
KILEKATRLKVIGRAGIGVDNVEIPAATAKGVIVMNTPFGNSITTAEHAITMMLALAREI
HHHHHHHHEEEEECCCCCCCCEECCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHC
PAADASTQAGKWEKNRFMGVEITAKTLGVIGCGNIGSIAADRALGLKMKVIAFDPFLSPE
CCCCCCCCCCCCCCCCEEEEEEEHHHEEEEECCCCCCHHHHHHCCCEEEEEEECCCCCCH
RARDLGVEKVELEDLFKRADFITLHTPLTDKTKNIIDAAAIAKMKKGVRIINCARGGLVD
HHHHCCCCEECHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCC
EQALAEALKSGQVAGAAFDVFSEEPATSNVLFGLPNVICTPHLGASTTEAQENVALQVAE
HHHHHHHHHCCCCCCEEEEHHCCCCCCCCEEECCCCCEECCCCCCCCCHHHHHHHHHHHH
QMSDYLLNGAITNAVNFPSITAEEAPKLKPFIELAEKLGSFAGQLTETGITKVTITYEGE
HHHHHHHHCHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEECCC
VAEMKIKALTSAVLSGLLRPMLGDINVVSAPVIAKERGMVVDEIVRAAESDYESLITLTV
HHHHHHHHHHHHHHHHHHHHHHCCCEEECCCEEECCCCCHHHHHHHHHHCCCCEEEEEEE
ATEKQERSVSGTVYADGKPRLVDIKGIRVDAEFGQSMIYVTNEDKPGFIGKFASLLGDAK
ECCHHHCCCCCEEEECCCCEEEEEEEEEEEHHHCCEEEEEECCCCCCHHHHHHHHHCCCE
VNIATFNLGRHSQGGDAIALVEIDGPAPADVIAKVQALPQVKQAKALAF
EEEEEEECCCCCCCCCEEEEEEECCCCCHHHHHHHHHCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]