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The map label for this gene is pyrC [H]

Identifier: 86748243

GI number: 86748243

Start: 1287015

End: 1288349

Strand: Direct

Name: pyrC [H]

Synonym: RPB_1118

Alternate gene names: 86748243

Gene position: 1287015-1288349 (Clockwise)

Preceding gene: 86748240

Following gene: 86748245

Centisome position: 24.14

GC content: 68.01

Gene sequence:

>1335_bases
ATGACCGCCACATTCGATACCATTCTGAAAGGCGCCACGATCGTCAACCACGACGGCGAGGGCATCGGCGACATCGGAAT
CAGCGGCGGCCGGATCGCGGCGCTGGGCTCGCTCGGCGCCGAAAAGGCCGGCGAGACGATCGATTGCGGCGGCCTGCATG
TGCTGCCGGGCGTGATCGACACCCAGGTGCATTTCCGCGAACCGGGCCTCACCCACAAGGAAGACCTCGAAACCGGCTCG
CGCAGCGCGGTGATGGGCGGCGTCACCGCGGTGTTCGAAATGCCGAACACCAACCCGCTGACCGTCACCGAAGAGACCTT
CACCGACAAGGTGAAACGCGCCGAGCACCGGATGCATTGCGACTTCGCGTTCTTCATCGGCGGCACCCGCGACAATGTCG
ATGAGCTGCCGAAGCTCGAGCGCGCCCGCGGCTGCGCCGGCGTCAAGGTGTTCATCGGCTCCTCGACCGGCAGCCTCTTG
GTCGAGGACGATCCGAGCCTGCGCCGCATCCTCAACGTGATCCAGCGCCGCGCCGCGTTCCACGCCGAGGACGAGTACCG
GCTCGAGGACCGCAAGGGCGAGCGCATCGAGGGCGATCCGCGCTCGCATCCGGTGTGGCGCGACGACATCGCCGCATTGA
CGGCGACGCAGCGGCTGGTGGCGATCGCGCGTGAGACCGGCAAGCGCATCCACGTGCTGCACGTCTCGACCCGTCAGGAG
ATGGAGTTTCTGCGCGAGCACAAGGACGTCGCGTCGGTCGAGGTGACGCCGCATCATCTGACGCTGGTCGGACCGGAGTG
CTACGAGCGGCTCGGCACCAAGGCGCAGATGAATCCGCCGGTGCGCGATGCGTGGCATCGCGACGGCATCTGGCACGGCC
TGGCGCAGGGCGTCGTCGACGTGCTCGGCTCGGATCATGCGCCGCACACGCTGGAGGAAAAGGCCAAGACCTATCCGGCC
TCGCCGTCCGGCATGACCGGGGTGCAGACGCTGGTGCCGACCATGCTCGACCACGTCAACGCCGGAAAATTGTCGCTGGC
GCGCTTCGTCGATCTCACCAGCGCGGGGCCGGCGCGGCTGTTTGGCATCGCCTGCAAGGGCCGCATCGCCGCCGGCTACG
ACGCCGACTTCACGGTGGTCGATCTGAAGCGCAGCGAGACCATCACCAACGACTGGGTCGCCTCGCGCGCCGGCTGGACG
CCCTATGACGGCGTCCGCGTCACCGGCTGGCCGGTCGGCACCTTCGTGCGCGGCGCCAGGGTGATGTGGCAGGGCGAACT
CGCAACGCCCGCGACCGGCGAGCCGGTGCGGTTTCTGGAGACGCTGAAGCCGTAA

Upstream 100 bases:

>100_bases
ACCGGCCGGCTGGATAAGACATTTCAAGGTAAGCGGCCGGGCTCCGGCCAACAAGAGTTGCAAGACTCGCGCCGGACCAT
CCGAGGGGTATTCGACCAGC

Downstream 100 bases:

>100_bases
GCGGCTTCAGCCTGGCACGTCGATCGTGGTGTTGAACACCACGAGGTCGCCGCGGTAGAGGCCGGTCGAGAAGAACACGA
TCTCGTCTTTGCGGTTGGTG

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 444; Mature: 443

Protein sequence:

>444_residues
MTATFDTILKGATIVNHDGEGIGDIGISGGRIAALGSLGAEKAGETIDCGGLHVLPGVIDTQVHFREPGLTHKEDLETGS
RSAVMGGVTAVFEMPNTNPLTVTEETFTDKVKRAEHRMHCDFAFFIGGTRDNVDELPKLERARGCAGVKVFIGSSTGSLL
VEDDPSLRRILNVIQRRAAFHAEDEYRLEDRKGERIEGDPRSHPVWRDDIAALTATQRLVAIARETGKRIHVLHVSTRQE
MEFLREHKDVASVEVTPHHLTLVGPECYERLGTKAQMNPPVRDAWHRDGIWHGLAQGVVDVLGSDHAPHTLEEKAKTYPA
SPSGMTGVQTLVPTMLDHVNAGKLSLARFVDLTSAGPARLFGIACKGRIAAGYDADFTVVDLKRSETITNDWVASRAGWT
PYDGVRVTGWPVGTFVRGARVMWQGELATPATGEPVRFLETLKP

Sequences:

>Translated_444_residues
MTATFDTILKGATIVNHDGEGIGDIGISGGRIAALGSLGAEKAGETIDCGGLHVLPGVIDTQVHFREPGLTHKEDLETGS
RSAVMGGVTAVFEMPNTNPLTVTEETFTDKVKRAEHRMHCDFAFFIGGTRDNVDELPKLERARGCAGVKVFIGSSTGSLL
VEDDPSLRRILNVIQRRAAFHAEDEYRLEDRKGERIEGDPRSHPVWRDDIAALTATQRLVAIARETGKRIHVLHVSTRQE
MEFLREHKDVASVEVTPHHLTLVGPECYERLGTKAQMNPPVRDAWHRDGIWHGLAQGVVDVLGSDHAPHTLEEKAKTYPA
SPSGMTGVQTLVPTMLDHVNAGKLSLARFVDLTSAGPARLFGIACKGRIAAGYDADFTVVDLKRSETITNDWVASRAGWT
PYDGVRVTGWPVGTFVRGARVMWQGELATPATGEPVRFLETLKP
>Mature_443_residues
TATFDTILKGATIVNHDGEGIGDIGISGGRIAALGSLGAEKAGETIDCGGLHVLPGVIDTQVHFREPGLTHKEDLETGSR
SAVMGGVTAVFEMPNTNPLTVTEETFTDKVKRAEHRMHCDFAFFIGGTRDNVDELPKLERARGCAGVKVFIGSSTGSLLV
EDDPSLRRILNVIQRRAAFHAEDEYRLEDRKGERIEGDPRSHPVWRDDIAALTATQRLVAIARETGKRIHVLHVSTRQEM
EFLREHKDVASVEVTPHHLTLVGPECYERLGTKAQMNPPVRDAWHRDGIWHGLAQGVVDVLGSDHAPHTLEEKAKTYPAS
PSGMTGVQTLVPTMLDHVNAGKLSLARFVDLTSAGPARLFGIACKGRIAAGYDADFTVVDLKRSETITNDWVASRAGWTP
YDGVRVTGWPVGTFVRGARVMWQGELATPATGEPVRFLETLKP

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=425, Percent_Identity=31.2941176470588, Blast_Score=175, Evalue=7e-44,
Organism=Homo sapiens, GI19923821, Length=456, Percent_Identity=26.9736842105263, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI4503379, Length=444, Percent_Identity=25.4504504504505, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI4503375, Length=461, Percent_Identity=25.1626898047722, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI4503051, Length=444, Percent_Identity=24.5495495495495, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI62422571, Length=446, Percent_Identity=25.1121076233184, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI190194363, Length=454, Percent_Identity=25.3303964757709, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI4503377, Length=444, Percent_Identity=24.5495495495495, Blast_Score=102, Evalue=6e-22,
Organism=Escherichia coli, GI1786722, Length=441, Percent_Identity=32.6530612244898, Blast_Score=197, Evalue=2e-51,
Organism=Escherichia coli, GI87082175, Length=451, Percent_Identity=27.2727272727273, Blast_Score=156, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI193204318, Length=427, Percent_Identity=29.03981264637, Blast_Score=172, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI71989490, Length=461, Percent_Identity=24.295010845987, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17539558, Length=452, Percent_Identity=25.2212389380531, Blast_Score=102, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI86575075, Length=443, Percent_Identity=24.1534988713318, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6322218, Length=388, Percent_Identity=29.639175257732, Blast_Score=136, Evalue=6e-33,
Organism=Drosophila melanogaster, GI24642586, Length=390, Percent_Identity=31.2820512820513, Blast_Score=186, Evalue=3e-47,
Organism=Drosophila melanogaster, GI18859883, Length=411, Percent_Identity=27.9805352798054, Blast_Score=118, Evalue=6e-27,
Organism=Drosophila melanogaster, GI221377917, Length=444, Percent_Identity=26.5765765765766, Blast_Score=107, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 48381; Mature: 48250

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTATFDTILKGATIVNHDGEGIGDIGISGGRIAALGSLGAEKAGETIDCGGLHVLPGVID
CCCCHHHHHCCCEEEECCCCCCCCCCCCCCCEEEEECCCHHHCCCEECCCCEEECCCCCC
TQVHFREPGLTHKEDLETGSRSAVMGGVTAVFEMPNTNPLTVTEETFTDKVKRAEHRMHC
CEEEECCCCCCCHHHHCCCCCHHHHCCEEEEEECCCCCCEEEEHHHHHHHHHHHHHHHCC
DFAFFIGGTRDNVDELPKLERARGCAGVKVFIGSSTGSLLVEDDPSLRRILNVIQRRAAF
EEEEEECCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHC
HAEDEYRLEDRKGERIEGDPRSHPVWRDDIAALTATQRLVAIARETGKRIHVLHVSTRQE
CCCCCCEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCHHH
MEFLREHKDVASVEVTPHHLTLVGPECYERLGTKAQMNPPVRDAWHRDGIWHGLAQGVVD
HHHHHHCCCCEEEEECCCEEEEECHHHHHHCCCCCCCCCCHHHHHHCCCHHHHHHHHHHH
VLGSDHAPHTLEEKAKTYPASPSGMTGVQTLVPTMLDHVNAGKLSLARFVDLTSAGPARL
HHCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCE
FGIACKGRIAAGYDADFTVVDLKRSETITNDWVASRAGWTPYDGVRVTGWPVGTFVRGAR
EEEEECCCEECCCCCCEEEEEECCCCCCCHHHHHHCCCCCCCCCEEEECCCHHHHHHCCE
VMWQGELATPATGEPVRFLETLKP
EEEECCCCCCCCCCHHHHHHHCCC
>Mature Secondary Structure 
TATFDTILKGATIVNHDGEGIGDIGISGGRIAALGSLGAEKAGETIDCGGLHVLPGVID
CCCHHHHHCCCEEEECCCCCCCCCCCCCCCEEEEECCCHHHCCCEECCCCEEECCCCCC
TQVHFREPGLTHKEDLETGSRSAVMGGVTAVFEMPNTNPLTVTEETFTDKVKRAEHRMHC
CEEEECCCCCCCHHHHCCCCCHHHHCCEEEEEECCCCCCEEEEHHHHHHHHHHHHHHHCC
DFAFFIGGTRDNVDELPKLERARGCAGVKVFIGSSTGSLLVEDDPSLRRILNVIQRRAAF
EEEEEECCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCEEEECCHHHHHHHHHHHHHHHC
HAEDEYRLEDRKGERIEGDPRSHPVWRDDIAALTATQRLVAIARETGKRIHVLHVSTRQE
CCCCCCEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCHHH
MEFLREHKDVASVEVTPHHLTLVGPECYERLGTKAQMNPPVRDAWHRDGIWHGLAQGVVD
HHHHHHCCCCEEEEECCCEEEEECHHHHHHCCCCCCCCCCHHHHHHCCCHHHHHHHHHHH
VLGSDHAPHTLEEKAKTYPASPSGMTGVQTLVPTMLDHVNAGKLSLARFVDLTSAGPARL
HHCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCE
FGIACKGRIAAGYDADFTVVDLKRSETITNDWVASRAGWTPYDGVRVTGWPVGTFVRGAR
EEEEECCCEECCCCCCEEEEEECCCCCCCHHHHHHCCCCCCCCCEEEECCCHHHHHHCCE
VMWQGELATPATGEPVRFLETLKP
EEEECCCCCCCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA