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The map label for this gene is ffh [H]

Identifier: 86747479

GI number: 86747479

Start: 395757

End: 397301

Strand: Reverse

Name: ffh [H]

Synonym: RPB_0353

Alternate gene names: 86747479

Gene position: 397301-395757 (Counterclockwise)

Preceding gene: 86747483

Following gene: 86747478

Centisome position: 7.45

GC content: 67.9

Gene sequence:

>1545_bases
ATGTTCGACAATCTGTCGGAAAAGCTGGGTGGGATTCTCGATCGGCTGACCGGGCGCGGGTCGCTGAGCGAGGCCGATGT
CGATGCGGCGATGCGCGAGATCCGCCGCGCGCTGCTCGAGGCCGACGTCGCGCTCGAAGTGGTGCGCTCGTTCACCGACA
AGGTCCGCGAGCAGGCGGTCGGCGCCACCGTCGTCAAATCGGTCAAGCCCGGCCAGATGGTGGTCAAGATCGTCAATGAC
GAGCTGATCGCCATGCTGGGCTCCGACAGCCAGGCGATCGACCTCAATGCCGTGGCGCCGGTGCCGATCATGATGGTCGG
CCTGCAGGGCTCGGGCAAGACCACCACCACCGCCAAGCTGGCGCGCCGGATGACCAGCCGCGACAAGCGCAAGGTGCTGA
TGGCGTCGCTCGACGTCTATCGCCCGGCGGCGATGGAGCAGCTCGCGGTGCTCGGCCGCGACCTTTCGATCGACACGCTG
CCGATCGTCGCCGGGCAGAAGCCGCCGGATATCGCGCGGCGCGCGATGGAAGCCGGACGGCTCGGCGGCTACGACGTGGT
GCTGCTCGACACCGCCGGCCGCACCACGCTCGACGAAGACATGATGACCGAGGCGGCCGAGATCAAAGCCGCCGCCAATC
CGCACGAAGTGCTGCTGGTCGCGGACTCGCTGACCGGCCAGGACGCGGTCAATCTGGCGCGCGCCTTCGACGAACGCGTC
GGCCTCACCGGCATCGTGCTGACGCGGATCGATGGTGACGGCCGCGGCGGCGCGGCGTTGTCGATGCGCGCGGTCACCGG
CAAGCCGATCAAGCTGATGGGCACCGGCGAAAAGACCGATGCGCTGGAAGATTTCCACCCGAGCCGGATCGCCGGCCGCA
TCCTCGGCATGGGCGACGTCGTCTCGCTGGTCGAGAAGGCCGCCTCGACGCTCGACGCCGAGAAGGCCGCCGCTGCCGTC
GAGAAGATGCGCAAGGGCAAGTTCGACCTCGCCGACATGCGCGAACAGCTCGAGCAGATGACCAAGATGGGCGGCATCGG
CGGGCTGATGGGCATGATGCCCGGCATCTCCAAGATGAAGAACCAGATCGCCGCCGCCGGCGTCGACGACAAGATCCTCA
AGCGCCAGGTCGCGATCATCGATTCGATGACCCGCGAGGAGCGCAAGAACCCCGACATCCTCAAGGCCAGCCGCAAGAAG
CGGATCGCCGCCGGCGCCGGCATCAAGGTCGAGGACGTCAACAAGCTGCTGAAAATGCACCGCAACATGGCCGACATGAT
GAAGGCCGTGGGCCGCGGCAAGGGCGGCCCGATGGCCGGCCTGGCGCAGGCGATGGGCTTCGGCGGCGGCTTGCCCTCGG
CCGAGCAGATCAAGGCGATGCAGGACAAGATGCAGTCGGGCGAGATGCCCGGCGGGCTGCCCGAGCTGCCGAAGGATCTG
CCGCCGAGCCTGCGTGGCGGCCTGCCCAATCTGCCCGGCCTCACGGGTCTTTCCGGCAAGCCGACCCTGCCCGGCCTCGG
CGGCCTGTTCGGGAAGAAGAAATGA

Upstream 100 bases:

>100_bases
GACCGGAGGTCAACGCCCGACAGCGCGATGCGCCCTCGGGCGCCATAAGTGTTTGCTTCTGTAGGCCTTTCACCGGAAGG
CCGTCGCTGGAACTGGGCCG

Downstream 100 bases:

>100_bases
CATGTTTGAATCCGCCTCTAATCTGGCAGTTCCGATCATATCCGCCCTTGCCTCGATCGGAGCTTCGGTGGTCTCAGCTA
GCGTTTCCGTATGGGCATCA

Product: signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 514; Mature: 514

Protein sequence:

>514_residues
MFDNLSEKLGGILDRLTGRGSLSEADVDAAMREIRRALLEADVALEVVRSFTDKVREQAVGATVVKSVKPGQMVVKIVND
ELIAMLGSDSQAIDLNAVAPVPIMMVGLQGSGKTTTTAKLARRMTSRDKRKVLMASLDVYRPAAMEQLAVLGRDLSIDTL
PIVAGQKPPDIARRAMEAGRLGGYDVVLLDTAGRTTLDEDMMTEAAEIKAAANPHEVLLVADSLTGQDAVNLARAFDERV
GLTGIVLTRIDGDGRGGAALSMRAVTGKPIKLMGTGEKTDALEDFHPSRIAGRILGMGDVVSLVEKAASTLDAEKAAAAV
EKMRKGKFDLADMREQLEQMTKMGGIGGLMGMMPGISKMKNQIAAAGVDDKILKRQVAIIDSMTREERKNPDILKASRKK
RIAAGAGIKVEDVNKLLKMHRNMADMMKAVGRGKGGPMAGLAQAMGFGGGLPSAEQIKAMQDKMQSGEMPGGLPELPKDL
PPSLRGGLPNLPGLTGLSGKPTLPGLGGLFGKKK

Sequences:

>Translated_514_residues
MFDNLSEKLGGILDRLTGRGSLSEADVDAAMREIRRALLEADVALEVVRSFTDKVREQAVGATVVKSVKPGQMVVKIVND
ELIAMLGSDSQAIDLNAVAPVPIMMVGLQGSGKTTTTAKLARRMTSRDKRKVLMASLDVYRPAAMEQLAVLGRDLSIDTL
PIVAGQKPPDIARRAMEAGRLGGYDVVLLDTAGRTTLDEDMMTEAAEIKAAANPHEVLLVADSLTGQDAVNLARAFDERV
GLTGIVLTRIDGDGRGGAALSMRAVTGKPIKLMGTGEKTDALEDFHPSRIAGRILGMGDVVSLVEKAASTLDAEKAAAAV
EKMRKGKFDLADMREQLEQMTKMGGIGGLMGMMPGISKMKNQIAAAGVDDKILKRQVAIIDSMTREERKNPDILKASRKK
RIAAGAGIKVEDVNKLLKMHRNMADMMKAVGRGKGGPMAGLAQAMGFGGGLPSAEQIKAMQDKMQSGEMPGGLPELPKDL
PPSLRGGLPNLPGLTGLSGKPTLPGLGGLFGKKK
>Mature_514_residues
MFDNLSEKLGGILDRLTGRGSLSEADVDAAMREIRRALLEADVALEVVRSFTDKVREQAVGATVVKSVKPGQMVVKIVND
ELIAMLGSDSQAIDLNAVAPVPIMMVGLQGSGKTTTTAKLARRMTSRDKRKVLMASLDVYRPAAMEQLAVLGRDLSIDTL
PIVAGQKPPDIARRAMEAGRLGGYDVVLLDTAGRTTLDEDMMTEAAEIKAAANPHEVLLVADSLTGQDAVNLARAFDERV
GLTGIVLTRIDGDGRGGAALSMRAVTGKPIKLMGTGEKTDALEDFHPSRIAGRILGMGDVVSLVEKAASTLDAEKAAAAV
EKMRKGKFDLADMREQLEQMTKMGGIGGLMGMMPGISKMKNQIAAAGVDDKILKRQVAIIDSMTREERKNPDILKASRKK
RIAAGAGIKVEDVNKLLKMHRNMADMMKAVGRGKGGPMAGLAQAMGFGGGLPSAEQIKAMQDKMQSGEMPGGLPELPKDL
PPSLRGGLPNLPGLTGLSGKPTLPGLGGLFGKKK

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=442, Percent_Identity=30.5429864253394, Blast_Score=206, Evalue=4e-53,
Organism=Homo sapiens, GI226371618, Length=343, Percent_Identity=33.2361516034985, Blast_Score=186, Evalue=4e-47,
Organism=Homo sapiens, GI23308697, Length=304, Percent_Identity=29.2763157894737, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI295424842, Length=304, Percent_Identity=29.2763157894737, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI89061728, Length=159, Percent_Identity=31.4465408805031, Blast_Score=100, Evalue=6e-21,
Organism=Escherichia coli, GI1788963, Length=424, Percent_Identity=52.5943396226415, Blast_Score=442, Evalue=1e-125,
Organism=Escherichia coli, GI1789874, Length=255, Percent_Identity=34.9019607843137, Blast_Score=134, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17539958, Length=443, Percent_Identity=29.1196388261851, Blast_Score=201, Evalue=6e-52,
Organism=Caenorhabditis elegans, GI193206261, Length=306, Percent_Identity=29.4117647058824, Blast_Score=107, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6325345, Length=490, Percent_Identity=30.2040816326531, Blast_Score=227, Evalue=4e-60,
Organism=Saccharomyces cerevisiae, GI6320498, Length=315, Percent_Identity=25.3968253968254, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17647949, Length=449, Percent_Identity=30.0668151447661, Blast_Score=187, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24641198, Length=305, Percent_Identity=29.8360655737705, Blast_Score=102, Evalue=5e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 54333; Mature: 54333

Theoretical pI: Translated: 10.18; Mature: 10.18

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
6.4 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
6.4 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDNLSEKLGGILDRLTGRGSLSEADVDAAMREIRRALLEADVALEVVRSFTDKVREQAV
CCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GATVVKSVKPGQMVVKIVNDELIAMLGSDSQAIDLNAVAPVPIMMVGLQGSGKTTTTAKL
HHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCEEEEEECCCCCCHHHHHH
ARRMTSRDKRKVLMASLDVYRPAAMEQLAVLGRDLSIDTLPIVAGQKPPDIARRAMEAGR
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHCC
LGGYDVVLLDTAGRTTLDEDMMTEAAEIKAAANPHEVLLVADSLTGQDAVNLARAFDERV
CCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHC
GLTGIVLTRIDGDGRGGAALSMRAVTGKPIKLMGTGEKTDALEDFHPSRIAGRILGMGDV
CCEEEEEEEECCCCCCCCEEEEEEECCCCEEEEECCCCHHHHHHCCHHHHHHHHCCHHHH
VSLVEKAASTLDAEKAAAAVEKMRKGKFDLADMREQLEQMTKMGGIGGLMGMMPGISKMK
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHH
NQIAAAGVDDKILKRQVAIIDSMTREERKNPDILKASRKKRIAAGAGIKVEDVNKLLKMH
HHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHH
RNMADMMKAVGRGKGGPMAGLAQAMGFGGGLPSAEQIKAMQDKMQSGEMPGGLPELPKDL
HHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCC
PPSLRGGLPNLPGLTGLSGKPTLPGLGGLFGKKK
CCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MFDNLSEKLGGILDRLTGRGSLSEADVDAAMREIRRALLEADVALEVVRSFTDKVREQAV
CCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GATVVKSVKPGQMVVKIVNDELIAMLGSDSQAIDLNAVAPVPIMMVGLQGSGKTTTTAKL
HHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCEEEEEECCCCCCHHHHHH
ARRMTSRDKRKVLMASLDVYRPAAMEQLAVLGRDLSIDTLPIVAGQKPPDIARRAMEAGR
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHCC
LGGYDVVLLDTAGRTTLDEDMMTEAAEIKAAANPHEVLLVADSLTGQDAVNLARAFDERV
CCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHC
GLTGIVLTRIDGDGRGGAALSMRAVTGKPIKLMGTGEKTDALEDFHPSRIAGRILGMGDV
CCEEEEEEEECCCCCCCCEEEEEEECCCCEEEEECCCCHHHHHHCCHHHHHHHHCCHHHH
VSLVEKAASTLDAEKAAAAVEKMRKGKFDLADMREQLEQMTKMGGIGGLMGMMPGISKMK
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHCCCHHHHH
NQIAAAGVDDKILKRQVAIIDSMTREERKNPDILKASRKKRIAAGAGIKVEDVNKLLKMH
HHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHH
RNMADMMKAVGRGKGGPMAGLAQAMGFGGGLPSAEQIKAMQDKMQSGEMPGGLPELPKDL
HHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCC
PPSLRGGLPNLPGLTGLSGKPTLPGLGGLFGKKK
CCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11557893 [H]