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The map label for this gene is sdhA [H]

Identifier: 86747451

GI number: 86747451

Start: 369667

End: 371490

Strand: Reverse

Name: sdhA [H]

Synonym: RPB_0325

Alternate gene names: 86747451

Gene position: 371490-369667 (Counterclockwise)

Preceding gene: 86747452

Following gene: 86747450

Centisome position: 6.97

GC content: 67.32

Gene sequence:

>1824_bases
ATGGCGGCGAACGGCAACGGCGCAGCGGCCGCGGGCGGCCACGCCTATCCGATCGAAGATCACGTCTATGATGTCGTCGT
GGTCGGCGCCGGCGGCGCCGGCCTGCGCGCGGTGGTGGGCTGCAGCGAAGCGGGGCTGCGCACCGCCTGCATCACCAAGG
TGTTTCCGACCCGCTCCCACACCGTGGCGGCGCAGGGCGGCATCTCGGCCTCGCTCGGCAACATGCACAAGGACGACTGG
CGCTGGCACATGTACGACACCGTCAAGGGGTCGGACTGGCTCGGCGATCAGGATTCGATCGAGTACATGGTGCGCAACGC
GCCCGAGGCGGTCTACGAGCTCGAACATTGGGGCGTGCCGTTCTCGCGCACCGAGGACGGCAAGATCTATCAGCGGCCGT
TCGGTGGCATGACGCTGGACTTCGGCAAGGGCCAGGCACAGCGCACCTGCGCGGCCGCCGACCGCACCGGCCACGCCATG
CTGCACACGATGTACGGCCAGGCGCTGCGTCATTCGGCCGAGTTCTACATCGAGTTCTTCGCCATCGACCTGATCATGGA
CGACCAGGGCGTCTGCCGCGGCGTCATTGCGCTCAAGCTCGACGACGGCACCATCCACCGCTTCAAGGCGCAGACCACGA
TCCTGGCCACCGGCGGCTACGGCCGCGCCTACGCCTCCTGCACCTCGGCGCACACCTGCACCGGCGACGGCGGCGCGATG
GCGCTGCGCGCCGGTCTGCCGCTGCAGGACATGGAGTTCGTGCAGTTTCACCCGACCGGCATCTACGGCTCGGGCTGCCT
CGTCACCGAAGGCGCCCGCGGCGAGGGCGGCTATCTGGTGAATTCCGAAGGCGAGCGCTTCATGGAGCGCTACGCGCCCT
CCGCCAAGGATCTCGCCTCGCGCGACGTCGTCTCGCGCGCGATGACGATCGAAATGCGCGAAGGCCGCGGCGTCGGCAAG
AAGAAGGACCACATCTTCCTGCACCTCGACCATCTGGCGCCGGAAGTGCTGCACGAGCGGCTGCCGGGCATCTCCGAATC
GGCGCGGATCTTCGCCGGCGTCGACGTCACCCGCGAGCCGATCCCGATCCTGCCGACCGTGCACTACAACATGGGCGGCA
TCCCGACCAACTTCCACGGCGAAGTCGTCACCAAGAAGGACGGCGACGACAACGCGGTGGTGCCGGGCCTGATGGCGATC
GGCGAGGCCGCCTGCGTGTCGGTGCACGGCGCCAACCGCCTCGGCTCGAATTCGCTGATCGACCTCGTGGTGTTCGGCCG
CGCCGCCGCCTTGCGCTGCGCCGAGAAGCTGACCCCCAACGGCAAGCAGCCGGAGCTGCCGGCGGATTCCGCCGACCTGT
CGCTCGGCCGGCTCGACAAATATCGCTACGCCAAGGGCGGTACCCCGACCGCCAAGCTGCGCGAAAGCATGCAATCGGTG
ATGCAGAACAATTGCGCGGTGTTCCGCACCGGCGAGGTTCTGTCCGAGGGCAAGGATCTGATCCGCAAGGTGTATGGCGG
CGTCGGCGACGTCGGCGTGTCGGACCGTTCGCTGGTGTGGAATTCCGATCTGGTCGAGACGCTGGAGTTCGACAATCTGA
TCATCCAGGCGGTGGTGACGATGAATTCCGCCGCCAACCGCACCGAAAGCCGCGGCGCCCATGCGCGCGAGGATTTTCCG
GATCGCGACGACACCCAGTGGATGAAGCACACGCTGGCGTGGATCGGCGACGACGGCGGCACCACGATCGATTACCGCCC
GGTGCACGACTACACGATGACCAACGACGTCCAGTACATCCCGCCGAAGCCGCGGGTGTATTGA

Upstream 100 bases:

>100_bases
GCTCAAGCTCGTCACGGTGATGGCCAACAATTTCTTTTCGATCGCCGTGGCGCTCGCCGCGATCTTCGCGATCTTCAAAC
TCGCATCCGGAGTGTAACGC

Downstream 100 bases:

>100_bases
TCCAAGATCGTCATGCCCGGGCTTGACCCGGGCATCCATCGCTCTTCGCAAGAAGATGGATTGCCGGGTCAAGCCCGGCA
ATGACGAACAGAGCCAGAGG

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 607; Mature: 606

Protein sequence:

>607_residues
MAANGNGAAAAGGHAYPIEDHVYDVVVVGAGGAGLRAVVGCSEAGLRTACITKVFPTRSHTVAAQGGISASLGNMHKDDW
RWHMYDTVKGSDWLGDQDSIEYMVRNAPEAVYELEHWGVPFSRTEDGKIYQRPFGGMTLDFGKGQAQRTCAAADRTGHAM
LHTMYGQALRHSAEFYIEFFAIDLIMDDQGVCRGVIALKLDDGTIHRFKAQTTILATGGYGRAYASCTSAHTCTGDGGAM
ALRAGLPLQDMEFVQFHPTGIYGSGCLVTEGARGEGGYLVNSEGERFMERYAPSAKDLASRDVVSRAMTIEMREGRGVGK
KKDHIFLHLDHLAPEVLHERLPGISESARIFAGVDVTREPIPILPTVHYNMGGIPTNFHGEVVTKKDGDDNAVVPGLMAI
GEAACVSVHGANRLGSNSLIDLVVFGRAAALRCAEKLTPNGKQPELPADSADLSLGRLDKYRYAKGGTPTAKLRESMQSV
MQNNCAVFRTGEVLSEGKDLIRKVYGGVGDVGVSDRSLVWNSDLVETLEFDNLIIQAVVTMNSAANRTESRGAHAREDFP
DRDDTQWMKHTLAWIGDDGGTTIDYRPVHDYTMTNDVQYIPPKPRVY

Sequences:

>Translated_607_residues
MAANGNGAAAAGGHAYPIEDHVYDVVVVGAGGAGLRAVVGCSEAGLRTACITKVFPTRSHTVAAQGGISASLGNMHKDDW
RWHMYDTVKGSDWLGDQDSIEYMVRNAPEAVYELEHWGVPFSRTEDGKIYQRPFGGMTLDFGKGQAQRTCAAADRTGHAM
LHTMYGQALRHSAEFYIEFFAIDLIMDDQGVCRGVIALKLDDGTIHRFKAQTTILATGGYGRAYASCTSAHTCTGDGGAM
ALRAGLPLQDMEFVQFHPTGIYGSGCLVTEGARGEGGYLVNSEGERFMERYAPSAKDLASRDVVSRAMTIEMREGRGVGK
KKDHIFLHLDHLAPEVLHERLPGISESARIFAGVDVTREPIPILPTVHYNMGGIPTNFHGEVVTKKDGDDNAVVPGLMAI
GEAACVSVHGANRLGSNSLIDLVVFGRAAALRCAEKLTPNGKQPELPADSADLSLGRLDKYRYAKGGTPTAKLRESMQSV
MQNNCAVFRTGEVLSEGKDLIRKVYGGVGDVGVSDRSLVWNSDLVETLEFDNLIIQAVVTMNSAANRTESRGAHAREDFP
DRDDTQWMKHTLAWIGDDGGTTIDYRPVHDYTMTNDVQYIPPKPRVY
>Mature_606_residues
AANGNGAAAAGGHAYPIEDHVYDVVVVGAGGAGLRAVVGCSEAGLRTACITKVFPTRSHTVAAQGGISASLGNMHKDDWR
WHMYDTVKGSDWLGDQDSIEYMVRNAPEAVYELEHWGVPFSRTEDGKIYQRPFGGMTLDFGKGQAQRTCAAADRTGHAML
HTMYGQALRHSAEFYIEFFAIDLIMDDQGVCRGVIALKLDDGTIHRFKAQTTILATGGYGRAYASCTSAHTCTGDGGAMA
LRAGLPLQDMEFVQFHPTGIYGSGCLVTEGARGEGGYLVNSEGERFMERYAPSAKDLASRDVVSRAMTIEMREGRGVGKK
KDHIFLHLDHLAPEVLHERLPGISESARIFAGVDVTREPIPILPTVHYNMGGIPTNFHGEVVTKKDGDDNAVVPGLMAIG
EAACVSVHGANRLGSNSLIDLVVFGRAAALRCAEKLTPNGKQPELPADSADLSLGRLDKYRYAKGGTPTAKLRESMQSVM
QNNCAVFRTGEVLSEGKDLIRKVYGGVGDVGVSDRSLVWNSDLVETLEFDNLIIQAVVTMNSAANRTESRGAHAREDFPD
RDDTQWMKHTLAWIGDDGGTTIDYRPVHDYTMTNDVQYIPPKPRVY

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=612, Percent_Identity=62.2549019607843, Blast_Score=753, Evalue=0.0,
Organism=Escherichia coli, GI1786942, Length=551, Percent_Identity=55.3539019963702, Blast_Score=580, Evalue=1e-167,
Organism=Escherichia coli, GI1790597, Length=578, Percent_Identity=41.522491349481, Blast_Score=409, Evalue=1e-115,
Organism=Escherichia coli, GI1788928, Length=562, Percent_Identity=29.7153024911032, Blast_Score=196, Evalue=5e-51,
Organism=Caenorhabditis elegans, GI17550100, Length=628, Percent_Identity=60.5095541401274, Blast_Score=748, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505833, Length=615, Percent_Identity=59.0243902439024, Blast_Score=711, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322701, Length=611, Percent_Identity=66.4484451718494, Blast_Score=806, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322416, Length=597, Percent_Identity=65.4941373534338, Blast_Score=771, Evalue=0.0,
Organism=Drosophila melanogaster, GI17137288, Length=612, Percent_Identity=63.2352941176471, Blast_Score=780, Evalue=0.0,
Organism=Drosophila melanogaster, GI24655642, Length=612, Percent_Identity=63.2352941176471, Blast_Score=780, Evalue=0.0,
Organism=Drosophila melanogaster, GI24655647, Length=612, Percent_Identity=63.2352941176471, Blast_Score=780, Evalue=0.0,
Organism=Drosophila melanogaster, GI24663005, Length=613, Percent_Identity=55.4649265905383, Blast_Score=682, Evalue=0.0,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 65776; Mature: 65645

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAANGNGAAAAGGHAYPIEDHVYDVVVVGAGGAGLRAVVGCSEAGLRTACITKVFPTRSH
CCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCEEEEECCCCCCHHHHHHHCCCCCCC
TVAAQGGISASLGNMHKDDWRWHMYDTVKGSDWLGDQDSIEYMVRNAPEAVYELEHWGVP
EEEECCCCCHHHCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHCCCHHHHHHHHCCCC
FSRTEDGKIYQRPFGGMTLDFGKGQAQRTCAAADRTGHAMLHTMYGQALRHSAEFYIEFF
CCCCCCCEEEECCCCCEEEECCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHEEEEE
AIDLIMDDQGVCRGVIALKLDDGTIHRFKAQTTILATGGYGRAYASCTSAHTCTGDGGAM
EEEEEECCCCCEEEEEEEEECCCCEEEEEEEEEEEEECCCCCHHHHCCCCCEECCCCCEE
ALRAGLPLQDMEFVQFHPTGIYGSGCLVTEGARGEGGYLVNSEGERFMERYAPSAKDLAS
EEECCCCCCCCCEEEEECCCEECCCEEEECCCCCCCCEEECCCHHHHHHHHCCCHHHHHH
RDVVSRAMTIEMREGRGVGKKKDHIFLHLDHLAPEVLHERLPGISESARIFAGVDVTREP
HHHHHHHEEEEEECCCCCCCCCCEEEEEEHHCCHHHHHHHCCCCCCCCEEEEECCCCCCC
IPILPTVHYNMGGIPTNFHGEVVTKKDGDDNAVVPGLMAIGEAACVSVHGANRLGSNSLI
CCCCEEEECCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHCCEEEEEEECCCCCCCCCEE
DLVVFGRAAALRCAEKLTPNGKQPELPADSADLSLGRLDKYRYAKGGTPTAKLRESMQSV
EEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHH
MQNNCAVFRTGEVLSEGKDLIRKVYGGVGDVGVSDRSLVWNSDLVETLEFDNLIIQAVVT
HHCCCEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHH
MNSAANRTESRGAHAREDFPDRDDTQWMKHTLAWIGDDGGTTIDYRPVHDYTMTNDVQYI
HCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHEEECCCCCEEEEECCCCCEECCCCEEC
PPKPRVY
CCCCCCC
>Mature Secondary Structure 
AANGNGAAAAGGHAYPIEDHVYDVVVVGAGGAGLRAVVGCSEAGLRTACITKVFPTRSH
CCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCEEEEECCCCCCHHHHHHHCCCCCCC
TVAAQGGISASLGNMHKDDWRWHMYDTVKGSDWLGDQDSIEYMVRNAPEAVYELEHWGVP
EEEECCCCCHHHCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHCCCHHHHHHHHCCCC
FSRTEDGKIYQRPFGGMTLDFGKGQAQRTCAAADRTGHAMLHTMYGQALRHSAEFYIEFF
CCCCCCCEEEECCCCCEEEECCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHEEEEE
AIDLIMDDQGVCRGVIALKLDDGTIHRFKAQTTILATGGYGRAYASCTSAHTCTGDGGAM
EEEEEECCCCCEEEEEEEEECCCCEEEEEEEEEEEEECCCCCHHHHCCCCCEECCCCCEE
ALRAGLPLQDMEFVQFHPTGIYGSGCLVTEGARGEGGYLVNSEGERFMERYAPSAKDLAS
EEECCCCCCCCCEEEEECCCEECCCEEEECCCCCCCCEEECCCHHHHHHHHCCCHHHHHH
RDVVSRAMTIEMREGRGVGKKKDHIFLHLDHLAPEVLHERLPGISESARIFAGVDVTREP
HHHHHHHEEEEEECCCCCCCCCCEEEEEEHHCCHHHHHHHCCCCCCCCEEEEECCCCCCC
IPILPTVHYNMGGIPTNFHGEVVTKKDGDDNAVVPGLMAIGEAACVSVHGANRLGSNSLI
CCCCEEEECCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHCCEEEEEEECCCCCCCCCEE
DLVVFGRAAALRCAEKLTPNGKQPELPADSADLSLGRLDKYRYAKGGTPTAKLRESMQSV
EEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHH
MQNNCAVFRTGEVLSEGKDLIRKVYGGVGDVGVSDRSLVWNSDLVETLEFDNLIIQAVVT
HHCCCEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHH
MNSAANRTESRGAHAREDFPDRDDTQWMKHTLAWIGDDGGTTIDYRPVHDYTMTNDVQYI
HCCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHEEECCCCCEEEEECCCCCEECCCCEEC
PPKPRVY
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA