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The map label for this gene is hmuU [H]

Identifier: 86747294

GI number: 86747294

Start: 179654

End: 180739

Strand: Direct

Name: hmuU [H]

Synonym: RPB_0167

Alternate gene names: 86747294

Gene position: 179654-180739 (Clockwise)

Preceding gene: 86747293

Following gene: 86747295

Centisome position: 3.37

GC content: 70.17

Gene sequence:

>1086_bases
ATGACGGTGATGGAGATCGGACGCCGGCGGGTGGCGAGGTCGTTCCGGCCGCGCTCCGGCGTCACCCTGGCGGTGTTGCT
CGTGTTGCTGCTGATCTGCCTGGCGCTGGCGCTGACCGTCGGCGCCGCCGGCATTCCGCTGTCGCGCCTGCCCGCCGCGC
TCGGGCTGCTGCCCGCCGCCGATGCCGGGCCGATGGCGGCGCGCGATCAAATGGTGTTGTGGTCGATCCGGCTGCCGCGC
ATCCTCACCGCCGCGATCGTCGGCAGCCTGCTGGCGGCATCGGGCGCGCTGATGCAGGGGCTGTTCCGCAATCCGCTGGC
CGATCCGGCGCTGGTCGGCGTCTCCAGCGGCGGCGCGTTCGCGGCCGCGTCGTCGATCGTGCTGCTCGATCATGCGCTCG
GCGACAATCTGCGCTTCCTGCAGGATCATCTGCTGCCTGTCGCCGCTTTCGCCGGCTCGCTGGTCACCACCATCGCGCTG
TACCGGATCGCCAGCCGCGCCGGCCGCACCTCGATCGCGCTGTTCCTGCTCGCCGGCCTCGCCATCGCGGCCATCGCCAA
TGCGGGGATCGGCGTTCTGGTGTATCTCGCCGACGACCGGCAGTTGCGCGACATCACCTTCTGGATGATGGGATCGCTCA
GCGGCGCCAACTGGGCCAAGGCGTCGTCGACCGCGCTGGTGCTGCTGATCGCGCTTGCGGTGTTCGTCAAGGTCGCGCGC
CATCTCGATCTGCTCGTACTCGGCGAGTCGGAGGCGTTTCACACCGGCGTCGACGTCGAACGGCTGAAGCGCCTGTCGAT
CGTGCTGGTGTCGCTGATGACCGGCGTCGCGGTCTCGGTCTGCGGCGTGATCGGCTTCGTCGGCATTGTGGTGCCGCATC
TGCTGCGGCTGTTGATCGGCCCGTCGCACCGGCTGCTGCTGCCCGCCTCTGCCTGCCTCGGCGCGGTGATGCTGGTCGCC
GCCGACACCGTGGCCCGCACCATCGTGGCGCCGGCCGAGATGCCGATCGGCATTCTCACCGCGGCGATCGGCGCGCCGTT
CTTCCTCGTCATCCTGCTGCGGCAGCGCAAGCTGGTCGGGCTGTGA

Upstream 100 bases:

>100_bases
CTCCGGCCGCCGCGCGCGACGTCGCCGCGACGCTGTATCCGCAGCTCGCGAGCCAGGCCGGCGACTTCAAGCCGAAGGCG
GCGTCGGCCGTTTGCCGCCC

Downstream 100 bases:

>100_bases
GCACCGCGCTCGAGGCCCGCAAGGCCGGCTTTGCGACAGGCGGCGCGACGCTGGTCCACAATGTCGATCTCGCCGTCGCA
CAGGGCGAGCTGATCGCTAT

Product: transport system permease protein

Products: ADP; phosphate; cob(I)alamin [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 361; Mature: 360

Protein sequence:

>361_residues
MTVMEIGRRRVARSFRPRSGVTLAVLLVLLLICLALALTVGAAGIPLSRLPAALGLLPAADAGPMAARDQMVLWSIRLPR
ILTAAIVGSLLAASGALMQGLFRNPLADPALVGVSSGGAFAAASSIVLLDHALGDNLRFLQDHLLPVAAFAGSLVTTIAL
YRIASRAGRTSIALFLLAGLAIAAIANAGIGVLVYLADDRQLRDITFWMMGSLSGANWAKASSTALVLLIALAVFVKVAR
HLDLLVLGESEAFHTGVDVERLKRLSIVLVSLMTGVAVSVCGVIGFVGIVVPHLLRLLIGPSHRLLLPASACLGAVMLVA
ADTVARTIVAPAEMPIGILTAAIGAPFFLVILLRQRKLVGL

Sequences:

>Translated_361_residues
MTVMEIGRRRVARSFRPRSGVTLAVLLVLLLICLALALTVGAAGIPLSRLPAALGLLPAADAGPMAARDQMVLWSIRLPR
ILTAAIVGSLLAASGALMQGLFRNPLADPALVGVSSGGAFAAASSIVLLDHALGDNLRFLQDHLLPVAAFAGSLVTTIAL
YRIASRAGRTSIALFLLAGLAIAAIANAGIGVLVYLADDRQLRDITFWMMGSLSGANWAKASSTALVLLIALAVFVKVAR
HLDLLVLGESEAFHTGVDVERLKRLSIVLVSLMTGVAVSVCGVIGFVGIVVPHLLRLLIGPSHRLLLPASACLGAVMLVA
ADTVARTIVAPAEMPIGILTAAIGAPFFLVILLRQRKLVGL
>Mature_360_residues
TVMEIGRRRVARSFRPRSGVTLAVLLVLLLICLALALTVGAAGIPLSRLPAALGLLPAADAGPMAARDQMVLWSIRLPRI
LTAAIVGSLLAASGALMQGLFRNPLADPALVGVSSGGAFAAASSIVLLDHALGDNLRFLQDHLLPVAAFAGSLVTTIALY
RIASRAGRTSIALFLLAGLAIAAIANAGIGVLVYLADDRQLRDITFWMMGSLSGANWAKASSTALVLLIALAVFVKVARH
LDLLVLGESEAFHTGVDVERLKRLSIVLVSLMTGVAVSVCGVIGFVGIVVPHLLRLLIGPSHRLLLPASACLGAVMLVAA
DTVARTIVAPAEMPIGILTAAIGAPFFLVILLRQRKLVGL

Specific function: Part of the binding-protein-dependent transport system for hemin; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788004, Length=287, Percent_Identity=39.0243902439024, Blast_Score=165, Evalue=4e-42,
Organism=Escherichia coli, GI1790740, Length=324, Percent_Identity=35.8024691358025, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI1790741, Length=315, Percent_Identity=33.6507936507937, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI1786805, Length=311, Percent_Identity=33.4405144694534, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1786347, Length=287, Percent_Identity=32.404181184669, Blast_Score=104, Evalue=9e-24,
Organism=Escherichia coli, GI1786804, Length=288, Percent_Identity=30.9027777777778, Blast_Score=104, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 37458; Mature: 37327

Theoretical pI: Translated: 11.57; Mature: 11.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVMEIGRRRVARSFRPRSGVTLAVLLVLLLICLALALTVGAAGIPLSRLPAALGLLPAA
CCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCC
DAGPMAARDQMVLWSIRLPRILTAAIVGSLLAASGALMQGLFRNPLADPALVGVSSGGAF
CCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCH
AAASSIVLLDHALGDNLRFLQDHLLPVAAFAGSLVTTIALYRIASRAGRTSIALFLLAGL
HHHHHHHEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
AIAAIANAGIGVLVYLADDRQLRDITFWMMGSLSGANWAKASSTALVLLIALAVFVKVAR
HHHHHHCCCCEEEEEEECCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
HLDLLVLGESEAFHTGVDVERLKRLSIVLVSLMTGVAVSVCGVIGFVGIVVPHLLRLLIG
HCCEEEECCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PSHRLLLPASACLGAVMLVAADTVARTIVAPAEMPIGILTAAIGAPFFLVILLRQRKLVG
CCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
L
C
>Mature Secondary Structure 
TVMEIGRRRVARSFRPRSGVTLAVLLVLLLICLALALTVGAAGIPLSRLPAALGLLPAA
CHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCC
DAGPMAARDQMVLWSIRLPRILTAAIVGSLLAASGALMQGLFRNPLADPALVGVSSGGAF
CCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCH
AAASSIVLLDHALGDNLRFLQDHLLPVAAFAGSLVTTIALYRIASRAGRTSIALFLLAGL
HHHHHHHEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
AIAAIANAGIGVLVYLADDRQLRDITFWMMGSLSGANWAKASSTALVLLIALAVFVKVAR
HHHHHHCCCCEEEEEEECCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
HLDLLVLGESEAFHTGVDVERLKRLSIVLVSLMTGVAVSVCGVIGFVGIVVPHLLRLLIG
HCCEEEECCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PSHRLLLPASACLGAVMLVAADTVARTIVAPAEMPIGILTAAIGAPFFLVILLRQRKLVG
CCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
L
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; cob(I)alamin [Periplasm]; H2O [C]

Specific reaction: ATP + cob(I)alamin [Periplasm] + H2O = ADP + phosphate + cob(I)alamin [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9026634; 11586360; 12142430 [H]