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The map label for this gene is glyA [H]

Identifier: 86610234

GI number: 86610234

Start: 2912030

End: 2913313

Strand: Direct

Name: glyA [H]

Synonym: CYB_2810

Alternate gene names: 86610234

Gene position: 2912030-2913313 (Clockwise)

Preceding gene: 86610230

Following gene: 86610235

Centisome position: 95.58

GC content: 61.29

Gene sequence:

>1284_bases
TTGGCCATCCTGGCGGAAACGGATCCCGTTGTTTACCGCCTGATCCAGCAAGAGCTCAACCGGCAGCGGGATCACCTGGA
GATGATTGCCAGCGAGAACTTCACCTCTCCTGCCGTCTTGGCAGCCCAGGGCTCGGTGCTCACCAACAAGTATGCAGAAG
GGCTGCCGGGCAAGCGCTACTACGGCGGCTGCGAGTTTATTGACGAGATTGAACAACTGGCCATTGACCGCGCCAAGCAA
CTGTTTGGGGCGGCTCACGCCAACGTGCAACCCCACTCCGGGGCGCAGGCCAATTTCGCTGTTTTCTTGGCCCTGCTGCA
GCCGGGGGACACGATCATGGGCATGGATTTGTCTCATGGCGGCCACCTCACCCACGGCTCGCCGGTGAATGTCTCCGGCA
AGTGGTTCCGCGTGGTGCACTACGGGGTGCATCCGCAGACGGAGCGGATTGATTTTGACCAAGTGCGGGATCTGGCTTTG
CAGCATCGGCCTAAGCTGATCATCTGCGGCTACTCCGCCTACCCGCGGGCAATCGACTTTGCTGCTTTCCGCACCATTGC
CGATGAGGTGGGAGCTTATCTGCTGGCCGACATTGCCCATATTGCCGGCCTGGTGGCCACCGGACACCACCCCAACCCCG
TGCCCCTCTGCGATGTGGTGACCACCACCACCCACAAGACGTTGCGCGGGCCGCGTGGAGGGCTCATTCTCACCCGCGAC
CCAGAGCTGGGCAAAAAGCTGGATAAGGCAGTGTTCCCCGGCAGTCAAGGGGGGCCGCTGGAGCATGTTATTGCTGGCAA
GGCGGTGGCCTTTGGAGAAGCCCTGCAGCCCAGCTTTGCCCAGTACTCGGCCCAAGTTATCGCCAATGCCCAAGCCCTGG
CGGGATCCCTGCAACGGCGAGGCATCCGGCTAGTTTCGGGGGGCACCGACAATCACCTGATGTTGCTGGATCTGCGCTCG
GTTTCGGCGGTGCTGGAAAAAACTGGGGCGGCGGATCCGGTAATGACGGGCAAACGGGCGGATCGGCTGATGGGGAAGAT
CCACATCACCGCCAATAAGAACACCATTCCCTTCGACCCACAGCCGCCCTTTGTAGCTAGCGGCCTGCGTCTGGGATCCC
CAGCCTTGACCACCCGCGGCCTGGGGCCGGTAGAATTTGAAGAAATTGGGGAGATCATCGCCGATTGTCTGTTTCAGCCT
GAGGAGCCTGCTGTGTTGGAAGAGTGTCGCCAGCGGGTGGCTCAGCTCTGTCGTCGTTTCCCCCTCTACCCCCACTTGGG
ATAA

Upstream 100 bases:

>100_bases
CGCGACGGCGAAGCAGTTCTTGCCCATTCCTCCTGCGAAGTTCGGTCTTGGCGTCATCATGGTAGCTGCTCCACAAAGTC
TGACCACCTCACGGGATAGC

Downstream 100 bases:

>100_bases
CCGCAATCCTCGCCACGGCTTGCTATGCCCTACTTGGTTGCCTTTCTGGCTGCTGCCTGTGTGGTTCTGTGGGCAACCCC
GGTGGTGAAGGCGGTCGGGA

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT; Serine methylase [H]

Number of amino acids: Translated: 427; Mature: 426

Protein sequence:

>427_residues
MAILAETDPVVYRLIQQELNRQRDHLEMIASENFTSPAVLAAQGSVLTNKYAEGLPGKRYYGGCEFIDEIEQLAIDRAKQ
LFGAAHANVQPHSGAQANFAVFLALLQPGDTIMGMDLSHGGHLTHGSPVNVSGKWFRVVHYGVHPQTERIDFDQVRDLAL
QHRPKLIICGYSAYPRAIDFAAFRTIADEVGAYLLADIAHIAGLVATGHHPNPVPLCDVVTTTTHKTLRGPRGGLILTRD
PELGKKLDKAVFPGSQGGPLEHVIAGKAVAFGEALQPSFAQYSAQVIANAQALAGSLQRRGIRLVSGGTDNHLMLLDLRS
VSAVLEKTGAADPVMTGKRADRLMGKIHITANKNTIPFDPQPPFVASGLRLGSPALTTRGLGPVEFEEIGEIIADCLFQP
EEPAVLEECRQRVAQLCRRFPLYPHLG

Sequences:

>Translated_427_residues
MAILAETDPVVYRLIQQELNRQRDHLEMIASENFTSPAVLAAQGSVLTNKYAEGLPGKRYYGGCEFIDEIEQLAIDRAKQ
LFGAAHANVQPHSGAQANFAVFLALLQPGDTIMGMDLSHGGHLTHGSPVNVSGKWFRVVHYGVHPQTERIDFDQVRDLAL
QHRPKLIICGYSAYPRAIDFAAFRTIADEVGAYLLADIAHIAGLVATGHHPNPVPLCDVVTTTTHKTLRGPRGGLILTRD
PELGKKLDKAVFPGSQGGPLEHVIAGKAVAFGEALQPSFAQYSAQVIANAQALAGSLQRRGIRLVSGGTDNHLMLLDLRS
VSAVLEKTGAADPVMTGKRADRLMGKIHITANKNTIPFDPQPPFVASGLRLGSPALTTRGLGPVEFEEIGEIIADCLFQP
EEPAVLEECRQRVAQLCRRFPLYPHLG
>Mature_426_residues
AILAETDPVVYRLIQQELNRQRDHLEMIASENFTSPAVLAAQGSVLTNKYAEGLPGKRYYGGCEFIDEIEQLAIDRAKQL
FGAAHANVQPHSGAQANFAVFLALLQPGDTIMGMDLSHGGHLTHGSPVNVSGKWFRVVHYGVHPQTERIDFDQVRDLALQ
HRPKLIICGYSAYPRAIDFAAFRTIADEVGAYLLADIAHIAGLVATGHHPNPVPLCDVVTTTTHKTLRGPRGGLILTRDP
ELGKKLDKAVFPGSQGGPLEHVIAGKAVAFGEALQPSFAQYSAQVIANAQALAGSLQRRGIRLVSGGTDNHLMLLDLRSV
SAVLEKTGAADPVMTGKRADRLMGKIHITANKNTIPFDPQPPFVASGLRLGSPALTTRGLGPVEFEEIGEIIADCLFQPE
EPAVLEECRQRVAQLCRRFPLYPHLG

Specific function: Interconversion of serine and glycine [H]

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family [H]

Homologues:

Organism=Homo sapiens, GI261862352, Length=463, Percent_Identity=45.5723542116631, Blast_Score=357, Evalue=9e-99,
Organism=Homo sapiens, GI261862350, Length=463, Percent_Identity=45.5723542116631, Blast_Score=357, Evalue=9e-99,
Organism=Homo sapiens, GI261862348, Length=463, Percent_Identity=45.5723542116631, Blast_Score=357, Evalue=9e-99,
Organism=Homo sapiens, GI19923315, Length=463, Percent_Identity=45.5723542116631, Blast_Score=357, Evalue=1e-98,
Organism=Homo sapiens, GI261862346, Length=458, Percent_Identity=44.9781659388646, Blast_Score=340, Evalue=2e-93,
Organism=Homo sapiens, GI22547186, Length=413, Percent_Identity=48.18401937046, Blast_Score=338, Evalue=8e-93,
Organism=Homo sapiens, GI22547189, Length=399, Percent_Identity=45.8646616541353, Blast_Score=304, Evalue=1e-82,
Organism=Escherichia coli, GI1788902, Length=422, Percent_Identity=56.1611374407583, Blast_Score=471, Evalue=1e-134,
Organism=Caenorhabditis elegans, GI25144729, Length=412, Percent_Identity=46.6019417475728, Blast_Score=352, Evalue=2e-97,
Organism=Caenorhabditis elegans, GI25144732, Length=412, Percent_Identity=46.6019417475728, Blast_Score=352, Evalue=3e-97,
Organism=Saccharomyces cerevisiae, GI6319739, Length=443, Percent_Identity=42.4379232505643, Blast_Score=345, Evalue=1e-95,
Organism=Saccharomyces cerevisiae, GI6323087, Length=413, Percent_Identity=42.6150121065375, Blast_Score=323, Evalue=2e-89,
Organism=Drosophila melanogaster, GI24640005, Length=464, Percent_Identity=44.1810344827586, Blast_Score=366, Evalue=1e-101,
Organism=Drosophila melanogaster, GI221329721, Length=464, Percent_Identity=43.75, Blast_Score=366, Evalue=1e-101,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798 [H]

Pfam domain/function: PF00464 SHMT [H]

EC number: =2.1.2.1 [H]

Molecular weight: Translated: 46207; Mature: 46075

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAILAETDPVVYRLIQQELNRQRDHLEMIASENFTSPAVLAAQGSVLTNKYAEGLPGKRY
CEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHCCCCCCCC
YGGCEFIDEIEQLAIDRAKQLFGAAHANVQPHSGAQANFAVFLALLQPGDTIMGMDLSHG
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHEEEECCCCCEEEEEEECCC
GHLTHGSPVNVSGKWFRVVHYGVHPQTERIDFDQVRDLALQHRPKLIICGYSAYPRAIDF
CCCCCCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCHHHH
AAFRTIADEVGAYLLADIAHIAGLVATGHHPNPVPLCDVVTTTTHKTLRGPRGGLILTRD
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHEEECCCHHHHCCCCCCEEEECC
PELGKKLDKAVFPGSQGGPLEHVIAGKAVAFGEALQPSFAQYSAQVIANAQALAGSLQRR
HHHHHHHHHHHCCCCCCCCHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHC
GIRLVSGGTDNHLMLLDLRSVSAVLEKTGAADPVMTGKRADRLMGKIHITANKNTIPFDP
CEEEEECCCCCEEEEEEHHHHHHHHHHCCCCCCCCCCHHHHHCEEEEEEEECCCCCCCCC
QPPFVASGLRLGSPALTTRGLGPVEFEEIGEIIADCLFQPEEPAVLEECRQRVAQLCRRF
CCCHHHCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHC
PLYPHLG
CCCCCCC
>Mature Secondary Structure 
AILAETDPVVYRLIQQELNRQRDHLEMIASENFTSPAVLAAQGSVLTNKYAEGLPGKRY
EEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHCCCCCCCC
YGGCEFIDEIEQLAIDRAKQLFGAAHANVQPHSGAQANFAVFLALLQPGDTIMGMDLSHG
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHEEEECCCCCEEEEEEECCC
GHLTHGSPVNVSGKWFRVVHYGVHPQTERIDFDQVRDLALQHRPKLIICGYSAYPRAIDF
CCCCCCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCCHHHH
AAFRTIADEVGAYLLADIAHIAGLVATGHHPNPVPLCDVVTTTTHKTLRGPRGGLILTRD
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHEEECCCHHHHCCCCCCEEEECC
PELGKKLDKAVFPGSQGGPLEHVIAGKAVAFGEALQPSFAQYSAQVIANAQALAGSLQRR
HHHHHHHHHHHCCCCCCCCHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHC
GIRLVSGGTDNHLMLLDLRSVSAVLEKTGAADPVMTGKRADRLMGKIHITANKNTIPFDP
CEEEEECCCCCEEEEEEHHHHHHHHHHCCCCCCCCCCHHHHHCEEEEEEEECCCCCCCCC
QPPFVASGLRLGSPALTTRGLGPVEFEEIGEIIADCLFQPEEPAVLEECRQRVAQLCRRF
CCCHHHCCCCCCCCCHHHCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHC
PLYPHLG
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA