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The map label for this gene is hisN [H]

Identifier: 86609896

GI number: 86609896

Start: 2559382

End: 2560230

Strand: Direct

Name: hisN [H]

Synonym: CYB_2462

Alternate gene names: 86609896

Gene position: 2559382-2560230 (Clockwise)

Preceding gene: 86609893

Following gene: 86609899

Centisome position: 84.01

GC content: 59.84

Gene sequence:

>849_bases
ATGCTAAGAAAGGGAAGGGGCAGATGGGGTGGGCAAAAGGTGGTCAAGGCAGAGTGGATTGAACTGGCCCAGGCCCTGGC
CGATGCTGCCGGAGCGGTGATTCGCCCCCTGTTTCGCGGAGAACTGCAAGCCGAATACAAAGAGGCCCGCTCCCCAATTG
TGACGGTGGCCGACCGGGAGGCAGAGCGGGCCATGCGAGCTTTGCTGATGGCCCAAGTGCCAGAACACAGCATCCTTGGC
GAAGAGTTTGGTTTTCACCAGACGGGATCCCTCTACACTTGGGTTCTGGATCCCTTGGATGGCACCATCGCCTTTTCCAC
CGGCAAGCCCACCTTTGCCACTTTGATTGCCCTCTTGGAAGAAGACCGCCCCATTTTGGGCATCATCGATCAGCCGGTGT
TGCGCGAACGCTGGCTGGGGGTACGGGGACAGCCCACTCAATGGATAACCCCCTCCCACCGGCAAGCCGTCCGAGCCAAG
GCCAATACCGACCTCAGCCGCGCCTACTTGAGCTGTACCACCCCTGATTTGTTCACCCAACCCGACCAACAACGGTGCTT
CCAGGGGCTCAGCCAAGCAGTTCACATTACCTCCTATGGGGGCGATGGCTACCAGTACGGCCTGCTGGCCAGCGGCTGTG
TGGATCTGGTGATGGAGTGTGGCCTTGCCCTCTACGATTTTGCTGCCCTTGTGCCGGTGATTGAGGGATCCGGTGGCGTG
ATTACCGATTGGCGAGGGGATCCCTTAACCCGCACCTCCACGGGAGAAGTGTTGGCGGCAGCCAACCCCAGCTTGCATCG
ACAGGCCCTGGCCGCGATTCAAAAAAGCGGGATCTACCCAGCGAAATAA

Upstream 100 bases:

>100_bases
GTGCCCAAAATGGTCAGGAGGACCCCAATCGCCGTCCAAAGCCATTCCAGAGGAGTTAAGAGCAAGCCAGACCGCATAAA
CCGAGAGGAAATTTTTCCCT

Downstream 100 bases:

>100_bases
GCAGGCTCATTGCCAGGTTTCCACTTGATGTTGCAGCCCAGGCTGGGCTTTTGGTCGGGATCGATGGGCTTGCCGGCCAG
AAGGTTATCCAGCGCCGCCC

Product: inositol monophosphatase family protein

Products: NA

Alternate protein names: HolPase; Histidinol-phosphate phosphatase [H]

Number of amino acids: Translated: 282; Mature: 282

Protein sequence:

>282_residues
MLRKGRGRWGGQKVVKAEWIELAQALADAAGAVIRPLFRGELQAEYKEARSPIVTVADREAERAMRALLMAQVPEHSILG
EEFGFHQTGSLYTWVLDPLDGTIAFSTGKPTFATLIALLEEDRPILGIIDQPVLRERWLGVRGQPTQWITPSHRQAVRAK
ANTDLSRAYLSCTTPDLFTQPDQQRCFQGLSQAVHITSYGGDGYQYGLLASGCVDLVMECGLALYDFAALVPVIEGSGGV
ITDWRGDPLTRTSTGEVLAAANPSLHRQALAAIQKSGIYPAK

Sequences:

>Translated_282_residues
MLRKGRGRWGGQKVVKAEWIELAQALADAAGAVIRPLFRGELQAEYKEARSPIVTVADREAERAMRALLMAQVPEHSILG
EEFGFHQTGSLYTWVLDPLDGTIAFSTGKPTFATLIALLEEDRPILGIIDQPVLRERWLGVRGQPTQWITPSHRQAVRAK
ANTDLSRAYLSCTTPDLFTQPDQQRCFQGLSQAVHITSYGGDGYQYGLLASGCVDLVMECGLALYDFAALVPVIEGSGGV
ITDWRGDPLTRTSTGEVLAAANPSLHRQALAAIQKSGIYPAK
>Mature_282_residues
MLRKGRGRWGGQKVVKAEWIELAQALADAAGAVIRPLFRGELQAEYKEARSPIVTVADREAERAMRALLMAQVPEHSILG
EEFGFHQTGSLYTWVLDPLDGTIAFSTGKPTFATLIALLEEDRPILGIIDQPVLRERWLGVRGQPTQWITPSHRQAVRAK
ANTDLSRAYLSCTTPDLFTQPDQQRCFQGLSQAVHITSYGGDGYQYGLLASGCVDLVMECGLALYDFAALVPVIEGSGGV
ITDWRGDPLTRTSTGEVLAAANPSLHRQALAAIQKSGIYPAK

Specific function: Catalyzes the dephosphorylation of histidinol-phosphate to histidinol, the direct precursor of histidine [H]

COG id: COG0483

COG function: function code G; Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the inositol monophosphatase family [H]

Homologues:

Organism=Homo sapiens, GI221625487, Length=271, Percent_Identity=25.0922509225092, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI5031789, Length=271, Percent_Identity=25.0922509225092, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI7657236, Length=246, Percent_Identity=27.6422764227642, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI1788882, Length=234, Percent_Identity=26.4957264957265, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI193202572, Length=274, Percent_Identity=24.4525547445255, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI193202570, Length=277, Percent_Identity=24.5487364620939, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21357329, Length=258, Percent_Identity=24.8062015503876, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI21357303, Length=232, Percent_Identity=25.4310344827586, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011809
- InterPro:   IPR020583
- InterPro:   IPR000760
- InterPro:   IPR020550 [H]

Pfam domain/function: PF00459 Inositol_P [H]

EC number: =3.1.3.15 [H]

Molecular weight: Translated: 30746; Mature: 30746

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: PS00629 IMP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRKGRGRWGGQKVVKAEWIELAQALADAAGAVIRPLFRGELQAEYKEARSPIVTVADRE
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECHH
AERAMRALLMAQVPEHSILGEEFGFHQTGSLYTWVLDPLDGTIAFSTGKPTFATLIALLE
HHHHHHHHHHHHCCCHHHHHHHCCCCCCCCEEEEEEECCCCEEEEECCCHHHHHHHHHHH
EDRPILGIIDQPVLRERWLGVRGQPTQWITPSHRQAVRAKANTDLSRAYLSCTTPDLFTQ
CCCCEEEECCCHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHEECCCCHHCCC
PDQQRCFQGLSQAVHITSYGGDGYQYGLLASGCVDLVMECGLALYDFAALVPVIEGSGGV
CCHHHHHHHHHHEEEEEEECCCCEEEHHHHHHHHHHHHHCCHHHHHHHHHHHHEECCCCE
ITDWRGDPLTRTSTGEVLAAANPSLHRQALAAIQKSGIYPAK
EECCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MLRKGRGRWGGQKVVKAEWIELAQALADAAGAVIRPLFRGELQAEYKEARSPIVTVADRE
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECHH
AERAMRALLMAQVPEHSILGEEFGFHQTGSLYTWVLDPLDGTIAFSTGKPTFATLIALLE
HHHHHHHHHHHHCCCHHHHHHHCCCCCCCCEEEEEEECCCCEEEEECCCHHHHHHHHHHH
EDRPILGIIDQPVLRERWLGVRGQPTQWITPSHRQAVRAKANTDLSRAYLSCTTPDLFTQ
CCCCEEEECCCHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHEECCCCHHCCC
PDQQRCFQGLSQAVHITSYGGDGYQYGLLASGCVDLVMECGLALYDFAALVPVIEGSGGV
CCHHHHHHHHHHEEEEEEECCCCEEEHHHHHHHHHHHHHCCHHHHHHHHHHHHEECCCCE
ITDWRGDPLTRTSTGEVLAAANPSLHRQALAAIQKSGIYPAK
EECCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8626508 [H]