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The map label for this gene is mutL [H]

Identifier: 86609718

GI number: 86609718

Start: 2381533

End: 2383281

Strand: Direct

Name: mutL [H]

Synonym: CYB_2276

Alternate gene names: 86609718

Gene position: 2381533-2383281 (Clockwise)

Preceding gene: 86609714

Following gene: 86609719

Centisome position: 78.17

GC content: 63.01

Gene sequence:

>1749_bases
ATGTCCAAAATCCAACCCCTGAACCCAGAGCGGATCGCCCAGATGGCCGCGGGAGAGGTGATCGACTCGCTGGGGGCTGC
TCTGCGAGAATTGCTGGAAAATGCCCTCGATGCTCAGGCCACCCGCATTCAGGTGGAGATCTGGCCCAGCCGCTGGCAGG
TGCGGGTGGCCGATAACGGCCAAGGGATCCCCGCTTCGGAGCTGGAGCAGGTGGCCCGTCGCCACACCACCAGCAAGTTG
GACGGTTGCAGCCTGGGGTTTCGGGGCGAAGCCTTGCACAGCCTGGCCCGGCTGGGATCCCTGGCTATCCAAACCCGCCA
CGTTTCTGATGCTCACGGCTGGCTGGCCGCCTACGACCGACAGGGGGAGCTGATCCACAAGCAGCCGGCAGCCACTGCCT
TGGGAACGGTGGTCACGGTTGCGGATTTGTTTGCCGACTGGCCTCTGCGCCGTCGGGCCTTGCCCCAAACTCGCCCGCTC
CTGACCCTGGTGCAGAATGCAGCCCTAGCCCATCCCTGGGTCAGTTGGCAGGTGCATCAGGAAGGGCAATTGCTGCTCAG
CCTCTGGCCGGGAAAATCTCTGCAAGATCTGCTGCTGCAGGTGTTGCCGCAGGTGGATCCCACGGATCTGCGCTATCGGC
GGATCCAGGATGGGGATAGCGATTGGGAAGTGGTGCTGGGCCTGCCGGATCGCCTGCATCGCCCCCACCCCGATTGGATC
CGTGTGGCCGTAAACGGACGGTTTGTGCAGATGCCCGACTGGCAACGGCTGATCCAGTCGGTTTTTCACCACGCGTTGCC
TCGCCACCGTCATCCACTGGTGGTTGTTCACCTGCGCCTGCCCCCAGAGCAGGTGGATTGGAACCGTCATCCTGCCAAAA
GCGAGCTCTACCTGGAGAATCTGACGGCCCGCCAGGAGCAGTTGCGCCAACACCTGCACTCCCTTCTGCAATTGGGATCC
GGGCAAGCCAGCCGCCGCTCTGTGCATCTGATCCGGGCCAGCGAGGCCAAGGTGGTCTATCGAGTCTCGCCCGATTTTCA
GAGCCATCTTCCTCCCTCTGACCGCCCAACTTCTCCCTTGCCTCCCCTCAGGGCGCTGGCCCAACTGCATCGGATCTACA
TCTTGGCGGAGCATCCCCAGGGGCTATGGCTGGTGGAGCAGCACCTGGCCCACGAGCGAGTTCGCTACGAGTACATCCGG
CAGCATTGGCAACTGGTAGCACCGGAGACGCCCATAACGCTGCAAGGACTATCGCCCCAAGCCCTGGAGCGGTTGGAGCA
GTTGGGGCTGGAGCCAGAACCCTTTGGCCCCAATACCCATCTCATTCGACGCATCCCTCTGGCTTTAGGGTCGGAAGATC
CGGAAGAGGTACAGGGATCCCTGCTGGAGCTCAGTGGTTGTCAAGATTTGCAGGCAGCCCAGGTAACAGTGGCCTGTCGT
GGCGCCCTGCGCAACGGGATCCCGCTGACCCTGGAGCAGATGCAAAAGCTGTTGGAAGCTTGGCAGCGCACCGCCAATCC
CCACACTTGTCCCCATGGCCGACCGGTGTACCTGGCCCTGGCAGAAAGAGATCTAGCCCGCTACTTCCGCCGCCGTTGGG
GTCTCTGCGACCGGCCTATCTCCGACTCCAAACTGGGATCCCTGGGGGAGCTGGATCCGCTGGGAGATAGGTTTGCCGCC
CAGGTGCGGCGCTCAAGCGGCTCTTCTGCGTCGGAGCCCACGGACGAGGCCAGTTCTGCCCCACTATAA

Upstream 100 bases:

>100_bases
TCCACTGGCAACAGAGGGAGAGAGCTAAGCTAAAGCTCGGCGCTGTTGGCCTTTTGGCGACAAGCTGGCAGGAAGAGAGT
CTGCTTTCTCAACTCACTCC

Downstream 100 bases:

>100_bases
TCGGGGGTGTCCAACTGCTGAAACCCCTGAAACGCCATGGCTTCTTATCTCAAACTCAAAGCCCAAGAAGAGACCTGGCT
GCAGCGCCATTCCCGTCTGA

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 582; Mature: 581

Protein sequence:

>582_residues
MSKIQPLNPERIAQMAAGEVIDSLGAALRELLENALDAQATRIQVEIWPSRWQVRVADNGQGIPASELEQVARRHTTSKL
DGCSLGFRGEALHSLARLGSLAIQTRHVSDAHGWLAAYDRQGELIHKQPAATALGTVVTVADLFADWPLRRRALPQTRPL
LTLVQNAALAHPWVSWQVHQEGQLLLSLWPGKSLQDLLLQVLPQVDPTDLRYRRIQDGDSDWEVVLGLPDRLHRPHPDWI
RVAVNGRFVQMPDWQRLIQSVFHHALPRHRHPLVVVHLRLPPEQVDWNRHPAKSELYLENLTARQEQLRQHLHSLLQLGS
GQASRRSVHLIRASEAKVVYRVSPDFQSHLPPSDRPTSPLPPLRALAQLHRIYILAEHPQGLWLVEQHLAHERVRYEYIR
QHWQLVAPETPITLQGLSPQALERLEQLGLEPEPFGPNTHLIRRIPLALGSEDPEEVQGSLLELSGCQDLQAAQVTVACR
GALRNGIPLTLEQMQKLLEAWQRTANPHTCPHGRPVYLALAERDLARYFRRRWGLCDRPISDSKLGSLGELDPLGDRFAA
QVRRSSGSSASEPTDEASSAPL

Sequences:

>Translated_582_residues
MSKIQPLNPERIAQMAAGEVIDSLGAALRELLENALDAQATRIQVEIWPSRWQVRVADNGQGIPASELEQVARRHTTSKL
DGCSLGFRGEALHSLARLGSLAIQTRHVSDAHGWLAAYDRQGELIHKQPAATALGTVVTVADLFADWPLRRRALPQTRPL
LTLVQNAALAHPWVSWQVHQEGQLLLSLWPGKSLQDLLLQVLPQVDPTDLRYRRIQDGDSDWEVVLGLPDRLHRPHPDWI
RVAVNGRFVQMPDWQRLIQSVFHHALPRHRHPLVVVHLRLPPEQVDWNRHPAKSELYLENLTARQEQLRQHLHSLLQLGS
GQASRRSVHLIRASEAKVVYRVSPDFQSHLPPSDRPTSPLPPLRALAQLHRIYILAEHPQGLWLVEQHLAHERVRYEYIR
QHWQLVAPETPITLQGLSPQALERLEQLGLEPEPFGPNTHLIRRIPLALGSEDPEEVQGSLLELSGCQDLQAAQVTVACR
GALRNGIPLTLEQMQKLLEAWQRTANPHTCPHGRPVYLALAERDLARYFRRRWGLCDRPISDSKLGSLGELDPLGDRFAA
QVRRSSGSSASEPTDEASSAPL
>Mature_581_residues
SKIQPLNPERIAQMAAGEVIDSLGAALRELLENALDAQATRIQVEIWPSRWQVRVADNGQGIPASELEQVARRHTTSKLD
GCSLGFRGEALHSLARLGSLAIQTRHVSDAHGWLAAYDRQGELIHKQPAATALGTVVTVADLFADWPLRRRALPQTRPLL
TLVQNAALAHPWVSWQVHQEGQLLLSLWPGKSLQDLLLQVLPQVDPTDLRYRRIQDGDSDWEVVLGLPDRLHRPHPDWIR
VAVNGRFVQMPDWQRLIQSVFHHALPRHRHPLVVVHLRLPPEQVDWNRHPAKSELYLENLTARQEQLRQHLHSLLQLGSG
QASRRSVHLIRASEAKVVYRVSPDFQSHLPPSDRPTSPLPPLRALAQLHRIYILAEHPQGLWLVEQHLAHERVRYEYIRQ
HWQLVAPETPITLQGLSPQALERLEQLGLEPEPFGPNTHLIRRIPLALGSEDPEEVQGSLLELSGCQDLQAAQVTVACRG
ALRNGIPLTLEQMQKLLEAWQRTANPHTCPHGRPVYLALAERDLARYFRRRWGLCDRPISDSKLGSLGELDPLGDRFAAQ
VRRSSGSSASEPTDEASSAPL

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=334, Percent_Identity=27.8443113772455, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI310128478, Length=334, Percent_Identity=28.4431137724551, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI4505913, Length=334, Percent_Identity=28.4431137724551, Blast_Score=113, Evalue=5e-25,
Organism=Homo sapiens, GI189458898, Length=314, Percent_Identity=24.5222929936306, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI4505911, Length=314, Percent_Identity=24.5222929936306, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI189458896, Length=308, Percent_Identity=24.3506493506494, Blast_Score=94, Evalue=4e-19,
Organism=Homo sapiens, GI91992162, Length=213, Percent_Identity=28.169014084507, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI91992160, Length=213, Percent_Identity=28.169014084507, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI310128480, Length=283, Percent_Identity=27.208480565371, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI263191589, Length=240, Percent_Identity=23.75, Blast_Score=80, Evalue=4e-15,
Organism=Escherichia coli, GI1790612, Length=329, Percent_Identity=29.1793313069909, Blast_Score=115, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI17562796, Length=343, Percent_Identity=27.6967930029155, Blast_Score=130, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI71991825, Length=321, Percent_Identity=25.8566978193146, Blast_Score=98, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6323819, Length=331, Percent_Identity=29.0030211480363, Blast_Score=130, Evalue=7e-31,
Organism=Saccharomyces cerevisiae, GI6324247, Length=343, Percent_Identity=26.8221574344023, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6325093, Length=345, Percent_Identity=22.0289855072464, Blast_Score=87, Evalue=8e-18,
Organism=Drosophila melanogaster, GI17136968, Length=332, Percent_Identity=29.5180722891566, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI17136970, Length=160, Percent_Identity=35.625, Blast_Score=108, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 65565; Mature: 65433

Theoretical pI: Translated: 7.86; Mature: 7.86

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKIQPLNPERIAQMAAGEVIDSLGAALRELLENALDAQATRIQVEIWPSRWQVRVADNG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCEEEEECCCC
QGIPASELEQVARRHTTSKLDGCSLGFRGEALHSLARLGSLAIQTRHVSDAHGWLAAYDR
CCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHEEECCCCCCCHHEEECC
QGELIHKQPAATALGTVVTVADLFADWPLRRRALPQTRPLLTLVQNAALAHPWVSWQVHQ
CCCEECCCCHHHHHHHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHCCCCCEEEECC
EGQLLLSLWPGKSLQDLLLQVLPQVDPTDLRYRRIQDGDSDWEVVLGLPDRLHRPHPDWI
CCCEEEEECCCCCHHHHHHHHHCCCCCCCCHHHHCCCCCCCCEEEEECCHHHCCCCCCEE
RVAVNGRFVQMPDWQRLIQSVFHHALPRHRHPLVVVHLRLPPEQVDWNRHPAKSELYLEN
EEEECCEEEECCCHHHHHHHHHHHHCCCCCCCEEEEEEECCHHHCCCCCCCCCHHHHHHH
LTARQEQLRQHLHSLLQLGSGQASRRSVHLIRASEAKVVYRVSPDFQSHLPPSDRPTSPL
HHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCEEEEEECCCHHHCCCCCCCCCCCC
PPLRALAQLHRIYILAEHPQGLWLVEQHLAHERVRYEYIRQHWQLVAPETPITLQGLSPQ
CHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEECCCHH
ALERLEQLGLEPEPFGPNTHLIRRIPLALGSEDPEEVQGSLLELSGCQDLQAAQVTVACR
HHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHH
GALRNGIPLTLEQMQKLLEAWQRTANPHTCPHGRPVYLALAERDLARYFRRRWGLCDRPI
HHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEHHHHHHHHHHHHCCCCCCCC
SDSKLGSLGELDPLGDRFAAQVRRSSGSSASEPTDEASSAPL
CCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SKIQPLNPERIAQMAAGEVIDSLGAALRELLENALDAQATRIQVEIWPSRWQVRVADNG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCCEEEEECCCC
QGIPASELEQVARRHTTSKLDGCSLGFRGEALHSLARLGSLAIQTRHVSDAHGWLAAYDR
CCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHEEECCCCCCCHHEEECC
QGELIHKQPAATALGTVVTVADLFADWPLRRRALPQTRPLLTLVQNAALAHPWVSWQVHQ
CCCEECCCCHHHHHHHHHHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHCCCCCEEEECC
EGQLLLSLWPGKSLQDLLLQVLPQVDPTDLRYRRIQDGDSDWEVVLGLPDRLHRPHPDWI
CCCEEEEECCCCCHHHHHHHHHCCCCCCCCHHHHCCCCCCCCEEEEECCHHHCCCCCCEE
RVAVNGRFVQMPDWQRLIQSVFHHALPRHRHPLVVVHLRLPPEQVDWNRHPAKSELYLEN
EEEECCEEEECCCHHHHHHHHHHHHCCCCCCCEEEEEEECCHHHCCCCCCCCCHHHHHHH
LTARQEQLRQHLHSLLQLGSGQASRRSVHLIRASEAKVVYRVSPDFQSHLPPSDRPTSPL
HHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCEEEEEECCCHHHCCCCCCCCCCCC
PPLRALAQLHRIYILAEHPQGLWLVEQHLAHERVRYEYIRQHWQLVAPETPITLQGLSPQ
CHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEECCCHH
ALERLEQLGLEPEPFGPNTHLIRRIPLALGSEDPEEVQGSLLELSGCQDLQAAQVTVACR
HHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHH
GALRNGIPLTLEQMQKLLEAWQRTANPHTCPHGRPVYLALAERDLARYFRRRWGLCDRPI
HHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEHHHHHHHHHHHHCCCCCCCC
SDSKLGSLGELDPLGDRFAAQVRRSSGSSASEPTDEASSAPL
CCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA