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The map label for this gene is ldh [H]

Identifier: 86609612

GI number: 86609612

Start: 2268252

End: 2269172

Strand: Direct

Name: ldh [H]

Synonym: CYB_2165

Alternate gene names: 86609612

Gene position: 2268252-2269172 (Clockwise)

Preceding gene: 86609611

Following gene: 86609613

Centisome position: 74.45

GC content: 60.04

Gene sequence:

>921_bases
TTGAAGGGATCCATCATCGGCGCCGGCCAGGTAGGCATGGCCTGTGCCTACTCGATGGTAATCCAGAACACTCTGGATGA
GCTGGTCCTTCACGACATCGACCGCAACAAGCTGGAAGGGGAAGTGATGGATCTGGTGCACGGGATCCCCTTTGTGGAGC
CGACGCGGATACGGGCAGGGGAACTGGCGGATTGCGCCGGGTCAGATGTAGTGATTTTAACGGCAGGAGCCAAGCAGCGG
CCTGGAGAAACCCGTTTGGATTTGGTGCAGCGCAACGTCGAGATCTTCAAAGGCTTGATCCCGGCCTTGATGGCGCATTG
CCCTGACACACTCCTTTTGGTGGTGAGCAATCCCGTTGACATCATGACTTACGTTTCCCTGAAGTTGTCGGGGTTGCCGG
CAGGGCAGGTAATTGGGTCGGGGACGGTTTTGGACACAGCCCGCTTTCGCTATCTTTTGGCGGAGCGCCTGGGGGTGGAT
CCGCGTAGCCTGCACGCCTACATCATCGGCGAACATGGAGATAGCGAGGTGGCCGTTTGGAGCAAGGTGAACATCGCCGG
CACCCCGATTGGGGAACTCTCGCCGGACTGGGATCCCGCCTATTTGGGGGATATCTTCGAGCAGGTGCGCAACGCTGCCT
ACGAGATCATCCGTCGCAAAGGGGCCACCAGCTACGCCATCGGGTTAGGGGTGACGCAAATTGTCCAAGCCCTGCTGCGG
GATCAACACCGCGTTTTAACCGTGAGCAGCCTCACCCAAGGGGAGTACGATCTGCCAGAGGTCTGTCTCAGCTTGCCCAG
AGTGGTCGGGCGGCAGGGGGTGGAACGCACGCTGGCCATGTCCCTCACCGAGAGCGAGCGCAAGCAGCTGCACCGCTCGG
CCCAGATCTTGCGGCAAGTCATCGACAGCATCCGGTGGTAG

Upstream 100 bases:

>100_bases
TGGAGAACGAAGAGTAGCGGCTGCAGCCATGACTGTTTCTAAGCACCAACCCAAGCAGCGCTCCCAGCAGCAGGTCGAGG
GGCTGACTTCTCGCCGCCTT

Downstream 100 bases:

>100_bases
CCTAGATCTCCTGGACTTTTGTCGCTCCCCTCCAAGCTGGGGGATCCCTTGGTCAGTGGGCGAGGGCCGCAGCTGGCGGC
AGGAGGTGGTCTATGGAAGC

Product: L-lactate dehydrogenase

Products: NA

Alternate protein names: L-LDH [H]

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MKGSIIGAGQVGMACAYSMVIQNTLDELVLHDIDRNKLEGEVMDLVHGIPFVEPTRIRAGELADCAGSDVVILTAGAKQR
PGETRLDLVQRNVEIFKGLIPALMAHCPDTLLLVVSNPVDIMTYVSLKLSGLPAGQVIGSGTVLDTARFRYLLAERLGVD
PRSLHAYIIGEHGDSEVAVWSKVNIAGTPIGELSPDWDPAYLGDIFEQVRNAAYEIIRRKGATSYAIGLGVTQIVQALLR
DQHRVLTVSSLTQGEYDLPEVCLSLPRVVGRQGVERTLAMSLTESERKQLHRSAQILRQVIDSIRW

Sequences:

>Translated_306_residues
MKGSIIGAGQVGMACAYSMVIQNTLDELVLHDIDRNKLEGEVMDLVHGIPFVEPTRIRAGELADCAGSDVVILTAGAKQR
PGETRLDLVQRNVEIFKGLIPALMAHCPDTLLLVVSNPVDIMTYVSLKLSGLPAGQVIGSGTVLDTARFRYLLAERLGVD
PRSLHAYIIGEHGDSEVAVWSKVNIAGTPIGELSPDWDPAYLGDIFEQVRNAAYEIIRRKGATSYAIGLGVTQIVQALLR
DQHRVLTVSSLTQGEYDLPEVCLSLPRVVGRQGVERTLAMSLTESERKQLHRSAQILRQVIDSIRW
>Mature_306_residues
MKGSIIGAGQVGMACAYSMVIQNTLDELVLHDIDRNKLEGEVMDLVHGIPFVEPTRIRAGELADCAGSDVVILTAGAKQR
PGETRLDLVQRNVEIFKGLIPALMAHCPDTLLLVVSNPVDIMTYVSLKLSGLPAGQVIGSGTVLDTARFRYLLAERLGVD
PRSLHAYIIGEHGDSEVAVWSKVNIAGTPIGELSPDWDPAYLGDIFEQVRNAAYEIIRRKGATSYAIGLGVTQIVQALLR
DQHRVLTVSSLTQGEYDLPEVCLSLPRVVGRQGVERTLAMSLTESERKQLHRSAQILRQVIDSIRW

Specific function: Catalyzes The Reversible Oxidation Of Malate To Oxaloacetate. [C]

COG id: COG0039

COG function: function code C; Malate/lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH/MDH superfamily. LDH family [H]

Homologues:

Organism=Homo sapiens, GI15082234, Length=310, Percent_Identity=46.1290322580645, Blast_Score=285, Evalue=4e-77,
Organism=Homo sapiens, GI9257228, Length=305, Percent_Identity=48.8524590163934, Blast_Score=285, Evalue=4e-77,
Organism=Homo sapiens, GI4504973, Length=305, Percent_Identity=48.8524590163934, Blast_Score=285, Evalue=4e-77,
Organism=Homo sapiens, GI47059044, Length=310, Percent_Identity=46.1290322580645, Blast_Score=284, Evalue=9e-77,
Organism=Homo sapiens, GI221136809, Length=310, Percent_Identity=46.1290322580645, Blast_Score=284, Evalue=9e-77,
Organism=Homo sapiens, GI291575128, Length=305, Percent_Identity=46.5573770491803, Blast_Score=282, Evalue=3e-76,
Organism=Homo sapiens, GI4557032, Length=305, Percent_Identity=46.5573770491803, Blast_Score=282, Evalue=3e-76,
Organism=Homo sapiens, GI5031857, Length=302, Percent_Identity=46.3576158940397, Blast_Score=277, Evalue=7e-75,
Organism=Homo sapiens, GI260099723, Length=302, Percent_Identity=46.3576158940397, Blast_Score=277, Evalue=8e-75,
Organism=Homo sapiens, GI260099727, Length=196, Percent_Identity=53.5714285714286, Blast_Score=218, Evalue=5e-57,
Organism=Homo sapiens, GI260099725, Length=196, Percent_Identity=53.5714285714286, Blast_Score=216, Evalue=2e-56,
Organism=Homo sapiens, GI207028494, Length=301, Percent_Identity=34.8837209302326, Blast_Score=178, Evalue=6e-45,
Organism=Homo sapiens, GI103472011, Length=285, Percent_Identity=34.3859649122807, Blast_Score=163, Evalue=2e-40,
Organism=Homo sapiens, GI103472015, Length=181, Percent_Identity=37.5690607734807, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI21735621, Length=308, Percent_Identity=28.2467532467532, Blast_Score=85, Evalue=9e-17,
Organism=Escherichia coli, GI1789632, Length=318, Percent_Identity=27.9874213836478, Blast_Score=78, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17535107, Length=299, Percent_Identity=49.8327759197324, Blast_Score=291, Evalue=3e-79,
Organism=Drosophila melanogaster, GI17136226, Length=305, Percent_Identity=49.8360655737705, Blast_Score=288, Evalue=3e-78,
Organism=Drosophila melanogaster, GI45550422, Length=305, Percent_Identity=36.0655737704918, Blast_Score=186, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24647881, Length=312, Percent_Identity=26.9230769230769, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24663599, Length=317, Percent_Identity=23.9747634069401, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: 2640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 260 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2380 Molecules/Cell In: Stationary-Phase, Rich-Media (Based on E. coli). 260 Molecules/Cell In: Stationary Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001557
- InterPro:   IPR011304
- InterPro:   IPR018177
- InterPro:   IPR022383
- InterPro:   IPR001236
- InterPro:   IPR015955
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02866 Ldh_1_C; PF00056 Ldh_1_N [H]

EC number: =1.1.1.27 [H]

Molecular weight: Translated: 33428; Mature: 33428

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00064 L_LDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGSIIGAGQVGMACAYSMVIQNTLDELVLHDIDRNKLEGEVMDLVHGIPFVEPTRIRAG
CCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCC
ELADCAGSDVVILTAGAKQRPGETRLDLVQRNVEIFKGLIPALMAHCPDTLLLVVSNPVD
CCHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHH
IMTYVSLKLSGLPAGQVIGSGTVLDTARFRYLLAERLGVDPRSLHAYIIGEHGDSEVAVW
HHHHHHHEECCCCCCCEECCCCHHHHHHHHHHHHHHHCCCHHHEEEEEEECCCCCCEEEE
SKVNIAGTPIGELSPDWDPAYLGDIFEQVRNAAYEIIRRKGATSYAIGLGVTQIVQALLR
EEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHC
DQHRVLTVSSLTQGEYDLPEVCLSLPRVVGRQGVERTLAMSLTESERKQLHRSAQILRQV
CCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IDSIRW
HHHHCC
>Mature Secondary Structure
MKGSIIGAGQVGMACAYSMVIQNTLDELVLHDIDRNKLEGEVMDLVHGIPFVEPTRIRAG
CCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCC
ELADCAGSDVVILTAGAKQRPGETRLDLVQRNVEIFKGLIPALMAHCPDTLLLVVSNPVD
CCHHCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHH
IMTYVSLKLSGLPAGQVIGSGTVLDTARFRYLLAERLGVDPRSLHAYIIGEHGDSEVAVW
HHHHHHHEECCCCCCCEECCCCHHHHHHHHHHHHHHHCCCHHHEEEEEEECCCCCCEEEE
SKVNIAGTPIGELSPDWDPAYLGDIFEQVRNAAYEIIRRKGATSYAIGLGVTQIVQALLR
EEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHC
DQHRVLTVSSLTQGEYDLPEVCLSLPRVVGRQGVERTLAMSLTESERKQLHRSAQILRQV
CCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IDSIRW
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA