Click here to switch to the map view.

The map label for this gene is ppiA [C]

Identifier: 86609551

GI number: 86609551

Start: 2199443

End: 2200213

Strand: Direct

Name: ppiA [C]

Synonym: CYB_2104

Alternate gene names: 86609551

Gene position: 2199443-2200213 (Clockwise)

Preceding gene: 86609550

Following gene: 86609552

Centisome position: 72.19

GC content: 61.09

Gene sequence:

>771_bases
ATGAAATTCGCCAAGCTGGGGCGAATGAGCCGCTGCAGAGTGGGAGTGGGCTTAGTTCTGGGATACCTCTGTCTCGGGCT
GTTGGCTTGTCGCAGTACACCCCCCCTCTCAGAATCCCCCTCTGGGATCCCGGCGGCCTATGCTAGCCGCCCGCAACTGC
AAGGGAAGGCAGTGGTGGAGATGGAGGTGCAAACTGCTGAGGGGGTAGGCAAGGTGATCTTGGCGATCCACGGGGAAGCG
GCACCCCTGACCGGCGGCCAGTTCGTGGATTTGGTTCAGCGGGGCTTTTACAATGGCCTCACCTTCCATCGGGTGGAAAA
GGATCCGCAGCCTTTTGTGGTGCAGGGTGGGGATCCCCGTGGTGACGGTACAGGGGGTGCAACAGAGCCGGGGAGCAACC
GCCTGCGCACCATCCCCCTGGAAATTCAGCTGCGTGGGGAACCCTACCCCCGCTACAACACCTTGATCCAGGATCCCGCT
GCTCTGAGTAAGTTGCTCTTGCCCCATCGTTTGGGGGCGGTGGCCATGGCCCGTTCTAGCCCACTTGACTCAGCCTCTTC
CCAGTTTTACATCACCCTCTCTGCTCTGCCGATTTTGGACGGGCGCTATGCCGTGTTCGGCTACGTCACCGAGGGGATGG
AGTGGGTGGAGCGCATCCAGGTGGGAGATGTGATCCGCTCGGCGCGGGTGTTGGAAGGAGCGGACTTGCTTAGGGTGCCG
GGATCCCAACCGGAAAGAGCAGATCAGATGGAGGATCCCGGCAGTTTATGA

Upstream 100 bases:

>100_bases
TTGGGGCTGTCGCAGCGGATCTGAATCACCTGGATAGGGATCCCTGCTGGGTTGAGCAGCGCCTGGAGGGTGGGAGATTC
GATTGAAGGAGAAGGGGCAG

Downstream 100 bases:

>100_bases
TGGGCAGCAACTCTGCTGCTGGTTTGGTTGTTGTGGCTCTGGCTTTTGCCTTGGGGAAGGGCAAGTTTTGCCCCCGTCCC
CTCCGCCAACACCTGGGCAC

Product: peptidyl-prolyl cis-trans isomerase, cyclophilin-type

Products: NA

Alternate protein names: PPIase sll0227; Rotamase sll0227 [H]

Number of amino acids: Translated: 256; Mature: 256

Protein sequence:

>256_residues
MKFAKLGRMSRCRVGVGLVLGYLCLGLLACRSTPPLSESPSGIPAAYASRPQLQGKAVVEMEVQTAEGVGKVILAIHGEA
APLTGGQFVDLVQRGFYNGLTFHRVEKDPQPFVVQGGDPRGDGTGGATEPGSNRLRTIPLEIQLRGEPYPRYNTLIQDPA
ALSKLLLPHRLGAVAMARSSPLDSASSQFYITLSALPILDGRYAVFGYVTEGMEWVERIQVGDVIRSARVLEGADLLRVP
GSQPERADQMEDPGSL

Sequences:

>Translated_256_residues
MKFAKLGRMSRCRVGVGLVLGYLCLGLLACRSTPPLSESPSGIPAAYASRPQLQGKAVVEMEVQTAEGVGKVILAIHGEA
APLTGGQFVDLVQRGFYNGLTFHRVEKDPQPFVVQGGDPRGDGTGGATEPGSNRLRTIPLEIQLRGEPYPRYNTLIQDPA
ALSKLLLPHRLGAVAMARSSPLDSASSQFYITLSALPILDGRYAVFGYVTEGMEWVERIQVGDVIRSARVLEGADLLRVP
GSQPERADQMEDPGSL
>Mature_256_residues
MKFAKLGRMSRCRVGVGLVLGYLCLGLLACRSTPPLSESPSGIPAAYASRPQLQGKAVVEMEVQTAEGVGKVILAIHGEA
APLTGGQFVDLVQRGFYNGLTFHRVEKDPQPFVVQGGDPRGDGTGGATEPGSNRLRTIPLEIQLRGEPYPRYNTLIQDPA
ALSKLLLPHRLGAVAMARSSPLDSASSQFYITLSALPILDGRYAVFGYVTEGMEWVERIQVGDVIRSARVLEGADLLRVP
GSQPERADQMEDPGSL

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI7706339, Length=170, Percent_Identity=30, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI4505991, Length=203, Percent_Identity=31.5270935960591, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI4758950, Length=174, Percent_Identity=34.4827586206897, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17506311, Length=186, Percent_Identity=32.7956989247312, Blast_Score=88, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17506307, Length=177, Percent_Identity=31.638418079096, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17552780, Length=180, Percent_Identity=33.3333333333333, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI17986117, Length=178, Percent_Identity=32.0224719101124, Blast_Score=88, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 27469; Mature: 27469

Theoretical pI: Translated: 7.44; Mature: 7.44

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFAKLGRMSRCRVGVGLVLGYLCLGLLACRSTPPLSESPSGIPAAYASRPQLQGKAVVE
CCCHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCCCCCCEEEE
MEVQTAEGVGKVILAIHGEAAPLTGGQFVDLVQRGFYNGLTFHRVEKDPQPFVVQGGDPR
EEEECCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCEEEECCCCC
GDGTGGATEPGSNRLRTIPLEIQLRGEPYPRYNTLIQDPAALSKLLLPHRLGAVAMARSS
CCCCCCCCCCCCCCEEEEEEEEEECCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHCCC
PLDSASSQFYITLSALPILDGRYAVFGYVTEGMEWVERIQVGDVIRSARVLEGADLLRVP
CCCCCCCEEEEEEEECEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECC
GSQPERADQMEDPGSL
CCCCCHHHCCCCCCCC
>Mature Secondary Structure
MKFAKLGRMSRCRVGVGLVLGYLCLGLLACRSTPPLSESPSGIPAAYASRPQLQGKAVVE
CCCHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCCCCCCEEEE
MEVQTAEGVGKVILAIHGEAAPLTGGQFVDLVQRGFYNGLTFHRVEKDPQPFVVQGGDPR
EEEECCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCEEEECCCCC
GDGTGGATEPGSNRLRTIPLEIQLRGEPYPRYNTLIQDPAALSKLLLPHRLGAVAMARSS
CCCCCCCCCCCCCCEEEEEEEEEECCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHCCC
PLDSASSQFYITLSALPILDGRYAVFGYVTEGMEWVERIQVGDVIRSARVLEGADLLRVP
CCCCCCCEEEEEEEECEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECC
GSQPERADQMEDPGSL
CCCCCHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]