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The map label for this gene is argH

Identifier: 86609518

GI number: 86609518

Start: 2166882

End: 2168315

Strand: Direct

Name: argH

Synonym: CYB_2070

Alternate gene names: 86609518

Gene position: 2166882-2168315 (Clockwise)

Preceding gene: 86609517

Following gene: 86609520

Centisome position: 71.12

GC content: 61.09

Gene sequence:

>1434_bases
ATGTCTGAGCCGACGGTAACTTCCACCCCTCGCCCCTGGAGCCAACGCTTCGAGGGATCCCTGCATCCTGCCATCGCCCG
CTTCAACGCCAGCATCGGCTTCGACATCCGCCTGCTGCCCTACGATGTGGCCGGATCCCTGGCTCATGTGCAGATGTTGG
CCGCTTGTGGCATCCTGACCCAGCAAGAGGCCGACCAGATCCGGTGGGGATTGGAGCAGATCCAACAGGAAGCGGCTGCC
GGCACCTTCCGGCCCGATCCAGAGGCAGAGGATGTCCACTACGCCGTCGAGCGTCGTTTGGTGGCTTTGGTGGGGGAAGT
GGGAAAAAAACTGCATACCGGGCGCTCCCGCAATGACCAAGTGGCCACCGATCTGCGTCTCTATCTGCGAGATCAGATCG
ATCACCTTCGTCAAGCCCTCTGGGAGCTGCGCGGAGTTTTGTTGGACTTGGCTGAGCGGCATCTGGAGACAATCCTGCCC
GGCTACACCCATCTGCAACGGGCTCAGCCGATTAGCTTGGCCCACCACCTCTTGGCCTATGAAGAAATGTTCTGGCGAGA
CTGGCAACGGCTGGGGCGGGTGCGGGAAGAGGTGAATGTCTGCCCCCTCGGATCCGGGGCTTTGGCCGGCACTTCTCTGC
CCATCGATCGGCAGCTCACCGCCCATCTGCTGGGATTTGAGCGGATCAGCGCCAACAGCTTGGATGCCGTCAGCGACCGG
GACTACCTGGTGGAGTTCCACGCTGCCGCCAGCTTGATTTTGGTGCATCTCAGCCGCCTCTCGGAAGAGGTGATCCTCTG
GGCTTCCCAGGAGTTCGGCTTTGTCACCCTCACCGATGCCTGTGCCACCGGCTCCAGCCTCATGCCCCAGAAGAAAAATC
CCGATGTGCCGGAGTTGGTGCGCGGCAAGGCGGGGCGGGTGTTTGGCCATCTCCAGGCTTTGTTGGTCACCTTGAAGGGG
CTGCCGCTGGCCTACAACAAAGATCTCCAAGAAGACAAAGAGGGACTATTCGACACGGTCGATACCCTGAAAGCCTGCCT
AGAGGCGATGACCCTTCTGCTGCGGGAAGGGATCCAATTTCAACCTGAGCGCATGGCGGCTGCTGTGCAGGAAGATTTCT
CCAACGCCACCGATGTGGCCGACTACTTGGTGCGCAAAGGGATCCCCTTTCGCACAGCCCATGATTTGGTGGGGCAGATT
GTGCGCATTTGTTTGGCAGAGGGGATCCTGCTGCGGGATCTGCCCTTGGAGCGCTGGAAAACCTTCCACCCGGCCTTTGA
GGCGGACATTTTGACGGCCATTGAGCCCCGCCAGGTGGTGGCCACGCGGCTCAGCGCCGGGGGAACGGGCTTTGCTGTGG
TGCGAGAAGCCCTGCAACGGGCCCAGGCCCGCCACCAGCAGCCAGAGCCATCGGAAGAAACTCCACAAACTTAA

Upstream 100 bases:

>100_bases
AGTTGGCCTGAGCCGGCGGGGTTTTGGCCGTCGGTATTTGGTTTTTGTGCTTTTTCTTCTGCAGCGGGGTCTTTCTTCCC
ATTCTTCCGGTTCCCAGCCG

Downstream 100 bases:

>100_bases
AGTAAACTACCCGACCCTGACTGCTTCGCAGTACAGGGGGGGCTTTCAGTAGCCCTGCAGTTGGCAAGCCAACCACGAAC
CTCTAGGCTGGTTTACGACA

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase

Number of amino acids: Translated: 477; Mature: 476

Protein sequence:

>477_residues
MSEPTVTSTPRPWSQRFEGSLHPAIARFNASIGFDIRLLPYDVAGSLAHVQMLAACGILTQQEADQIRWGLEQIQQEAAA
GTFRPDPEAEDVHYAVERRLVALVGEVGKKLHTGRSRNDQVATDLRLYLRDQIDHLRQALWELRGVLLDLAERHLETILP
GYTHLQRAQPISLAHHLLAYEEMFWRDWQRLGRVREEVNVCPLGSGALAGTSLPIDRQLTAHLLGFERISANSLDAVSDR
DYLVEFHAAASLILVHLSRLSEEVILWASQEFGFVTLTDACATGSSLMPQKKNPDVPELVRGKAGRVFGHLQALLVTLKG
LPLAYNKDLQEDKEGLFDTVDTLKACLEAMTLLLREGIQFQPERMAAAVQEDFSNATDVADYLVRKGIPFRTAHDLVGQI
VRICLAEGILLRDLPLERWKTFHPAFEADILTAIEPRQVVATRLSAGGTGFAVVREALQRAQARHQQPEPSEETPQT

Sequences:

>Translated_477_residues
MSEPTVTSTPRPWSQRFEGSLHPAIARFNASIGFDIRLLPYDVAGSLAHVQMLAACGILTQQEADQIRWGLEQIQQEAAA
GTFRPDPEAEDVHYAVERRLVALVGEVGKKLHTGRSRNDQVATDLRLYLRDQIDHLRQALWELRGVLLDLAERHLETILP
GYTHLQRAQPISLAHHLLAYEEMFWRDWQRLGRVREEVNVCPLGSGALAGTSLPIDRQLTAHLLGFERISANSLDAVSDR
DYLVEFHAAASLILVHLSRLSEEVILWASQEFGFVTLTDACATGSSLMPQKKNPDVPELVRGKAGRVFGHLQALLVTLKG
LPLAYNKDLQEDKEGLFDTVDTLKACLEAMTLLLREGIQFQPERMAAAVQEDFSNATDVADYLVRKGIPFRTAHDLVGQI
VRICLAEGILLRDLPLERWKTFHPAFEADILTAIEPRQVVATRLSAGGTGFAVVREALQRAQARHQQPEPSEETPQT
>Mature_476_residues
SEPTVTSTPRPWSQRFEGSLHPAIARFNASIGFDIRLLPYDVAGSLAHVQMLAACGILTQQEADQIRWGLEQIQQEAAAG
TFRPDPEAEDVHYAVERRLVALVGEVGKKLHTGRSRNDQVATDLRLYLRDQIDHLRQALWELRGVLLDLAERHLETILPG
YTHLQRAQPISLAHHLLAYEEMFWRDWQRLGRVREEVNVCPLGSGALAGTSLPIDRQLTAHLLGFERISANSLDAVSDRD
YLVEFHAAASLILVHLSRLSEEVILWASQEFGFVTLTDACATGSSLMPQKKNPDVPELVRGKAGRVFGHLQALLVTLKGL
PLAYNKDLQEDKEGLFDTVDTLKACLEAMTLLLREGIQFQPERMAAAVQEDFSNATDVADYLVRKGIPFRTAHDLVGQIV
RICLAEGILLRDLPLERWKTFHPAFEADILTAIEPRQVVATRLSAGGTGFAVVREALQRAQARHQQPEPSEETPQT

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI31541964, Length=457, Percent_Identity=46.8271334792123, Blast_Score=407, Evalue=1e-113,
Organism=Homo sapiens, GI68303542, Length=457, Percent_Identity=46.8271334792123, Blast_Score=407, Evalue=1e-113,
Organism=Homo sapiens, GI68303549, Length=457, Percent_Identity=44.4201312910284, Blast_Score=374, Evalue=1e-104,
Organism=Homo sapiens, GI68303547, Length=457, Percent_Identity=43.7636761487965, Blast_Score=368, Evalue=1e-102,
Organism=Escherichia coli, GI1790398, Length=456, Percent_Identity=46.4912280701754, Blast_Score=399, Evalue=1e-112,
Organism=Saccharomyces cerevisiae, GI6321806, Length=459, Percent_Identity=43.5729847494553, Blast_Score=365, Evalue=1e-102,
Organism=Drosophila melanogaster, GI221473854, Length=455, Percent_Identity=42.8571428571429, Blast_Score=355, Evalue=3e-98,
Organism=Drosophila melanogaster, GI78706858, Length=455, Percent_Identity=42.8571428571429, Blast_Score=355, Evalue=3e-98,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLY_SYNJB (Q2JJY4)

Other databases:

- EMBL:   CP000240
- RefSeq:   YP_478280.1
- ProteinModelPortal:   Q2JJY4
- SMR:   Q2JJY4
- STRING:   Q2JJY4
- GeneID:   3901980
- GenomeReviews:   CP000240_GR
- KEGG:   cyb:CYB_2070
- TIGR:   CYB_2070
- eggNOG:   COG0165
- HOGENOM:   HBG539632
- OMA:   MAEDLIF
- PhylomeDB:   Q2JJY4
- ProtClustDB:   PRK00855
- BioCyc:   SSP321332:CYB_2070-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00006
- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PANTHER:   PTHR11444:SF3
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00838

Pfam domain/function: PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.1

Molecular weight: Translated: 53218; Mature: 53087

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEPTVTSTPRPWSQRFEGSLHPAIARFNASIGFDIRLLPYDVAGSLAHVQMLAACGILT
CCCCCCCCCCCCHHHHHCCCCCHHHHHHCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHH
QQEADQIRWGLEQIQQEAAAGTFRPDPEAEDVHYAVERRLVALVGEVGKKLHTGRSRNDQ
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
VATDLRLYLRDQIDHLRQALWELRGVLLDLAERHLETILPGYTHLQRAQPISLAHHLLAY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHH
EEMFWRDWQRLGRVREEVNVCPLGSGALAGTSLPIDRQLTAHLLGFERISANSLDAVSDR
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCC
DYLVEFHAAASLILVHLSRLSEEVILWASQEFGFVTLTDACATGSSLMPQKKNPDVPELV
HHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEEHHHCCCCCCCCCCCCCCHHHHH
RGKAGRVFGHLQALLVTLKGLPLAYNKDLQEDKEGLFDTVDTLKACLEAMTLLLREGIQF
CCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
QPERMAAAVQEDFSNATDVADYLVRKGIPFRTAHDLVGQIVRICLAEGILLRDLPLERWK
CHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHCCCHHHHH
TFHPAFEADILTAIEPRQVVATRLSAGGTGFAVVREALQRAQARHQQPEPSEETPQT
HHCCCHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
SEPTVTSTPRPWSQRFEGSLHPAIARFNASIGFDIRLLPYDVAGSLAHVQMLAACGILT
CCCCCCCCCCCHHHHHCCCCCHHHHHHCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHH
QQEADQIRWGLEQIQQEAAAGTFRPDPEAEDVHYAVERRLVALVGEVGKKLHTGRSRNDQ
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCH
VATDLRLYLRDQIDHLRQALWELRGVLLDLAERHLETILPGYTHLQRAQPISLAHHLLAY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCHHHHHHHHHHH
EEMFWRDWQRLGRVREEVNVCPLGSGALAGTSLPIDRQLTAHLLGFERISANSLDAVSDR
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCC
DYLVEFHAAASLILVHLSRLSEEVILWASQEFGFVTLTDACATGSSLMPQKKNPDVPELV
HHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEEHHHCCCCCCCCCCCCCCHHHHH
RGKAGRVFGHLQALLVTLKGLPLAYNKDLQEDKEGLFDTVDTLKACLEAMTLLLREGIQF
CCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
QPERMAAAVQEDFSNATDVADYLVRKGIPFRTAHDLVGQIVRICLAEGILLRDLPLERWK
CHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHCCCHHHHH
TFHPAFEADILTAIEPRQVVATRLSAGGTGFAVVREALQRAQARHQQPEPSEETPQT
HHCCCHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA