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The map label for this gene is hisA [H]

Identifier: 86609414

GI number: 86609414

Start: 2060409

End: 2061194

Strand: Direct

Name: hisA [H]

Synonym: CYB_1964

Alternate gene names: 86609414

Gene position: 2060409-2061194 (Clockwise)

Preceding gene: 86609411

Following gene: 86609415

Centisome position: 67.63

GC content: 63.1

Gene sequence:

>786_bases
ATGCCTTACACCAGCGCCTTCTTAGAGGTGATCCCCGCCATCGACCTTTTGCAGGGCCGCGCCGTGCGCCTTTACCAGGG
GGATTACGCCCAGGCAGAACAGGTAGCCGACGACCCGATCCAACAGGCCGAAGCTTGGGCGGCACAGGGTGCTCCTCGCC
TGCATGTGGTGGATTTGGACGGGGCCAAAAGCGGGGATCCAGTCAACCTGCCCATCATTGAGCGCATTGTCCGCAGCCTG
GCCATCCCGGTGCAGGTGGGGGGTGGGATCCGATCCCTTGAACGGGCGCGGCAGTTGTTGGATTTGGGGGTGGATCGGGT
GATCGTTGGCACCCTAGCCGTAGAGGATCCCGACACCCTGGAGGCTATGACCCAAGCCTTCCCCGGTCGGGTTTGGGTGG
GGATCGACGCTCGGCAAGGGCAGGTGGCCACCCGCGGCTGGCTGAGCACCACTCCCCTGCGGGCTCCTGAGCTAGTGCAA
CGGGTGCAAGCCCAAGGAGCTGCCGGGATCATCTATACCGACATTAGCCGGGATGGCACCCTGGCCGGGCCCAATTTAGA
ACAGCTGCGCCAGATTCTAGCCGTCTCTCAAGTGCCTGTAATTGCTTCGGGAGGGATCGGCTCGCTGACCGATTTGCTGG
CTTTGTTGAGCTTGCCCCGTTTGACAGGGGCCATTTTGGGCAAGGCCCTCTACTCAGGGGCGATCTCCTTGCAGGAAGCT
TTGCGAGCAGTGGGGCCGGGCCGCTGGCAAGATCTACCGCCGGAAACCGGATCCCTGTGGGCCTAG

Upstream 100 bases:

>100_bases
GTCAGCGGTGTGGAGCACTTTAGGGTCTAGAGATCCAGATCTCCGCTGGAGCAAGGCCGCTCCCAGGCGATACTGGAGAA
GCCCCTAAGGGATCCCAATC

Downstream 100 bases:

>100_bases
GTATCCATCCAGAGATCGAGCGAAAGACAGCCCTGGCAAAACCTCTGCCATACTGGTGAAATCAACAGGCAACTTCATGC
GACAACACCAGCCGCTGGTG

Product: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase [H]

Number of amino acids: Translated: 261; Mature: 260

Protein sequence:

>261_residues
MPYTSAFLEVIPAIDLLQGRAVRLYQGDYAQAEQVADDPIQQAEAWAAQGAPRLHVVDLDGAKSGDPVNLPIIERIVRSL
AIPVQVGGGIRSLERARQLLDLGVDRVIVGTLAVEDPDTLEAMTQAFPGRVWVGIDARQGQVATRGWLSTTPLRAPELVQ
RVQAQGAAGIIYTDISRDGTLAGPNLEQLRQILAVSQVPVIASGGIGSLTDLLALLSLPRLTGAILGKALYSGAISLQEA
LRAVGPGRWQDLPPETGSLWA

Sequences:

>Translated_261_residues
MPYTSAFLEVIPAIDLLQGRAVRLYQGDYAQAEQVADDPIQQAEAWAAQGAPRLHVVDLDGAKSGDPVNLPIIERIVRSL
AIPVQVGGGIRSLERARQLLDLGVDRVIVGTLAVEDPDTLEAMTQAFPGRVWVGIDARQGQVATRGWLSTTPLRAPELVQ
RVQAQGAAGIIYTDISRDGTLAGPNLEQLRQILAVSQVPVIASGGIGSLTDLLALLSLPRLTGAILGKALYSGAISLQEA
LRAVGPGRWQDLPPETGSLWA
>Mature_260_residues
PYTSAFLEVIPAIDLLQGRAVRLYQGDYAQAEQVADDPIQQAEAWAAQGAPRLHVVDLDGAKSGDPVNLPIIERIVRSLA
IPVQVGGGIRSLERARQLLDLGVDRVIVGTLAVEDPDTLEAMTQAFPGRVWVGIDARQGQVATRGWLSTTPLRAPELVQR
VQAQGAAGIIYTDISRDGTLAGPNLEQLRQILAVSQVPVIASGGIGSLTDLLALLSLPRLTGAILGKALYSGAISLQEAL
RAVGPGRWQDLPPETGSLWA

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family [H]

Homologues:

Organism=Escherichia coli, GI87082028, Length=249, Percent_Identity=39.7590361445783, Blast_Score=157, Evalue=7e-40,
Organism=Escherichia coli, GI1788336, Length=241, Percent_Identity=28.2157676348548, Blast_Score=100, Evalue=8e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00977 His_biosynth [H]

EC number: =5.3.1.16 [H]

Molecular weight: Translated: 27683; Mature: 27552

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPYTSAFLEVIPAIDLLQGRAVRLYQGDYAQAEQVADDPIQQAEAWAAQGAPRLHVVDLD
CCHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHCCHHHHHHHHHHCCCCEEEEEECC
GAKSGDPVNLPIIERIVRSLAIPVQVGGGIRSLERARQLLDLGVDRVIVGTLAVEDPDTL
CCCCCCCCCCHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHCHHHEEEEEEECCCCHHH
EAMTQAFPGRVWVGIDARQGQVATRGWLSTTPLRAPELVQRVQAQGAAGIIYTDISRDGT
HHHHHHCCCEEEEEEECCCCCCHHCCCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCC
LAGPNLEQLRQILAVSQVPVIASGGIGSLTDLLALLSLPRLTGAILGKALYSGAISLQEA
CCCCCHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRAVGPGRWQDLPPETGSLWA
HHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PYTSAFLEVIPAIDLLQGRAVRLYQGDYAQAEQVADDPIQQAEAWAAQGAPRLHVVDLD
CHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHCCHHHHHHHHHHCCCCEEEEEECC
GAKSGDPVNLPIIERIVRSLAIPVQVGGGIRSLERARQLLDLGVDRVIVGTLAVEDPDTL
CCCCCCCCCCHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHCHHHEEEEEEECCCCHHH
EAMTQAFPGRVWVGIDARQGQVATRGWLSTTPLRAPELVQRVQAQGAAGIIYTDISRDGT
HHHHHHCCCEEEEEEECCCCCCHHCCCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCC
LAGPNLEQLRQILAVSQVPVIASGGIGSLTDLLALLSLPRLTGAILGKALYSGAISLQEA
CCCCCHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRAVGPGRWQDLPPETGSLWA
HHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA