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The map label for this gene is hemC [H]

Identifier: 86609244

GI number: 86609244

Start: 1873483

End: 1874415

Strand: Reverse

Name: hemC [H]

Synonym: CYB_1786

Alternate gene names: 86609244

Gene position: 1874415-1873483 (Counterclockwise)

Preceding gene: 86609249

Following gene: 86609234

Centisome position: 61.52

GC content: 61.2

Gene sequence:

>933_bases
GTGCGGATCGCCTCTCGAAAAAGCGAGTTGGCTTTGGTGCAGACCCAGTGGGTGATGGGTCAGTTGCAAGAACACCATCC
GGGATTACCTCTGGAGCTCAACACCCTCTCCACCCAGGGAGACATCATCCTGGATGTAGCCCTGGCCAAAATTGGAGACA
AAGGTCTCTTTACCAAGGAATTGGAGGTTAGCCTGCTCAACGGCAGCAGCGACTTGGCGGTACACAGCCTTAAAGACTTG
CCCACTCGCCTGCCGGAGGGCTTGGTGTTGGGGGCGATCACGCGGCGGGAGGATCCCCTGGATGCTTTGGTGGTGGGGGA
AAAGTTCCGGGATTACCGACTGGCCACCCTGCCAGAGGGGACGGTGATCGGCACTTCATCGCTGCGGCGGCTGGCCCAAC
TGCGCCATGCCTTTCCCCACTTGCACTTTAAGGATGTGCGGGGCAACCTCAACACCCGCTTGGCCAAGCTGGAGCGGGGA
GAGTACGACGGCCTGATTTTGGCGGTGGCCGGCTTGAAGCGTCTGGGCAAAGCCGACCGGATCCACGAGGTGCTGGATCC
CGGCGTGTCTCTGTACGCGGTTGGGCAGGGATCCCTGGGAATCGAGTGTCGGCAGGGAGATGAGCGGATTCTGGAGCTTA
TCCGACCCTTGGCCGATGCGGAGGCCACAGCCCGCTGCTTGGCAGAGCGAGCTTTCCTGCGGGCTTTGGAAGGAGGGTGT
CAAGTGCCCATTGGCGTTCACAGCCAAGTCCAAGGGGAGGCGCTGCACCTAACCGGTATGGTGGCCGACCTGGATGGCCG
GCGGCTCATCCGCGATACTCAGACGGGATCCACCGCCGATCCCGAGGCAGTGGGGATGGCTCTTGCAGAAAAGCTAAAAC
AGCAGGGGGCCGACGAGATTTTGCAAGCCATTTTTGCCCAGGCCCGCCGTTAG

Upstream 100 bases:

>100_bases
ACAGATTCGGCTAGCGTGAGAGGCAGTGTTCTTTTTTGCGGCAGCCATGAGTGAACTGGCTTCGACCCCCTTCAAACCCT
CTGCTGGGATCACCAAGCCG

Downstream 100 bases:

>100_bases
GCTTTCCTACTTTTTCTGAGTAGGCTTTGAGAACTTCAGCTAGGGTCAGCTGAAGAAAAGGGGGAACAATGAAGTCCCCC
CTACGTGAATTGCACTCAAA

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MRIASRKSELALVQTQWVMGQLQEHHPGLPLELNTLSTQGDIILDVALAKIGDKGLFTKELEVSLLNGSSDLAVHSLKDL
PTRLPEGLVLGAITRREDPLDALVVGEKFRDYRLATLPEGTVIGTSSLRRLAQLRHAFPHLHFKDVRGNLNTRLAKLERG
EYDGLILAVAGLKRLGKADRIHEVLDPGVSLYAVGQGSLGIECRQGDERILELIRPLADAEATARCLAERAFLRALEGGC
QVPIGVHSQVQGEALHLTGMVADLDGRRLIRDTQTGSTADPEAVGMALAEKLKQQGADEILQAIFAQARR

Sequences:

>Translated_310_residues
MRIASRKSELALVQTQWVMGQLQEHHPGLPLELNTLSTQGDIILDVALAKIGDKGLFTKELEVSLLNGSSDLAVHSLKDL
PTRLPEGLVLGAITRREDPLDALVVGEKFRDYRLATLPEGTVIGTSSLRRLAQLRHAFPHLHFKDVRGNLNTRLAKLERG
EYDGLILAVAGLKRLGKADRIHEVLDPGVSLYAVGQGSLGIECRQGDERILELIRPLADAEATARCLAERAFLRALEGGC
QVPIGVHSQVQGEALHLTGMVADLDGRRLIRDTQTGSTADPEAVGMALAEKLKQQGADEILQAIFAQARR
>Mature_310_residues
MRIASRKSELALVQTQWVMGQLQEHHPGLPLELNTLSTQGDIILDVALAKIGDKGLFTKELEVSLLNGSSDLAVHSLKDL
PTRLPEGLVLGAITRREDPLDALVVGEKFRDYRLATLPEGTVIGTSSLRRLAQLRHAFPHLHFKDVRGNLNTRLAKLERG
EYDGLILAVAGLKRLGKADRIHEVLDPGVSLYAVGQGSLGIECRQGDERILELIRPLADAEATARCLAERAFLRALEGGC
QVPIGVHSQVQGEALHLTGMVADLDGRRLIRDTQTGSTADPEAVGMALAEKLKQQGADEILQAIFAQARR

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI20149500, Length=298, Percent_Identity=51.6778523489933, Blast_Score=293, Evalue=1e-79,
Organism=Homo sapiens, GI66933009, Length=299, Percent_Identity=51.505016722408, Blast_Score=292, Evalue=2e-79,
Organism=Escherichia coli, GI48994974, Length=306, Percent_Identity=50, Blast_Score=277, Evalue=6e-76,
Organism=Saccharomyces cerevisiae, GI6319996, Length=316, Percent_Identity=43.3544303797468, Blast_Score=235, Evalue=5e-63,
Organism=Drosophila melanogaster, GI20130425, Length=283, Percent_Identity=51.9434628975265, Blast_Score=285, Evalue=2e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 33720; Mature: 33720

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIASRKSELALVQTQWVMGQLQEHHPGLPLELNTLSTQGDIILDVALAKIGDKGLFTKE
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCEEEEHHHHHHCCCCCEEHE
LEVSLLNGSSDLAVHSLKDLPTRLPEGLVLGAITRREDPLDALVVGEKFRDYRLATLPEG
EEEEEECCCCCHHHHHHHHHHHHCCCCEEEEEHHCCCCCCHHEEECCHHHCCEEEECCCC
TVIGTSSLRRLAQLRHAFPHLHFKDVRGNLNTRLAKLERGEYDGLILAVAGLKRLGKADR
CEECHHHHHHHHHHHHHCCCCEEHHHCCCHHHHHHHHHCCCCCCEEHHHHHHHHHCCHHH
IHEVLDPGVSLYAVGQGSLGIECRQGDERILELIRPLADAEATARCLAERAFLRALEGGC
HHHHHCCCCEEEEECCCCCCEEECCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCC
QVPIGVHSQVQGEALHLTGMVADLDGRRLIRDTQTGSTADPEAVGMALAEKLKQQGADEI
CCCCCCCCCCCCCEEEEEEEEECCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCHHHH
LQAIFAQARR
HHHHHHHHCC
>Mature Secondary Structure
MRIASRKSELALVQTQWVMGQLQEHHPGLPLELNTLSTQGDIILDVALAKIGDKGLFTKE
CCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCEEEEHHHHHHCCCCCEEHE
LEVSLLNGSSDLAVHSLKDLPTRLPEGLVLGAITRREDPLDALVVGEKFRDYRLATLPEG
EEEEEECCCCCHHHHHHHHHHHHCCCCEEEEEHHCCCCCCHHEEECCHHHCCEEEECCCC
TVIGTSSLRRLAQLRHAFPHLHFKDVRGNLNTRLAKLERGEYDGLILAVAGLKRLGKADR
CEECHHHHHHHHHHHHHCCCCEEHHHCCCHHHHHHHHHCCCCCCEEHHHHHHHHHCCHHH
IHEVLDPGVSLYAVGQGSLGIECRQGDERILELIRPLADAEATARCLAERAFLRALEGGC
HHHHHCCCCEEEEECCCCCCEEECCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCC
QVPIGVHSQVQGEALHLTGMVADLDGRRLIRDTQTGSTADPEAVGMALAEKLKQQGADEI
CCCCCCCCCCCCCEEEEEEEEECCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHCCHHHH
LQAIFAQARR
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12240834 [H]