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The map label for this gene is pdxA

Identifier: 86609224

GI number: 86609224

Start: 1850375

End: 1851397

Strand: Direct

Name: pdxA

Synonym: CYB_1766

Alternate gene names: 86609224

Gene position: 1850375-1851397 (Clockwise)

Preceding gene: 86609218

Following gene: 86609225

Centisome position: 60.73

GC content: 61.09

Gene sequence:

>1023_bases
ATGAGCATTCCACGGCCCAAACTGGCCCTGACCTTGGGGGATCCCGCGGGAATTGGGCCGGAAATTGTGCTCAAGGCGCT
GGCGGATCCTGAGGTGCAGTCTTGCGCCCACATCACGGTTGTAGGGGATCGGCAGGTTCTAGAAGCCACCTATCGCCTGC
TGAGAGATCGGTCGCCGGCTCCATTGGCCCATCCGGCAGGGATCCCGATGCTGGAATGCGACACAGGCTTTCGGTTACAG
CCTGGCTGTATTGGTCAAGGGGATGCCGACAGTGGTGCGGTTAGTTTTGCTTACCTGAGAACGGCGGTCGAACGGACGTT
GCAGGGGGAGTTTCAGGGGATCGTGACAGCGCCCATCGCCAAGTATCTCTGGCATCGAGCCGGCCATCGGTTCCCTGGTC
AAACAGAAGTTTTGGCCCAGCTGAGTCGGTCTGAGCACTACGGGATGATGTTTGTTGCCCGTTCCCCCCACAGCGGTTGG
CAGATGCGGGTTTTGCTGGCCACCACCCATATTCCCCTCGGCCAGGTGCCCACCGTGCTGACCCCAGAGCGGGTGCGGAC
AGCGCTGGATTTGCTGGTGGGATCCCTGCGCCACACCTTTGGGATCCCGGATCCTGTGATTGCAGTAGCCGGCCTGAATC
CCCATGCCGGCGAACAGGGGCAACTGGGATCGGAGGAAAAAGAATGGCTGACCGAGCTGCTGCGCACCTATGCCCACGCC
CAAATTTGGGGGCCGCTTCCCCCCGACACCATGTGGCTGGCTCCCGCGCAAGCCTGGCATGGCCAGGGATCTCCAGCCGT
GGCAGATGCCTACTTGGCTCTCTATCATGATCAAGGTTTGATCCCGGTGAAGATGCTGGCTTTTGACCGGGCAGTCAACC
TGACAACTGGGTTGCCTTTTGTTCGCACCTCTCCCGATCATGGCACCGCCTTCGACATTGCCGGCCAAGGGGTGGCCCGA
TGCGAGAGCCTCAAGCAGGCGATCCTGCTGGCGGCAGAACTGCTGGGCAAAAACCCCTCCTGA

Upstream 100 bases:

>100_bases
AATTCTTGCTCAAAGGGATGGCGACCTTCCCCACAGCTTTCCTCAGCACTCTCTTTCCCCTGGAACATGGGGATCGTCCG
TCTTCTCAAGAAAAGACACC

Downstream 100 bases:

>100_bases
GGGAAACCATGCCTGTGCCCGGCCATCTGAAGCTGTCTCCCGCCTCTGGGGGGTGATTTGATGGGAGTTGCTGGCATCAC
CTCAACCGGAATGCTTTACC

Product: 4-hydroxythreonine-4-phosphate dehydrogenase

Products: NA

Alternate protein names: 4-(phosphohydroxy)-L-threonine dehydrogenase

Number of amino acids: Translated: 340; Mature: 339

Protein sequence:

>340_residues
MSIPRPKLALTLGDPAGIGPEIVLKALADPEVQSCAHITVVGDRQVLEATYRLLRDRSPAPLAHPAGIPMLECDTGFRLQ
PGCIGQGDADSGAVSFAYLRTAVERTLQGEFQGIVTAPIAKYLWHRAGHRFPGQTEVLAQLSRSEHYGMMFVARSPHSGW
QMRVLLATTHIPLGQVPTVLTPERVRTALDLLVGSLRHTFGIPDPVIAVAGLNPHAGEQGQLGSEEKEWLTELLRTYAHA
QIWGPLPPDTMWLAPAQAWHGQGSPAVADAYLALYHDQGLIPVKMLAFDRAVNLTTGLPFVRTSPDHGTAFDIAGQGVAR
CESLKQAILLAAELLGKNPS

Sequences:

>Translated_340_residues
MSIPRPKLALTLGDPAGIGPEIVLKALADPEVQSCAHITVVGDRQVLEATYRLLRDRSPAPLAHPAGIPMLECDTGFRLQ
PGCIGQGDADSGAVSFAYLRTAVERTLQGEFQGIVTAPIAKYLWHRAGHRFPGQTEVLAQLSRSEHYGMMFVARSPHSGW
QMRVLLATTHIPLGQVPTVLTPERVRTALDLLVGSLRHTFGIPDPVIAVAGLNPHAGEQGQLGSEEKEWLTELLRTYAHA
QIWGPLPPDTMWLAPAQAWHGQGSPAVADAYLALYHDQGLIPVKMLAFDRAVNLTTGLPFVRTSPDHGTAFDIAGQGVAR
CESLKQAILLAAELLGKNPS
>Mature_339_residues
SIPRPKLALTLGDPAGIGPEIVLKALADPEVQSCAHITVVGDRQVLEATYRLLRDRSPAPLAHPAGIPMLECDTGFRLQP
GCIGQGDADSGAVSFAYLRTAVERTLQGEFQGIVTAPIAKYLWHRAGHRFPGQTEVLAQLSRSEHYGMMFVARSPHSGWQ
MRVLLATTHIPLGQVPTVLTPERVRTALDLLVGSLRHTFGIPDPVIAVAGLNPHAGEQGQLGSEEKEWLTELLRTYAHAQ
IWGPLPPDTMWLAPAQAWHGQGSPAVADAYLALYHDQGLIPVKMLAFDRAVNLTTGLPFVRTSPDHGTAFDIAGQGVARC
ESLKQAILLAAELLGKNPS

Specific function: Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)

COG id: COG1995

COG function: function code H; Pyridoxal phosphate biosynthesis protein

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pdxA family

Homologues:

Organism=Escherichia coli, GI1786237, Length=334, Percent_Identity=35.9281437125749, Blast_Score=179, Evalue=2e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXA_SYNJB (Q2JKQ8)

Other databases:

- EMBL:   CP000240
- RefSeq:   YP_477986.1
- ProteinModelPortal:   Q2JKQ8
- SMR:   Q2JKQ8
- STRING:   Q2JKQ8
- GeneID:   3901422
- GenomeReviews:   CP000240_GR
- KEGG:   cyb:CYB_1766
- TIGR:   CYB_1766
- eggNOG:   COG1995
- HOGENOM:   HBG451136
- OMA:   TCWLSAA
- PhylomeDB:   Q2JKQ8
- ProtClustDB:   PRK02746
- BioCyc:   SSP321332:CYB_1766-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00536
- InterPro:   IPR005255
- TIGRFAMs:   TIGR00557

Pfam domain/function: PF04166 PdxA

EC number: =1.1.1.262

Molecular weight: Translated: 36627; Mature: 36495

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: NA

Important sites: BINDING 135-135 BINDING 284-284 BINDING 293-293 BINDING 302-302

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIPRPKLALTLGDPAGIGPEIVLKALADPEVQSCAHITVVGDRQVLEATYRLLRDRSPA
CCCCCCCEEEEECCCCCCCHHHHHHHHCCCCHHCCEEEEEECCHHHHHHHHHHHHCCCCC
PLAHPAGIPMLECDTGFRLQPGCIGQGDADSGAVSFAYLRTAVERTLQGEFQGIVTAPIA
CCCCCCCCCEEECCCCCEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEHHHHH
KYLWHRAGHRFPGQTEVLAQLSRSEHYGMMFVARSPHSGWQMRVLLATTHIPLGQVPTVL
HHHHHHHCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEEEEEECCCCCCCCCCC
TPERVRTALDLLVGSLRHTFGIPDPVIAVAGLNPHAGEQGQLGSEEKEWLTELLRTYAHA
CHHHHHHHHHHHHHHHHHHCCCCCHHEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
QIWGPLPPDTMWLAPAQAWHGQGSPAVADAYLALYHDQGLIPVKMLAFDRAVNLTTGLPF
EECCCCCCCCEEECCCHHHCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCC
VRTSPDHGTAFDIAGQGVARCESLKQAILLAAELLGKNPS
EEECCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SIPRPKLALTLGDPAGIGPEIVLKALADPEVQSCAHITVVGDRQVLEATYRLLRDRSPA
CCCCCCEEEEECCCCCCCHHHHHHHHCCCCHHCCEEEEEECCHHHHHHHHHHHHCCCCC
PLAHPAGIPMLECDTGFRLQPGCIGQGDADSGAVSFAYLRTAVERTLQGEFQGIVTAPIA
CCCCCCCCCEEECCCCCEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCEEHHHHH
KYLWHRAGHRFPGQTEVLAQLSRSEHYGMMFVARSPHSGWQMRVLLATTHIPLGQVPTVL
HHHHHHHCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEEEEEECCCCCCCCCCC
TPERVRTALDLLVGSLRHTFGIPDPVIAVAGLNPHAGEQGQLGSEEKEWLTELLRTYAHA
CHHHHHHHHHHHHHHHHHHCCCCCHHEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
QIWGPLPPDTMWLAPAQAWHGQGSPAVADAYLALYHDQGLIPVKMLAFDRAVNLTTGLPF
EECCCCCCCCEEECCCHHHCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCC
VRTSPDHGTAFDIAGQGVARCESLKQAILLAAELLGKNPS
EEECCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA