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The map label for this gene is ycdW [C]

Identifier: 86609137

GI number: 86609137

Start: 1753189

End: 1754115

Strand: Direct

Name: ycdW [C]

Synonym: CYB_1677

Alternate gene names: 86609137

Gene position: 1753189-1754115 (Clockwise)

Preceding gene: 86609128

Following gene: 86609142

Centisome position: 57.54

GC content: 62.24

Gene sequence:

>927_bases
ATGGGCATCCAAGGCAAACGCATTGCCGTCGAACCCGGCCATCTTCGCCCCTGGCTCAAAGAGGCTGTTTTGGCGGGGGG
CGGCGAAATTGTGCCCCTGGCAGAAGCAGAAGCCTTGGTCTGGGCTGATGCCTTTGATGTGCCTGGCCTGAAGCGTTGTC
TGGCGGAAGGGAAAGGGATCCGCTGGGTGCAGCTGCCCTGGGCAGGGGTGGAACCCTTTGTTCGGGCGGGAGTCTTGGAT
CCCGCTTATGTGTGGACTTGTGGCAAGGGGGTCTATGCTCAACCGGTGGCGGAACATGCCTTGGCCTTGACCTTGGCCGG
CTTGCGCGACTTGAAGATCCGCGCCTTGGCCCAAACTTGGCAGGAGGGCTCCGGTACCAGCCTCTGGGGTAGCCGTGTGG
TCATTTTCGGGGCCGGGGGCATCGCCCAAGAGTTGATCAAGCTGTTGCAGCCTTTTCAATGCTCCGTCGACGTGGTGCGT
CGCAAGGCGGATCCCTTGCCGGGTGCCACACGGGTGGTGACGCTCGCGGAACGGCAAACGGTGTTGGCAGGGGCAGATGT
GGTGATCCTGGCTTTGGCCCTCACGCCGGAAACCGAGGGGATCATCGCCCAAGCTGAGTTGGAGCAGATGGGATCCCAGT
GTTGGTTGGTGAATGTGGCGCGAGGCAAGCACATCGTGACCTCCGACTTGGTGGCCGCCCTGCAGCAGGGGGTCATTCGC
GGGGCCGCCTTGGATGTCACGGATCCCGAGCCCCTACCGGATGGGCATCCCCTCTGGAGCTTGCCCAACTGCCTGATTAC
CCCCCACACTGCTCTTACCGATGCCATGATTGTCCCAGCCCTCTCTAAGCGGGTGCGAGAAAATGTGCAGCGCTTCCGGA
CCGGGGATCCCTTGCTAGGGGTGGTGGATCCGGTTTTGGGGTATTGA

Upstream 100 bases:

>100_bases
GATCCCTTAACACTCGACACCGGTTTGGCTGCCCGTGCATGCCATCTCTCGCTCTGCCGACAGTATCCTGGCAAGGGGAA
AGCCTTATCCAACGGTTCCT

Downstream 100 bases:

>100_bases
GTCCTCTAGCCCCCCTCCCTTGGGGAGCCTGGGATCAGAAACATTTGGCGCCAAACCCTACTGCAAAGCCATCTCCTGCA
CGCGGGCAGCAATGGCCTTG

Product: D-isomer specific 2-hydroxyacid dehydrogenase

Products: NADPH; glyoxylate; glycerate [C]

Alternate protein names: NA

Number of amino acids: Translated: 308; Mature: 307

Protein sequence:

>308_residues
MGIQGKRIAVEPGHLRPWLKEAVLAGGGEIVPLAEAEALVWADAFDVPGLKRCLAEGKGIRWVQLPWAGVEPFVRAGVLD
PAYVWTCGKGVYAQPVAEHALALTLAGLRDLKIRALAQTWQEGSGTSLWGSRVVIFGAGGIAQELIKLLQPFQCSVDVVR
RKADPLPGATRVVTLAERQTVLAGADVVILALALTPETEGIIAQAELEQMGSQCWLVNVARGKHIVTSDLVAALQQGVIR
GAALDVTDPEPLPDGHPLWSLPNCLITPHTALTDAMIVPALSKRVRENVQRFRTGDPLLGVVDPVLGY

Sequences:

>Translated_308_residues
MGIQGKRIAVEPGHLRPWLKEAVLAGGGEIVPLAEAEALVWADAFDVPGLKRCLAEGKGIRWVQLPWAGVEPFVRAGVLD
PAYVWTCGKGVYAQPVAEHALALTLAGLRDLKIRALAQTWQEGSGTSLWGSRVVIFGAGGIAQELIKLLQPFQCSVDVVR
RKADPLPGATRVVTLAERQTVLAGADVVILALALTPETEGIIAQAELEQMGSQCWLVNVARGKHIVTSDLVAALQQGVIR
GAALDVTDPEPLPDGHPLWSLPNCLITPHTALTDAMIVPALSKRVRENVQRFRTGDPLLGVVDPVLGY
>Mature_307_residues
GIQGKRIAVEPGHLRPWLKEAVLAGGGEIVPLAEAEALVWADAFDVPGLKRCLAEGKGIRWVQLPWAGVEPFVRAGVLDP
AYVWTCGKGVYAQPVAEHALALTLAGLRDLKIRALAQTWQEGSGTSLWGSRVVIFGAGGIAQELIKLLQPFQCSVDVVRR
KADPLPGATRVVTLAERQTVLAGADVVILALALTPETEGIIAQAELEQMGSQCWLVNVARGKHIVTSDLVAALQQGVIRG
AALDVTDPEPLPDGHPLWSLPNCLITPHTALTDAMIVPALSKRVRENVQRFRTGDPLLGVVDPVLGY

Specific function: Unknown

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=146, Percent_Identity=36.3013698630137, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI4557497, Length=194, Percent_Identity=29.8969072164948, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI61743967, Length=194, Percent_Identity=29.8969072164948, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI87081824, Length=217, Percent_Identity=33.1797235023041, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI87082289, Length=188, Percent_Identity=29.2553191489362, Blast_Score=65, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6320925, Length=217, Percent_Identity=29.4930875576037, Blast_Score=63, Evalue=6e-11,
Organism=Drosophila melanogaster, GI28571528, Length=191, Percent_Identity=32.4607329842932, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24585514, Length=178, Percent_Identity=32.5842696629214, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI28574282, Length=178, Percent_Identity=32.5842696629214, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI28574284, Length=178, Percent_Identity=32.5842696629214, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI45552429, Length=178, Percent_Identity=32.5842696629214, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI45551003, Length=178, Percent_Identity=32.5842696629214, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI28574286, Length=182, Percent_Identity=32.4175824175824, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24585516, Length=188, Percent_Identity=30.8510638297872, Blast_Score=82, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02826 2-Hacid_dh_C [H]

EC number: NA

Molecular weight: Translated: 32882; Mature: 32750

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIQGKRIAVEPGHLRPWLKEAVLAGGGEIVPLAEAEALVWADAFDVPGLKRCLAEGKGI
CCCCCCEEEECCCCCCHHHHHHHHHCCCCEEEECCCCEEEEECCCCCCHHHHHHHCCCCC
RWVQLPWAGVEPFVRAGVLDPAYVWTCGKGVYAQPVAEHALALTLAGLRDLKIRALAQTW
EEEECCCCCCCHHHHHCCCCCHHEEEECCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHH
QEGSGTSLWGSRVVIFGAGGIAQELIKLLQPFQCSVDVVRRKADPLPGATRVVTLAERQT
HCCCCCCCCCCEEEEEECCHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCEEEEEEHHHH
VLAGADVVILALALTPETEGIIAQAELEQMGSQCWLVNVARGKHIVTSDLVAALQQGVIR
HHCCCCEEEEEEEECCCCCCEEEHHHHHHCCCCEEEEEECCCCEEHHHHHHHHHHHHHHC
GAALDVTDPEPLPDGHPLWSLPNCLITPHTALTDAMIVPALSKRVRENVQRFRTGDPLLG
CCEECCCCCCCCCCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
VVDPVLGY
HHHHHHCC
>Mature Secondary Structure 
GIQGKRIAVEPGHLRPWLKEAVLAGGGEIVPLAEAEALVWADAFDVPGLKRCLAEGKGI
CCCCCEEEECCCCCCHHHHHHHHHCCCCEEEECCCCEEEEECCCCCCHHHHHHHCCCCC
RWVQLPWAGVEPFVRAGVLDPAYVWTCGKGVYAQPVAEHALALTLAGLRDLKIRALAQTW
EEEECCCCCCCHHHHHCCCCCHHEEEECCCCCCCHHHHHHHHHHHHCHHHHHHHHHHHHH
QEGSGTSLWGSRVVIFGAGGIAQELIKLLQPFQCSVDVVRRKADPLPGATRVVTLAERQT
HCCCCCCCCCCEEEEEECCHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCEEEEEEHHHH
VLAGADVVILALALTPETEGIIAQAELEQMGSQCWLVNVARGKHIVTSDLVAALQQGVIR
HHCCCCEEEEEEEECCCCCCEEEHHHHHHCCCCEEEEEECCCCEEHHHHHHHHHHHHHHC
GAALDVTDPEPLPDGHPLWSLPNCLITPHTALTDAMIVPALSKRVRENVQRFRTGDPLLG
CCEECCCCCCCCCCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
VVDPVLGY
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: glycolate; NADP; hydroxypyruvate; NADPH [C]

Specific reaction: glycolate + NADP = NADPH + glyoxylate hydroxypyruvate + NADPH = glycerate + NADP [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12948626 [H]