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The map label for this gene is hisG

Identifier: 86609015

GI number: 86609015

Start: 1625446

End: 1626153

Strand: Direct

Name: hisG

Synonym: CYB_1550

Alternate gene names: 86609015

Gene position: 1625446-1626153 (Clockwise)

Preceding gene: 86609011

Following gene: 86609016

Centisome position: 53.35

GC content: 61.16

Gene sequence:

>708_bases
ATGCTGGATGGCCGTCCCGACAGCCCACCCATCACGATTGCCCTGGCCAAGGGGGCCTTGCTGCCTGAGGCCATTCAATG
CCTGCAGCAGGTGGGGATCGATTTCAGCCGTTTTTTGGATCCCGGCAATCGCCTGCTGCGGATTGAATCCCCCACCCGGC
TGAACGGACAACGCTACGAAGCGCTGCTGGTGCGCACTCACGATGTGCCGGTGTACGTGGAGTACGGGCAGGCGCAGTTG
GGCATTGTCGGCTACGACGTCTTGCGGGAGCGCTATGCCGGCACCGAAGCGCGGGTGGCCCACCTGTTGGATCTCCAATT
TGGCCACTGTCGCATGTCGGTGGCCCTTCCCCAAGATAGCCCCTACCACTCGGCAGCTCAGTTGCCTGCTCATGCCCGCG
TGGCTTCTAAGTTTGTCGGCTGCGCCCGGGAGTATTTTGACCGCCTGGATTTGCCGGTGGAGCTTATCTCTCTCTATGGT
TCGGTGGAGTTGGCCCCCCTCACCGGCATGGCCGATGCCATCGTCGACTTGGTAGCCACAGGGCGCACCCTGAGGGAAAA
CGGCCTGATTGAGCGAGACTGCCTATTCGAGAGTACAGCTCGCCTGATTGCCCATCCCATCAGCTACCGTGTCAACCAAC
AGCCTATCCGCGAGTTGATCACCCAGATTCGGGAACGCTGGCTGGGATCCCTGTTGGTGGGTGGCTAA

Upstream 100 bases:

>100_bases
TTCCACCCGGCAGACGGGGATCCCAGCATTCTTACATTGATTGCTCCTGGCCCAAGATTCAGACGGATGTATCAGACAAA
TGTAGTAGATCCTGAAAAAG

Downstream 100 bases:

>100_bases
TTTTGAGGCACTTCCTCTGAGGGGGATCACGATTGCGTACAATGGGGGCATTCGGGCTTATTTCCCCCAGCAGCGTTCAG
ATTCAAAAAAGGTTTTTCGA

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 235; Mature: 235

Protein sequence:

>235_residues
MLDGRPDSPPITIALAKGALLPEAIQCLQQVGIDFSRFLDPGNRLLRIESPTRLNGQRYEALLVRTHDVPVYVEYGQAQL
GIVGYDVLRERYAGTEARVAHLLDLQFGHCRMSVALPQDSPYHSAAQLPAHARVASKFVGCAREYFDRLDLPVELISLYG
SVELAPLTGMADAIVDLVATGRTLRENGLIERDCLFESTARLIAHPISYRVNQQPIRELITQIRERWLGSLLVGG

Sequences:

>Translated_235_residues
MLDGRPDSPPITIALAKGALLPEAIQCLQQVGIDFSRFLDPGNRLLRIESPTRLNGQRYEALLVRTHDVPVYVEYGQAQL
GIVGYDVLRERYAGTEARVAHLLDLQFGHCRMSVALPQDSPYHSAAQLPAHARVASKFVGCAREYFDRLDLPVELISLYG
SVELAPLTGMADAIVDLVATGRTLRENGLIERDCLFESTARLIAHPISYRVNQQPIRELITQIRERWLGSLLVGG
>Mature_235_residues
MLDGRPDSPPITIALAKGALLPEAIQCLQQVGIDFSRFLDPGNRLLRIESPTRLNGQRYEALLVRTHDVPVYVEYGQAQL
GIVGYDVLRERYAGTEARVAHLLDLQFGHCRMSVALPQDSPYHSAAQLPAHARVASKFVGCAREYFDRLDLPVELISLYG
SVELAPLTGMADAIVDLVATGRTLRENGLIERDCLFESTARLIAHPISYRVNQQPIRELITQIRERWLGSLLVGG

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=171, Percent_Identity=38.0116959064327, Blast_Score=96, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6320896, Length=170, Percent_Identity=33.5294117647059, Blast_Score=89, Evalue=8e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_SYNJB (Q2JL97)

Other databases:

- EMBL:   CP000240
- RefSeq:   YP_477777.1
- ProteinModelPortal:   Q2JL97
- SMR:   Q2JL97
- STRING:   Q2JL97
- GeneID:   3901570
- GenomeReviews:   CP000240_GR
- KEGG:   cyb:CYB_1550
- TIGR:   CYB_1550
- eggNOG:   COG0040
- HOGENOM:   HBG391868
- OMA:   GCAREYF
- PhylomeDB:   Q2JL97
- ProtClustDB:   PRK01686
- BioCyc:   SSP321332:CYB_1550-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01018
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070

Pfam domain/function: PF01634 HisG

EC number: =2.4.2.17

Molecular weight: Translated: 26084; Mature: 26084

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDGRPDSPPITIALAKGALLPEAIQCLQQVGIDFSRFLDPGNRLLRIESPTRLNGQRYE
CCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCHHHHCCCCCCEEEECCCCCCCCCEEE
ALLVRTHDVPVYVEYGQAQLGIVGYDVLRERYAGTEARVAHLLDLQFGHCRMSVALPQDS
EEEEEECCCEEEEECCCEEECHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEEECCCCC
PYHSAAQLPAHARVASKFVGCAREYFDRLDLPVELISLYGSVELAPLTGMADAIVDLVAT
CCCHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCEEECCCCHHHHHHHHHHC
GRTLRENGLIERDCLFESTARLIAHPISYRVNQQPIRELITQIRERWLGSLLVGG
CCHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLDGRPDSPPITIALAKGALLPEAIQCLQQVGIDFSRFLDPGNRLLRIESPTRLNGQRYE
CCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCHHHHCCCCCCEEEECCCCCCCCCEEE
ALLVRTHDVPVYVEYGQAQLGIVGYDVLRERYAGTEARVAHLLDLQFGHCRMSVALPQDS
EEEEEECCCEEEEECCCEEECHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEEEEECCCCC
PYHSAAQLPAHARVASKFVGCAREYFDRLDLPVELISLYGSVELAPLTGMADAIVDLVAT
CCCHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCEEECCCCHHHHHHHHHHC
GRTLRENGLIERDCLFESTARLIAHPISYRVNQQPIRELITQIRERWLGSLLVGG
CCHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA