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The map label for this gene is pyrG [H]

Identifier: 86608945

GI number: 86608945

Start: 1552234

End: 1553868

Strand: Reverse

Name: pyrG [H]

Synonym: CYB_1478

Alternate gene names: 86608945

Gene position: 1553868-1552234 (Counterclockwise)

Preceding gene: 86608946

Following gene: 86608942

Centisome position: 51.0

GC content: 60.12

Gene sequence:

>1635_bases
ATGACCAAGTTTGTCTTCGTCACCGGTGGAGTGGTCTCCAGCATCGGCAAAGGCATTGTGGCGGCCAGCTTGGGTCGCCT
GCTCAAATCCCGTAACTACACGGTGTCGATTTTGAAGCTGGATCCCTATATCAATGTGGATCCCGGCACCATGAGCCCCT
ACCAACATGGGGAAGTGTTTGTTACCGACGATGGCGCCGAGACGGACTTGGACTTGGGCCACTACGAGCGCTTCACCGAC
ACCAACATGTCCAAGCTCAACAACGTTACCACCGGCGCCATCTACCAGGCGGTGATCCACAAAGAGCGGCGGGGGGATTA
CCAGGGCAGCACGGTGCAGGTGATCCCCCACGTCACCCAAGAGATTAAAGAGCGCATCCGGCGAGTGGCCCGCGAGACCA
ACCCCGACGTGGTGCTGGTGGAGGTGGGGGGCACGGTGGGGGATATCGAGTCTTTGCCCTTTTTGGAGGCCATCCGCCAA
TTTCGCAAGGATGTGGGCCGGGCCAATGTCGCCTATGTGCATGTCACCCTGGTGCCCCTGATCAAAGCGGCAGGGGAGAT
GAAAACCAAGCCCACCCAGCACTCGGTGAAGGAGCTGCGCTCTATTGGTATCCAGCCGGACGTGTTGGTGTGCCGCTGCG
AACAGCCATTGCCCCGCGGGATCAAGGAGAAGATCTCCGAGTTTTGCGATGTGCCGGTGGAATGTGTGATTCAGGCTCAG
GATGCCCCCAGTATCTACGATGTGCCTTTGGTGCTCGAGCAGGAGGGGTTGGCGCAGCGGGTTTTGGAGATCCTCAACCT
GGATCCCCAGCAGCCCGACCTACGGGAGTGGGAGCTCCTGGTGCAGCGGCTGCACCACCCCCAAGAGCAGGTGGAGATTG
CCATTGTCGGCAAATACGTGCGCCTTACGGATGCCTATCTTTCGGTGGCCGAGGCCCTGCGCCATGCCGGGTTGGCCCTC
AATGCCGGCGTCACGCTGCGCTGGATCTCTTCTGAGGAGATCGAAGAGCGGGGACCAGAGGCATTGCTTTCCGGCGTGGA
TGGAGTGGTGGTGCCAGGGGGGTTTGGCAATCGCGGCATCGAGGGCAAAGTGGCCAGTATTTGCTACGTGAGGGAGCGGG
GCATTCCCTTTCTGGGCCTGTGTCTGGGCATGCAATGCGCGGTGATCGACTGGGGATGTCACATTGCCCAACTGGAGCGG
GCCAATAGCTATGAGTTTGACCCCGATACCCCCCACCCTGTCATCAGCCTGCTGCCGGAGCAGAAAGATGTAGAGGATCT
GGGAGGAACCCTGCGGCTGGGCCTCTATCCCTGTCGCATCATGCCCAATACCCTAGCGGCCAAGCTCTACGGTGAGGCCA
TCATCTACGAGCGGCACCGCCATCGCTATGAGTTTAACAATGCCTACCGCAGCCTTTTTCTAGACTCCGGCTATGTTATC
AGCGGAGTCTCGCCGGATAACCGCTTGGTGGAGATTATCGAGCTGCCCAGCCACCCCTTCTTCATCGCCACCCAATTCCA
TCCGGAGTTTCGCTCCCGCCCCAACCGCCCCCACCCCCTCTTTTTGGGGTTGATCGAAGCTGCCCTGCGCAGCCGCCCTC
AGCCTCGCCCCCTGCAGTTGCAGAAGATGGGCTAG

Upstream 100 bases:

>100_bases
CACCATCCTCTACAACGGCCCCATCCGCTCCCGCCGCTGACGGCAGCCTGGGATCCCTGCCATCCTTGGCATAATCAGAA
AAGGGCGAGGGATCCGGGGT

Downstream 100 bases:

>100_bases
TTGACAGATCCCTTGTCCAAAAGTGGGGGCACGCCTCTGGTCCTGGTTCTGCAGAGCTTTGCTGAACATAAACTGCTGCG
GAATCCTGGGTTTCGCCTGT

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase [H]

Number of amino acids: Translated: 544; Mature: 543

Protein sequence:

>544_residues
MTKFVFVTGGVVSSIGKGIVAASLGRLLKSRNYTVSILKLDPYINVDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFTD
TNMSKLNNVTTGAIYQAVIHKERRGDYQGSTVQVIPHVTQEIKERIRRVARETNPDVVLVEVGGTVGDIESLPFLEAIRQ
FRKDVGRANVAYVHVTLVPLIKAAGEMKTKPTQHSVKELRSIGIQPDVLVCRCEQPLPRGIKEKISEFCDVPVECVIQAQ
DAPSIYDVPLVLEQEGLAQRVLEILNLDPQQPDLREWELLVQRLHHPQEQVEIAIVGKYVRLTDAYLSVAEALRHAGLAL
NAGVTLRWISSEEIEERGPEALLSGVDGVVVPGGFGNRGIEGKVASICYVRERGIPFLGLCLGMQCAVIDWGCHIAQLER
ANSYEFDPDTPHPVISLLPEQKDVEDLGGTLRLGLYPCRIMPNTLAAKLYGEAIIYERHRHRYEFNNAYRSLFLDSGYVI
SGVSPDNRLVEIIELPSHPFFIATQFHPEFRSRPNRPHPLFLGLIEAALRSRPQPRPLQLQKMG

Sequences:

>Translated_544_residues
MTKFVFVTGGVVSSIGKGIVAASLGRLLKSRNYTVSILKLDPYINVDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFTD
TNMSKLNNVTTGAIYQAVIHKERRGDYQGSTVQVIPHVTQEIKERIRRVARETNPDVVLVEVGGTVGDIESLPFLEAIRQ
FRKDVGRANVAYVHVTLVPLIKAAGEMKTKPTQHSVKELRSIGIQPDVLVCRCEQPLPRGIKEKISEFCDVPVECVIQAQ
DAPSIYDVPLVLEQEGLAQRVLEILNLDPQQPDLREWELLVQRLHHPQEQVEIAIVGKYVRLTDAYLSVAEALRHAGLAL
NAGVTLRWISSEEIEERGPEALLSGVDGVVVPGGFGNRGIEGKVASICYVRERGIPFLGLCLGMQCAVIDWGCHIAQLER
ANSYEFDPDTPHPVISLLPEQKDVEDLGGTLRLGLYPCRIMPNTLAAKLYGEAIIYERHRHRYEFNNAYRSLFLDSGYVI
SGVSPDNRLVEIIELPSHPFFIATQFHPEFRSRPNRPHPLFLGLIEAALRSRPQPRPLQLQKMG
>Mature_543_residues
TKFVFVTGGVVSSIGKGIVAASLGRLLKSRNYTVSILKLDPYINVDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFTDT
NMSKLNNVTTGAIYQAVIHKERRGDYQGSTVQVIPHVTQEIKERIRRVARETNPDVVLVEVGGTVGDIESLPFLEAIRQF
RKDVGRANVAYVHVTLVPLIKAAGEMKTKPTQHSVKELRSIGIQPDVLVCRCEQPLPRGIKEKISEFCDVPVECVIQAQD
APSIYDVPLVLEQEGLAQRVLEILNLDPQQPDLREWELLVQRLHHPQEQVEIAIVGKYVRLTDAYLSVAEALRHAGLALN
AGVTLRWISSEEIEERGPEALLSGVDGVVVPGGFGNRGIEGKVASICYVRERGIPFLGLCLGMQCAVIDWGCHIAQLERA
NSYEFDPDTPHPVISLLPEQKDVEDLGGTLRLGLYPCRIMPNTLAAKLYGEAIIYERHRHRYEFNNAYRSLFLDSGYVIS
GVSPDNRLVEIIELPSHPFFIATQFHPEFRSRPNRPHPLFLGLIEAALRSRPQPRPLQLQKMG

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen [H]

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Homo sapiens, GI148491070, Length=551, Percent_Identity=48.0943738656987, Blast_Score=506, Evalue=1e-143,
Organism=Homo sapiens, GI28559085, Length=547, Percent_Identity=46.9835466179159, Blast_Score=492, Evalue=1e-139,
Organism=Homo sapiens, GI28559083, Length=547, Percent_Identity=46.9835466179159, Blast_Score=492, Evalue=1e-139,
Organism=Homo sapiens, GI221316689, Length=547, Percent_Identity=46.9835466179159, Blast_Score=492, Evalue=1e-139,
Organism=Escherichia coli, GI1789142, Length=537, Percent_Identity=54.5623836126629, Blast_Score=582, Evalue=1e-167,
Organism=Caenorhabditis elegans, GI25148299, Length=602, Percent_Identity=38.0398671096345, Blast_Score=423, Evalue=1e-118,
Organism=Saccharomyces cerevisiae, GI6322563, Length=559, Percent_Identity=43.4704830053667, Blast_Score=462, Evalue=1e-131,
Organism=Saccharomyces cerevisiae, GI6319432, Length=558, Percent_Identity=43.010752688172, Blast_Score=459, Evalue=1e-130,
Organism=Drosophila melanogaster, GI24664469, Length=548, Percent_Identity=47.6277372262774, Blast_Score=493, Evalue=1e-139,
Organism=Drosophila melanogaster, GI21357815, Length=493, Percent_Identity=46.4503042596349, Blast_Score=419, Evalue=1e-117,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991 [H]

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase [H]

EC number: =6.3.4.2 [H]

Molecular weight: Translated: 60679; Mature: 60547

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKFVFVTGGVVSSIGKGIVAASLGRLLKSRNYTVSILKLDPYINVDPGTMSPYQHGEVF
CCEEEEEECHHHHHHCCHHHHHHHHHHHHCCCCEEEEEEECCEEECCCCCCCCCCCCEEE
VTDDGAETDLDLGHYERFTDTNMSKLNNVTTGAIYQAVIHKERRGDYQGSTVQVIPHVTQ
EECCCCCCCCCCCHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHCCCCCCCEEEECHHHHH
EIKERIRRVARETNPDVVLVEVGGTVGDIESLPFLEAIRQFRKDVGRANVAYVHVTLVPL
HHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEHHHHH
IKAAGEMKTKPTQHSVKELRSIGIQPDVLVCRCEQPLPRGIKEKISEFCDVPVECVIQAQ
HHHHCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCEEEEEEEC
DAPSIYDVPLVLEQEGLAQRVLEILNLDPQQPDLREWELLVQRLHHPQEQVEIAIVGKYV
CCCCEECCCEEECCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHEEEEEEEHHH
RLTDAYLSVAEALRHAGLALNAGVTLRWISSEEIEERGPEALLSGVDGVVVPGGFGNRGI
HHHHHHHHHHHHHHHCCEEEECCEEEEECCCHHHHHCCHHHHHCCCCCEEECCCCCCCCC
EGKVASICYVRERGIPFLGLCLGMQCAVIDWGCHIAQLERANSYEFDPDTPHPVISLLPE
CCCHHEEEEEHHCCCCHHHHHHCCEEEEEECCCHHHHHHCCCCCCCCCCCCCHHHHHCCC
QKDVEDLGGTLRLGLYPCRIMPNTLAAKLYGEAIIYERHRHRYEFNNAYRSLFLDSGYVI
CCCHHHCCCEEEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCEEE
SGVSPDNRLVEIIELPSHPFFIATQFHPEFRSRPNRPHPLFLGLIEAALRSRPQPRPLQL
ECCCCCCCEEEEEECCCCCEEEEEECCHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCC
QKMG
CCCC
>Mature Secondary Structure 
TKFVFVTGGVVSSIGKGIVAASLGRLLKSRNYTVSILKLDPYINVDPGTMSPYQHGEVF
CEEEEEECHHHHHHCCHHHHHHHHHHHHCCCCEEEEEEECCEEECCCCCCCCCCCCEEE
VTDDGAETDLDLGHYERFTDTNMSKLNNVTTGAIYQAVIHKERRGDYQGSTVQVIPHVTQ
EECCCCCCCCCCCHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHCCCCCCCEEEECHHHHH
EIKERIRRVARETNPDVVLVEVGGTVGDIESLPFLEAIRQFRKDVGRANVAYVHVTLVPL
HHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEHHHHH
IKAAGEMKTKPTQHSVKELRSIGIQPDVLVCRCEQPLPRGIKEKISEFCDVPVECVIQAQ
HHHHCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCEEEEEEEC
DAPSIYDVPLVLEQEGLAQRVLEILNLDPQQPDLREWELLVQRLHHPQEQVEIAIVGKYV
CCCCEECCCEEECCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCHHHEEEEEEEHHH
RLTDAYLSVAEALRHAGLALNAGVTLRWISSEEIEERGPEALLSGVDGVVVPGGFGNRGI
HHHHHHHHHHHHHHHCCEEEECCEEEEECCCHHHHHCCHHHHHCCCCCEEECCCCCCCCC
EGKVASICYVRERGIPFLGLCLGMQCAVIDWGCHIAQLERANSYEFDPDTPHPVISLLPE
CCCHHEEEEEHHCCCCHHHHHHCCEEEEEECCCHHHHHHCCCCCCCCCCCCCHHHHHCCC
QKDVEDLGGTLRLGLYPCRIMPNTLAAKLYGEAIIYERHRHRYEFNNAYRSLFLDSGYVI
CCCHHHCCCEEEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCEEE
SGVSPDNRLVEIIELPSHPFFIATQFHPEFRSRPNRPHPLFLGLIEAALRSRPQPRPLQL
ECCCCCCCEEEEEECCCCCEEEEEECCHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCC
QKMG
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA