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The map label for this gene is mutM [H]

Identifier: 86608720

GI number: 86608720

Start: 1292499

End: 1293338

Strand: Reverse

Name: mutM [H]

Synonym: CYB_1244

Alternate gene names: 86608720

Gene position: 1293338-1292499 (Counterclockwise)

Preceding gene: 86608721

Following gene: 86608719

Centisome position: 42.45

GC content: 60.71

Gene sequence:

>840_bases
GTGCCTGAACTGCCGGAAGTTGAAACAGTTCGGCAAGATTTGCAACGCCTCACCTTGGGGCCGCGGATACTTGCGGTGGA
GGTGCTCCTGGCCCGCACCATTGCCTACCCTGCAGGGGAGATGTTTGGGCGGAGCTTGATTGGCACCCGTTTTACCCAGT
GGCAGCGGCGAGGAAAGTATCTCCTGGGATCCCTGGATTCGAGAGCTGTTCTGGGCGTGCATCTGCGCATGACCGGGCAG
TTGCTCTGGGTGCAGGGATCCACCCCTTTATCAGCTCACACTCGTGTTCGTTTGGCCTTCGAGGAAGGGTGGGACTTGCG
CTTTGTGGATCAGCGCACCTTTGGCCAGATGTGGCTGGTGCCTGCCGGTGTTGAGCTGGAGGCGGTGATCCCCACCCTGC
AGACTTTGGGGCCGGAGCCCTTTTCGCCAGCTTTTTCTGAGGCCTATTTCCAGGCTGCCCTGCAGAAGAGCCGCCGTCTT
ATTAAAGCCGCGCTGCTGGATCAATCGCTGGTAGCCGGGGTGGGCAACATTTACGCCGACGAAGCCCTGTTTCTGAGCGG
CATTCACCCTTTGACGCCAGCAGTTCAGCTTTCGGATGTGGCCAAGGCACGCCTGCGAGAAGCTTTGATCGAGGTGTTAC
GGGCCGGGCTGGAGCAGCGGGGCACCACCTTGCGGGATTACCGGGATCTGCGTGGGCTCAACGGCAACTATCAAGGGCAA
GCGTGGGTGTACGGTCGGGAAGGGGATCCCTGTCGCCTCTGTGGCACCCCAATTCAGCGGATGAAGCTGGCAGGTCGGTC
GGCTCACTTTTGCCCCCACTGCCAGCCGCAACAGAGCTAG

Upstream 100 bases:

>100_bases
GAACTGGAAGTGTTGGAAGCTCCCAAAGCCAAGGCCAAAGCTGCGGCCAGCTAAGCCAAAGTTCTGATGCCGGGGACTGT
GTTCTTGAGCAAGTCGTTCT

Downstream 100 bases:

>100_bases
TGGCGCTCCTCAAGATATGGGGGATCCCTGGGGAAATGGGCCAGAGCGGCTACCATCAGCAGTAGGAGGGGATCCCGGTG
AAAACCATGGGATGGGCACG

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM [H]

Number of amino acids: Translated: 279; Mature: 278

Protein sequence:

>279_residues
MPELPEVETVRQDLQRLTLGPRILAVEVLLARTIAYPAGEMFGRSLIGTRFTQWQRRGKYLLGSLDSRAVLGVHLRMTGQ
LLWVQGSTPLSAHTRVRLAFEEGWDLRFVDQRTFGQMWLVPAGVELEAVIPTLQTLGPEPFSPAFSEAYFQAALQKSRRL
IKAALLDQSLVAGVGNIYADEALFLSGIHPLTPAVQLSDVAKARLREALIEVLRAGLEQRGTTLRDYRDLRGLNGNYQGQ
AWVYGREGDPCRLCGTPIQRMKLAGRSAHFCPHCQPQQS

Sequences:

>Translated_279_residues
MPELPEVETVRQDLQRLTLGPRILAVEVLLARTIAYPAGEMFGRSLIGTRFTQWQRRGKYLLGSLDSRAVLGVHLRMTGQ
LLWVQGSTPLSAHTRVRLAFEEGWDLRFVDQRTFGQMWLVPAGVELEAVIPTLQTLGPEPFSPAFSEAYFQAALQKSRRL
IKAALLDQSLVAGVGNIYADEALFLSGIHPLTPAVQLSDVAKARLREALIEVLRAGLEQRGTTLRDYRDLRGLNGNYQGQ
AWVYGREGDPCRLCGTPIQRMKLAGRSAHFCPHCQPQQS
>Mature_278_residues
PELPEVETVRQDLQRLTLGPRILAVEVLLARTIAYPAGEMFGRSLIGTRFTQWQRRGKYLLGSLDSRAVLGVHLRMTGQL
LWVQGSTPLSAHTRVRLAFEEGWDLRFVDQRTFGQMWLVPAGVELEAVIPTLQTLGPEPFSPAFSEAYFQAALQKSRRLI
KAALLDQSLVAGVGNIYADEALFLSGIHPLTPAVQLSDVAKARLREALIEVLRAGLEQRGTTLRDYRDLRGLNGNYQGQA
WVYGREGDPCRLCGTPIQRMKLAGRSAHFCPHCQPQQS

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger [H]

Homologues:

Organism=Escherichia coli, GI1790066, Length=275, Percent_Identity=40.3636363636364, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI1786932, Length=287, Percent_Identity=26.8292682926829, Blast_Score=78, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663 [H]

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS [H]

EC number: =3.2.2.23; =4.2.99.18 [H]

Molecular weight: Translated: 31103; Mature: 30972

Theoretical pI: Translated: 9.45; Mature: 9.45

Prosite motif: PS01242 ZF_FPG_1 ; PS51066 ZF_FPG_2 ; PS51068 FPG_CAT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVETVRQDLQRLTLGPRILAVEVLLARTIAYPAGEMFGRSLIGTRFTQWQRRGKY
CCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCC
LLGSLDSRAVLGVHLRMTGQLLWVQGSTPLSAHTRVRLAFEEGWDLRFVDQRTFGQMWLV
EECCCCCCEEEEEEEEEECEEEEEECCCCCCCCEEEEEEECCCCCEEEECCCCCCCEEEE
PAGVELEAVIPTLQTLGPEPFSPAFSEAYFQAALQKSRRLIKAALLDQSLVAGVGNIYAD
ECCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EALFLSGIHPLTPAVQLSDVAKARLREALIEVLRAGLEQRGTTLRDYRDLRGLNGNYQGQ
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCC
AWVYGREGDPCRLCGTPIQRMKLAGRSAHFCPHCQPQQS
EEEECCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PELPEVETVRQDLQRLTLGPRILAVEVLLARTIAYPAGEMFGRSLIGTRFTQWQRRGKY
CCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCC
LLGSLDSRAVLGVHLRMTGQLLWVQGSTPLSAHTRVRLAFEEGWDLRFVDQRTFGQMWLV
EECCCCCCEEEEEEEEEECEEEEEECCCCCCCCEEEEEEECCCCCEEEECCCCCCCEEEE
PAGVELEAVIPTLQTLGPEPFSPAFSEAYFQAALQKSRRLIKAALLDQSLVAGVGNIYAD
ECCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EALFLSGIHPLTPAVQLSDVAKARLREALIEVLRAGLEQRGTTLRDYRDLRGLNGNYQGQ
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCC
AWVYGREGDPCRLCGTPIQRMKLAGRSAHFCPHCQPQQS
EEEECCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8278517 [H]