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The map label for this gene is degU [H]

Identifier: 86608718

GI number: 86608718

Start: 1291088

End: 1291684

Strand: Reverse

Name: degU [H]

Synonym: CYB_1242

Alternate gene names: 86608718

Gene position: 1291684-1291088 (Counterclockwise)

Preceding gene: 86608719

Following gene: 86608717

Centisome position: 42.4

GC content: 62.48

Gene sequence:

>597_bases
ATGACTTCCCCTGTCCGCGTTCTCATTGCCGACGATCATCCCCTCTTCCGGCTGGGGCTGAAGTTTGCCCTGCAAGCGCA
AGGATTTGAGGTGGTGGCCGAAGCCGAGACGGGATCCCAGGCCGTTCAGTACTGCCGCAGTTGCCCCATCGACGTGGCCA
TTTTGGATGTGCGCATGCCGGATGGGGATGGGATCGCCGCCTGCCAGCAAATCACCGAGCTGGGCCTGCCGGTGGTGGTG
GTGATGATGACCACCTTTCAGGAGCCGGGTCTGATTGAGGCAGCCCGCCGCGCCGGGGCCAAAGGCTACCTTTCCAAAGA
GACCGACCCGGCGGAATTGGCCCGCGTCATCCGTCAGATTTTGTCCAACCCCGAACGAGACTGGCTGCCTGCCCGACAGG
AGCTGCCCAAGCTCACCCCCCGCGAGCTGTGTGTGCTGCAACTGATGAAAGAGGGCCTGGCCAACAAGCAGATTGCCCGC
CGCCTGGGCCTGAGCATCGAAACTGTCAAAGAATACGCCAGCACCGCCTACCGCAAGCTGGATGCCAGCGACCGCGTCAC
CGCCCTCCTCAAGGCGCAACAACTGGGGATTTTGTGA

Upstream 100 bases:

>100_bases
CCTCTCCCCAAGGGAGAGGGGCTGGGGGTGAGGGCGCTTTATTTGGGATCCCCCCTTGGGCAGATTAAAACCAGCACCCC
CTCGGCTGGGATCCCCTGCC

Downstream 100 bases:

>100_bases
AAGGATATTGAGGATTCTTAAGAATCTTGCAGAGAGGGGGCTGGCAGCTCCCCCCAGCGGTGGGGATGTCCGAAACTCCG
GATCCCTTGCATACTGTTGC

Product: DNA-binding response regulator

Products: NA

Alternate protein names: Protease production enhancer protein [H]

Number of amino acids: Translated: 198; Mature: 197

Protein sequence:

>198_residues
MTSPVRVLIADDHPLFRLGLKFALQAQGFEVVAEAETGSQAVQYCRSCPIDVAILDVRMPDGDGIAACQQITELGLPVVV
VMMTTFQEPGLIEAARRAGAKGYLSKETDPAELARVIRQILSNPERDWLPARQELPKLTPRELCVLQLMKEGLANKQIAR
RLGLSIETVKEYASTAYRKLDASDRVTALLKAQQLGIL

Sequences:

>Translated_198_residues
MTSPVRVLIADDHPLFRLGLKFALQAQGFEVVAEAETGSQAVQYCRSCPIDVAILDVRMPDGDGIAACQQITELGLPVVV
VMMTTFQEPGLIEAARRAGAKGYLSKETDPAELARVIRQILSNPERDWLPARQELPKLTPRELCVLQLMKEGLANKQIAR
RLGLSIETVKEYASTAYRKLDASDRVTALLKAQQLGIL
>Mature_197_residues
TSPVRVLIADDHPLFRLGLKFALQAQGFEVVAEAETGSQAVQYCRSCPIDVAILDVRMPDGDGIAACQQITELGLPVVVV
MMTTFQEPGLIEAARRAGAKGYLSKETDPAELARVIRQILSNPERDWLPARQELPKLTPRELCVLQLMKEGLANKQIARR
LGLSIETVKEYASTAYRKLDASDRVTALLKAQQLGIL

Specific function: Regulating factor for the production of extracellular proteases. The N-terminal region acts as an inhibitor, whereas the C-terminal region carries enhancing activity [H]

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788521, Length=209, Percent_Identity=35.8851674641148, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1788222, Length=192, Percent_Identity=32.2916666666667, Blast_Score=99, Evalue=1e-22,
Organism=Escherichia coli, GI1786747, Length=190, Percent_Identity=27.8947368421053, Blast_Score=91, Evalue=4e-20,
Organism=Escherichia coli, GI1787473, Length=208, Percent_Identity=32.2115384615385, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1790102, Length=188, Percent_Identity=30.8510638297872, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1788712, Length=195, Percent_Identity=24.1025641025641, Blast_Score=66, Evalue=1e-12,
Organism=Escherichia coli, GI1788546, Length=199, Percent_Identity=25.6281407035176, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1788550, Length=121, Percent_Identity=33.8842975206612, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 21770; Mature: 21638

Theoretical pI: Translated: 7.14; Mature: 7.14

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSPVRVLIADDHPLFRLGLKFALQAQGFEVVAEAETGSQAVQYCRSCPIDVAILDVRMP
CCCCEEEEEECCCCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHCCCCCEEEEEEECC
DGDGIAACQQITELGLPVVVVMMTTFQEPGLIEAARRAGAKGYLSKETDPAELARVIRQI
CCCCHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHH
LSNPERDWLPARQELPKLTPRELCVLQLMKEGLANKQIARRLGLSIETVKEYASTAYRKL
HCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHC
DASDRVTALLKAQQLGIL
CCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TSPVRVLIADDHPLFRLGLKFALQAQGFEVVAEAETGSQAVQYCRSCPIDVAILDVRMP
CCCEEEEEECCCCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHCCCCCEEEEEEECC
DGDGIAACQQITELGLPVVVVMMTTFQEPGLIEAARRAGAKGYLSKETDPAELARVIRQI
CCCCHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHH
LSNPERDWLPARQELPKLTPRELCVLQLMKEGLANKQIARRLGLSIETVKEYASTAYRKL
HCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHC
DASDRVTALLKAQQLGIL
CCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3136143; 3141378; 3141377; 9384377 [H]