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The map label for this gene is appC [H]

Identifier: 86608662

GI number: 86608662

Start: 1223892

End: 1225124

Strand: Direct

Name: appC [H]

Synonym: CYB_1186

Alternate gene names: 86608662

Gene position: 1223892-1225124 (Clockwise)

Preceding gene: 86608661

Following gene: 86608664

Centisome position: 40.17

GC content: 59.85

Gene sequence:

>1233_bases
GTGACACCTTGCAGCCCTCTCTGCAACTGGAACAAGACACGATCAGCTACACTGCTGGCATTTGGTTCAACTGGACTCGA
CTGGAATCTTTGCCTCATGCAGTGGTGGAAACGGCTTCGCCAAAACCGATGGGCCCAAGTAGGAGCTTACATTCTCCTTG
TTTTCTACGCCTGCGCCATTTTTGCCGAGTTCGTTGCCCCCTACAGCCCACTGGAATCTCAACCGGGGGGATCCCTTCTG
CCGCCCACCGCCATTCACTTTTGGGATGAATCGGGCGCTTGGATTGGGCCCCACGTTTATCCAACCCGCCAGGGGCCAGT
GGATCTGGAAACGGGAGAACGCCCGCTCTTGGTGGATACCAGCCGTCCAGCCGGGATCCGCTTGTTTGTGGCCGGTACTC
CCTACCGTTGGTTGGGGTTGATCCCCTCCAATCGGCATCTGTTTGGCACCGTCCCGCTGCGGCCTGTTGCAGAAGAGGGA
CAGGTGGGATCCCCAATCGGCGAAGAGCCCTCTGTGGCACGGCTACACCTGCTGGGCACCGATGATCAAGGTCGGGACTA
TTTCAGTCGCTTGGTCTATGGCGGGCGCGTCAGCCTGTTTATCGGCTTGGTGGGCATTGGCATCTCTTTCCCCATTGGTC
TGCTGGTGGGGGCCATATCCGGCTACCTTGGGGGCTGGGTGGATACGCTCCTGATGCGCTTGGCAGAGGTGTTGATGTCG
ATTCCGACGCTGTATCTGCTGGTGTCGCTGGCAGCGGTGTTGCAGGTGAATCCGCTGACCGGGGTGCCCTTCAGCAATGC
CGAGCGCTTCTTGGTGATTGTGGTGATCCTCTCTTTTGTGGGTTGGGCGGGCCTAGCCAGGGTGATTCGTGGGCAGGTGC
TGTCCTTGCGAGAGCGGGACTTTGTGCAGGCAGCGCGGGTAGCCGGGGCTGGATCCCTGTACCTGCTGGTGCGGCATATT
TTGCCCCAGACAGCCACTTATGTGGTGATCTCGGCAACCTTGGCGGTGCCCGGCTACATTGCGGCAGAGTCGGTGCTGAG
CCTCATTGGGTTGGGGATCCAACAGCCGGATGCCTCTTGGGGCAACATGCTCTCGCTGGCCACCAACGCTTCGGTGATCA
TCCTACAACCCTGGCTGGTGCTGGCCCCAACGCTGATGGTGGTGCTGACCTCTCTATCCTTTAACCTGCTGGGGGATGGT
TTGCGGGACGCCCTCGATCCTCGGGAAGGGTGA

Upstream 100 bases:

>100_bases
GTGCGGATGGAGATGACGGCCCTCTACAGCCCCAGCTATTCCTTGGCAGGCTGAGCTTGTCTTGGACTGGGGAAGGGACT
CGTCCTGCCAGCATGAATCG

Downstream 100 bases:

>100_bases
GCTGCTTCCCCATTGCGCCGAGTGAAGGGAATGGAGTGGCCTGCAAATCACCGCTTTCCGTCGGGATAGAGCCGGTTTAG
ACCCTTGCGAGCCTTAGCAT

Product: oligopeptide ABC transporter, permease protein

Products: ADP; phosphate; oligopeptides [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 410; Mature: 409

Protein sequence:

>410_residues
MTPCSPLCNWNKTRSATLLAFGSTGLDWNLCLMQWWKRLRQNRWAQVGAYILLVFYACAIFAEFVAPYSPLESQPGGSLL
PPTAIHFWDESGAWIGPHVYPTRQGPVDLETGERPLLVDTSRPAGIRLFVAGTPYRWLGLIPSNRHLFGTVPLRPVAEEG
QVGSPIGEEPSVARLHLLGTDDQGRDYFSRLVYGGRVSLFIGLVGIGISFPIGLLVGAISGYLGGWVDTLLMRLAEVLMS
IPTLYLLVSLAAVLQVNPLTGVPFSNAERFLVIVVILSFVGWAGLARVIRGQVLSLRERDFVQAARVAGAGSLYLLVRHI
LPQTATYVVISATLAVPGYIAAESVLSLIGLGIQQPDASWGNMLSLATNASVIILQPWLVLAPTLMVVLTSLSFNLLGDG
LRDALDPREG

Sequences:

>Translated_410_residues
MTPCSPLCNWNKTRSATLLAFGSTGLDWNLCLMQWWKRLRQNRWAQVGAYILLVFYACAIFAEFVAPYSPLESQPGGSLL
PPTAIHFWDESGAWIGPHVYPTRQGPVDLETGERPLLVDTSRPAGIRLFVAGTPYRWLGLIPSNRHLFGTVPLRPVAEEG
QVGSPIGEEPSVARLHLLGTDDQGRDYFSRLVYGGRVSLFIGLVGIGISFPIGLLVGAISGYLGGWVDTLLMRLAEVLMS
IPTLYLLVSLAAVLQVNPLTGVPFSNAERFLVIVVILSFVGWAGLARVIRGQVLSLRERDFVQAARVAGAGSLYLLVRHI
LPQTATYVVISATLAVPGYIAAESVLSLIGLGIQQPDASWGNMLSLATNASVIILQPWLVLAPTLMVVLTSLSFNLLGDG
LRDALDPREG
>Mature_409_residues
TPCSPLCNWNKTRSATLLAFGSTGLDWNLCLMQWWKRLRQNRWAQVGAYILLVFYACAIFAEFVAPYSPLESQPGGSLLP
PTAIHFWDESGAWIGPHVYPTRQGPVDLETGERPLLVDTSRPAGIRLFVAGTPYRWLGLIPSNRHLFGTVPLRPVAEEGQ
VGSPIGEEPSVARLHLLGTDDQGRDYFSRLVYGGRVSLFIGLVGIGISFPIGLLVGAISGYLGGWVDTLLMRLAEVLMSI
PTLYLLVSLAAVLQVNPLTGVPFSNAERFLVIVVILSFVGWAGLARVIRGQVLSLRERDFVQAARVAGAGSLYLLVRHIL
PQTATYVVISATLAVPGYIAAESVLSLIGLGIQQPDASWGNMLSLATNASVIILQPWLVLAPTLMVVLTSLSFNLLGDGL
RDALDPREG

Specific function: This protein is a component of an oligopeptide permease, a binding protein-dependent transport system. This APP system can completely substitute for the OPP system in both sporulation and genetic competence, though, unlike OPP, is incapable of transportin

COG id: COG1173

COG function: function code EP; ABC-type dipeptide/oligopeptide/nickel transport systems, permease components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1787498, Length=240, Percent_Identity=40.8333333333333, Blast_Score=169, Evalue=4e-43,
Organism=Escherichia coli, GI1787054, Length=233, Percent_Identity=39.4849785407725, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1787760, Length=241, Percent_Identity=39.8340248962656, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI1789964, Length=237, Percent_Identity=39.2405063291139, Blast_Score=132, Evalue=5e-32,
Organism=Escherichia coli, GI1789889, Length=233, Percent_Identity=35.6223175965665, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI1788505, Length=376, Percent_Identity=26.5957446808511, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI1787549, Length=229, Percent_Identity=31.4410480349345, Blast_Score=84, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 44409; Mature: 44278

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPCSPLCNWNKTRSATLLAFGSTGLDWNLCLMQWWKRLRQNRWAQVGAYILLVFYACAI
CCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FAEFVAPYSPLESQPGGSLLPPTAIHFWDESGAWIGPHVYPTRQGPVDLETGERPLLVDT
HHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCCEECCCCCCCCCCCCCCCCCCCCEEEEC
SRPAGIRLFVAGTPYRWLGLIPSNRHLFGTVPLRPVAEEGQVGSPIGEEPSVARLHLLGT
CCCCCEEEEEECCCCEEEEECCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEECC
DDQGRDYFSRLVYGGRVSLFIGLVGIGISFPIGLLVGAISGYLGGWVDTLLMRLAEVLMS
CCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IPTLYLLVSLAAVLQVNPLTGVPFSNAERFLVIVVILSFVGWAGLARVIRGQVLSLRERD
HHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FVQAARVAGAGSLYLLVRHILPQTATYVVISATLAVPGYIAAESVLSLIGLGIQQPDASW
HHHHHHHCCCCHHHHHHHHHHCCCHHEEEEEEHHHCCCHHHHHHHHHHHHCCCCCCCCCC
GNMLSLATNASVIILQPWLVLAPTLMVVLTSLSFNLLGDGLRDALDPREG
CCEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCC
>Mature Secondary Structure 
TPCSPLCNWNKTRSATLLAFGSTGLDWNLCLMQWWKRLRQNRWAQVGAYILLVFYACAI
CCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FAEFVAPYSPLESQPGGSLLPPTAIHFWDESGAWIGPHVYPTRQGPVDLETGERPLLVDT
HHHHHCCCCCCCCCCCCCCCCCCEEEEECCCCCEECCCCCCCCCCCCCCCCCCCCEEEEC
SRPAGIRLFVAGTPYRWLGLIPSNRHLFGTVPLRPVAEEGQVGSPIGEEPSVARLHLLGT
CCCCCEEEEEECCCCEEEEECCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEEECC
DDQGRDYFSRLVYGGRVSLFIGLVGIGISFPIGLLVGAISGYLGGWVDTLLMRLAEVLMS
CCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IPTLYLLVSLAAVLQVNPLTGVPFSNAERFLVIVVILSFVGWAGLARVIRGQVLSLRERD
HHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FVQAARVAGAGSLYLLVRHILPQTATYVVISATLAVPGYIAAESVLSLIGLGIQQPDASW
HHHHHHHCCCCHHHHHHHHHHCCCHHEEEEEEHHHCCCHHHHHHHHHHHHCCCCCCCCCC
GNMLSLATNASVIILQPWLVLAPTLMVVLTSLSFNLLGDGLRDALDPREG
CCEEEECCCCCEEEECCHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; oligopeptides [Periplasm]; H2O [C]

Specific reaction: ATP + oligopeptides [Periplasm] + H2O = ADP + phosphate + oligopeptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7997159; 9384377 [H]