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The map label for this gene is lytC [H]

Identifier: 86607857

GI number: 86607857

Start: 375308

End: 377185

Strand: Reverse

Name: lytC [H]

Synonym: CYB_0360

Alternate gene names: 86607857

Gene position: 377185-375308 (Counterclockwise)

Preceding gene: 86607861

Following gene: 86607856

Centisome position: 12.38

GC content: 62.62

Gene sequence:

>1878_bases
GTGGGGAGTGGATGGAAGGTCATGCCCGAATTTGGCAAGCCGGGGTCAAGGCAGATATGGGGGGCGATGCTGCTGTTGAG
CTTGGCGGGGGCAGGGCTGTTTCCCCCGGAATCTGTCCAGGCTCAGGCGATTACAGCCCCAGGTTTATCGCGCATTGAGC
GTTGGTACTACGACCCCCAGCAGGGGCGGCTGGAAGTTAACACCCAGGGCGAGGTGCGGCCTTTTCTGTTCGTGCTGCAG
AATCCGCCTCGGGTTGTGCTGGATTTTCCCAACACCCGCTTCGGACGGGAGCCCCAGACCCAGACCTTTGCAGGCCGTGT
CACCTCTCTGCAGATTAGCCAGCTTACGGATACCATTACCCGCTTTGTGCTGTATCTGCAGCCGGATCAGCCTCTCAGCC
TCAACCAACTGCAACTGCTCACTGCCGGCCCCTCCCGCTGGGCTGTTCAACTCACCCAGGCCGGATCTCTCTCTTCTTCT
CCCCCTTCATCTGTCGGCTTATTGGGAGGTTCCAGGGATCCCTTCCCGCCGTCCCCGCCTTTGCCGACACTGCCTCCCCG
ACGCCCGGCACCCACCCCATCTCCTCGCTCCGGCCATCAAATTTTAGAGGTATCCCCGCAAGCAGAAGGCTTTTTTATCC
GTACCCAAGGCAGCCCCTCCACTACGGTGCGGCGCATCCTCGATCCGGATCGGGTAGTGGTGGATTTTCTCAACACCACC
CTCAGCCCTGCCCTCACCCAGCGAGCTTATGTCATCAACCGTCTGGGGGTTTCGCGGCTGCGTATCGGGCAGTTTGAGCC
CACCGTTGCTCGGGTAGTGCTGGATGTGGATTCCTCCGGTGGCGACTGGGAAGCCCGCTACGACCCACAGCGAGGTGGGA
TCTGGATCCAGCCTGCCGGGGGTGCTGCCCAGGCCAGCCTTTTGCCCGAGGTCAGCTCTGTCAACAGCAGTGGGCCGCTG
GCCACGTTGCAATCGGTTCAGCTCCAGGGCAACCAGTTGATCATCAGCGCCGATGGATTCATGTTCTACCGGGCCGGCTG
GGATCCCGAGAGTGGCGGCTACCGCATCAATGTGGCGCCGGCGCGCCTGCCCCAGTCTATGCCGGATCCCGGCTTGCCGG
TTGGAGGGCCGGTGGAGCGGATCCGCTTTGTCCAGGAAGATGCCCGCACGGTCAGCATTCTGGTGCAGCCCGCCGAGGAG
TTCAATGTCTTCGAGCCCAACCCCGGCCAGGGATCCCGCCGCATTACCTTGGAGCTGCGACCTCTGAATGCTCCTCCACC
AATACCTCAGCCGCAGACGCCCGGCCCTGCCTCCCCTTCCACCCCCCAATCTCTGAACCGGACGGTCATTGCCATCGACC
CCGGCCACGGGGGACGGGATCCCGGTGCCATCGGGGTAGATGGGATCCAGGAGAAGGACATCGTGCTCTCCGTTGCCCAC
CAGGTGCAACGACTGCTGCAGGAGCGGGGGTACGGGGTGGTGATGACCCGCACCGATGACCGGGAAGTGCTGCTGCAACC
GCGGGTGGATATGGCCGTTCAGGCCAATGCTGCCCTGCTGGTGAGCATTCATGCCAACGCCCTGGATCGCTCCGGCATTC
ACGGCATCGAGACCTATTACCTGCGACCCGATAGCGCCGAGCTGGCCGCCATCTTGCACCGCAGCTTGGTCAGGGCCACC
GGTGCTGCTGACCGGGGGGTGAGACGAGCCCGCTTTTTTGTGGTGCGGGAAACACCTGTGGGTATGCCCTCCGTGCTGCT
GGAGTTGGGATACGTAACCAACCCAACCGAAGGGCGAAAATTGGCTACTGCCGAATATCAGGCTCTCTTGGCGCGGGCCA
TTGCCGATGGCATTGAGACTTTCTTGCGCAGTCGCTAG

Upstream 100 bases:

>100_bases
AGGGGCGAGCCTCTACCCATCATCCCCCAGCCCTGCAGGCAAGAGCGGAATTGCGCTCCTTCCCAGGCTGCTCCGAAAGC
AGGTTGGTATAGTTGCAGGT

Downstream 100 bases:

>100_bases
CCGTTGGCTGAGCTTGTTCATGTCTATCGGATCTCTCAATTGATCCTTAATTGAAATTGATCGAATTGACGATCCAGTTG
GCCCAGTTGATCTCAGAGGG

Product: N-acetylmuramoyl-L-alanine amidase

Products: NA

Alternate protein names: Cell wall hydrolase; Cell wall-associated polypeptide CWBP49; CWBP49; Major autolysin [H]

Number of amino acids: Translated: 625; Mature: 624

Protein sequence:

>625_residues
MGSGWKVMPEFGKPGSRQIWGAMLLLSLAGAGLFPPESVQAQAITAPGLSRIERWYYDPQQGRLEVNTQGEVRPFLFVLQ
NPPRVVLDFPNTRFGREPQTQTFAGRVTSLQISQLTDTITRFVLYLQPDQPLSLNQLQLLTAGPSRWAVQLTQAGSLSSS
PPSSVGLLGGSRDPFPPSPPLPTLPPRRPAPTPSPRSGHQILEVSPQAEGFFIRTQGSPSTTVRRILDPDRVVVDFLNTT
LSPALTQRAYVINRLGVSRLRIGQFEPTVARVVLDVDSSGGDWEARYDPQRGGIWIQPAGGAAQASLLPEVSSVNSSGPL
ATLQSVQLQGNQLIISADGFMFYRAGWDPESGGYRINVAPARLPQSMPDPGLPVGGPVERIRFVQEDARTVSILVQPAEE
FNVFEPNPGQGSRRITLELRPLNAPPPIPQPQTPGPASPSTPQSLNRTVIAIDPGHGGRDPGAIGVDGIQEKDIVLSVAH
QVQRLLQERGYGVVMTRTDDREVLLQPRVDMAVQANAALLVSIHANALDRSGIHGIETYYLRPDSAELAAILHRSLVRAT
GAADRGVRRARFFVVRETPVGMPSVLLELGYVTNPTEGRKLATAEYQALLARAIADGIETFLRSR

Sequences:

>Translated_625_residues
MGSGWKVMPEFGKPGSRQIWGAMLLLSLAGAGLFPPESVQAQAITAPGLSRIERWYYDPQQGRLEVNTQGEVRPFLFVLQ
NPPRVVLDFPNTRFGREPQTQTFAGRVTSLQISQLTDTITRFVLYLQPDQPLSLNQLQLLTAGPSRWAVQLTQAGSLSSS
PPSSVGLLGGSRDPFPPSPPLPTLPPRRPAPTPSPRSGHQILEVSPQAEGFFIRTQGSPSTTVRRILDPDRVVVDFLNTT
LSPALTQRAYVINRLGVSRLRIGQFEPTVARVVLDVDSSGGDWEARYDPQRGGIWIQPAGGAAQASLLPEVSSVNSSGPL
ATLQSVQLQGNQLIISADGFMFYRAGWDPESGGYRINVAPARLPQSMPDPGLPVGGPVERIRFVQEDARTVSILVQPAEE
FNVFEPNPGQGSRRITLELRPLNAPPPIPQPQTPGPASPSTPQSLNRTVIAIDPGHGGRDPGAIGVDGIQEKDIVLSVAH
QVQRLLQERGYGVVMTRTDDREVLLQPRVDMAVQANAALLVSIHANALDRSGIHGIETYYLRPDSAELAAILHRSLVRAT
GAADRGVRRARFFVVRETPVGMPSVLLELGYVTNPTEGRKLATAEYQALLARAIADGIETFLRSR
>Mature_624_residues
GSGWKVMPEFGKPGSRQIWGAMLLLSLAGAGLFPPESVQAQAITAPGLSRIERWYYDPQQGRLEVNTQGEVRPFLFVLQN
PPRVVLDFPNTRFGREPQTQTFAGRVTSLQISQLTDTITRFVLYLQPDQPLSLNQLQLLTAGPSRWAVQLTQAGSLSSSP
PSSVGLLGGSRDPFPPSPPLPTLPPRRPAPTPSPRSGHQILEVSPQAEGFFIRTQGSPSTTVRRILDPDRVVVDFLNTTL
SPALTQRAYVINRLGVSRLRIGQFEPTVARVVLDVDSSGGDWEARYDPQRGGIWIQPAGGAAQASLLPEVSSVNSSGPLA
TLQSVQLQGNQLIISADGFMFYRAGWDPESGGYRINVAPARLPQSMPDPGLPVGGPVERIRFVQEDARTVSILVQPAEEF
NVFEPNPGQGSRRITLELRPLNAPPPIPQPQTPGPASPSTPQSLNRTVIAIDPGHGGRDPGAIGVDGIQEKDIVLSVAHQ
VQRLLQERGYGVVMTRTDDREVLLQPRVDMAVQANAALLVSIHANALDRSGIHGIETYYLRPDSAELAAILHRSLVRATG
AADRGVRRARFFVVRETPVGMPSVLLELGYVTNPTEGRKLATAEYQALLARAIADGIETFLRSR

Specific function: Autolysins are involved in some important biological processes such as cell separation, cell-wall turnover, competence for genetic transformation, formation of the flagella - in particular of its basal body - and sporulation. Has a high affinity for teich

COG id: COG0860

COG function: function code M; N-acetylmuramoyl-L-alanine amidase

Gene ontology:

Cell location: Secreted, cell wall [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the N-acetylmuramoyl-L-alanine amidase 3 family [H]

Homologues:

Organism=Escherichia coli, GI1788776, Length=237, Percent_Identity=29.535864978903, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI87082163, Length=243, Percent_Identity=29.2181069958848, Blast_Score=89, Evalue=8e-19,
Organism=Escherichia coli, GI1790611, Length=237, Percent_Identity=28.2700421940928, Blast_Score=79, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007253
- InterPro:   IPR002508 [H]

Pfam domain/function: PF01520 Amidase_3; PF04122 CW_binding_2 [H]

EC number: =3.5.1.28 [H]

Molecular weight: Translated: 67778; Mature: 67647

Theoretical pI: Translated: 9.58; Mature: 9.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSGWKVMPEFGKPGSRQIWGAMLLLSLAGAGLFPPESVQAQAITAPGLSRIERWYYDPQ
CCCCCEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCHHHHHHHCCCCC
QGRLEVNTQGEVRPFLFVLQNPPRVVLDFPNTRFGREPQTQTFAGRVTSLQISQLTDTIT
CCEEEECCCCCCCEEEEEECCCCEEEEECCCCCCCCCCCCHHHHCCEEEEEHHHHHHHHH
RFVLYLQPDQPLSLNQLQLLTAGPSRWAVQLTQAGSLSSSPPSSVGLLGGSRDPFPPSPP
HEEEEECCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCCCCCCEEECCCCCCCCCCCCC
LPTLPPRRPAPTPSPRSGHQILEVSPQAEGFFIRTQGSPSTTVRRILDPDRVVVDFLNTT
CCCCCCCCCCCCCCCCCCCEEEEECCCCCEEEEEECCCCHHHHHHHCCCHHHHHHHHHHH
LSPALTQRAYVINRLGVSRLRIGQFEPTVARVVLDVDSSGGDWEARYDPQRGGIWIQPAG
HCHHHHHHHHHHHHCCCCCEECCCCCCCEEEEEEEECCCCCCCCEEECCCCCCEEEEECC
GAAQASLLPEVSSVNSSGPLATLQSVQLQGNQLIISADGFMFYRAGWDPESGGYRINVAP
CCCHHHHCCHHHCCCCCCCEEEHEEEEECCCEEEEEECCEEEEEECCCCCCCCEEEEECH
ARLPQSMPDPGLPVGGPVERIRFVQEDARTVSILVQPAEEFNVFEPNPGQGSRRITLELR
HHCCCCCCCCCCCCCCHHHHHHHHHHCCEEEEEEEECHHHCCCCCCCCCCCCEEEEEEEE
PLNAPPPIPQPQTPGPASPSTPQSLNRTVIAIDPGHGGRDPGAIGVDGIQEKDIVLSVAH
ECCCCCCCCCCCCCCCCCCCCCHHHCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHH
QVQRLLQERGYGVVMTRTDDREVLLQPRVDMAVQANAALLVSIHANALDRSGIHGIETYY
HHHHHHHHCCCEEEEEECCCCEEEECCCCCEEEECCEEEEEEEECCCCCCCCCCCEEEEE
LRPDSAELAAILHRSLVRATGAADRGVRRARFFVVRETPVGMPSVLLELGYVTNPTEGRK
ECCCCHHHHHHHHHHHHHHCCCHHCCCEEEEEEEEECCCCCCHHHHHHHCCCCCCCCCCE
LATAEYQALLARAIADGIETFLRSR
EEHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
GSGWKVMPEFGKPGSRQIWGAMLLLSLAGAGLFPPESVQAQAITAPGLSRIERWYYDPQ
CCCCEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCHHHHHHHCCCCC
QGRLEVNTQGEVRPFLFVLQNPPRVVLDFPNTRFGREPQTQTFAGRVTSLQISQLTDTIT
CCEEEECCCCCCCEEEEEECCCCEEEEECCCCCCCCCCCCHHHHCCEEEEEHHHHHHHHH
RFVLYLQPDQPLSLNQLQLLTAGPSRWAVQLTQAGSLSSSPPSSVGLLGGSRDPFPPSPP
HEEEEECCCCCCCCCEEEEEECCCCCEEEEEEECCCCCCCCCCCEEECCCCCCCCCCCCC
LPTLPPRRPAPTPSPRSGHQILEVSPQAEGFFIRTQGSPSTTVRRILDPDRVVVDFLNTT
CCCCCCCCCCCCCCCCCCCEEEEECCCCCEEEEEECCCCHHHHHHHCCCHHHHHHHHHHH
LSPALTQRAYVINRLGVSRLRIGQFEPTVARVVLDVDSSGGDWEARYDPQRGGIWIQPAG
HCHHHHHHHHHHHHCCCCCEECCCCCCCEEEEEEEECCCCCCCCEEECCCCCCEEEEECC
GAAQASLLPEVSSVNSSGPLATLQSVQLQGNQLIISADGFMFYRAGWDPESGGYRINVAP
CCCHHHHCCHHHCCCCCCCEEEHEEEEECCCEEEEEECCEEEEEECCCCCCCCEEEEECH
ARLPQSMPDPGLPVGGPVERIRFVQEDARTVSILVQPAEEFNVFEPNPGQGSRRITLELR
HHCCCCCCCCCCCCCCHHHHHHHHHHCCEEEEEEEECHHHCCCCCCCCCCCCEEEEEEEE
PLNAPPPIPQPQTPGPASPSTPQSLNRTVIAIDPGHGGRDPGAIGVDGIQEKDIVLSVAH
ECCCCCCCCCCCCCCCCCCCCCHHHCCEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHH
QVQRLLQERGYGVVMTRTDDREVLLQPRVDMAVQANAALLVSIHANALDRSGIHGIETYY
HHHHHHHHCCCEEEEEECCCCEEEECCCCCEEEECCEEEEEEEECCCCCCCCCCCEEEEE
LRPDSAELAAILHRSLVRATGAADRGVRRARFFVVRETPVGMPSVLLELGYVTNPTEGRK
ECCCCHHHHHHHHHHHHHHCCCHHCCCEEEEEEEEECCCCCCHHHHHHHCCCCCCCCCCE
LATAEYQALLARAIADGIETFLRSR
EEHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1357079; 1682302; 9384377 [H]