Click here to switch to the map view.

The map label for this gene is fba [H]

Identifier: 86607854

GI number: 86607854

Start: 372178

End: 373257

Strand: Reverse

Name: fba [H]

Synonym: CYB_0357

Alternate gene names: 86607854

Gene position: 373257-372178 (Counterclockwise)

Preceding gene: 86607856

Following gene: 86607851

Centisome position: 12.25

GC content: 59.26

Gene sequence:

>1080_bases
ATGGCTCTCGTTGCAATGCGGACGCTACTGGATCATGCCGCCGAACATGGCTACGGCATTCCTGCCTTCAACGTCAACAA
CATGGAGCAGATCCAAGCAATCATGCAGGCAGCCCATGAAACCAACAGCCCCGTTATCCTGCAAGCCTCTCGAGGGGCAC
GCAAGTATGCGGGCGAGAACTTTCTGCGGCACCTGATCCTGGCGGCAGTGGAGACCTACCCCCACATCCCCGTCGCCATG
CACCAAGACCACGGCAATAGCCCGGCTACCTGCTATTCCGCCATCCGCAACGGCTTCACCAGCGTCATGATGGATGGATC
CCTCAAGGAAGATGCCAAAACCCCGGCCAGCTACGAGTACAACGTGGCCGTTACCTCCGAGGTGGTGAAAGTGGCTCATG
CAATCGGGGTGAGTGTGGAAGGGGAACTGGGCTGCCTGGGATCCCTGGAGACGGGCCGTGGGGAAGCGGAAGATGGCCAC
GGCGCGGAAGAGGCGCTCAGCCATGACCAACTCCTCACCGACCCCGACCAAGCGGTGGACTTTGTGGAGCGAACTCAGGT
GGATGCGCTGGCCGTAGCCATTGGTACCAGCCATGGCGCCTACAAGTTCTCCCGGAAGCCCACTGGTGACATCCTCGACA
TGGAGCGCATTGCTGAGATCCACCGCCGCCTGCCCAACACGCACCTGGTGATGCACGGTTCCTCCTCGGTGCCCAAGGAG
CTGATCGACATCATCAACGAATACGGCGGCTCCATTCCCGAGACTTACGGTGTGCCGCTGGAAGAAATTCAGCGGGGCAT
CCAAAATGGAGTGCGCAAAGTAAACATCGACACCGACAACCGCCTGGCCATCACAGCTGCCGTGCGCCGCGCTCTGGCCG
AGAATCCGAAAGAGTTTGACCCCCGCCACTTCCTCAAGCCTTCCATCAAGGAAATGCAAAAAGTCTGTGCTGAGCGCTAC
ATTGCCTTCGGCTGTGCTGGCCATGGCACCAAAGTTCCGGTGGTTACCTTGGATGAGATGGCAGCCAAGTATGCTTCTGG
AGCTTTGGCGGCTCAGGTGAAGAAGACCGTTGCGGTCTAG

Upstream 100 bases:

>100_bases
CAGATCCCCGGCGGCTTATCCGCCAAAACGTAAAAAGTATCTTAAGATCAACGGTAAGCAAATCTCATACCCACTAGGTC
AGCACCTCAGGAGGTAACCG

Downstream 100 bases:

>100_bases
TCCCCACATCCTGCAAGAACTCTAGAATGCTTGCCGGGGCGCTTCCAGGGTTTTCCTTGGAGATCAGCTAGGTCACTGGA
CTCAGATTGGACAAATAAGG

Product: fructose-1,6-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase; Fructose-bisphosphate aldolase class II [H]

Number of amino acids: Translated: 359; Mature: 358

Protein sequence:

>359_residues
MALVAMRTLLDHAAEHGYGIPAFNVNNMEQIQAIMQAAHETNSPVILQASRGARKYAGENFLRHLILAAVETYPHIPVAM
HQDHGNSPATCYSAIRNGFTSVMMDGSLKEDAKTPASYEYNVAVTSEVVKVAHAIGVSVEGELGCLGSLETGRGEAEDGH
GAEEALSHDQLLTDPDQAVDFVERTQVDALAVAIGTSHGAYKFSRKPTGDILDMERIAEIHRRLPNTHLVMHGSSSVPKE
LIDIINEYGGSIPETYGVPLEEIQRGIQNGVRKVNIDTDNRLAITAAVRRALAENPKEFDPRHFLKPSIKEMQKVCAERY
IAFGCAGHGTKVPVVTLDEMAAKYASGALAAQVKKTVAV

Sequences:

>Translated_359_residues
MALVAMRTLLDHAAEHGYGIPAFNVNNMEQIQAIMQAAHETNSPVILQASRGARKYAGENFLRHLILAAVETYPHIPVAM
HQDHGNSPATCYSAIRNGFTSVMMDGSLKEDAKTPASYEYNVAVTSEVVKVAHAIGVSVEGELGCLGSLETGRGEAEDGH
GAEEALSHDQLLTDPDQAVDFVERTQVDALAVAIGTSHGAYKFSRKPTGDILDMERIAEIHRRLPNTHLVMHGSSSVPKE
LIDIINEYGGSIPETYGVPLEEIQRGIQNGVRKVNIDTDNRLAITAAVRRALAENPKEFDPRHFLKPSIKEMQKVCAERY
IAFGCAGHGTKVPVVTLDEMAAKYASGALAAQVKKTVAV
>Mature_358_residues
ALVAMRTLLDHAAEHGYGIPAFNVNNMEQIQAIMQAAHETNSPVILQASRGARKYAGENFLRHLILAAVETYPHIPVAMH
QDHGNSPATCYSAIRNGFTSVMMDGSLKEDAKTPASYEYNVAVTSEVVKVAHAIGVSVEGELGCLGSLETGRGEAEDGHG
AEEALSHDQLLTDPDQAVDFVERTQVDALAVAIGTSHGAYKFSRKPTGDILDMERIAEIHRRLPNTHLVMHGSSSVPKEL
IDIINEYGGSIPETYGVPLEEIQRGIQNGVRKVNIDTDNRLAITAAVRRALAENPKEFDPRHFLKPSIKEMQKVCAERYI
AFGCAGHGTKVPVVTLDEMAAKYASGALAAQVKKTVAV

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis [H]

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family [H]

Homologues:

Organism=Escherichia coli, GI1789526, Length=329, Percent_Identity=35.5623100303951, Blast_Score=171, Evalue=6e-44,
Organism=Escherichia coli, GI87082041, Length=327, Percent_Identity=33.3333333333333, Blast_Score=161, Evalue=5e-41,
Organism=Escherichia coli, GI1788072, Length=329, Percent_Identity=31.0030395136778, Blast_Score=115, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6322790, Length=357, Percent_Identity=27.7310924369748, Blast_Score=79, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006412
- InterPro:   IPR000771 [H]

Pfam domain/function: PF01116 F_bP_aldolase [H]

EC number: =4.1.2.13 [H]

Molecular weight: Translated: 38827; Mature: 38696

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS00602 ALDOLASE_CLASS_II_1 ; PS00806 ALDOLASE_CLASS_II_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALVAMRTLLDHAAEHGYGIPAFNVNNMEQIQAIMQAAHETNSPVILQASRGARKYAGEN
CHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHH
FLRHLILAAVETYPHIPVAMHQDHGNSPATCYSAIRNGFTSVMMDGSLKEDAKTPASYEY
HHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHCHHHHHCCCCCHHHCCCCCCEEE
NVAVTSEVVKVAHAIGVSVEGELGCLGSLETGRGEAEDGHGAEEALSHDQLLTDPDQAVD
EEHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCHHHHHH
FVERTQVDALAVAIGTSHGAYKFSRKPTGDILDMERIAEIHRRLPNTHLVMHGSSSVPKE
HHHHHHHHHHEEEEECCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCHHH
LIDIINEYGGSIPETYGVPLEEIQRGIQNGVRKVNIDTDNRLAITAAVRRALAENPKEFD
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCEEEECCCCCCCHHHHHHHHHHHCCCCCCC
PRHFLKPSIKEMQKVCAERYIAFGCAGHGTKVPVVTLDEMAAKYASGALAAQVKKTVAV
CHHHCCCCHHHHHHHHHHHHHHHEECCCCCCCCEEEHHHHHHHHHCCHHHHHHHHHHCC
>Mature Secondary Structure 
ALVAMRTLLDHAAEHGYGIPAFNVNNMEQIQAIMQAAHETNSPVILQASRGARKYAGEN
HHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHH
FLRHLILAAVETYPHIPVAMHQDHGNSPATCYSAIRNGFTSVMMDGSLKEDAKTPASYEY
HHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHCHHHHHCCCCCHHHCCCCCCEEE
NVAVTSEVVKVAHAIGVSVEGELGCLGSLETGRGEAEDGHGAEEALSHDQLLTDPDQAVD
EEHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCHHHHHH
FVERTQVDALAVAIGTSHGAYKFSRKPTGDILDMERIAEIHRRLPNTHLVMHGSSSVPKE
HHHHHHHHHHEEEEECCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCHHH
LIDIINEYGGSIPETYGVPLEEIQRGIQNGVRKVNIDTDNRLAITAAVRRALAENPKEFD
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCEEEECCCCCCCHHHHHHHHHHHCCCCCCC
PRHFLKPSIKEMQKVCAERYIAFGCAGHGTKVPVVTLDEMAAKYASGALAAQVKKTVAV
CHHHCCCCHHHHHHHHHHHHHHHEECCCCCCCCEEEHHHHHHHHHCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231; 9298645 [H]