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The map label for this gene is trx-1 [H]

Identifier: 86607693

GI number: 86607693

Start: 206258

End: 206599

Strand: Direct

Name: trx-1 [H]

Synonym: CYB_0192

Alternate gene names: 86607693

Gene position: 206258-206599 (Clockwise)

Preceding gene: 86607692

Following gene: 86607694

Centisome position: 6.77

GC content: 52.34

Gene sequence:

>342_bases
ATGTCTGCAGCAATAGATATCGCTGATGCTACCTTTGAGGCAGAGGTGCTGCGCAGCGATATTCCAGTTCTGGTTGATTT
TTGGGCACCTTGGTGTGGCCCCTGTCGGATGGTGGCTCCTGTGGTTCAGGAGATAGCTGAGCAGTATGTTGGCAAAGTTA
AGGTTGTAAAAATCAACACCGACGAGAACCCTCAAACTGCCAGCCAGTACGGTATTCGCAGCATTCCCACCCTGATGTTG
TTCAAGGGCGGCCAGAAAGTGGATGTGGTGGTCGGCGCCGTACCCAAGGCAACTCTAACCACGATTTTGGAAAAGCACTT
CGACACACCTGCCGAAGCCTGA

Upstream 100 bases:

>100_bases
TCCGTGTAGTAGCAATGGAACAGGCTGAGGTCACCAGCAGCCTGGGGGCTGTGCTAAGATCAGAGACCATGACAGGTGTT
GTTTCAGGAGTTCTCCAAGC

Downstream 100 bases:

>100_bases
GGGCTATGCCTTGGGTGTTTCAGAATGTAACTTTTGGGTTCTGGATTAGAACCCAGCTGCCATTTTGTGCCGAGAACTGA
TTAAAGTAATTCCAGAGAAC

Product: thioredoxin

Products: NA

Alternate protein names: Trx-1; Thioredoxin-M [H]

Number of amino acids: Translated: 113; Mature: 112

Protein sequence:

>113_residues
MSAAIDIADATFEAEVLRSDIPVLVDFWAPWCGPCRMVAPVVQEIAEQYVGKVKVVKINTDENPQTASQYGIRSIPTLML
FKGGQKVDVVVGAVPKATLTTILEKHFDTPAEA

Sequences:

>Translated_113_residues
MSAAIDIADATFEAEVLRSDIPVLVDFWAPWCGPCRMVAPVVQEIAEQYVGKVKVVKINTDENPQTASQYGIRSIPTLML
FKGGQKVDVVVGAVPKATLTTILEKHFDTPAEA
>Mature_112_residues
SAAIDIADATFEAEVLRSDIPVLVDFWAPWCGPCRMVAPVVQEIAEQYVGKVKVVKINTDENPQTASQYGIRSIPTLMLF
KGGQKVDVVVGAVPKATLTTILEKHFDTPAEA

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=94, Percent_Identity=35.1063829787234, Blast_Score=74, Evalue=3e-14,
Organism=Homo sapiens, GI5031973, Length=85, Percent_Identity=38.8235294117647, Blast_Score=71, Evalue=2e-13,
Organism=Homo sapiens, GI50592994, Length=85, Percent_Identity=37.6470588235294, Blast_Score=67, Evalue=3e-12,
Organism=Homo sapiens, GI24308127, Length=78, Percent_Identity=37.1794871794872, Blast_Score=67, Evalue=4e-12,
Organism=Homo sapiens, GI21361657, Length=109, Percent_Identity=30.2752293577982, Blast_Score=63, Evalue=4e-11,
Organism=Escherichia coli, GI87082331, Length=103, Percent_Identity=50.4854368932039, Blast_Score=123, Evalue=2e-30,
Organism=Escherichia coli, GI1788936, Length=102, Percent_Identity=49.0196078431373, Blast_Score=116, Evalue=4e-28,
Organism=Escherichia coli, GI87081747, Length=84, Percent_Identity=35.7142857142857, Blast_Score=70, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI212646193, Length=93, Percent_Identity=37.6344086021505, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17510299, Length=89, Percent_Identity=41.5730337078652, Blast_Score=79, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17507705, Length=89, Percent_Identity=35.9550561797753, Blast_Score=76, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71998175, Length=89, Percent_Identity=40.4494382022472, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17509965, Length=72, Percent_Identity=40.2777777777778, Blast_Score=68, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI115532378, Length=72, Percent_Identity=41.6666666666667, Blast_Score=68, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI115532380, Length=72, Percent_Identity=41.6666666666667, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71980565, Length=102, Percent_Identity=28.4313725490196, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17544108, Length=72, Percent_Identity=41.6666666666667, Blast_Score=66, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI71980562, Length=82, Percent_Identity=31.7073170731707, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17556044, Length=78, Percent_Identity=35.8974358974359, Blast_Score=65, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6321648, Length=91, Percent_Identity=40.6593406593407, Blast_Score=81, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6323072, Length=86, Percent_Identity=41.8604651162791, Blast_Score=77, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6319925, Length=91, Percent_Identity=31.8681318681319, Blast_Score=66, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24639826, Length=91, Percent_Identity=40.6593406593407, Blast_Score=90, Evalue=2e-19,
Organism=Drosophila melanogaster, GI28573567, Length=94, Percent_Identity=35.1063829787234, Blast_Score=76, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24664269, Length=82, Percent_Identity=41.4634146341463, Blast_Score=74, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17648013, Length=74, Percent_Identity=41.8918918918919, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24583090, Length=74, Percent_Identity=41.8918918918919, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI19921434, Length=82, Percent_Identity=34.1463414634146, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24658597, Length=94, Percent_Identity=34.0425531914894, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24639068, Length=93, Percent_Identity=27.9569892473118, Blast_Score=63, Evalue=5e-11,
Organism=Drosophila melanogaster, GI21358065, Length=81, Percent_Identity=34.5679012345679, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 12258; Mature: 12127

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAAIDIADATFEAEVLRSDIPVLVDFWAPWCGPCRMVAPVVQEIAEQYVGKVKVVKINT
CCCCCCCCCCHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEECC
DENPQTASQYGIRSIPTLMLFKGGQKVDVVVGAVPKATLTTILEKHFDTPAEA
CCCCCHHHHCCCCCCCCEEEECCCCEEEEEEECCCHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SAAIDIADATFEAEVLRSDIPVLVDFWAPWCGPCRMVAPVVQEIAEQYVGKVKVVKINT
CCCCCCCCCHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEECC
DENPQTASQYGIRSIPTLMLFKGGQKVDVVVGAVPKATLTTILEKHFDTPAEA
CCCCCHHHHCCCCCCCCEEEECCCCEEEEEEECCCHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3096973; 3926769 [H]