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The map label for this gene is hmuU [H]

Identifier: 86606673

GI number: 86606673

Start: 2050008

End: 2051051

Strand: Reverse

Name: hmuU [H]

Synonym: CYA_2033

Alternate gene names: 86606673

Gene position: 2051051-2050008 (Counterclockwise)

Preceding gene: 86606674

Following gene: 86606672

Centisome position: 69.94

GC content: 68.68

Gene sequence:

>1044_bases
ATGCTGGCCAATCAAGGGCGTCTGTCATCAGGAGTTGACTCGGAGACACGCTGGGGGCAGGCCAGGCGGATCCTCTCCCC
GGTCGGCTTGGCGGTTTTGCTACTGAGTGTCATCCTCTTGCTGCTTTGGATCTCGATTGCCTTGGGATCCGTTCCCATGA
CTTTTGCGGAGCTGTGGCAGGCCCTGTGGGGGCAAGGGGATCCAGTCCGGCAGACCATTGTCTGGCAGTTGCGGCTGCCG
CGGGCACTTTTGGCCCAGTTGCTGGGGGCGGCCTTGGGGATGGCGGGGGCCCTGCTGCAGGGGATGTTGGGCAATGGGCT
GGCGGATCCCTACCTGCTGGGCATCTCGGCGGGGGCGGGCCTGGCGGCGGTGGGGCTGCTCACCTGGGGGGAGTGGACGG
CTTGGGTGCCCTTGGCGGCTTGGGTGGGCGGGGTGCTGACCACGGTGTTGGTGTATGGCCTGGCGCGCACCCGCTCCGGG
CTGGCGGTGGAGCGGCTGATCTTGGCGGGGGTGGCCGTCAGCGCGCTCTTTGGGGCCATTAGCTCCACCTTATTGTTGAT
GGCCGATGAGCGGGTGCAGGTGGCCCTGACGTGGTTGATCGGCAGCCTGAGCGGGCGGGGCTGGCCGGAGGTGCGGGTGG
CCGGGGTGTACATCCTGGTCGGGCTGGGGCTGGGCTGGGCGCAGGCGCGGGCTTTGAACCTGCTGGGCCTGGGAGAAGAG
ATGGCGGTGAGCTTGGGGATCCCGTTGGCGCGGACGCGGGTGGCCATCGGCCTGGTGGCAGCTTTGTTGGCGGCGGCAGC
CGTCAGCGTGGGGGGGTTGATCGGCTTTGTGGGGTTGGTGGTGCCCCACATGGTGCGCCAGGGGGTGGGATCGGATCACC
GCTGGCTGTTGCCCCTTTCGGCCCTCGGGGGGGCAGCTCTGTTGAGCGGCGCCGATCTCCTCACCCGGCTGGGGGCTGTG
GAGCTGCCGGTGGGGATCGTCACGGCGTTGATGGGGGCGCCGTTTTTCGGCTGGCTGCTGCGGCAGCAGGGGGCAGAGCG
ATGA

Upstream 100 bases:

>100_bases
CAACAAGCTGGAAAGCTTGGCGGGGTTGGGCTCGCTGCTCTGGCGAGCCGGTCGGAGCTGTCTTGCGGATCTCCCCCTCT
CAAAAGTCCTGAGGTTTGCG

Downstream 100 bases:

>100_bases
GGGAGGGCCGGCCAATTTTGCAGGCCGAGGGGCTGAGCGGGGGCTATGGCTCGCGGCAGGTGATCCATCAGGTGAGCTTC
AGCCTGCAGGCGGGGGAATG

Product: iron chelate ABC transporter permease protein

Products: ADP; phosphate; iron dicitrate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MLANQGRLSSGVDSETRWGQARRILSPVGLAVLLLSVILLLLWISIALGSVPMTFAELWQALWGQGDPVRQTIVWQLRLP
RALLAQLLGAALGMAGALLQGMLGNGLADPYLLGISAGAGLAAVGLLTWGEWTAWVPLAAWVGGVLTTVLVYGLARTRSG
LAVERLILAGVAVSALFGAISSTLLLMADERVQVALTWLIGSLSGRGWPEVRVAGVYILVGLGLGWAQARALNLLGLGEE
MAVSLGIPLARTRVAIGLVAALLAAAAVSVGGLIGFVGLVVPHMVRQGVGSDHRWLLPLSALGGAALLSGADLLTRLGAV
ELPVGIVTALMGAPFFGWLLRQQGAER

Sequences:

>Translated_347_residues
MLANQGRLSSGVDSETRWGQARRILSPVGLAVLLLSVILLLLWISIALGSVPMTFAELWQALWGQGDPVRQTIVWQLRLP
RALLAQLLGAALGMAGALLQGMLGNGLADPYLLGISAGAGLAAVGLLTWGEWTAWVPLAAWVGGVLTTVLVYGLARTRSG
LAVERLILAGVAVSALFGAISSTLLLMADERVQVALTWLIGSLSGRGWPEVRVAGVYILVGLGLGWAQARALNLLGLGEE
MAVSLGIPLARTRVAIGLVAALLAAAAVSVGGLIGFVGLVVPHMVRQGVGSDHRWLLPLSALGGAALLSGADLLTRLGAV
ELPVGIVTALMGAPFFGWLLRQQGAER
>Mature_347_residues
MLANQGRLSSGVDSETRWGQARRILSPVGLAVLLLSVILLLLWISIALGSVPMTFAELWQALWGQGDPVRQTIVWQLRLP
RALLAQLLGAALGMAGALLQGMLGNGLADPYLLGISAGAGLAAVGLLTWGEWTAWVPLAAWVGGVLTTVLVYGLARTRSG
LAVERLILAGVAVSALFGAISSTLLLMADERVQVALTWLIGSLSGRGWPEVRVAGVYILVGLGLGWAQARALNLLGLGEE
MAVSLGIPLARTRVAIGLVAALLAAAAVSVGGLIGFVGLVVPHMVRQGVGSDHRWLLPLSALGGAALLSGADLLTRLGAV
ELPVGIVTALMGAPFFGWLLRQQGAER

Specific function: Part of the binding-protein-dependent transport system for hemin; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790740, Length=304, Percent_Identity=41.7763157894737, Blast_Score=169, Evalue=2e-43,
Organism=Escherichia coli, GI1790741, Length=336, Percent_Identity=35.7142857142857, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1788004, Length=284, Percent_Identity=38.7323943661972, Blast_Score=128, Evalue=6e-31,
Organism=Escherichia coli, GI1786805, Length=304, Percent_Identity=37.828947368421, Blast_Score=124, Evalue=7e-30,
Organism=Escherichia coli, GI1786804, Length=305, Percent_Identity=36.0655737704918, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI1786347, Length=288, Percent_Identity=34.375, Blast_Score=104, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 35945; Mature: 35945

Theoretical pI: Translated: 11.28; Mature: 11.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLANQGRLSSGVDSETRWGQARRILSPVGLAVLLLSVILLLLWISIALGSVPMTFAELWQ
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
ALWGQGDPVRQTIVWQLRLPRALLAQLLGAALGMAGALLQGMLGNGLADPYLLGISAGAG
HHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCH
LAAVGLLTWGEWTAWVPLAAWVGGVLTTVLVYGLARTRSGLAVERLILAGVAVSALFGAI
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
SSTLLLMADERVQVALTWLIGSLSGRGWPEVRVAGVYILVGLGLGWAQARALNLLGLGEE
HHHHHHEECCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCHH
MAVSLGIPLARTRVAIGLVAALLAAAAVSVGGLIGFVGLVVPHMVRQGVGSDHRWLLPLS
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHH
ALGGAALLSGADLLTRLGAVELPVGIVTALMGAPFFGWLLRQQGAER
HCCHHHHHHHHHHHHHHCCHHCCHHHHHHHHCCHHHHHHHHHCCCCC
>Mature Secondary Structure
MLANQGRLSSGVDSETRWGQARRILSPVGLAVLLLSVILLLLWISIALGSVPMTFAELWQ
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
ALWGQGDPVRQTIVWQLRLPRALLAQLLGAALGMAGALLQGMLGNGLADPYLLGISAGAG
HHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCH
LAAVGLLTWGEWTAWVPLAAWVGGVLTTVLVYGLARTRSGLAVERLILAGVAVSALFGAI
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
SSTLLLMADERVQVALTWLIGSLSGRGWPEVRVAGVYILVGLGLGWAQARALNLLGLGEE
HHHHHHEECCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCHH
MAVSLGIPLARTRVAIGLVAALLAAAAVSVGGLIGFVGLVVPHMVRQGVGSDHRWLLPLS
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHH
ALGGAALLSGADLLTRLGAVELPVGIVTALMGAPFFGWLLRQQGAER
HCCHHHHHHHHHHHHHHCCHHCCHHHHHHHHCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron dicitrate [Periplasm]; H2O [C]

Specific reaction: ATP + iron dicitrate [Periplasm] + H2O = ADP + phosphate + iron dicitrate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9026634; 11586360; 12142430 [H]