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The map label for this gene is apt

Identifier: 86606660

GI number: 86606660

Start: 2034498

End: 2035025

Strand: Reverse

Name: apt

Synonym: CYA_2018

Alternate gene names: 86606660

Gene position: 2035025-2034498 (Counterclockwise)

Preceding gene: 86606662

Following gene: 86606656

Centisome position: 69.39

GC content: 60.8

Gene sequence:

>528_bases
ATGGATTTGCGCGCCTTCATCCGCTTGGTGCCCGATTTTCCCAAACCCGGGATCCTCTTTCGCGACATAACCCCCCTGCT
GCGGGATCCAGCAGGCTTTCGGGCGGCAATTGAACAGTTGGCTGCCGGTACTGCCACTATGGGATCCCTGGACTATGTGG
TGGGCATTGAGTCGCGGGGGTTTATTCTGGGGGCTGCTTTGGCTCAGCATTTGGGGTTGGGATTTGTCCCGGTTCGCAAA
CCCGGCAAGTTGCCACCGCCGGTGCTTAGCCAAAGCTATAGTCTAGAGTACGGCCAAGACCAGCTGCAACTCCATGCCCA
CGCCCTGCGCCCCGGCGACCGGGTGGTGATCGTGGATGATGTCATCGCCACCGGGGGCACTGCTGCCGCCACCGCTCAGT
TGGTGGCCCAGAGCGGCGCTGAGGTGGGAGGGTTTGCCTTTCTAATTGAGCTGGCTTTCTTGTCGGGCCGCAAGCTCCTG
CCCCCTGAGATCCCCACCCATGTGGTGATGGTGGACGAATCCAACTAG

Upstream 100 bases:

>100_bases
GCTGCCGAACGGACAAAAAGGCATTCCATCTGCCCTTAAGCTAAGTGGGTATGATGGGTTGCGTTCTTTCGGCAAGCCAC
TGGCCAGCGAGGAAAACAGG

Downstream 100 bases:

>100_bases
GGGATCCACACCTCACCGCAGGCGCAGCGGCTGGCGGACGGCCACCTCTGTTGCTTTGGCTTTGGGCAGGGGTTGGGTCA
AGTGGCTGAGCTGAGCCTGG

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 175; Mature: 175

Protein sequence:

>175_residues
MDLRAFIRLVPDFPKPGILFRDITPLLRDPAGFRAAIEQLAAGTATMGSLDYVVGIESRGFILGAALAQHLGLGFVPVRK
PGKLPPPVLSQSYSLEYGQDQLQLHAHALRPGDRVVIVDDVIATGGTAAATAQLVAQSGAEVGGFAFLIELAFLSGRKLL
PPEIPTHVVMVDESN

Sequences:

>Translated_175_residues
MDLRAFIRLVPDFPKPGILFRDITPLLRDPAGFRAAIEQLAAGTATMGSLDYVVGIESRGFILGAALAQHLGLGFVPVRK
PGKLPPPVLSQSYSLEYGQDQLQLHAHALRPGDRVVIVDDVIATGGTAAATAQLVAQSGAEVGGFAFLIELAFLSGRKLL
PPEIPTHVVMVDESN
>Mature_175_residues
MDLRAFIRLVPDFPKPGILFRDITPLLRDPAGFRAAIEQLAAGTATMGSLDYVVGIESRGFILGAALAQHLGLGFVPVRK
PGKLPPPVLSQSYSLEYGQDQLQLHAHALRPGDRVVIVDDVIATGGTAAATAQLVAQSGAEVGGFAFLIELAFLSGRKLL
PPEIPTHVVMVDESN

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=158, Percent_Identity=53.7974683544304, Blast_Score=164, Evalue=5e-41,
Organism=Homo sapiens, GI71773201, Length=121, Percent_Identity=57.8512396694215, Blast_Score=140, Evalue=5e-34,
Organism=Escherichia coli, GI1786675, Length=169, Percent_Identity=48.5207100591716, Blast_Score=161, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17509087, Length=177, Percent_Identity=42.3728813559322, Blast_Score=132, Evalue=7e-32,
Organism=Saccharomyces cerevisiae, GI6323619, Length=162, Percent_Identity=43.8271604938272, Blast_Score=123, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6320649, Length=162, Percent_Identity=33.3333333333333, Blast_Score=82, Evalue=6e-17,
Organism=Drosophila melanogaster, GI17136334, Length=157, Percent_Identity=40.7643312101911, Blast_Score=116, Evalue=9e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_SYNJA (Q2JT47)

Other databases:

- EMBL:   CP000239
- RefSeq:   YP_475423.1
- HSSP:   P07741
- ProteinModelPortal:   Q2JT47
- SMR:   Q2JT47
- STRING:   Q2JT47
- GeneID:   3899521
- GenomeReviews:   CP000239_GR
- KEGG:   cya:CYA_2018
- TIGR:   CYA_2018
- eggNOG:   COG0503
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- ProtClustDB:   PRK02304
- BioCyc:   SSP321327:CYA_2018-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 18548; Mature: 18548

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLRAFIRLVPDFPKPGILFRDITPLLRDPAGFRAAIEQLAAGTATMGSLDYVVGIESRG
CCHHHHHHHCCCCCCCCEEHHCCCHHHCCCCHHHHHHHHHHCCCCCCCCCEEEEEECCCC
FILGAALAQHLGLGFVPVRKPGKLPPPVLSQSYSLEYGQDQLQLHAHALRPGDRVVIVDD
EEHHHHHHHHHCCCCEECCCCCCCCCHHHCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEC
VIATGGTAAATAQLVAQSGAEVGGFAFLIELAFLSGRKLLPPEIPTHVVMVDESN
EECCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCC
>Mature Secondary Structure
MDLRAFIRLVPDFPKPGILFRDITPLLRDPAGFRAAIEQLAAGTATMGSLDYVVGIESRG
CCHHHHHHHCCCCCCCCEEHHCCCHHHCCCCHHHHHHHHHHCCCCCCCCCEEEEEECCCC
FILGAALAQHLGLGFVPVRKPGKLPPPVLSQSYSLEYGQDQLQLHAHALRPGDRVVIVDD
EEHHHHHHHHHCCCCEECCCCCCCCCHHHCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEC
VIATGGTAAATAQLVAQSGAEVGGFAFLIELAFLSGRKLLPPEIPTHVVMVDESN
EECCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA