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The map label for this gene is purK

Identifier: 86606424

GI number: 86606424

Start: 1777438

End: 1778568

Strand: Reverse

Name: purK

Synonym: CYA_1770

Alternate gene names: 86606424

Gene position: 1778568-1777438 (Counterclockwise)

Preceding gene: 86606438

Following gene: 86606423

Centisome position: 60.64

GC content: 63.22

Gene sequence:

>1131_bases
GTGGGGGTGATCGGCGGTGGGCAGTTGGCGCAGATGTTGGCTTTGGCGGCTCGCCCATTGGGGATCCCGCTGATTGTTCA
GGCTGCCGCTCCTACCGATCCGGCGGTGGCCGTGGCCGACGGCGTGGTCTGGGGTGCCGTGACCGACACCCAGGCCACAG
CCCAGTTGCTGCAACGCTGCCCGGTGGTAACTTTTGAGAACGAGTTCATCCCGCTGGCGGAGCTGCAAAAACTGGATCCG
CAGGGATCCCGCTTTCGTCCTCGCCTGAGCACGCTAGAGCCGCTGCTGGACAAGTTGCACCAACGGCAGTTTCTGGCAGA
GCTGGGGTTGCCGGTGCCGGCTTTTTGGCCGGCAGAGACGGCAGATCTATCTAGCCTGAGCTTTCCCTTGGTGCTCAAGC
GGCGGCGGCAGGGCTACGATGGGCAGGGCACCCGCATCCTGCCCGACCCAGCAACCTTGCAACAGGCTCTGGCTGAGTAT
GCCGGGATCCCGCTGCTGGTTGAAGAGTGGATCCCGTTTGAGCGGGAGCTGGCGGTGATGGTGGCGCGAGGGCTGACGGG
AGAAATCCAGATCTACCCCGTGGTGGAGACGGTTCAAGTTAACCAAGTCTGTCGCCACGTCTTGGTGCCCGCCCGCATCC
CTTCCTCTGTTGAGGCCGAGATCCGGGATTTGGCGGTCAAGGTGATGGAAAAATTGGATGCGGTGGGCGTGTTTGCCATC
GAGCTGTTCTGGGTGCCGCCGCCCCACCCCAAGGCCGGGATCTGGATCAACGAAATCTCGCCGCGGGTCCACAATTCCGG
CCACTACACCCTGGAAGCCTGCCACACCTCACAATTCGAGCAACACCTGCGGGCCATCCTCGGCCTGCCCTTGGGGGATC
CCTCCCTCAAGTGTGGGGGGGCAGTGATGGTGAACCTCTTGGGCTATGAGCACTCCACCAGCGACTATGCCGAGAAGCGG
CAGCGCCTGGCCCAGCTCCCCAATGCCACGGTGCATTGGTACCACAAAACCCCCGCCCGCCCAGGGCGAAAACTGGGCCA
TGTAACCGTCTGTCTGCCGACTGCTCCCTCTCCTTTCGAAGCAGCAGCCCTTGTTCGCACCCTCGAATCCCTCTGGTACC
CCCAGCCATGA

Upstream 100 bases:

>100_bases
GATCCCATAATGGGTTTTGGATCCAAGCAGGCACACCCGTCAGTATAGCGAGACAGTGGTGGAACCCCAGGTATCCCCAA
AAAACCAGAGCTTCCAACCG

Downstream 100 bases:

>100_bases
GCCAAGCGCAGGATCCCTCCTTCTCCCCAGACATTCAAGCCCTGATCCAGGCGATGCAACGGCGGGATGTGCCCGCGGTA
GCTCAGCAGGTCAACGGCCT

Product: phosphoribosylaminoimidazole carboxylase ATPase subunit

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 376; Mature: 375

Protein sequence:

>376_residues
MGVIGGGQLAQMLALAARPLGIPLIVQAAAPTDPAVAVADGVVWGAVTDTQATAQLLQRCPVVTFENEFIPLAELQKLDP
QGSRFRPRLSTLEPLLDKLHQRQFLAELGLPVPAFWPAETADLSSLSFPLVLKRRRQGYDGQGTRILPDPATLQQALAEY
AGIPLLVEEWIPFERELAVMVARGLTGEIQIYPVVETVQVNQVCRHVLVPARIPSSVEAEIRDLAVKVMEKLDAVGVFAI
ELFWVPPPHPKAGIWINEISPRVHNSGHYTLEACHTSQFEQHLRAILGLPLGDPSLKCGGAVMVNLLGYEHSTSDYAEKR
QRLAQLPNATVHWYHKTPARPGRKLGHVTVCLPTAPSPFEAAALVRTLESLWYPQP

Sequences:

>Translated_376_residues
MGVIGGGQLAQMLALAARPLGIPLIVQAAAPTDPAVAVADGVVWGAVTDTQATAQLLQRCPVVTFENEFIPLAELQKLDP
QGSRFRPRLSTLEPLLDKLHQRQFLAELGLPVPAFWPAETADLSSLSFPLVLKRRRQGYDGQGTRILPDPATLQQALAEY
AGIPLLVEEWIPFERELAVMVARGLTGEIQIYPVVETVQVNQVCRHVLVPARIPSSVEAEIRDLAVKVMEKLDAVGVFAI
ELFWVPPPHPKAGIWINEISPRVHNSGHYTLEACHTSQFEQHLRAILGLPLGDPSLKCGGAVMVNLLGYEHSTSDYAEKR
QRLAQLPNATVHWYHKTPARPGRKLGHVTVCLPTAPSPFEAAALVRTLESLWYPQP
>Mature_375_residues
GVIGGGQLAQMLALAARPLGIPLIVQAAAPTDPAVAVADGVVWGAVTDTQATAQLLQRCPVVTFENEFIPLAELQKLDPQ
GSRFRPRLSTLEPLLDKLHQRQFLAELGLPVPAFWPAETADLSSLSFPLVLKRRRQGYDGQGTRILPDPATLQQALAEYA
GIPLLVEEWIPFERELAVMVARGLTGEIQIYPVVETVQVNQVCRHVLVPARIPSSVEAEIRDLAVKVMEKLDAVGVFAIE
LFWVPPPHPKAGIWINEISPRVHNSGHYTLEACHTSQFEQHLRAILGLPLGDPSLKCGGAVMVNLLGYEHSTSDYAEKRQ
RLAQLPNATVHWYHKTPARPGRKLGHVTVCLPTAPSPFEAAALVRTLESLWYPQP

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=377, Percent_Identity=32.8912466843501, Blast_Score=145, Evalue=5e-36,
Organism=Escherichia coli, GI1788155, Length=375, Percent_Identity=24.2666666666667, Blast_Score=64, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324702, Length=365, Percent_Identity=34.5205479452055, Blast_Score=223, Evalue=4e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02222 ATP-grasp [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 41207; Mature: 41076

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVIGGGQLAQMLALAARPLGIPLIVQAAAPTDPAVAVADGVVWGAVTDTQATAQLLQRC
CCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHCCCEEEECCCCHHHHHHHHHHC
PVVTFENEFIPLAELQKLDPQGSRFRPRLSTLEPLLDKLHQRQFLAELGLPVPAFWPAET
CEEEECCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
ADLSSLSFPLVLKRRRQGYDGQGTRILPDPATLQQALAEYAGIPLLVEEWIPFERELAVM
CCCCCCCHHHHHHHHHCCCCCCCCEECCCHHHHHHHHHHHCCCCEEHHHCCCHHHHHHHH
VARGLTGEIQIYPVVETVQVNQVCRHVLVPARIPSSVEAEIRDLAVKVMEKLDAVGVFAI
HHCCCCCCEEEEEEHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCEEEEE
ELFWVPPPHPKAGIWINEISPRVHNSGHYTLEACHTSQFEQHLRAILGLPLGDPSLKCGG
EEEECCCCCCCCCEEEECCCCCEECCCCEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCH
AVMVNLLGYEHSTSDYAEKRQRLAQLPNATVHWYHKTPARPGRKLGHVTVCLPTAPSPFE
HHEEHHHCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCEEEEEECCCCCCHH
AAALVRTLESLWYPQP
HHHHHHHHHHHCCCCC
>Mature Secondary Structure 
GVIGGGQLAQMLALAARPLGIPLIVQAAAPTDPAVAVADGVVWGAVTDTQATAQLLQRC
CCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHCCCEEEECCCCHHHHHHHHHHC
PVVTFENEFIPLAELQKLDPQGSRFRPRLSTLEPLLDKLHQRQFLAELGLPVPAFWPAET
CEEEECCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
ADLSSLSFPLVLKRRRQGYDGQGTRILPDPATLQQALAEYAGIPLLVEEWIPFERELAVM
CCCCCCCHHHHHHHHHCCCCCCCCEECCCHHHHHHHHHHHCCCCEEHHHCCCHHHHHHHH
VARGLTGEIQIYPVVETVQVNQVCRHVLVPARIPSSVEAEIRDLAVKVMEKLDAVGVFAI
HHCCCCCCEEEEEEHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCEEEEE
ELFWVPPPHPKAGIWINEISPRVHNSGHYTLEACHTSQFEQHLRAILGLPLGDPSLKCGG
EEEECCCCCCCCCEEEECCCCCEECCCCEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCH
AVMVNLLGYEHSTSDYAEKRQRLAQLPNATVHWYHKTPARPGRKLGHVTVCLPTAPSPFE
HHEEHHHCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCEEEEEECCCCCCHH
AAALVRTLESLWYPQP
HHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA