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The map label for this gene is fmt

Identifier: 86606347

GI number: 86606347

Start: 1690555

End: 1691523

Strand: Reverse

Name: fmt

Synonym: CYA_1691

Alternate gene names: 86606347

Gene position: 1691523-1690555 (Counterclockwise)

Preceding gene: 86606348

Following gene: 86606343

Centisome position: 57.68

GC content: 65.43

Gene sequence:

>969_bases
ATGCGGGTTGTTTTCTTTGGCACGCCGGAGTTTGCTCTGCCCTCACTGCAGATCTTGTTGCAGCCGCAGTCTCCCTTTGA
AGTGGTGGGATTGGTCTGCCAGCCGGATCGGCCGCAGGGGCGAGGACAGAAGGTGCTCCCCCCGCCCACCAAGATCCTCG
CCCAAGCCCACGGGATCCCGGTGTGGCAGCCTGGCCGGCTGCGGCGGGATCCAGAGGTGCTGGCGGCGCTAGAGGCGCTG
GCTGCCGATGTGTTTGTGGTGGTGGCCTACGGCCAGATCTTGCCGCCGGCGGTGCTGCAGATGCCCAAGCTGGGCTGCAT
CAATGTCCACGCTTCCCTCCTGCCGGCCTATCGCGGCGCCGCCCCCATCCAGTGGGCCATTGCCAACGGCGAGACCGAGA
CCGGCGTCACCACCATGCTCATGGACGAAGGCATGGATACGGGGGCCATCTTGCTGCAGGCCAAGCTGCCCATCGAGCCG
GAGCAGACCGGCTTGGAGCTGGCCTCCCAACTGGCCCAACGGGGGGCAGAGCTGCTGGTGGAAACCCTGGTGAAACTGGA
AAAAGGAGAGCTGACCCCCATTCCCCAGGATGACTCGCGGGCAACCTATGCCCCCCTGCTTAAAAAACAGGACTTCCAGC
TCGACTGGCAGCGCCCGGCCCAGGCCTTGCACAACCAAATCCGCGCCTTTTCCCCGGACTGTTTTACCGGCTTGCAGGGG
CAGCGGATTAAGATTGTCCGCTCCGCCGCTCCCCAGTTGCACCCGCCACCTGCCGAGCTTCCCCCGGGCAGCCCCGGAGA
AGTGGTGGGACTGGCCAGGGGAGAAGGGGTGTATGTGGCCACAGGGGAGGGATCCCTCCTCATCCGGCGGGCCCAACTGC
CCGGCAGGAAGGAACAGTCGGCCTGTGATCTGGTCAACGGCGGCCAACTCAGGGTGGGCATGCGCTTTGAGGTGCTGCCG
GATCCCTAG

Upstream 100 bases:

>100_bases
TTCTCCCTTTCCTTCTCCAGCAGCCGACGCCGCCGAGGGCGAGCCCTCTCCACCTTCCCCGGCCGCTCTAGACTAAAGGG
CAGGGCTCAGGGGGTCGGCC

Downstream 100 bases:

>100_bases
CCCCGGCCCCCCTCTTGTCCCCCCGCCTGCGGGGGGATGTAGGGGGGCGGGGGTGGTCGCGTTAGCGGCGCGGAGCGCTT
GGAACTACTCGGGCTGGGGA

Product: methionyl-tRNA formyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 322; Mature: 322

Protein sequence:

>322_residues
MRVVFFGTPEFALPSLQILLQPQSPFEVVGLVCQPDRPQGRGQKVLPPPTKILAQAHGIPVWQPGRLRRDPEVLAALEAL
AADVFVVVAYGQILPPAVLQMPKLGCINVHASLLPAYRGAAPIQWAIANGETETGVTTMLMDEGMDTGAILLQAKLPIEP
EQTGLELASQLAQRGAELLVETLVKLEKGELTPIPQDDSRATYAPLLKKQDFQLDWQRPAQALHNQIRAFSPDCFTGLQG
QRIKIVRSAAPQLHPPPAELPPGSPGEVVGLARGEGVYVATGEGSLLIRRAQLPGRKEQSACDLVNGGQLRVGMRFEVLP
DP

Sequences:

>Translated_322_residues
MRVVFFGTPEFALPSLQILLQPQSPFEVVGLVCQPDRPQGRGQKVLPPPTKILAQAHGIPVWQPGRLRRDPEVLAALEAL
AADVFVVVAYGQILPPAVLQMPKLGCINVHASLLPAYRGAAPIQWAIANGETETGVTTMLMDEGMDTGAILLQAKLPIEP
EQTGLELASQLAQRGAELLVETLVKLEKGELTPIPQDDSRATYAPLLKKQDFQLDWQRPAQALHNQIRAFSPDCFTGLQG
QRIKIVRSAAPQLHPPPAELPPGSPGEVVGLARGEGVYVATGEGSLLIRRAQLPGRKEQSACDLVNGGQLRVGMRFEVLP
DP
>Mature_322_residues
MRVVFFGTPEFALPSLQILLQPQSPFEVVGLVCQPDRPQGRGQKVLPPPTKILAQAHGIPVWQPGRLRRDPEVLAALEAL
AADVFVVVAYGQILPPAVLQMPKLGCINVHASLLPAYRGAAPIQWAIANGETETGVTTMLMDEGMDTGAILLQAKLPIEP
EQTGLELASQLAQRGAELLVETLVKLEKGELTPIPQDDSRATYAPLLKKQDFQLDWQRPAQALHNQIRAFSPDCFTGLQG
QRIKIVRSAAPQLHPPPAELPPGSPGEVVGLARGEGVYVATGEGSLLIRRAQLPGRKEQSACDLVNGGQLRVGMRFEVLP
DP

Specific function: Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-

COG id: COG0223

COG function: function code J; Methionyl-tRNA formyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fmt family

Homologues:

Organism=Homo sapiens, GI21614513, Length=293, Percent_Identity=30.0341296928328, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI238814322, Length=298, Percent_Identity=29.5302013422819, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI164663775, Length=318, Percent_Identity=27.0440251572327, Blast_Score=86, Evalue=5e-17,
Organism=Escherichia coli, GI1789683, Length=310, Percent_Identity=44.5161290322581, Blast_Score=232, Evalue=2e-62,
Organism=Escherichia coli, GI1788589, Length=295, Percent_Identity=31.1864406779661, Blast_Score=142, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI133930964, Length=263, Percent_Identity=28.1368821292776, Blast_Score=97, Evalue=8e-21,
Organism=Saccharomyces cerevisiae, GI6319458, Length=282, Percent_Identity=27.3049645390071, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45550868, Length=311, Percent_Identity=30.8681672025724, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI28571984, Length=230, Percent_Identity=33.4782608695652, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24585660, Length=234, Percent_Identity=29.4871794871795, Blast_Score=92, Evalue=5e-19,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): FMT_SYNJA (Q2JTY2)

Other databases:

- EMBL:   CP000239
- RefSeq:   YP_475110.1
- STRING:   Q2JTY2
- GeneID:   3897535
- GenomeReviews:   CP000239_GR
- KEGG:   cya:CYA_1691
- TIGR:   CYA_1691
- eggNOG:   COG0223
- HOGENOM:   HBG571560
- OMA:   IMQMDEG
- ProtClustDB:   PRK00005
- BioCyc:   SSP321327:CYA_1691-MONOMER
- HAMAP:   MF_00182
- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR001555
- InterPro:   IPR015518
- Gene3D:   G3DSA:3.10.25.10
- Gene3D:   G3DSA:3.40.50.170
- PANTHER:   PTHR11138
- TIGRFAMs:   TIGR00460

Pfam domain/function: PF02911 Formyl_trans_C; PF00551 Formyl_trans_N; SSF50486 FMT_C_like; SSF53328 formyl_transf

EC number: =2.1.2.9

Molecular weight: Translated: 34734; Mature: 34734

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS00373 GART

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVVFFGTPEFALPSLQILLQPQSPFEVVGLVCQPDRPQGRGQKVLPPPTKILAQAHGIP
CEEEEECCCCCCCCCEEEEECCCCCHHHEEEEECCCCCCCCCCCCCCCHHHHHHHHCCCC
VWQPGRLRRDPEVLAALEALAADVFVVVAYGQILPPAVLQMPKLGCINVHASLLPAYRGA
CCCCCCCCCCHHHHHHHHHHHHHHHHEEHHCCCCCHHHHHCCCCCEEEHHHHHHHHHCCC
APIQWAIANGETETGVTTMLMDEGMDTGAILLQAKLPIEPEQTGLELASQLAQRGAELLV
CCEEEEEECCCCCCCEEEEEECCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHH
ETLVKLEKGELTPIPQDDSRATYAPLLKKQDFQLDWQRPAQALHNQIRAFSPDCFTGLQG
HHHHHHCCCCCCCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHCCCCC
QRIKIVRSAAPQLHPPPAELPPGSPGEVVGLARGEGVYVATGEGSLLIRRAQLPGRKEQS
CEEEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCEEEEEECCCCEEEEECCCCCCCCCC
ACDLVNGGQLRVGMRFEVLPDP
HHCCCCCCEEEEEEEEEECCCC
>Mature Secondary Structure
MRVVFFGTPEFALPSLQILLQPQSPFEVVGLVCQPDRPQGRGQKVLPPPTKILAQAHGIP
CEEEEECCCCCCCCCEEEEECCCCCHHHEEEEECCCCCCCCCCCCCCCHHHHHHHHCCCC
VWQPGRLRRDPEVLAALEALAADVFVVVAYGQILPPAVLQMPKLGCINVHASLLPAYRGA
CCCCCCCCCCHHHHHHHHHHHHHHHHEEHHCCCCCHHHHHCCCCCEEEHHHHHHHHHCCC
APIQWAIANGETETGVTTMLMDEGMDTGAILLQAKLPIEPEQTGLELASQLAQRGAELLV
CCEEEEEECCCCCCCEEEEEECCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHH
ETLVKLEKGELTPIPQDDSRATYAPLLKKQDFQLDWQRPAQALHNQIRAFSPDCFTGLQG
HHHHHHCCCCCCCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHCCCCC
QRIKIVRSAAPQLHPPPAELPPGSPGEVVGLARGEGVYVATGEGSLLIRRAQLPGRKEQS
CEEEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCEEEEEECCCCEEEEECCCCCCCCCC
ACDLVNGGQLRVGMRFEVLPDP
HHCCCCCCEEEEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA