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The map label for this gene is guaA

Identifier: 86606329

GI number: 86606329

Start: 1673291

End: 1674907

Strand: Reverse

Name: guaA

Synonym: CYA_1673

Alternate gene names: 86606329

Gene position: 1674907-1673291 (Counterclockwise)

Preceding gene: 86606332

Following gene: 86606328

Centisome position: 57.11

GC content: 60.67

Gene sequence:

>1617_bases
GTGAACTCTTCTACCTCTCCCCTCCCTCCCGGCCTTTTTCCTTCCTCCCTCAAGGTGCAGCGCCAGATGATTGTTATTCT
CGATTTTGGATCCCAGTACTCTGAGCTCATTGCCCGGCGTATTCGCGAAACCCACGTCTATTCGGAAATCCTTTCCTACC
GCACCACTGCCGAGCAACTGCGGCAACTGCGGCCCCAGGGCATCATCCTCTCCGGCGGCCCCAACTCGGTCTATGAGCCG
GGCGCTCCCGCTTGTGACCTGGAGATCTGGAACTTGGGGATCCCCATCCTGGGCGTGTGCTACGGTATGCAGCTTATGGT
GCAGCAGTTGGGGGGCAAGGTGGAGCCGGCCCAGAAGGGGGAATACGGCCGTGCCGCCCTGCACATTTTGGATCCCACCG
ATCTGCTCACCAACCTGCCAGAAAGCAGCATCATGTGGATGAGCCACGGAGACTCGGTGACCGAGTTGCCCCCGGGCTTT
CATTCGCTGGCTTACACTGACAACACCCCCTTTGCCGCCATTGCCGATCCGGCGCGCCGTCTCTACGGGGTGCAATTTCA
CCCAGAGGTGGCCCACTCGGAGGCCGGTACCTTTCTCATTCGCAATTTTGTCTATCACATCTGCGGCTGCGAGCCCACCT
GGACAACGGAAGCTTTTCTGGAGGAGGCCATTCGGGAAGTCCGTGCCCGCGTGGGCGACAAGAGGGTGCTGTTGGCCCTT
TCGGGGGGGGTGGACAGCTCTACTTTGGCTTTTCTGCTACACAAGGCCATTGGGGATCAGCTCACCTGCGTGTTCATCGA
CCAGGGGTTCATGCGCAAAGATGAGCCGCAGCGGCTGCTGCGCCTTTTCCAAGAGCAATTTCACATCCCTGTCCACTACG
TGGACGGACAAGAGCGCTTTCTCCGCCAGTTGCAGGGGGTCACCGATCCCGAGGAGAAGCGCAAACGCATCGGGGCAGAG
TTTATTCGCGTGTTTGAGGAGGAGTCGCAGCGGCTGGGCCCCTTCGAGTACCTGGCCCAGGGCACCCTTTACCCCGATGT
GATCGAGTCGGCCAACACCAATGTGGATCCGGTTACCGGAGAGCGCATTGCCGTCAAGATCAAAAGCCACCACAACGTCG
GCGGCTTGCCGGAGAATCTGCGCTTTAAGCTGGTAGAACCTCTGCGCAAGCTCTTCAAAGATGAGGTACGGCAACTGGCC
CGTTCGTTGGGCTTGCCGGAAGAAATTGTTGGCCGCCATCCTTTCCCGGGGCCGGGCCTGGCCATCCGCATTGTGGGCGA
GGTCACCAAAGAGCGGCTGGAGATCCTGCGCGAGGCCGACATGATTGTCCGCCAGGAGATCAACCGCTCCGGCTACTATC
CCAAGCTGTGGCAAGCCTTTGCCGTGTTGCTGCCGGAAGTGCGCTCGGTGGGGGTGATGGGGGATAAGCGCACCTATGCC
TGCCCGGTGGTGGTGCGACTGGTCACCAGCGAAGACGGCATGACGGCGGACTGGGCTAGGGTGCCCTACGACCTCTTGGC
CACCATCTCCAACCGCATCGTCAACGAGGTGCCGGGCGTCAACCGCGTAGTCTACGACATCACCTCCAAGCCCCCCGGCA
CCATCGAGTGGGAGTGA

Upstream 100 bases:

>100_bases
GCCTCCATCCCTGTTACGATGGAAGAGCCCTTAATGTTTCTTATCCACAGCCGAGTTAGTCGCTAGGCCCGGCTTTCTCA
TTCTGCACTTGCGAGGTTTT

Downstream 100 bases:

>100_bases
TGCTGGTCGGGCGGGATCCCTTGCCTCTGGCCTCAAGGCCGGACTGGAGCGATTACCTATGGCCTGCTTCCGGCAGGGAA
TAGGAAGGGCTTGAGCTGAA

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 538; Mature: 538

Protein sequence:

>538_residues
MNSSTSPLPPGLFPSSLKVQRQMIVILDFGSQYSELIARRIRETHVYSEILSYRTTAEQLRQLRPQGIILSGGPNSVYEP
GAPACDLEIWNLGIPILGVCYGMQLMVQQLGGKVEPAQKGEYGRAALHILDPTDLLTNLPESSIMWMSHGDSVTELPPGF
HSLAYTDNTPFAAIADPARRLYGVQFHPEVAHSEAGTFLIRNFVYHICGCEPTWTTEAFLEEAIREVRARVGDKRVLLAL
SGGVDSSTLAFLLHKAIGDQLTCVFIDQGFMRKDEPQRLLRLFQEQFHIPVHYVDGQERFLRQLQGVTDPEEKRKRIGAE
FIRVFEEESQRLGPFEYLAQGTLYPDVIESANTNVDPVTGERIAVKIKSHHNVGGLPENLRFKLVEPLRKLFKDEVRQLA
RSLGLPEEIVGRHPFPGPGLAIRIVGEVTKERLEILREADMIVRQEINRSGYYPKLWQAFAVLLPEVRSVGVMGDKRTYA
CPVVVRLVTSEDGMTADWARVPYDLLATISNRIVNEVPGVNRVVYDITSKPPGTIEWE

Sequences:

>Translated_538_residues
MNSSTSPLPPGLFPSSLKVQRQMIVILDFGSQYSELIARRIRETHVYSEILSYRTTAEQLRQLRPQGIILSGGPNSVYEP
GAPACDLEIWNLGIPILGVCYGMQLMVQQLGGKVEPAQKGEYGRAALHILDPTDLLTNLPESSIMWMSHGDSVTELPPGF
HSLAYTDNTPFAAIADPARRLYGVQFHPEVAHSEAGTFLIRNFVYHICGCEPTWTTEAFLEEAIREVRARVGDKRVLLAL
SGGVDSSTLAFLLHKAIGDQLTCVFIDQGFMRKDEPQRLLRLFQEQFHIPVHYVDGQERFLRQLQGVTDPEEKRKRIGAE
FIRVFEEESQRLGPFEYLAQGTLYPDVIESANTNVDPVTGERIAVKIKSHHNVGGLPENLRFKLVEPLRKLFKDEVRQLA
RSLGLPEEIVGRHPFPGPGLAIRIVGEVTKERLEILREADMIVRQEINRSGYYPKLWQAFAVLLPEVRSVGVMGDKRTYA
CPVVVRLVTSEDGMTADWARVPYDLLATISNRIVNEVPGVNRVVYDITSKPPGTIEWE
>Mature_538_residues
MNSSTSPLPPGLFPSSLKVQRQMIVILDFGSQYSELIARRIRETHVYSEILSYRTTAEQLRQLRPQGIILSGGPNSVYEP
GAPACDLEIWNLGIPILGVCYGMQLMVQQLGGKVEPAQKGEYGRAALHILDPTDLLTNLPESSIMWMSHGDSVTELPPGF
HSLAYTDNTPFAAIADPARRLYGVQFHPEVAHSEAGTFLIRNFVYHICGCEPTWTTEAFLEEAIREVRARVGDKRVLLAL
SGGVDSSTLAFLLHKAIGDQLTCVFIDQGFMRKDEPQRLLRLFQEQFHIPVHYVDGQERFLRQLQGVTDPEEKRKRIGAE
FIRVFEEESQRLGPFEYLAQGTLYPDVIESANTNVDPVTGERIAVKIKSHHNVGGLPENLRFKLVEPLRKLFKDEVRQLA
RSLGLPEEIVGRHPFPGPGLAIRIVGEVTKERLEILREADMIVRQEINRSGYYPKLWQAFAVLLPEVRSVGVMGDKRTYA
CPVVVRLVTSEDGMTADWARVPYDLLATISNRIVNEVPGVNRVVYDITSKPPGTIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=553, Percent_Identity=37.6130198915009, Blast_Score=317, Evalue=2e-86,
Organism=Escherichia coli, GI1788854, Length=529, Percent_Identity=49.3383742911153, Blast_Score=538, Evalue=1e-154,
Organism=Escherichia coli, GI1789760, Length=188, Percent_Identity=29.7872340425532, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI133901714, Length=573, Percent_Identity=37.696335078534, Blast_Score=317, Evalue=1e-86,
Organism=Caenorhabditis elegans, GI71992710, Length=575, Percent_Identity=37.5652173913043, Blast_Score=317, Evalue=1e-86,
Organism=Caenorhabditis elegans, GI71992717, Length=575, Percent_Identity=37.5652173913043, Blast_Score=317, Evalue=1e-86,
Organism=Saccharomyces cerevisiae, GI6323873, Length=521, Percent_Identity=48.1765834932822, Blast_Score=500, Evalue=1e-142,
Organism=Drosophila melanogaster, GI281365319, Length=555, Percent_Identity=38.1981981981982, Blast_Score=301, Evalue=6e-82,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR001962
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00733 Asn_synthase; PF00117 GATase; PF00958 GMP_synt_C [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 60432; Mature: 60432

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSSTSPLPPGLFPSSLKVQRQMIVILDFGSQYSELIARRIRETHVYSEILSYRTTAEQL
CCCCCCCCCCCCCCCHHHCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RQLRPQGIILSGGPNSVYEPGAPACDLEIWNLGIPILGVCYGMQLMVQQLGGKVEPAQKG
HHCCCCCEEEECCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCC
EYGRAALHILDPTDLLTNLPESSIMWMSHGDSVTELPPGFHSLAYTDNTPFAAIADPARR
CCCCEEEEEECHHHHHHCCCCCCEEEEECCCCCCCCCCCCHHEEECCCCCCCHHCCHHHH
LYGVQFHPEVAHSEAGTFLIRNFVYHICGCEPTWTTEAFLEEAIREVRARVGDKRVLLAL
HCCCCCCCHHHHCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEE
SGGVDSSTLAFLLHKAIGDQLTCVFIDQGFMRKDEPQRLLRLFQEQFHIPVHYVDGQERF
ECCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCEEEECCHHHH
LRQLQGVTDPEEKRKRIGAEFIRVFEEESQRLGPFEYLAQGTLYPDVIESANTNVDPVTG
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHCCCCCCCCCC
ERIAVKIKSHHNVGGLPENLRFKLVEPLRKLFKDEVRQLARSLGLPEEIVGRHPFPGPGL
CEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCE
AIRIVGEVTKERLEILREADMIVRQEINRSGYYPKLWQAFAVLLPEVRSVGVMGDKRTYA
EEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEE
CPVVVRLVTSEDGMTADWARVPYDLLATISNRIVNEVPGVNRVVYDITSKPPGTIEWE
CCEEEEEEECCCCCCCHHHHCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MNSSTSPLPPGLFPSSLKVQRQMIVILDFGSQYSELIARRIRETHVYSEILSYRTTAEQL
CCCCCCCCCCCCCCCHHHCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RQLRPQGIILSGGPNSVYEPGAPACDLEIWNLGIPILGVCYGMQLMVQQLGGKVEPAQKG
HHCCCCCEEEECCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCC
EYGRAALHILDPTDLLTNLPESSIMWMSHGDSVTELPPGFHSLAYTDNTPFAAIADPARR
CCCCEEEEEECHHHHHHCCCCCCEEEEECCCCCCCCCCCCHHEEECCCCCCCHHCCHHHH
LYGVQFHPEVAHSEAGTFLIRNFVYHICGCEPTWTTEAFLEEAIREVRARVGDKRVLLAL
HCCCCCCCHHHHCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEE
SGGVDSSTLAFLLHKAIGDQLTCVFIDQGFMRKDEPQRLLRLFQEQFHIPVHYVDGQERF
ECCCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCEEEECCHHHH
LRQLQGVTDPEEKRKRIGAEFIRVFEEESQRLGPFEYLAQGTLYPDVIESANTNVDPVTG
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHCCCCCCCCCC
ERIAVKIKSHHNVGGLPENLRFKLVEPLRKLFKDEVRQLARSLGLPEEIVGRHPFPGPGL
CEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCE
AIRIVGEVTKERLEILREADMIVRQEINRSGYYPKLWQAFAVLLPEVRSVGVMGDKRTYA
EEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEE
CPVVVRLVTSEDGMTADWARVPYDLLATISNRIVNEVPGVNRVVYDITSKPPGTIEWE
CCEEEEEEECCCCCCCHHHHCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12240834 [H]