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The map label for this gene is rnz

Identifier: 86606310

GI number: 86606310

Start: 1650995

End: 1651969

Strand: Reverse

Name: rnz

Synonym: CYA_1654

Alternate gene names: 86606310

Gene position: 1651969-1650995 (Counterclockwise)

Preceding gene: 86606312

Following gene: 86606309

Centisome position: 56.33

GC content: 65.44

Gene sequence:

>975_bases
GTGACGGATCCCAACGCCATTCGTGTTACCTTTCTGGGCACCAGCTCCGGCATGCCCACCCGCCAGCGCAATGTCTCGGG
CGTGGCGGTGCAGTTTCCGCAGCGGTCAGAATGGTGGCTGTTTGACTGTGGCGAGGGCACCCAACACCAACTGCTGCGGC
TAGACGAGCTGCGCCCCAGCCAGTTGCGCCGCATTTTCATCACCCACATGCACGGGGATCACATCTACGGCCTGCCAGGG
CTGTTGGCCTCCTGCGGCCTGGGCAGCACCCCCCAACACATCGACATCTATGGCCCCCCCGGCCTGGAAGAGTACCTGAA
GACGGTGCTGCGCTACAGCGAGAGCCGAATTCCCTATTCCTTCCGGGTTCACACCGTCGAAACAGGGCTCATTCTTCAGG
ATCCCGAGTACTGGGTCTTCTGCGCCCCCCTGGATCACCGGGTGCCTGCCTTCGGCTACCGCGTGGTGGAGCAAGACCGG
CCCGGCACCTTCGACGTGGCCAAAGCCCAGGCAGACGGGATCCCGCCCGGCCCTCTCTACGGGCAGCTCAAGGCCGGCCA
ATCCATCCTCTGGCAAGGCCGCTGGTTCCACGGGCGAGATTACGTAGGGGCTCCGATCCCAGGGCGCAAGTTCTCCTACT
GCACCGACACCATCTTCTGCCGCAACGCCGTCGATCTCTCTCGCGCCGCCGATCTGGTCATCCACGAGGCCACCTACGCC
GAAGCGGATCGGGAGCTAGCCGAGCGCGCCAAGCACTCCACCGCCGCCATGGCCGCGCGGGTGGCCGCCGAAGCCAAGGC
CCAGACCCTCATCCTCACCCACTTCAGCCCCCGCTACACCTCAGAGGGCCCTATCACTTTGGAAGACCTGCTGGCCGAAG
CCCGGGCCATTTTTCCCAACACCATCCTGGCCCGGGATCGGATGACCTACGAGATCCCGCGCCGCAGCCCCGCTCCCCTG
CCGGTGGGAGTCTAG

Upstream 100 bases:

>100_bases
TTTATCCTAACAGGGGTTTTGGGCCGCCTTTTCCCCTCGCGCGGCAGGAACAGTTGATAAGCTAGGGATCCCGTTTCCTC
AAGCCTAACGTTCTGCCCTT

Downstream 100 bases:

>100_bases
ACCTGCCTTGCTAGCTAGAATGATAGGACCGACAGCCTCAACCTGCGATGACGGATCCCAGACCCTATCCCGAACGGCCC
AAAACCGAGCAACTGGAGCA

Product: ribonuclease Z

Products: NA

Alternate protein names: RNase Z; tRNA 3 endonuclease; tRNase Z [H]

Number of amino acids: Translated: 324; Mature: 323

Protein sequence:

>324_residues
MTDPNAIRVTFLGTSSGMPTRQRNVSGVAVQFPQRSEWWLFDCGEGTQHQLLRLDELRPSQLRRIFITHMHGDHIYGLPG
LLASCGLGSTPQHIDIYGPPGLEEYLKTVLRYSESRIPYSFRVHTVETGLILQDPEYWVFCAPLDHRVPAFGYRVVEQDR
PGTFDVAKAQADGIPPGPLYGQLKAGQSILWQGRWFHGRDYVGAPIPGRKFSYCTDTIFCRNAVDLSRAADLVIHEATYA
EADRELAERAKHSTAAMAARVAAEAKAQTLILTHFSPRYTSEGPITLEDLLAEARAIFPNTILARDRMTYEIPRRSPAPL
PVGV

Sequences:

>Translated_324_residues
MTDPNAIRVTFLGTSSGMPTRQRNVSGVAVQFPQRSEWWLFDCGEGTQHQLLRLDELRPSQLRRIFITHMHGDHIYGLPG
LLASCGLGSTPQHIDIYGPPGLEEYLKTVLRYSESRIPYSFRVHTVETGLILQDPEYWVFCAPLDHRVPAFGYRVVEQDR
PGTFDVAKAQADGIPPGPLYGQLKAGQSILWQGRWFHGRDYVGAPIPGRKFSYCTDTIFCRNAVDLSRAADLVIHEATYA
EADRELAERAKHSTAAMAARVAAEAKAQTLILTHFSPRYTSEGPITLEDLLAEARAIFPNTILARDRMTYEIPRRSPAPL
PVGV
>Mature_323_residues
TDPNAIRVTFLGTSSGMPTRQRNVSGVAVQFPQRSEWWLFDCGEGTQHQLLRLDELRPSQLRRIFITHMHGDHIYGLPGL
LASCGLGSTPQHIDIYGPPGLEEYLKTVLRYSESRIPYSFRVHTVETGLILQDPEYWVFCAPLDHRVPAFGYRVVEQDRP
GTFDVAKAQADGIPPGPLYGQLKAGQSILWQGRWFHGRDYVGAPIPGRKFSYCTDTIFCRNAVDLSRAADLVIHEATYAE
ADRELAERAKHSTAAMAARVAAEAKAQTLILTHFSPRYTSEGPITLEDLLAEARAIFPNTILARDRMTYEIPRRSPAPLP
VGV

Specific function: Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA [H]

COG id: COG1234

COG function: function code R; Metal-dependent hydrolases of the beta-lactamase superfamily III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNase Z family [H]

Homologues:

Organism=Homo sapiens, GI8922122, Length=365, Percent_Identity=35.0684931506849, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI260166619, Length=219, Percent_Identity=29.6803652968037, Blast_Score=68, Evalue=9e-12,
Organism=Escherichia coli, GI87082078, Length=309, Percent_Identity=43.3656957928803, Blast_Score=257, Evalue=8e-70,
Organism=Drosophila melanogaster, GI24652403, Length=221, Percent_Identity=28.9592760180996, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR013471 [H]

Pfam domain/function: PF00753 Lactamase_B [H]

EC number: =3.1.26.11 [H]

Molecular weight: Translated: 36215; Mature: 36083

Theoretical pI: Translated: 7.34; Mature: 7.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDPNAIRVTFLGTSSGMPTRQRNVSGVAVQFPQRSEWWLFDCGEGTQHQLLRLDELRPS
CCCCCEEEEEEEECCCCCCCHHCCCCEEEEECCCCCCCEEEECCCCCHHHHHHHHCCCHH
QLRRIFITHMHGDHIYGLPGLLASCGLGSTPQHIDIYGPPGLEEYLKTVLRYSESRIPYS
HEEEEEEEEECCCEEECCHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCEE
FRVHTVETGLILQDPEYWVFCAPLDHRVPAFGYRVVEQDRPGTFDVAKAQADGIPPGPLY
EEEEEEECCEEEECCCCEEEECCCCCCCCCCCEEEEECCCCCCEEEHHHHCCCCCCCCCC
GQLKAGQSILWQGRWFHGRDYVGAPIPGRKFSYCTDTIFCRNAVDLSRAADLVIHEATYA
CCCCCCCEEEECCCEECCCCCCCCCCCCCCCCHHHCCEEECCCHHHHHHHHEEEEHHHHH
EADRELAERAKHSTAAMAARVAAEAKAQTLILTHFSPRYTSEGPITLEDLLAEARAIFPN
HHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCEEHHHHHHHHHHHCCC
TILARDRMTYEIPRRSPAPLPVGV
CEEECCCEEEECCCCCCCCCCCCC
>Mature Secondary Structure 
TDPNAIRVTFLGTSSGMPTRQRNVSGVAVQFPQRSEWWLFDCGEGTQHQLLRLDELRPS
CCCCEEEEEEEECCCCCCCHHCCCCEEEEECCCCCCCEEEECCCCCHHHHHHHHCCCHH
QLRRIFITHMHGDHIYGLPGLLASCGLGSTPQHIDIYGPPGLEEYLKTVLRYSESRIPYS
HEEEEEEEEECCCEEECCHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCEE
FRVHTVETGLILQDPEYWVFCAPLDHRVPAFGYRVVEQDRPGTFDVAKAQADGIPPGPLY
EEEEEEECCEEEECCCCEEEECCCCCCCCCCCEEEEECCCCCCEEEHHHHCCCCCCCCCC
GQLKAGQSILWQGRWFHGRDYVGAPIPGRKFSYCTDTIFCRNAVDLSRAADLVIHEATYA
CCCCCCCEEEECCCEECCCCCCCCCCCCCCCCHHHCCEEECCCHHHHHHHHEEEEHHHHH
EADRELAERAKHSTAAMAARVAAEAKAQTLILTHFSPRYTSEGPITLEDLLAEARAIFPN
HHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCEEHHHHHHHHHHHCCC
TILARDRMTYEIPRRSPAPLPVGV
CEEECCCEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA