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The map label for this gene is hemH

Identifier: 86605730

GI number: 86605730

Start: 1052607

End: 1053632

Strand: Reverse

Name: hemH

Synonym: CYA_1034

Alternate gene names: 86605730

Gene position: 1053632-1052607 (Counterclockwise)

Preceding gene: 86605731

Following gene: 86605729

Centisome position: 35.93

GC content: 64.42

Gene sequence:

>1026_bases
ATGTCCAAAAGCGGCGTGCTCCTGCTGAACTTGGGGGGGCCAGAGACCCAGGCTGATGTGCAGCCCTTTCTCTACAACCT
CTTTGCCGATCCCGAGCTGATCCGCCTGCCCTTTCCCTTTTTGCAGAGGGCTTTTGCCTGGGCCATCTCCACGCTGCGGG
CGCCCAAATCCCGGCGCAACTACGCGGCCATCGGGGGGGGATCCCCTTTGCGGCGCATCACCGCCGCCCAGGCACAAGCG
TTGCAGGCTCAACTGGTGGCGGCGGGCTACGACGTGCCGGTGTATGTGGCCATGCGCTATTGGCACCCGCTGATCGAGTC
GGTGGTGCAGCAGATCAAGTCGGATGGGATCACCCGCCTGGTGGTGCTGCCGCTCTACCCGCAGTACTCCATCAGCACCA
CCGGCTCCAGCTTCAAACTCCTGGATCGCCTCTGGGCCGAAGACCCGGAGCTGGCCCGCATCGAGCGCCGCCAGATCTGC
TCTTGGTACGACCAGCCCCAGTATGTCCAGGCCATGGCTAGGGCCATCCGGGAGCAGTTGGATGCCTTCGAGGATCCGGC
AGGGGTGCATGTGCTCTTTAGCGCCCACGGCATTCCCGAAAGCTATGTCACCCAGGCCGGGGATCCCTACCAGCAGGAGA
TGGAGGCCTGCGTCCAGCTCATCTGGCGGGAAGTTGGGCGCCCCAATCGCCACACCCTCTCCTATCAGAGCCGGGTGGGC
TCGGTGCGCTGGCTGCAGCCCTATACCGAGACGGTGATCCCAGAGCTGGGAGCGTGCGGGGTCAGGCAACTGCTGGTGGT
GCCGATTAGCTTTGTGTCGGAGCACATCGAAACCCTGCAGGAGATCGACATCGAGTATCGGGAGCTGGCCCACCAGGCTG
GGATCCGCGAGTTTCGCCGCGTGCCCGCGTTGAATGCCGACCCGCTGTTTATTGCCGGGCTGGTGGCGTTGGTGCGGCCC
CATCTGCTCACTTCAGCACCTGCTTTTGTACCGGCGGCGGTGGGCGGCTCGCTGCTGGAGCGATAG

Upstream 100 bases:

>100_bases
CCGAGAGAAAGCTGAGAAAGGTTGCAAGAAAACTTAATGCCCCTTCCCCGCTGGGGGGCAAGACCTCCTACAGTGGATAA
GGAAGGTCATTGGGTTTGTC

Downstream 100 bases:

>100_bases
CTAAAAGGGATCCAGGCCGCGAGCGGGCCTGGGCAAGCGAGGGTCAAATCCCCAAAAGCAATCGCTTGTTTTTGCGCAGC
GGTCAGGTGAGGGTACGGCC

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 341; Mature: 340

Protein sequence:

>341_residues
MSKSGVLLLNLGGPETQADVQPFLYNLFADPELIRLPFPFLQRAFAWAISTLRAPKSRRNYAAIGGGSPLRRITAAQAQA
LQAQLVAAGYDVPVYVAMRYWHPLIESVVQQIKSDGITRLVVLPLYPQYSISTTGSSFKLLDRLWAEDPELARIERRQIC
SWYDQPQYVQAMARAIREQLDAFEDPAGVHVLFSAHGIPESYVTQAGDPYQQEMEACVQLIWREVGRPNRHTLSYQSRVG
SVRWLQPYTETVIPELGACGVRQLLVVPISFVSEHIETLQEIDIEYRELAHQAGIREFRRVPALNADPLFIAGLVALVRP
HLLTSAPAFVPAAVGGSLLER

Sequences:

>Translated_341_residues
MSKSGVLLLNLGGPETQADVQPFLYNLFADPELIRLPFPFLQRAFAWAISTLRAPKSRRNYAAIGGGSPLRRITAAQAQA
LQAQLVAAGYDVPVYVAMRYWHPLIESVVQQIKSDGITRLVVLPLYPQYSISTTGSSFKLLDRLWAEDPELARIERRQIC
SWYDQPQYVQAMARAIREQLDAFEDPAGVHVLFSAHGIPESYVTQAGDPYQQEMEACVQLIWREVGRPNRHTLSYQSRVG
SVRWLQPYTETVIPELGACGVRQLLVVPISFVSEHIETLQEIDIEYRELAHQAGIREFRRVPALNADPLFIAGLVALVRP
HLLTSAPAFVPAAVGGSLLER
>Mature_340_residues
SKSGVLLLNLGGPETQADVQPFLYNLFADPELIRLPFPFLQRAFAWAISTLRAPKSRRNYAAIGGGSPLRRITAAQAQAL
QAQLVAAGYDVPVYVAMRYWHPLIESVVQQIKSDGITRLVVLPLYPQYSISTTGSSFKLLDRLWAEDPELARIERRQICS
WYDQPQYVQAMARAIREQLDAFEDPAGVHVLFSAHGIPESYVTQAGDPYQQEMEACVQLIWREVGRPNRHTLSYQSRVGS
VRWLQPYTETVIPELGACGVRQLLVVPISFVSEHIETLQEIDIEYRELAHQAGIREFRRVPALNADPLFIAGLVALVRPH
LLTSAPAFVPAAVGGSLLER

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499021, Length=329, Percent_Identity=38.9057750759878, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI60499025, Length=329, Percent_Identity=38.9057750759878, Blast_Score=206, Evalue=3e-53,
Organism=Escherichia coli, GI1786681, Length=326, Percent_Identity=33.1288343558282, Blast_Score=142, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6324750, Length=339, Percent_Identity=35.1032448377581, Blast_Score=174, Evalue=2e-44,
Organism=Drosophila melanogaster, GI17864156, Length=326, Percent_Identity=36.1963190184049, Blast_Score=202, Evalue=2e-52,
Organism=Drosophila melanogaster, GI24651774, Length=256, Percent_Identity=33.203125, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI45552018, Length=164, Percent_Identity=40.2439024390244, Blast_Score=122, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 38141; Mature: 38010

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKSGVLLLNLGGPETQADVQPFLYNLFADPELIRLPFPFLQRAFAWAISTLRAPKSRRN
CCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHCCCCCCC
YAAIGGGSPLRRITAAQAQALQAQLVAAGYDVPVYVAMRYWHPLIESVVQQIKSDGITRL
EEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEE
VVLPLYPQYSISTTGSSFKLLDRLWAEDPELARIERRQICSWYDQPQYVQAMARAIREQL
EEEECCCCCEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
DAFEDPAGVHVLFSAHGIPESYVTQAGDPYQQEMEACVQLIWREVGRPNRHTLSYQSRVG
HHCCCCCCEEEEEECCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHCC
SVRWLQPYTETVIPELGACGVRQLLVVPISFVSEHIETLQEIDIEYRELAHQAGIREFRR
CEEEECHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
VPALNADPLFIAGLVALVRPHLLTSAPAFVPAAVGGSLLER
CCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
SKSGVLLLNLGGPETQADVQPFLYNLFADPELIRLPFPFLQRAFAWAISTLRAPKSRRN
CCCCEEEEECCCCCCCHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHHCCCCCCC
YAAIGGGSPLRRITAAQAQALQAQLVAAGYDVPVYVAMRYWHPLIESVVQQIKSDGITRL
EEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEE
VVLPLYPQYSISTTGSSFKLLDRLWAEDPELARIERRQICSWYDQPQYVQAMARAIREQL
EEEECCCCCEECCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
DAFEDPAGVHVLFSAHGIPESYVTQAGDPYQQEMEACVQLIWREVGRPNRHTLSYQSRVG
HHCCCCCCEEEEEECCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHCC
SVRWLQPYTETVIPELGACGVRQLLVVPISFVSEHIETLQEIDIEYRELAHQAGIREFRR
CEEEECHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHH
VPALNADPLFIAGLVALVRPHLLTSAPAFVPAAVGGSLLER
CCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA