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The map label for this gene is gnd

Identifier: 86605650

GI number: 86605650

Start: 959250

End: 960659

Strand: Reverse

Name: gnd

Synonym: CYA_0947

Alternate gene names: 86605650

Gene position: 960659-959250 (Counterclockwise)

Preceding gene: 86605651

Following gene: 86605646

Centisome position: 32.76

GC content: 62.2

Gene sequence:

>1410_bases
ATGAGCAAGCCCAGCTTCGCGGTCATTGGCCTAGCGGTAATGGGGGAAAACCTGGCCCTCAACGTCGAGCGCAATGGCTT
TCCGGTTGTCGTCTACAACCGAACTCGCGCCAAAACCGAGCAGTTTATCCAAGGGAGGGCCCAAGGCAAGCAGATTACCC
CCGCCTACAGCTTGCCGGAATTGGTGCAACTGATGGAGCGGCCCCGCAAAATCTTGATCATGGTTAAGGCAGGCCCGCCG
GTGGATGCCATCATCGACGAGCTTAAGCCCCTGCTGGAGCCAGGCGACATCCTCATCGATGGCGGCAACTCCCTCTACAG
CGACACCGACCGGCGCGCCGAGGTCCTAGAAGCCAGCGGGATCCACTTTGTCGGCATGGGGGTGAGCGGCGGGGAAGAAG
GTGCCCTCAACGGCCCCAGCCTCATGCCCGGCGGCAGCTTGGAAGCCTATCGGCAACTGGAGCCCATCCTCACCAAAATT
GCCGCTCAAGTGCCCGATGGCCCCTGCGTCACCTACCTGGGGCCTAAAGGGGGTGGGCACTACGTGAAGATGGTGCACAA
CGGCATCGAATACGGCGACATGCAACTGATTGCCGAGGCCTACGACCTCATGCGCAGGGGGCTGAAGCTGTCAGCCCCCC
AGATGCAGGAGATCTTCCAGGCCTGGAACGAGACGGAGCTGGAGTCGTTTTTGATTGAGATTACCGCCAAGATCTTGGGG
ACGCTGGATCCGGAGACGGGCAAGCCGCTGGTGGATCTCATTTTGGACAAGGCGGGGCAGAAGGGCACGGGCCTGTGGAC
GGTCAAGGACGCCCTGGATCTTGGGGTGCCGGTGCCCACCATTGAGGCGGCAGTGCAGGCTCGCATCCTCTCGTCGATGA
AAGAGGAACGGGTGGCCGCCTCCCAGCAGTTGCCAGGGCCAGGAACAACCTTGGAAGGGGATCCCGACAGCTTCCTTCAG
GATCTGCGCGCCGCCCTCTACTGTTCCAAGATCTGCTCCTATGCCCAGGGGATGGCCCTGCTCAGGCAAGCCACCGTTGC
CCACGGCTATGTGTACACCTTCAGCGAGATCCCTCGCATTTGGAAGGGGGGCTGTATCATCCGCGCCCGCCTCCTGGGCA
AAATCCAGTCGGCCTACCAAAGGGATCCGGAGCTAGTCAACCTCCTTTTGGATGAGGAGTTTAAGCGGGCCATCCAGGAA
CGGCAGGGATCCTGGCGGCGAGTGGTGGCCACTGCAGCAGCCTTGGGGATCCCGATCCCGGCCATCAGCGCCTCCCTGGC
CTACTACGACAGCTACCGCACCGCCGAGCTGCCCCAGAACCTCACCCAGGCCCAGCGGGATTTCTTCGGCGCCCACACCT
TTGAGCGCATCGACAGGCCGGGGGTTTTCCACCACGCCTGGAACGCCTAG

Upstream 100 bases:

>100_bases
GTCCTTGAAAGCCGGCAAAAAAAGGTGAAGAAAACAGGATCCCTGAACCCTCTTGGCCGGATCGCCCCTTAGATTGGGGG
AGGTGTTACCCTGCCCCACC

Downstream 100 bases:

>100_bases
GCAGGGCCCCGCCCTGGGGCAGCCGCCAGATCCAGCGGCGCTTGCTTAAACGTAGAGCCCCAGACTTCGGTGTGGAAAGG
CTCCCTTTCTTGGGGGAAAT

Product: 6-phosphogluconate dehydrogenase, decarboxylating

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 469; Mature: 468

Protein sequence:

>469_residues
MSKPSFAVIGLAVMGENLALNVERNGFPVVVYNRTRAKTEQFIQGRAQGKQITPAYSLPELVQLMERPRKILIMVKAGPP
VDAIIDELKPLLEPGDILIDGGNSLYSDTDRRAEVLEASGIHFVGMGVSGGEEGALNGPSLMPGGSLEAYRQLEPILTKI
AAQVPDGPCVTYLGPKGGGHYVKMVHNGIEYGDMQLIAEAYDLMRRGLKLSAPQMQEIFQAWNETELESFLIEITAKILG
TLDPETGKPLVDLILDKAGQKGTGLWTVKDALDLGVPVPTIEAAVQARILSSMKEERVAASQQLPGPGTTLEGDPDSFLQ
DLRAALYCSKICSYAQGMALLRQATVAHGYVYTFSEIPRIWKGGCIIRARLLGKIQSAYQRDPELVNLLLDEEFKRAIQE
RQGSWRRVVATAAALGIPIPAISASLAYYDSYRTAELPQNLTQAQRDFFGAHTFERIDRPGVFHHAWNA

Sequences:

>Translated_469_residues
MSKPSFAVIGLAVMGENLALNVERNGFPVVVYNRTRAKTEQFIQGRAQGKQITPAYSLPELVQLMERPRKILIMVKAGPP
VDAIIDELKPLLEPGDILIDGGNSLYSDTDRRAEVLEASGIHFVGMGVSGGEEGALNGPSLMPGGSLEAYRQLEPILTKI
AAQVPDGPCVTYLGPKGGGHYVKMVHNGIEYGDMQLIAEAYDLMRRGLKLSAPQMQEIFQAWNETELESFLIEITAKILG
TLDPETGKPLVDLILDKAGQKGTGLWTVKDALDLGVPVPTIEAAVQARILSSMKEERVAASQQLPGPGTTLEGDPDSFLQ
DLRAALYCSKICSYAQGMALLRQATVAHGYVYTFSEIPRIWKGGCIIRARLLGKIQSAYQRDPELVNLLLDEEFKRAIQE
RQGSWRRVVATAAALGIPIPAISASLAYYDSYRTAELPQNLTQAQRDFFGAHTFERIDRPGVFHHAWNA
>Mature_468_residues
SKPSFAVIGLAVMGENLALNVERNGFPVVVYNRTRAKTEQFIQGRAQGKQITPAYSLPELVQLMERPRKILIMVKAGPPV
DAIIDELKPLLEPGDILIDGGNSLYSDTDRRAEVLEASGIHFVGMGVSGGEEGALNGPSLMPGGSLEAYRQLEPILTKIA
AQVPDGPCVTYLGPKGGGHYVKMVHNGIEYGDMQLIAEAYDLMRRGLKLSAPQMQEIFQAWNETELESFLIEITAKILGT
LDPETGKPLVDLILDKAGQKGTGLWTVKDALDLGVPVPTIEAAVQARILSSMKEERVAASQQLPGPGTTLEGDPDSFLQD
LRAALYCSKICSYAQGMALLRQATVAHGYVYTFSEIPRIWKGGCIIRARLLGKIQSAYQRDPELVNLLLDEEFKRAIQER
QGSWRRVVATAAALGIPIPAISASLAYYDSYRTAELPQNLTQAQRDFFGAHTFERIDRPGVFHHAWNA

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH [H]

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=467, Percent_Identity=54.1755888650964, Blast_Score=486, Evalue=1e-137,
Organism=Escherichia coli, GI1788341, Length=468, Percent_Identity=54.9145299145299, Blast_Score=519, Evalue=1e-148,
Organism=Caenorhabditis elegans, GI17542558, Length=468, Percent_Identity=52.991452991453, Blast_Score=499, Evalue=1e-142,
Organism=Saccharomyces cerevisiae, GI6321695, Length=458, Percent_Identity=53.7117903930131, Blast_Score=489, Evalue=1e-139,
Organism=Saccharomyces cerevisiae, GI6321977, Length=451, Percent_Identity=52.7716186252772, Blast_Score=466, Evalue=1e-132,
Organism=Drosophila melanogaster, GI24639279, Length=465, Percent_Identity=52.9032258064516, Blast_Score=459, Evalue=1e-129,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: =1.1.1.44 [H]

Molecular weight: Translated: 51285; Mature: 51153

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKPSFAVIGLAVMGENLALNVERNGFPVVVYNRTRAKTEQFIQGRAQGKQITPAYSLPE
CCCCCEEEEEHEEECCCEEEEEECCCCEEEEECCCHHHHHHHHHHHHCCCCCCCCCCHHH
LVQLMERPRKILIMVKAGPPVDAIIDELKPLLEPGDILIDGGNSLYSDTDRRAEVLEASG
HHHHHHCCCEEEEEEECCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHCCC
IHFVGMGVSGGEEGALNGPSLMPGGSLEAYRQLEPILTKIAAQVPDGPCVTYLGPKGGGH
CEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCC
YVKMVHNGIEYGDMQLIAEAYDLMRRGLKLSAPQMQEIFQAWNETELESFLIEITAKILG
CHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHH
TLDPETGKPLVDLILDKAGQKGTGLWTVKDALDLGVPVPTIEAAVQARILSSMKEERVAA
CCCCCCCCHHHHHHHHCCCCCCCCEEEEHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
SQQLPGPGTTLEGDPDSFLQDLRAALYCSKICSYAQGMALLRQATVAHGYVYTFSEIPRI
HHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEHHHHHHH
WKGGCIIRARLLGKIQSAYQRDPELVNLLLDEEFKRAIQERQGSWRRVVATAAALGIPIP
HCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCH
AISASLAYYDSYRTAELPQNLTQAQRDFFGAHTFERIDRPGVFHHAWNA
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
SKPSFAVIGLAVMGENLALNVERNGFPVVVYNRTRAKTEQFIQGRAQGKQITPAYSLPE
CCCCEEEEEHEEECCCEEEEEECCCCEEEEECCCHHHHHHHHHHHHCCCCCCCCCCHHH
LVQLMERPRKILIMVKAGPPVDAIIDELKPLLEPGDILIDGGNSLYSDTDRRAEVLEASG
HHHHHHCCCEEEEEEECCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHCCC
IHFVGMGVSGGEEGALNGPSLMPGGSLEAYRQLEPILTKIAAQVPDGPCVTYLGPKGGGH
CEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCC
YVKMVHNGIEYGDMQLIAEAYDLMRRGLKLSAPQMQEIFQAWNETELESFLIEITAKILG
CHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHH
TLDPETGKPLVDLILDKAGQKGTGLWTVKDALDLGVPVPTIEAAVQARILSSMKEERVAA
CCCCCCCCHHHHHHHHCCCCCCCCEEEEHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
SQQLPGPGTTLEGDPDSFLQDLRAALYCSKICSYAQGMALLRQATVAHGYVYTFSEIPRI
HHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEHHHHHHH
WKGGCIIRARLLGKIQSAYQRDPELVNLLLDEEFKRAIQERQGSWRRVVATAAALGIPIP
HCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCH
AISASLAYYDSYRTAELPQNLTQAQRDFFGAHTFERIDRPGVFHHAWNA
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2113917 [H]