Click here to switch to the map view.

The map label for this gene is pcm

Identifier: 86605611

GI number: 86605611

Start: 917990

End: 918616

Strand: Reverse

Name: pcm

Synonym: CYA_0908

Alternate gene names: 86605611

Gene position: 918616-917990 (Counterclockwise)

Preceding gene: 86605612

Following gene: 86605609

Centisome position: 31.32

GC content: 64.75

Gene sequence:

>627_bases
ATGGATCCCTGGGCTGGCCAACGGGAGCGGATGGTGAGGGAGCAGATCTTGCAGCGAGGGATCCGCGATCCCCGGGTGCT
GGAGGCAATGCGCAAGGTGCCGCGCCACCTTTTCGTTCCCCCGGAGCTGCGGGAGCGCGCCTACAGGGATTGCCCGCTGC
CCATTGGCTACGGCCAGACGATTTCTCAGCCCTATATTGTCGCCTTTATGACTGAGGCGGCCCGCCTCACCCCTGAGTCG
GTGGTGCTGGAAATCGGCACCGGATCCGGCTATCAGGCGGCCATTTTGGCCGAGCTGGCCCGGCAAGTATATAGCCTGGA
GCGGCTGGCTCCCTTGGCCGCCCGCGCTCAGCAAACCCTGGCCTCCTTGGGCTACCGCAACGTGGAGGTGCGCCAGGGAG
ATGGCTATCAGGGTTGGCCGGAACACGCCCCCTACGACGCCATCGTGGTGACGGCAGCCCCCCCAACCCTGCCGACGCTG
CTGCTGGATCAACTGGCGGTGGGAGGTACCCTGGTGGTGCCGGTGGGCGAAAGCCAGGGATTCCAATCCTTGCTGATCCT
CCACAAAACCCCGGAGGGGGTGGTGCAAAAGGGGGCCTTCCCAGTGCAATTTGTGCCCATGGTTTAG

Upstream 100 bases:

>100_bases
AAAGTTGTTCTCGTCTCTTTTTAAGAGGACTTCTGACTCCTTGGCTGGGATCCCGGCTGCCGAGTTGGGCGCTCCTCAGT
CCTGTGCCGGCGATAGTGGC

Downstream 100 bases:

>100_bases
TCTTCTGCGGCCAGCCAGAGCTGGCGGCGAATTTGCAGCGCCAACTGAGGGTGGTCGGTGATCAGCCCCCGCACCGGCGG
CTCCTCCCCAGACGGGCGCA

Product: protein-L-isoaspartate(D-aspartate) O-methyltransferase

Products: NA

Alternate protein names: L-isoaspartyl protein carboxyl methyltransferase; Protein L-isoaspartyl methyltransferase; Protein-beta-aspartate methyltransferase; PIMT [H]

Number of amino acids: Translated: 208; Mature: 208

Protein sequence:

>208_residues
MDPWAGQRERMVREQILQRGIRDPRVLEAMRKVPRHLFVPPELRERAYRDCPLPIGYGQTISQPYIVAFMTEAARLTPES
VVLEIGTGSGYQAAILAELARQVYSLERLAPLAARAQQTLASLGYRNVEVRQGDGYQGWPEHAPYDAIVVTAAPPTLPTL
LLDQLAVGGTLVVPVGESQGFQSLLILHKTPEGVVQKGAFPVQFVPMV

Sequences:

>Translated_208_residues
MDPWAGQRERMVREQILQRGIRDPRVLEAMRKVPRHLFVPPELRERAYRDCPLPIGYGQTISQPYIVAFMTEAARLTPES
VVLEIGTGSGYQAAILAELARQVYSLERLAPLAARAQQTLASLGYRNVEVRQGDGYQGWPEHAPYDAIVVTAAPPTLPTL
LLDQLAVGGTLVVPVGESQGFQSLLILHKTPEGVVQKGAFPVQFVPMV
>Mature_208_residues
MDPWAGQRERMVREQILQRGIRDPRVLEAMRKVPRHLFVPPELRERAYRDCPLPIGYGQTISQPYIVAFMTEAARLTPES
VVLEIGTGSGYQAAILAELARQVYSLERLAPLAARAQQTLASLGYRNVEVRQGDGYQGWPEHAPYDAIVVTAAPPTLPTL
LLDQLAVGGTLVVPVGESQGFQSLLILHKTPEGVVQKGAFPVQFVPMV

Specific function: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins [H]

COG id: COG2518

COG function: function code O; Protein-L-isoaspartate carboxylmethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. L- isoaspartyl/D-aspartyl protein methyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI226530908, Length=200, Percent_Identity=33, Blast_Score=84, Evalue=1e-16,
Organism=Escherichia coli, GI1789100, Length=195, Percent_Identity=50.2564102564103, Blast_Score=182, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI71983477, Length=195, Percent_Identity=33.3333333333333, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI193207222, Length=193, Percent_Identity=32.6424870466321, Blast_Score=85, Evalue=3e-17,
Organism=Drosophila melanogaster, GI17981723, Length=218, Percent_Identity=33.4862385321101, Blast_Score=103, Evalue=9e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000682 [H]

Pfam domain/function: PF01135 PCMT [H]

EC number: =2.1.1.77 [H]

Molecular weight: Translated: 22936; Mature: 22936

Theoretical pI: Translated: 7.60; Mature: 7.60

Prosite motif: PS01279 PCMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDPWAGQRERMVREQILQRGIRDPRVLEAMRKVPRHLFVPPELRERAYRDCPLPIGYGQT
CCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCC
ISQPYIVAFMTEAARLTPESVVLEIGTGSGYQAAILAELARQVYSLERLAPLAARAQQTL
CCCCEEEEEEHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASLGYRNVEVRQGDGYQGWPEHAPYDAIVVTAAPPTLPTLLLDQLAVGGTLVVPVGESQG
HHCCCCCEEEECCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCEEEEECCCCCC
FQSLLILHKTPEGVVQKGAFPVQFVPMV
CCEEEEEECCCHHHHHCCCCCEEEECCC
>Mature Secondary Structure
MDPWAGQRERMVREQILQRGIRDPRVLEAMRKVPRHLFVPPELRERAYRDCPLPIGYGQT
CCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCC
ISQPYIVAFMTEAARLTPESVVLEIGTGSGYQAAILAELARQVYSLERLAPLAARAQQTL
CCCCEEEEEEHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ASLGYRNVEVRQGDGYQGWPEHAPYDAIVVTAAPPTLPTLLLDQLAVGGTLVVPVGESQG
HHCCCCCEEEECCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCEEEEECCCCCC
FQSLLILHKTPEGVVQKGAFPVQFVPMV
CCEEEEEECCCHHHHHCCCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA