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The map label for this gene is ubiE [C]

Identifier: 86605251

GI number: 86605251

Start: 550279

End: 550806

Strand: Reverse

Name: ubiE [C]

Synonym: CYA_0534

Alternate gene names: 86605251

Gene position: 550806-550279 (Counterclockwise)

Preceding gene: 86605252

Following gene: 86605250

Centisome position: 18.78

GC content: 61.55

Gene sequence:

>528_bases
ATGAAGGCTTTCTACCGGCAGGTGCTTTTTCCGAGGTTGCTGGATTGGGCTCTGGCCAGCGAGCGTCTGGAGAGCTATCG
GCGGCAGCTTCTGGCCCAGGTGCGGGGAGCGGTCTTGGAGATCGGCTTTGGCACCGGCCTCAACCTGGCCTGCTACCCAG
AGCACATTCAAAAAATTACAGTGGCAGATCCCAACCCCGGCATGGGATCCCTGGCCCGCCGCCGCATCGCGGCTTCCTCC
ATCGCCGTCGATTGGCTGGTGGCGGACGCCCAAGAGCTGCCTTTTTCGAACCAGAGTTTTGACAGCGTGGTCAGCACCTG
GACCCTGTGTAGCATCCCCGATTTGGCCAAGGCTTTGGGGGAAATCCGGCGGGTGCTGCGGGTGGGGGGCAAGCTGTTTT
TTCTCGAGCACGGCCTCAGCCCGGATCCCCAGGTGCAAAGCTGGCAAAGGCGTCTCAACCCTATCCAGAGGGCGATCGGA
GATGGCTGCAACCTAGACCGAGATATGGCTGGCCCTGGCAACCGTTAG

Upstream 100 bases:

>100_bases
GCTGCTGGCCTGCTACGGCCTCTACTCCCTGAAGCTGGCCCCCAACCCCGCTACGCTCGAACGGCCCGAAAATAGATCGC
GAACCTCTTGAGCCCGGCTT

Downstream 100 bases:

>100_bases
CCTGCCCTCAACTAGCTCTTTGATTGGCGTTCTCCCCCCTTTCATCCCCCGTATACGGGGGGAAAGGGGAAGAGCGGGAT
CTGCGCCGCCAAGGTTTCGG

Product: UbiE/COQ5 family methlytransferase

Products: S-Adenosyl-L-Homocysteine; @OCTA02.txt*2- Polyprenyl-3-Methyl-6-Methoxy-1,4-Benzoquinol!; Menaquinol. [C]

Alternate protein names: Methyltransferase; Ubiquinone/Menaquinone Biosynthesis Methyltransferase; SAM-Dependent Methyltransferase; Phosphatidylethanolamine N-Methyltransferase; Methyltransferase UbiE/COQ5 Family; UbiE/COQ5 Family Methlytransferase; Methyltransferase Domain Family; SAM-Dependent Methyltransferase UbiE/COQ5 Family; Ubiquinone/Menaquinone Biosynthesis Methyltransferase UbiE; Methylase Involved In Ubiquinone/Menaquinone Biosynthesis; UbiE Ubiquinone/Menaquinone Biosynthesis Methyltransferase; Generic Methyltransferase; Ubiquinone/Menaquinone Biosynthesis-Related Protein; Ubiquinone/Menaquinone Biosynthesis Methyl Transferase; Methyltransferase Domain Family Protein; Phospholipid Methyltransferase; UbiE/COQ5 Methyltransferase; Sam Dependent Methyltransferase; Response Regulator Receiver Protein

Number of amino acids: Translated: 175; Mature: 175

Protein sequence:

>175_residues
MKAFYRQVLFPRLLDWALASERLESYRRQLLAQVRGAVLEIGFGTGLNLACYPEHIQKITVADPNPGMGSLARRRIAASS
IAVDWLVADAQELPFSNQSFDSVVSTWTLCSIPDLAKALGEIRRVLRVGGKLFFLEHGLSPDPQVQSWQRRLNPIQRAIG
DGCNLDRDMAGPGNR

Sequences:

>Translated_175_residues
MKAFYRQVLFPRLLDWALASERLESYRRQLLAQVRGAVLEIGFGTGLNLACYPEHIQKITVADPNPGMGSLARRRIAASS
IAVDWLVADAQELPFSNQSFDSVVSTWTLCSIPDLAKALGEIRRVLRVGGKLFFLEHGLSPDPQVQSWQRRLNPIQRAIG
DGCNLDRDMAGPGNR
>Mature_175_residues
MKAFYRQVLFPRLLDWALASERLESYRRQLLAQVRGAVLEIGFGTGLNLACYPEHIQKITVADPNPGMGSLARRRIAASS
IAVDWLVADAQELPFSNQSFDSVVSTWTLCSIPDLAKALGEIRRVLRVGGKLFFLEHGLSPDPQVQSWQRRLNPIQRAIG
DGCNLDRDMAGPGNR

Specific function: Methyltransferase Required For The Conversion Of Dimethylmenaquinone (Dmkh2) To Menaquinone (Mkh2) And The Conversion Of 2-Polyprenyl-6-Methoxy-1,4-Benzoquinol (Ddmqh2) To 2-Polyprenyl-3-Methyl-6-Methoxy-1,4-Benzoquinol (Dmqh2). [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI164663805, Length=162, Percent_Identity=35.8024691358025, Blast_Score=93, Evalue=1e-19,
Organism=Homo sapiens, GI89145417, Length=164, Percent_Identity=31.7073170731707, Blast_Score=80, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 2.1.1.- [C]

Molecular weight: Translated: 19475; Mature: 19475

Theoretical pI: Translated: 9.31; Mature: 9.31

Prosite motif: PS01184 UBIE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAFYRQVLFPRLLDWALASERLESYRRQLLAQVRGAVLEIGFGTGLNLACYPEHIQKIT
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCEECHHHHCEEE
VADPNPGMGSLARRRIAASSIAVDWLVADAQELPFSNQSFDSVVSTWTLCSIPDLAKALG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHH
EIRRVLRVGGKLFFLEHGLSPDPQVQSWQRRLNPIQRAIGDGCNLDRDMAGPGNR
HHHHHHHHCCHHEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKAFYRQVLFPRLLDWALASERLESYRRQLLAQVRGAVLEIGFGTGLNLACYPEHIQKIT
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCEECHHHHCEEE
VADPNPGMGSLARRRIAASSIAVDWLVADAQELPFSNQSFDSVVSTWTLCSIPDLAKALG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHH
EIRRVLRVGGKLFFLEHGLSPDPQVQSWQRRLNPIQRAIGDGCNLDRDMAGPGNR
HHHHHHHHCCHHEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: S-Adenosyl-L-Methionine; 2-Polyprenyl-6- Methoxy-1,4-Benzoquinol; Demethylmenaquinol [C]

Specific reaction: S-Adenosyl-L-Methionine + @OCTA02.txt*2-Polyprenyl-6- Methoxy-1,4-Benzoquinol! = S-Adenosyl-L-Homocysteine + 2- Polyprenyl-3-Methyl-6-Methoxy -1,4-Benzoquinol S-Adenosyl-L-Methionine + Demethylmenaquinol = S-Adenosyl-L-Homocysteine + Menaquinol. [C]

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA