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The map label for this gene is acrE [H]

Identifier: 86605154

GI number: 86605154

Start: 454467

End: 455750

Strand: Reverse

Name: acrE [H]

Synonym: CYA_0435

Alternate gene names: 86605154

Gene position: 455750-454467 (Counterclockwise)

Preceding gene: 86605155

Following gene: 86605153

Centisome position: 15.54

GC content: 66.43

Gene sequence:

>1284_bases
ATGCGATTGCGAACAGTTCTGCCGCTGTTGGGTTTTTCTTTGCTCCTGGCTGCCTGTCGGCCCGGCGGGCCCCCTCGCGG
CATGGAGAGTGGAGAAGGCCAGCCGACACCGGTGGCCATCGGCGCCGTGGAAGAACGGCTCATTCAGGAGACGTCGGAGT
TCATCACCAGCCTCGGATCCCAGCAGGTGGCCAGTATTCGGCCCCAGGTGAGCGGCCAGGTGACCCAGGTGTTCGTGCGG
CTGGGATCCCAGGTTTCTGCCGGGGCGCCTCTGTTTGCCATCGACAGCCGGCAACAACAGGCGGCGGTGGCCGGCCAAGC
GGCCGGGATCGCGGCGGCTCAGGCCAACCTGGAGAGCAGCCGAGCCGTGCTCAGCCAATTGCGGGCGGATCGCCTGCGGC
TGGAGGCAGCGGCGGAGTTCGCCCGGGATCAACACCAGCGCAACCTGCGCCTCTTGGCCGAGGGGGCCATCAGCCAGGCG
CAAGTGGATCAGTCCAGCCGCGATCTGCGCCAGGCGGAGGCGGCCTTGGCGGCGCAACAGGAGCAGATCCGGGCCCAAGA
GGCGGCCATTGTGCGGGCAGAGCGGGAGGTGGAGCGGGCCCGGGCCGAGGCGGAGCGGCAGCAGGTGCAATTGCAGTTTT
TCCAGGTCACGGCTCCCTTTGCGGGCATTGTGGGGGATGTTTTGGTGAGGCAGGGAGACTACGTGACGCCTCAGACGGTT
TTGACCACCTTGACCCAAACCCAGGCGCTGGAGCTGAACCTCAACATCCCGTTGCAGCGGGCCCCCCAGCTGCGCATTGG
CACGCCGGTGCAGATCCTGGATAGCCGCGGCGAGGTGATCGGCAGCAGCCAAATCTCTTTCATTGCTCCCGAAGCCAACG
CCGCCACGCAATCGGTGCTGGCCAAGGCTCTTCTGGAGAACCCTGCCGGCCAGTTGCGCTCGGCCCAGTTTGTGCGGATT
CGGGTCATCTGGGAGGAGCGGCCAGCTTTGCTGGTGCCGGCAACGGCGGTAGCCCGTCTGGGCGCCCAAACCTTTGTCTA
CACGGTGCAGACGACAGAGCCACCTGAGGAGGGCAAGCCCCCCGGGGCGGTGGCGGTGCAAAGGCCGGTGCGGCTGGGAT
CCCTCTACGGCAACAGCTACGAGGTGCTGGAGGGGCTGAAGGCCAACGAGCCGATTGTGCTGAGCGGCCTGCAAAAAATC
CGCGATGGCGCCCCGATTGTCGATGAGGTGCTTTTGCAGCAGAGGATGCAAGGGGAGGGGAGACCGCCTGGATCCCCGCC
CTAG

Upstream 100 bases:

>100_bases
CACAGGCACAGGAAGGCACAGGCTCATTACCTTGGTTGGTTGAGCCAATGCAGATGGGGGATCCCTCTGTTTGGGTGCTC
GTTGGGGGAGCAGGTTGAGG

Downstream 100 bases:

>100_bases
ATTTCTCCTCTTGAGCGGTTTCCCAACTTGGTCATCCCCTTCTACTCCTTACGCGGATCCCTGGCCTATGTTTGTCGACT
TTTTCATTCGCCGTCCTGTT

Product: RND family efflux transporter MFP subunit

Products: NA

Alternate protein names: Protein envC [H]

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MRLRTVLPLLGFSLLLAACRPGGPPRGMESGEGQPTPVAIGAVEERLIQETSEFITSLGSQQVASIRPQVSGQVTQVFVR
LGSQVSAGAPLFAIDSRQQQAAVAGQAAGIAAAQANLESSRAVLSQLRADRLRLEAAAEFARDQHQRNLRLLAEGAISQA
QVDQSSRDLRQAEAALAAQQEQIRAQEAAIVRAEREVERARAEAERQQVQLQFFQVTAPFAGIVGDVLVRQGDYVTPQTV
LTTLTQTQALELNLNIPLQRAPQLRIGTPVQILDSRGEVIGSSQISFIAPEANAATQSVLAKALLENPAGQLRSAQFVRI
RVIWEERPALLVPATAVARLGAQTFVYTVQTTEPPEEGKPPGAVAVQRPVRLGSLYGNSYEVLEGLKANEPIVLSGLQKI
RDGAPIVDEVLLQQRMQGEGRPPGSPP

Sequences:

>Translated_427_residues
MRLRTVLPLLGFSLLLAACRPGGPPRGMESGEGQPTPVAIGAVEERLIQETSEFITSLGSQQVASIRPQVSGQVTQVFVR
LGSQVSAGAPLFAIDSRQQQAAVAGQAAGIAAAQANLESSRAVLSQLRADRLRLEAAAEFARDQHQRNLRLLAEGAISQA
QVDQSSRDLRQAEAALAAQQEQIRAQEAAIVRAEREVERARAEAERQQVQLQFFQVTAPFAGIVGDVLVRQGDYVTPQTV
LTTLTQTQALELNLNIPLQRAPQLRIGTPVQILDSRGEVIGSSQISFIAPEANAATQSVLAKALLENPAGQLRSAQFVRI
RVIWEERPALLVPATAVARLGAQTFVYTVQTTEPPEEGKPPGAVAVQRPVRLGSLYGNSYEVLEGLKANEPIVLSGLQKI
RDGAPIVDEVLLQQRMQGEGRPPGSPP
>Mature_427_residues
MRLRTVLPLLGFSLLLAACRPGGPPRGMESGEGQPTPVAIGAVEERLIQETSEFITSLGSQQVASIRPQVSGQVTQVFVR
LGSQVSAGAPLFAIDSRQQQAAVAGQAAGIAAAQANLESSRAVLSQLRADRLRLEAAAEFARDQHQRNLRLLAEGAISQA
QVDQSSRDLRQAEAALAAQQEQIRAQEAAIVRAEREVERARAEAERQQVQLQFFQVTAPFAGIVGDVLVRQGDYVTPQTV
LTTLTQTQALELNLNIPLQRAPQLRIGTPVQILDSRGEVIGSSQISFIAPEANAATQSVLAKALLENPAGQLRSAQFVRI
RVIWEERPALLVPATAVARLGAQTFVYTVQTTEPPEEGKPPGAVAVQRPVRLGSLYGNSYEVLEGLKANEPIVLSGLQKI
RDGAPIVDEVLLQQRMQGEGRPPGSPP

Specific function: May affect specific membrane functions, such as septum formation during cell division, and cell membrane permeability [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789665, Length=416, Percent_Identity=26.9230769230769, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1786668, Length=420, Percent_Identity=27.3809523809524, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1789929, Length=424, Percent_Identity=24.2924528301887, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI87082036, Length=401, Percent_Identity=25.1870324189526, Blast_Score=69, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 45793; Mature: 45793

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLRTVLPLLGFSLLLAACRPGGPPRGMESGEGQPTPVAIGAVEERLIQETSEFITSLGS
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCC
QQVASIRPQVSGQVTQVFVRLGSQVSAGAPLFAIDSRQQQAAVAGQAAGIAAAQANLESS
HHHHHCCCCCCHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCHHH
RAVLSQLRADRLRLEAAAEFARDQHQRNLRLLAEGAISQAQVDQSSRDLRQAEAALAAQQ
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCHHHHHHCHHHHHHHHHHHHHHHHH
EQIRAQEAAIVRAEREVERARAEAERQQVQLQFFQVTAPFAGIVGDVLVRQGDYVTPQTV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHCCCCCCHHHH
LTTLTQTQALELNLNIPLQRAPQLRIGTPVQILDSRGEVIGSSQISFIAPEANAATQSVL
HHHHHHCEEEEEEECCCCCCCCCCCCCCCHHHHCCCCCEECCCCEEEECCCCCHHHHHHH
AKALLENPAGQLRSAQFVRIRVIWEERPALLVPATAVARLGAQTFVYTVQTTEPPEEGKP
HHHHHHCCHHHHCCCEEEEEEEEEECCCCEEECHHHHHHCCCCEEEEEEECCCCCCCCCC
PGAVAVQRPVRLGSLYGNSYEVLEGLKANEPIVLSGLQKIRDGAPIVDEVLLQQRMQGEG
CCCEEECCCHHHHHHCCCCHHHHCCCCCCCCEEHHHHHHHHCCCCHHHHHHHHHHHCCCC
RPPGSPP
CCCCCCC
>Mature Secondary Structure
MRLRTVLPLLGFSLLLAACRPGGPPRGMESGEGQPTPVAIGAVEERLIQETSEFITSLGS
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHCCC
QQVASIRPQVSGQVTQVFVRLGSQVSAGAPLFAIDSRQQQAAVAGQAAGIAAAQANLESS
HHHHHCCCCCCHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCHHH
RAVLSQLRADRLRLEAAAEFARDQHQRNLRLLAEGAISQAQVDQSSRDLRQAEAALAAQQ
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCHHHHHHCHHHHHHHHHHHHHHHHH
EQIRAQEAAIVRAEREVERARAEAERQQVQLQFFQVTAPFAGIVGDVLVRQGDYVTPQTV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHCCCCCCHHHH
LTTLTQTQALELNLNIPLQRAPQLRIGTPVQILDSRGEVIGSSQISFIAPEANAATQSVL
HHHHHHCEEEEEEECCCCCCCCCCCCCCCHHHHCCCCCEECCCCEEEECCCCCHHHHHHH
AKALLENPAGQLRSAQFVRIRVIWEERPALLVPATAVARLGAQTFVYTVQTTEPPEEGKP
HHHHHHCCHHHHCCCEEEEEEEEEECCCCEEECHHHHHHCCCCEEEEEEECCCCCCCCCC
PGAVAVQRPVRLGSLYGNSYEVLEGLKANEPIVLSGLQKIRDGAPIVDEVLLQQRMQGEG
CCCEEECCCHHHHHHCCCCHHHHCCCCCCCCEEHHHHHHHHCCCCHHHHHHHHHHHCCCC
RPPGSPP
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1720861; 9278503 [H]