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The map label for this gene is mprA [H]

Identifier: 86605140

GI number: 86605140

Start: 440425

End: 441165

Strand: Reverse

Name: mprA [H]

Synonym: CYA_0421

Alternate gene names: 86605140

Gene position: 441165-440425 (Counterclockwise)

Preceding gene: 86605141

Following gene: 86605137

Centisome position: 15.04

GC content: 67.07

Gene sequence:

>741_bases
ATGGCGCGCATCTTGTTGGTGGACGACGAAGTGGAGCTGGCCGATTCCCTGGCCCAGCACCTGCGGCGAGAGGGCCACAG
CGTGGACGTGGCCTACGAGGGAAACAGCGCCTGGGAGCTGCTGCAGAAGCCCCCAGCCCCACCCTACGACTTGCTGGTAC
TGGACTGGATGTTGCCGGGCCTGTCCGGCCTCTCCCTCTGCCAACAGGTGCGACAGGTAGATCGCGCCACCCCCATCCTC
TTCCTGACCGCCAAAGATACTCTCGACGACCGGGTGGAAGGGCTGGACGCCGGCGCCGACGACTACCTGGTCAAGCCCTT
CGAGCTGCGGGAGCTGCTGGCGCGGGTGCGAGCCCTCTTGCGGCGGGCTGCCGGCCCCGGCGAAGGGATCCCTCGCCTGC
AAATTGGAGACCTAGAGCTGGATCGGGAGAACCAAGTGGCCTACCGCCAAGGACGGATGATCCACCTCTCCCAAAAAGAG
TTCCGCCTGCTGGAGTACTTCATGGCCCACCCCGGCCAGTTGCTCACCCACGAGCAGATCTACGAGCGGGTGTGGGCCGG
CGAGGATCCCCCCAGCAGCAACGTCCTGGCTGCTCAGGTGCGCCTGCTGCGGCGCCGCCTCCGTCTGCCCGGCTCCCCCG
AGTTGATCCACGCCGTCTATGGCAAAGGCTACCGCTTCGGGCCTGTGGCCGAGGATCCTCAGCAGCCGCCAACCCCCCTC
TCCCCCTGGGAGAGGGGCTGA

Upstream 100 bases:

>100_bases
CCTGTGGACGCGGCGCCGCCTTTACGATCTCTGCTTACAACTGGAGCCCCCTCCCTCCCTGGCCCCTCCGGCAAGCGACG
ACGAGACAGAATCCTAGAGC

Downstream 100 bases:

>100_bases
GGGTGAGGGATTACTTGGACTTGAGCTTCTCCGCCTTCTCGATGGCCTCCTCGATGGTGCCCACCAGATAGAAAGCCTGC
TCCGGCAGATGATCCAGTTC

Product: DNA-binding response regulator

Products: NA

Alternate protein names: Mycobacterial persistence regulator A [H]

Number of amino acids: Translated: 246; Mature: 245

Protein sequence:

>246_residues
MARILLVDDEVELADSLAQHLRREGHSVDVAYEGNSAWELLQKPPAPPYDLLVLDWMLPGLSGLSLCQQVRQVDRATPIL
FLTAKDTLDDRVEGLDAGADDYLVKPFELRELLARVRALLRRAAGPGEGIPRLQIGDLELDRENQVAYRQGRMIHLSQKE
FRLLEYFMAHPGQLLTHEQIYERVWAGEDPPSSNVLAAQVRLLRRRLRLPGSPELIHAVYGKGYRFGPVAEDPQQPPTPL
SPWERG

Sequences:

>Translated_246_residues
MARILLVDDEVELADSLAQHLRREGHSVDVAYEGNSAWELLQKPPAPPYDLLVLDWMLPGLSGLSLCQQVRQVDRATPIL
FLTAKDTLDDRVEGLDAGADDYLVKPFELRELLARVRALLRRAAGPGEGIPRLQIGDLELDRENQVAYRQGRMIHLSQKE
FRLLEYFMAHPGQLLTHEQIYERVWAGEDPPSSNVLAAQVRLLRRRLRLPGSPELIHAVYGKGYRFGPVAEDPQQPPTPL
SPWERG
>Mature_245_residues
ARILLVDDEVELADSLAQHLRREGHSVDVAYEGNSAWELLQKPPAPPYDLLVLDWMLPGLSGLSLCQQVRQVDRATPILF
LTAKDTLDDRVEGLDAGADDYLVKPFELRELLARVRALLRRAAGPGEGIPRLQIGDLELDRENQVAYRQGRMIHLSQKEF
RLLEYFMAHPGQLLTHEQIYERVWAGEDPPSSNVLAAQVRLLRRRLRLPGSPELIHAVYGKGYRFGPVAEDPQQPPTPLS
PWERG

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a tr

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=222, Percent_Identity=39.1891891891892, Blast_Score=152, Evalue=2e-38,
Organism=Escherichia coli, GI1789402, Length=225, Percent_Identity=37.7777777777778, Blast_Score=141, Evalue=5e-35,
Organism=Escherichia coli, GI87082012, Length=229, Percent_Identity=35.3711790393013, Blast_Score=136, Evalue=1e-33,
Organism=Escherichia coli, GI1790552, Length=222, Percent_Identity=37.3873873873874, Blast_Score=128, Evalue=3e-31,
Organism=Escherichia coli, GI1786599, Length=227, Percent_Identity=33.4801762114537, Blast_Score=128, Evalue=3e-31,
Organism=Escherichia coli, GI1789809, Length=232, Percent_Identity=34.4827586206897, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1788394, Length=229, Percent_Identity=35.3711790393013, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1790860, Length=223, Percent_Identity=35.4260089686099, Blast_Score=121, Evalue=4e-29,
Organism=Escherichia coli, GI2367329, Length=232, Percent_Identity=35.7758620689655, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1790863, Length=237, Percent_Identity=29.957805907173, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1786911, Length=227, Percent_Identity=33.0396475770925, Blast_Score=111, Evalue=5e-26,
Organism=Escherichia coli, GI1787375, Length=225, Percent_Identity=30.6666666666667, Blast_Score=105, Evalue=2e-24,
Organism=Escherichia coli, GI1787229, Length=229, Percent_Identity=32.7510917030568, Blast_Score=98, Evalue=4e-22,
Organism=Escherichia coli, GI145693140, Length=242, Percent_Identity=28.9256198347107, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1790437, Length=117, Percent_Identity=30.7692307692308, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1788550, Length=112, Percent_Identity=31.25, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27820; Mature: 27689

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARILLVDDEVELADSLAQHLRREGHSVDVAYEGNSAWELLQKPPAPPYDLLVLDWMLPG
CCEEEEECCHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHCC
LSGLSLCQQVRQVDRATPILFLTAKDTLDDRVEGLDAGADDYLVKPFELRELLARVRALL
CCHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHCCCCCCCCEECCHHHHHHHHHHHHHH
RRAAGPGEGIPRLQIGDLELDRENQVAYRQGRMIHLSQKEFRLLEYFMAHPGQLLTHEQI
HHCCCCCCCCCCEEECCEEECCCCCHHHHCCCEEEECHHHHHHHHHHHHCCCCHHHHHHH
YERVWAGEDPPSSNVLAAQVRLLRRRLRLPGSPELIHAVYGKGYRFGPVAEDPQQPPTPL
HHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCEEECCCCCCCCCCCCCC
SPWERG
CCCCCC
>Mature Secondary Structure 
ARILLVDDEVELADSLAQHLRREGHSVDVAYEGNSAWELLQKPPAPPYDLLVLDWMLPG
CEEEEECCHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHHHCC
LSGLSLCQQVRQVDRATPILFLTAKDTLDDRVEGLDAGADDYLVKPFELRELLARVRALL
CCHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHCCCCCCCCEECCHHHHHHHHHHHHHH
RRAAGPGEGIPRLQIGDLELDRENQVAYRQGRMIHLSQKEFRLLEYFMAHPGQLLTHEQI
HHCCCCCCCCCCEEECCEEECCCCCHHHHCCCEEEECHHHHHHHHHHHHCCCCHHHHHHH
YERVWAGEDPPSSNVLAAQVRLLRRRLRLPGSPELIHAVYGKGYRFGPVAEDPQQPPTPL
HHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCCEEECCCCCCCCCCCCCC
SPWERG
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA