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The map label for this gene is hemE

Identifier: 86605095

GI number: 86605095

Start: 392445

End: 393533

Strand: Reverse

Name: hemE

Synonym: CYA_0376

Alternate gene names: 86605095

Gene position: 393533-392445 (Counterclockwise)

Preceding gene: 86605100

Following gene: 86605094

Centisome position: 13.42

GC content: 62.17

Gene sequence:

>1089_bases
ATGTCCCACTCACCTGCTCAGCTCAGCGCTTCTCCTTCCTCCGTCGGCGATGGCGACCGTCTGCTGCGGGCGGCCCGCGG
GGAAGTGGTAGATCGTCCCCCCGTTTGGATGATGCGCCAGGCGGGTCGCTACATGGCGGCCTACCGCGAGCTGCAGAGCA
AATACACCTTCAAGCAGCGCTGCGAGATCCCGGAGCTGGCGATTGAGATCTCGCTGCAGCCGTTTCGCGCCTTTGCCCCC
GACGGCGTCATTATGTTCAGCGACATCCTCACCCCCCTCGAGGGCATGGGGATCCCCTTTGAGTTGGTGGAGCAGCAGGG
GCCGATCATCGACCCGCCGATCCGCTCCCAGGCCCAAGTTGAGCAAATCCGACTGCTAGAGCCGGAAGAAAGCCTGCCCT
TTATCAAGACCATCCTCAGCACTCTGCGCCGCGAGGTGGAAGGGAAGGCGACGCTGCTGGGCTTTGTCGGCTCCCCTTGG
ACCTTGGCCTGCTACGCCGTGGAGGGCCGCAGCTCCAAAGATTATGCCCATATCAAGAGCCTGGCCTTCACTCAGCCGCA
GGTGTTGCATCAGTTGCTGAGTAAGCTGGCGGATAGCATTGCCCGCTACGTGATCTACCAGATCGAGTGCGGCGCCCAGG
TGGTGCAGCTCTTCGACACCTGGGCCGGCCAGCTCAGCCCCGGCGACTACGAAACCTGGGCCTTGCCCTACCAAAAGCAA
ATTGTGGATCAGGTGAAAGCTCGGTGCCCGCAGGTGCCGCTCATTCTCTACATCAACGGCAGCGCTGCTTTGTTGGAGCG
GGTGGGCAAAGCTGGCATCGATGTGTTCAGCCTCGATTGGATGAGCGATATGGCCGAGGCCAGGGCCCGCCTGGGATCCC
TGGCGGTGCAGGGCAATCTCGACCCGATGGTGTTGCTGGGATCCCCGAAATTCATCCGGCAGCGCACCCTGGAGGTGATT
CAAAAGGCGGGATCTCGCGGCCACATCATGAACCTGGGCCACGGCGTGCACCACACCACTCCGGAGGCCAATGTCCATCA
CTTTTTCGAGACGGTGCGCCAGGCGGCAGAGCTGCTCAAAGCTCTCTAG

Upstream 100 bases:

>100_bases
ACCCCTAAGGAAAGGGTCAAGAGGAAGGGCCGCGAGCTTGCGCTAGCCGTCCCCCCAATGTCAGGATGCATTGAGGATCT
TGAACCGGCTTGGTCTTCCC

Downstream 100 bases:

>100_bases
CCGTATGGAAAAACCCCTTGACTTTAGGGGTAGGGTTTGCCTTACGAGCCAGGGATCCCCGGTGTACATCAGCGTCATCA
TCCCCACCTACAACCGCCGT

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D

Number of amino acids: Translated: 362; Mature: 361

Protein sequence:

>362_residues
MSHSPAQLSASPSSVGDGDRLLRAARGEVVDRPPVWMMRQAGRYMAAYRELQSKYTFKQRCEIPELAIEISLQPFRAFAP
DGVIMFSDILTPLEGMGIPFELVEQQGPIIDPPIRSQAQVEQIRLLEPEESLPFIKTILSTLRREVEGKATLLGFVGSPW
TLACYAVEGRSSKDYAHIKSLAFTQPQVLHQLLSKLADSIARYVIYQIECGAQVVQLFDTWAGQLSPGDYETWALPYQKQ
IVDQVKARCPQVPLILYINGSAALLERVGKAGIDVFSLDWMSDMAEARARLGSLAVQGNLDPMVLLGSPKFIRQRTLEVI
QKAGSRGHIMNLGHGVHHTTPEANVHHFFETVRQAAELLKAL

Sequences:

>Translated_362_residues
MSHSPAQLSASPSSVGDGDRLLRAARGEVVDRPPVWMMRQAGRYMAAYRELQSKYTFKQRCEIPELAIEISLQPFRAFAP
DGVIMFSDILTPLEGMGIPFELVEQQGPIIDPPIRSQAQVEQIRLLEPEESLPFIKTILSTLRREVEGKATLLGFVGSPW
TLACYAVEGRSSKDYAHIKSLAFTQPQVLHQLLSKLADSIARYVIYQIECGAQVVQLFDTWAGQLSPGDYETWALPYQKQ
IVDQVKARCPQVPLILYINGSAALLERVGKAGIDVFSLDWMSDMAEARARLGSLAVQGNLDPMVLLGSPKFIRQRTLEVI
QKAGSRGHIMNLGHGVHHTTPEANVHHFFETVRQAAELLKAL
>Mature_361_residues
SHSPAQLSASPSSVGDGDRLLRAARGEVVDRPPVWMMRQAGRYMAAYRELQSKYTFKQRCEIPELAIEISLQPFRAFAPD
GVIMFSDILTPLEGMGIPFELVEQQGPIIDPPIRSQAQVEQIRLLEPEESLPFIKTILSTLRREVEGKATLLGFVGSPWT
LACYAVEGRSSKDYAHIKSLAFTQPQVLHQLLSKLADSIARYVIYQIECGAQVVQLFDTWAGQLSPGDYETWALPYQKQI
VDQVKARCPQVPLILYINGSAALLERVGKAGIDVFSLDWMSDMAEARARLGSLAVQGNLDPMVLLGSPKFIRQRTLEVIQ
KAGSRGHIMNLGHGVHHTTPEANVHHFFETVRQAAELLKAL

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family

Homologues:

Organism=Homo sapiens, GI71051616, Length=352, Percent_Identity=36.9318181818182, Blast_Score=234, Evalue=9e-62,
Organism=Escherichia coli, GI2367337, Length=344, Percent_Identity=40.9883720930233, Blast_Score=275, Evalue=3e-75,
Organism=Saccharomyces cerevisiae, GI6320252, Length=346, Percent_Identity=35.2601156069364, Blast_Score=228, Evalue=2e-60,
Organism=Drosophila melanogaster, GI19921920, Length=356, Percent_Identity=37.9213483146067, Blast_Score=247, Evalue=8e-66,
Organism=Drosophila melanogaster, GI221330099, Length=353, Percent_Identity=37.9603399433428, Blast_Score=245, Evalue=3e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCUP_SYNJA (Q2JX97)

Other databases:

- EMBL:   CP000239
- RefSeq:   YP_473858.1
- ProteinModelPortal:   Q2JX97
- SMR:   Q2JX97
- STRING:   Q2JX97
- GeneID:   3897948
- GenomeReviews:   CP000239_GR
- KEGG:   cya:CYA_0376
- TIGR:   CYA_0376
- eggNOG:   COG0407
- HOGENOM:   HBG628392
- OMA:   AVQLFDS
- ProtClustDB:   PRK00115
- BioCyc:   SSP321327:CYA_0376-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00218
- InterPro:   IPR006361
- InterPro:   IPR000257
- PANTHER:   PTHR21091:SF2
- TIGRFAMs:   TIGR01464

Pfam domain/function: PF01208 URO-D

EC number: =4.1.1.37

Molecular weight: Translated: 40243; Mature: 40112

Theoretical pI: Translated: 7.01; Mature: 7.01

Prosite motif: PS00906 UROD_1; PS00907 UROD_2

Important sites: BINDING 88-88 BINDING 165-165 BINDING 220-220 BINDING 334-334

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHSPAQLSASPSSVGDGDRLLRAARGEVVDRPPVWMMRQAGRYMAAYRELQSKYTFKQR
CCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHH
CEIPELAIEISLQPFRAFAPDGVIMFSDILTPLEGMGIPFELVEQQGPIIDPPIRSQAQV
CCCCCEEEEEEECHHHHCCCCCEEHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCHHHH
EQIRLLEPEESLPFIKTILSTLRREVEGKATLLGFVGSPWTLACYAVEGRSSKDYAHIKS
HHHHCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEEEECCCCCCHHHHHHH
LAFTQPQVLHQLLSKLADSIARYVIYQIECGAQVVQLFDTWAGQLSPGDYETWALPYQKQ
HHCCCHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHCCCCCCCCCCEECCCHHHH
IVDQVKARCPQVPLILYINGSAALLERVGKAGIDVFSLDWMSDMAEARARLGSLAVQGNL
HHHHHHHHCCCCCEEEEECCCHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHCEEEECCC
DPMVLLGSPKFIRQRTLEVIQKAGSRGHIMNLGHGVHHTTPEANVHHFFETVRQAAELLK
CCEEEECCCHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHH
AL
CC
>Mature Secondary Structure 
SHSPAQLSASPSSVGDGDRLLRAARGEVVDRPPVWMMRQAGRYMAAYRELQSKYTFKQR
CCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHH
CEIPELAIEISLQPFRAFAPDGVIMFSDILTPLEGMGIPFELVEQQGPIIDPPIRSQAQV
CCCCCEEEEEEECHHHHCCCCCEEHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCHHHH
EQIRLLEPEESLPFIKTILSTLRREVEGKATLLGFVGSPWTLACYAVEGRSSKDYAHIKS
HHHHCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCEEEEEEECCCCCCHHHHHHH
LAFTQPQVLHQLLSKLADSIARYVIYQIECGAQVVQLFDTWAGQLSPGDYETWALPYQKQ
HHCCCHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHCCCCCCCCCCEECCCHHHH
IVDQVKARCPQVPLILYINGSAALLERVGKAGIDVFSLDWMSDMAEARARLGSLAVQGNL
HHHHHHHHCCCCCEEEEECCCHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHCEEEECCC
DPMVLLGSPKFIRQRTLEVIQKAGSRGHIMNLGHGVHHTTPEANVHHFFETVRQAAELLK
CCEEEECCCHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHH
AL
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA