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The map label for this gene is hemC

Identifier: 86604967

GI number: 86604967

Start: 246676

End: 247608

Strand: Reverse

Name: hemC

Synonym: CYA_0243

Alternate gene names: 86604967

Gene position: 247608-246676 (Counterclockwise)

Preceding gene: 86604977

Following gene: 86604957

Centisome position: 8.44

GC content: 63.02

Gene sequence:

>933_bases
GTGCGGATCGCCTCCCGCAAAAGTGAGCTGGCCTTGGCCCAGACCTACTGGGTAATGGGACAGTTGCAGGCCCACCATCC
AGGATTGCCGCTAGAGCTGCACACCCTTTCCACCCAGGGAGACATCATCCTGGATGTGGCGCTGGCCAAAATTGGCGATA
AGGGCCTGTTTACCAAGGAGCTGGAGGTCAGCCTGCTCAACGGCAGCAGCGATCTAGCGGTGCACAGCCTTAAGGATCTG
CCCACCCGTTTGCCGGAAGGCCTGGTCCTGGGGGCGATTACGCAGAGGGAGGATCCTTTGGACGCGCTGGTGCTGCGGGA
AGAGCTGCGCGGCTACCAACTGGCCACCCTGCCAGCAGGAACGGTGATCGGCACTTCATCTTTGCGGCGATTGGCCCAAC
TGCGCCACGCCTTTCCCCACCTGCAATTTAAGAATGTGCGGGGCAACCTCAACACTCGCTTGGCCAAGCTGGATCGGGGG
GAGTACGACGGCCTAATTTTGGCGGTGGCGGGGCTGAAGCGCCTGGGCCAAGAACAGCGGATCCACGAGGTGCTGGATCC
CAGTGTGTCTCTGTACGCGGTTGGCCAGGGATCCCTGGGGATCGAGTGCCGGCAGGGGGATGAGCGGATTCTGGAGCTCA
TCCGACCCTTAGCCGATGCGGAGGCCACAGCCCGCTGTTTGGCCGAGCGAGCTTTCCTGCGGGCCTTGGAGGGGGGGTGT
CAGGTGCCCATCGGCGTCCACAGCCAAGTCCAGGGGGAAGAGCTGCACCTGACCGGCATGGTGGCCGACCTGGAGGGGCG
ACAGCTCATCCGCGATACCCAGACGGGATCCACCGCCGATCCCGAGGCAGTGGGGATGGCTCTTGCAGAAAAGCTAAAAC
GGCAGGGGGCCGACGAGATTTTGCAGGCCATTTTTGCCCAGGCCCGCCGTTAG

Upstream 100 bases:

>100_bases
AAGTCAGTTAGCGTGAAAGACGGTGTTCTCGGATTTTGCAGCAGCCATGAGCGAACTGGCCTCAACTCCCTGGCAACCCT
CGGCAGGGGCTGCCCAGCCG

Downstream 100 bases:

>100_bases
GCTTTTCCACCCTTTCTGAGTAAGCTTTGAGGTCTGCAGCCAGGGGGAGTTGAAGAAAAGGGGGGCACGGAAGTCCCCCC
TAAGGCAAATTTCACTCAAC

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MRIASRKSELALAQTYWVMGQLQAHHPGLPLELHTLSTQGDIILDVALAKIGDKGLFTKELEVSLLNGSSDLAVHSLKDL
PTRLPEGLVLGAITQREDPLDALVLREELRGYQLATLPAGTVIGTSSLRRLAQLRHAFPHLQFKNVRGNLNTRLAKLDRG
EYDGLILAVAGLKRLGQEQRIHEVLDPSVSLYAVGQGSLGIECRQGDERILELIRPLADAEATARCLAERAFLRALEGGC
QVPIGVHSQVQGEELHLTGMVADLEGRQLIRDTQTGSTADPEAVGMALAEKLKRQGADEILQAIFAQARR

Sequences:

>Translated_310_residues
MRIASRKSELALAQTYWVMGQLQAHHPGLPLELHTLSTQGDIILDVALAKIGDKGLFTKELEVSLLNGSSDLAVHSLKDL
PTRLPEGLVLGAITQREDPLDALVLREELRGYQLATLPAGTVIGTSSLRRLAQLRHAFPHLQFKNVRGNLNTRLAKLDRG
EYDGLILAVAGLKRLGQEQRIHEVLDPSVSLYAVGQGSLGIECRQGDERILELIRPLADAEATARCLAERAFLRALEGGC
QVPIGVHSQVQGEELHLTGMVADLEGRQLIRDTQTGSTADPEAVGMALAEKLKRQGADEILQAIFAQARR
>Mature_310_residues
MRIASRKSELALAQTYWVMGQLQAHHPGLPLELHTLSTQGDIILDVALAKIGDKGLFTKELEVSLLNGSSDLAVHSLKDL
PTRLPEGLVLGAITQREDPLDALVLREELRGYQLATLPAGTVIGTSSLRRLAQLRHAFPHLQFKNVRGNLNTRLAKLDRG
EYDGLILAVAGLKRLGQEQRIHEVLDPSVSLYAVGQGSLGIECRQGDERILELIRPLADAEATARCLAERAFLRALEGGC
QVPIGVHSQVQGEELHLTGMVADLEGRQLIRDTQTGSTADPEAVGMALAEKLKRQGADEILQAIFAQARR

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI20149500, Length=298, Percent_Identity=51.006711409396, Blast_Score=293, Evalue=2e-79,
Organism=Homo sapiens, GI66933009, Length=299, Percent_Identity=50.8361204013378, Blast_Score=292, Evalue=2e-79,
Organism=Escherichia coli, GI48994974, Length=305, Percent_Identity=51.4754098360656, Blast_Score=291, Evalue=5e-80,
Organism=Saccharomyces cerevisiae, GI6319996, Length=316, Percent_Identity=43.9873417721519, Blast_Score=239, Evalue=5e-64,
Organism=Drosophila melanogaster, GI20130425, Length=283, Percent_Identity=52.6501766784452, Blast_Score=290, Evalue=6e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 33749; Mature: 33749

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIASRKSELALAQTYWVMGQLQAHHPGLPLELHTLSTQGDIILDVALAKIGDKGLFTKE
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEEEHHHHHHCCCCCEEHE
LEVSLLNGSSDLAVHSLKDLPTRLPEGLVLGAITQREDPLDALVLREELRGYQLATLPAG
EEEEEECCCCCHHHHHHHHHHHHCCCCEEEEEHHCCCCCHHHHHHHHHHCCCEEEECCCC
TVIGTSSLRRLAQLRHAFPHLQFKNVRGNLNTRLAKLDRGEYDGLILAVAGLKRLGQEQR
CEECHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHCHHHH
IHEVLDPSVSLYAVGQGSLGIECRQGDERILELIRPLADAEATARCLAERAFLRALEGGC
HHHHHCCCCEEEEECCCCCCEEECCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCC
QVPIGVHSQVQGEELHLTGMVADLEGRQLIRDTQTGSTADPEAVGMALAEKLKRQGADEI
CCCCCCCCCCCCCEEEEEEEEECCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCHHHH
LQAIFAQARR
HHHHHHHHCC
>Mature Secondary Structure
MRIASRKSELALAQTYWVMGQLQAHHPGLPLELHTLSTQGDIILDVALAKIGDKGLFTKE
CCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCEEEEHHHHHHCCCCCEEHE
LEVSLLNGSSDLAVHSLKDLPTRLPEGLVLGAITQREDPLDALVLREELRGYQLATLPAG
EEEEEECCCCCHHHHHHHHHHHHCCCCEEEEEHHCCCCCHHHHHHHHHHCCCEEEECCCC
TVIGTSSLRRLAQLRHAFPHLQFKNVRGNLNTRLAKLDRGEYDGLILAVAGLKRLGQEQR
CEECHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHCHHHH
IHEVLDPSVSLYAVGQGSLGIECRQGDERILELIRPLADAEATARCLAERAFLRALEGGC
HHHHHCCCCEEEEECCCCCCEEECCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCC
QVPIGVHSQVQGEELHLTGMVADLEGRQLIRDTQTGSTADPEAVGMALAEKLKRQGADEI
CCCCCCCCCCCCCEEEEEEEEECCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCHHHH
LQAIFAQARR
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]