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The map label for this gene is mutM

Identifier: 86604927

GI number: 86604927

Start: 208311

End: 209162

Strand: Reverse

Name: mutM

Synonym: CYA_0203

Alternate gene names: 86604927

Gene position: 209162-208311 (Counterclockwise)

Preceding gene: 86604928

Following gene: 86604926

Centisome position: 7.13

GC content: 65.85

Gene sequence:

>852_bases
GTGCCCGAGCTGCCGGAAGTTGAAACCGTCAGGCGGGATCTGCAGCGCCTCACCCTGGGTCTGTGCATCCTGTCGGTGGA
GGTGCTTCTCCCTCGCACCGTGGCCTACCCCGGCAAAGACGAGTTTGCGCAGGGGCTGGCAGGCAGCTGTTTGACCCAGT
GGCAGCGGCGAGGCAAATATCTTCTGGGATCCCTGGACTCTGGAGCGGTTCTGGGCGTGCATCTGCGCATGACCGGGCAA
CTGCTCTGGGTTCAGGGATCCGCGCCTTTGCCGATCCACACTCGCGTCCGGCTGCATTTGGAGCAGGGGTGGGAGCTGCG
CTTTGTTGATCTGCGCACCTTTGGCCAGATGTGGCTGGTGCCCGCCGGGGTGGAGCCGGAGACGGTGATCCCTGCCCTGC
AGAGCTTGGGGCCGGAGCCGCTTTCGCCGGCCTTTTCCGAGGCCTATTTCCAAGCTGCCTTGCAGAAGAGCCGCCGCCCC
ATCAAAGCCGCCTTGCTGGATCAGTCGCTGGTGGCGGGGGTGGGCAACATCTACGCCGACGAGGCCCTGTTTCTGAGCGG
CATCCACCCCTCAACACCCGCCGCGCAGCTTTCCGACGCTGCCAAGAGCCGCCTGCGAGAAAGCCTGATCCAGGTGTTAC
GGGCCGGGCTGGAGCAGCGGGGCACCACCCTGCGGGATTACCGGGATCTGCGTGGGCTCAACGGCAACTACCAGGGGCAG
GCGTGGGTGTACGGTCGAGAAGGGGATCCCTGTCGCCTCTGTGGCACCCCCATTCAGCGGAGTAAGCTCTCGGGCCGCTC
GGCCCACTTTTGCCCCCGCTGCCAGCCGCCTCCAGGCCGGGTTGAGACTTGA

Upstream 100 bases:

>100_bases
AGATGAGCTGGAAGTGGTGGAGGAGCCCAAGCCCAAAGCCAAAGCTTCCAGCTAAGGCTGCCCCTGCCAACTCAACCAAG
CTCTTTGGCTTCCTCTTCCT

Downstream 100 bases:

>100_bases
TGGCGTATCTCCCGCCAACGGCTATAGTTCTAGGTTGATCTCCAGCTCCCCTCTCCCTCTGGGAGAGGGGCCGGGGGTGA
GGGTCAGCCAGGAGGGATCC

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM [H]

Number of amino acids: Translated: 283; Mature: 282

Protein sequence:

>283_residues
MPELPEVETVRRDLQRLTLGLCILSVEVLLPRTVAYPGKDEFAQGLAGSCLTQWQRRGKYLLGSLDSGAVLGVHLRMTGQ
LLWVQGSAPLPIHTRVRLHLEQGWELRFVDLRTFGQMWLVPAGVEPETVIPALQSLGPEPLSPAFSEAYFQAALQKSRRP
IKAALLDQSLVAGVGNIYADEALFLSGIHPSTPAAQLSDAAKSRLRESLIQVLRAGLEQRGTTLRDYRDLRGLNGNYQGQ
AWVYGREGDPCRLCGTPIQRSKLSGRSAHFCPRCQPPPGRVET

Sequences:

>Translated_283_residues
MPELPEVETVRRDLQRLTLGLCILSVEVLLPRTVAYPGKDEFAQGLAGSCLTQWQRRGKYLLGSLDSGAVLGVHLRMTGQ
LLWVQGSAPLPIHTRVRLHLEQGWELRFVDLRTFGQMWLVPAGVEPETVIPALQSLGPEPLSPAFSEAYFQAALQKSRRP
IKAALLDQSLVAGVGNIYADEALFLSGIHPSTPAAQLSDAAKSRLRESLIQVLRAGLEQRGTTLRDYRDLRGLNGNYQGQ
AWVYGREGDPCRLCGTPIQRSKLSGRSAHFCPRCQPPPGRVET
>Mature_282_residues
PELPEVETVRRDLQRLTLGLCILSVEVLLPRTVAYPGKDEFAQGLAGSCLTQWQRRGKYLLGSLDSGAVLGVHLRMTGQL
LWVQGSAPLPIHTRVRLHLEQGWELRFVDLRTFGQMWLVPAGVEPETVIPALQSLGPEPLSPAFSEAYFQAALQKSRRPI
KAALLDQSLVAGVGNIYADEALFLSGIHPSTPAAQLSDAAKSRLRESLIQVLRAGLEQRGTTLRDYRDLRGLNGNYQGQA
WVYGREGDPCRLCGTPIQRSKLSGRSAHFCPRCQPPPGRVET

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger [H]

Homologues:

Organism=Escherichia coli, GI1790066, Length=275, Percent_Identity=41.0909090909091, Blast_Score=174, Evalue=4e-45,
Organism=Escherichia coli, GI1786932, Length=286, Percent_Identity=28.3216783216783, Blast_Score=86, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663 [H]

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS [H]

EC number: =3.2.2.23; =4.2.99.18 [H]

Molecular weight: Translated: 31182; Mature: 31051

Theoretical pI: Translated: 9.03; Mature: 9.03

Prosite motif: PS01242 ZF_FPG_1 ; PS51066 ZF_FPG_2 ; PS51068 FPG_CAT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVETVRRDLQRLTLGLCILSVEVLLPRTVAYPGKDEFAQGLAGSCLTQWQRRGKY
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCE
LLGSLDSGAVLGVHLRMTGQLLWVQGSAPLPIHTRVRLHLEQGWELRFVDLRTFGQMWLV
EEECCCCCCEEEEEEEEECEEEEEECCCCCCEEEEEEEEECCCCEEEEEEHHHCCCEEEE
PAGVEPETVIPALQSLGPEPLSPAFSEAYFQAALQKSRRPIKAALLDQSLVAGVGNIYAD
ECCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHC
EALFLSGIHPSTPAAQLSDAAKSRLRESLIQVLRAGLEQRGTTLRDYRDLRGLNGNYQGQ
CHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCC
AWVYGREGDPCRLCGTPIQRSKLSGRSAHFCPRCQPPPGRVET
EEEECCCCCCCEECCCCHHHHHCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PELPEVETVRRDLQRLTLGLCILSVEVLLPRTVAYPGKDEFAQGLAGSCLTQWQRRGKY
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCE
LLGSLDSGAVLGVHLRMTGQLLWVQGSAPLPIHTRVRLHLEQGWELRFVDLRTFGQMWLV
EEECCCCCCEEEEEEEEECEEEEEECCCCCCEEEEEEEEECCCCEEEEEEHHHCCCEEEE
PAGVEPETVIPALQSLGPEPLSPAFSEAYFQAALQKSRRPIKAALLDQSLVAGVGNIYAD
ECCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHC
EALFLSGIHPSTPAAQLSDAAKSRLRESLIQVLRAGLEQRGTTLRDYRDLRGLNGNYQGQ
CHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCC
AWVYGREGDPCRLCGTPIQRSKLSGRSAHFCPRCQPPPGRVET
EEEECCCCCCCEECCCCHHHHHCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA