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The map label for this gene is moeA

Identifier: 86604901

GI number: 86604901

Start: 169880

End: 171043

Strand: Reverse

Name: moeA

Synonym: CYA_0173

Alternate gene names: 86604901

Gene position: 171043-169880 (Counterclockwise)

Preceding gene: 86604902

Following gene: 86604900

Centisome position: 5.83

GC content: 54.9

Gene sequence:

>1164_bases
ATGGTCACTGTCCAGGAAGCTGAAGCCATTATTAAAGACCACTGGCTGCCAGCCAAAACCGAGTCGATCCCGATTGCAAG
CTGTGTGGGCCGGGTTTTGGCAGAGCCGATCTACGCCGATCGGGACTACCCGCCAATTAACCGGGTCCTGATGGACGGTA
TCGCCATCAACTATGCCGCTTATGCTGCTGGGCAGCGAAGCTTTGCTGTTGCAGGCATAGCCCCTGCGGGGACAAGCCCT
GCCACCCTGCCCGATCCGCAGCAGTGCTTGGAAGTGATGACTGGCTGTGCCCTGCCGCTGGGTAGTGATCTCGTCATTCC
CTACGAGCAAATTCGTATCGAGGGAGGAATTGCCACCATCACCCAGGAAGTCGAACGCAACAGGGGTGATTTTGTTCATC
CCCAAGGTAGCGATTGTTCTGCAGGAGCGCTGGTTCTCCGCCCCGGCATTACCCTCAAGAGCATCCACGTCGGGATCTTG
GCCTCCTTTGGCTACAGCCGCATCCAAGTTGAGAGGACTCCTCGCATCAAAGTTGTGGCAACTGGCAGCGAATTGATTCC
CATTGAGCAGACCCCTGCACCCTACCAACTGCGGCGCTCCAACGCTGAGGCCCTCCGAGCGGCTCTTCTTGCCTACGGGT
ATACCGAGGTTGAGACCGATCACCTTCCGGACGATCCTGCTGCCATTGCCACCCACTACCAAGCCAATACCCCAAACTAC
GACCTCTTGATTTACTCTGGGGGTGTTTCAAGGGGAAAGTGTGACTACTTGCCGGCCATCTGGCAAAGCTGTGGTGTTAC
TGCCTACATCCACGGCGTGGCGCAAAAGCCAGGCAAGCCAATGTGGTTTGGCATCGACCATCAGGCCAATACTATAGTTT
GGGGCCTCCCAGGCAACCCCATCTCAGCTCTTGTATGTTTGCATCGTTATCTCCTCAACCGTAACACTGACTCTGGGCAC
CTAAGTGAAGTCATTACCTTCAAACCCAATCTCACTCTTTTTGTGCCCGTTAAGATGAGCGCCAACCGAGTCTTTACACC
GATTATGCCTAACAACTCCGGAGACTTCATCGCTCTAACAGACAGCGATGGCTTTGTAGAGTTACCCCCGGCTCAAACTA
TCCTCAGCCCCGAGCAAAGCATCCAATTCTATCCGTGGTACTAA

Upstream 100 bases:

>100_bases
ACCCCGTTGCAGCGCTTTGCCCTCATTAAGCTCAGTCGCCCTGGCCACGAAAACCGCAATTTCCTACCCGCCTTTCAGGA
ATTTTCCGCACCCCACACCT

Downstream 100 bases:

>100_bases
GATGCAGCTAGTGGATCAATGGAATCGTCGCATTCGCAAGCTAAGGGTTTCTCTAACCGATCAATGCAACCTTCGCTGCC
GCTACTGCATGCCTTTGCAT

Product: molybdopterin biosynthesis protein MoeA

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MVTVQEAEAIIKDHWLPAKTESIPIASCVGRVLAEPIYADRDYPPINRVLMDGIAINYAAYAAGQRSFAVAGIAPAGTSP
ATLPDPQQCLEVMTGCALPLGSDLVIPYEQIRIEGGIATITQEVERNRGDFVHPQGSDCSAGALVLRPGITLKSIHVGIL
ASFGYSRIQVERTPRIKVVATGSELIPIEQTPAPYQLRRSNAEALRAALLAYGYTEVETDHLPDDPAAIATHYQANTPNY
DLLIYSGGVSRGKCDYLPAIWQSCGVTAYIHGVAQKPGKPMWFGIDHQANTIVWGLPGNPISALVCLHRYLLNRNTDSGH
LSEVITFKPNLTLFVPVKMSANRVFTPIMPNNSGDFIALTDSDGFVELPPAQTILSPEQSIQFYPWY

Sequences:

>Translated_387_residues
MVTVQEAEAIIKDHWLPAKTESIPIASCVGRVLAEPIYADRDYPPINRVLMDGIAINYAAYAAGQRSFAVAGIAPAGTSP
ATLPDPQQCLEVMTGCALPLGSDLVIPYEQIRIEGGIATITQEVERNRGDFVHPQGSDCSAGALVLRPGITLKSIHVGIL
ASFGYSRIQVERTPRIKVVATGSELIPIEQTPAPYQLRRSNAEALRAALLAYGYTEVETDHLPDDPAAIATHYQANTPNY
DLLIYSGGVSRGKCDYLPAIWQSCGVTAYIHGVAQKPGKPMWFGIDHQANTIVWGLPGNPISALVCLHRYLLNRNTDSGH
LSEVITFKPNLTLFVPVKMSANRVFTPIMPNNSGDFIALTDSDGFVELPPAQTILSPEQSIQFYPWY
>Mature_387_residues
MVTVQEAEAIIKDHWLPAKTESIPIASCVGRVLAEPIYADRDYPPINRVLMDGIAINYAAYAAGQRSFAVAGIAPAGTSP
ATLPDPQQCLEVMTGCALPLGSDLVIPYEQIRIEGGIATITQEVERNRGDFVHPQGSDCSAGALVLRPGITLKSIHVGIL
ASFGYSRIQVERTPRIKVVATGSELIPIEQTPAPYQLRRSNAEALRAALLAYGYTEVETDHLPDDPAAIATHYQANTPNY
DLLIYSGGVSRGKCDYLPAIWQSCGVTAYIHGVAQKPGKPMWFGIDHQANTIVWGLPGNPISALVCLHRYLLNRNTDSGH
LSEVITFKPNLTLFVPVKMSANRVFTPIMPNNSGDFIALTDSDGFVELPPAQTILSPEQSIQFYPWY

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=304, Percent_Identity=31.9078947368421, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI66932975, Length=304, Percent_Identity=31.9078947368421, Blast_Score=132, Evalue=6e-31,
Organism=Escherichia coli, GI1787049, Length=314, Percent_Identity=32.484076433121, Blast_Score=136, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI25147659, Length=370, Percent_Identity=26.4864864864865, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17562606, Length=182, Percent_Identity=25.2747252747253, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17136978, Length=319, Percent_Identity=28.8401253918495, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24638841, Length=319, Percent_Identity=28.8401253918495, Blast_Score=108, Evalue=5e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 42038; Mature: 42038

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTVQEAEAIIKDHWLPAKTESIPIASCVGRVLAEPIYADRDYPPINRVLMDGIAINYAA
CCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCHHHCCCCCCCHHHHHHHHHHEEEHH
YAAGQRSFAVAGIAPAGTSPATLPDPQQCLEVMTGCALPLGSDLVIPYEQIRIEGGIATI
HHCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCCCCCEEECHHHEEEECCHHHH
TQEVERNRGDFVHPQGSDCSAGALVLRPGITLKSIHVGILASFGYSRIQVERTPRIKVVA
HHHHHHCCCCCCCCCCCCCCCCEEEEECCCEEEHEEEEHHHHCCCEEEEEECCCEEEEEE
TGSELIPIEQTPAPYQLRRSNAEALRAALLAYGYTEVETDHLPDDPAAIATHYQANTPNY
CCCEEEECCCCCCCHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHEEEEEECCCCCE
DLLIYSGGVSRGKCDYLPAIWQSCGVTAYIHGVAQKPGKPMWFGIDHQANTIVWGLPGNP
EEEEEECCCCCCCCCCHHHHHHHCCEEEEEEEHHCCCCCCEEEEECCCCCEEEEECCCCH
ISALVCLHRYLLNRNTDSGHLSEVITFKPNLTLFVPVKMSANRVFTPIMPNNSGDFIALT
HHHHHHHHHHHHCCCCCCCCCEEEEEECCCEEEEEEEEECCCEEEEEECCCCCCCEEEEE
DSDGFVELPPAQTILSPEQSIQFYPWY
CCCCEEECCCCHHHCCCCCCEEEECCC
>Mature Secondary Structure
MVTVQEAEAIIKDHWLPAKTESIPIASCVGRVLAEPIYADRDYPPINRVLMDGIAINYAA
CCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCHHHCCCCCCCHHHHHHHHHHEEEHH
YAAGQRSFAVAGIAPAGTSPATLPDPQQCLEVMTGCALPLGSDLVIPYEQIRIEGGIATI
HHCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCCCCCEEECHHHEEEECCHHHH
TQEVERNRGDFVHPQGSDCSAGALVLRPGITLKSIHVGILASFGYSRIQVERTPRIKVVA
HHHHHHCCCCCCCCCCCCCCCCEEEEECCCEEEHEEEEHHHHCCCEEEEEECCCEEEEEE
TGSELIPIEQTPAPYQLRRSNAEALRAALLAYGYTEVETDHLPDDPAAIATHYQANTPNY
CCCEEEECCCCCCCHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHEEEEEECCCCCE
DLLIYSGGVSRGKCDYLPAIWQSCGVTAYIHGVAQKPGKPMWFGIDHQANTIVWGLPGNP
EEEEEECCCCCCCCCCHHHHHHHCCEEEEEEEHHCCCCCCEEEEECCCCCEEEEECCCCH
ISALVCLHRYLLNRNTDSGHLSEVITFKPNLTLFVPVKMSANRVFTPIMPNNSGDFIALT
HHHHHHHHHHHHCCCCCCCCCEEEEEECCCEEEEEEEEECCCEEEEEECCCCCCCEEEEE
DSDGFVELPPAQTILSPEQSIQFYPWY
CCCCEEECCCCHHHCCCCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]