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The map label for this gene is ppiA [C]

Identifier: 86604844

GI number: 86604844

Start: 108623

End: 109369

Strand: Reverse

Name: ppiA [C]

Synonym: CYA_0114

Alternate gene names: 86604844

Gene position: 109369-108623 (Counterclockwise)

Preceding gene: 86604845

Following gene: 86604843

Centisome position: 3.73

GC content: 62.52

Gene sequence:

>747_bases
ATGCAATTTACCAAGCTGGGGCGAATGAGCCGCTGCAGAGTGGGGTTGGGCTTGGCTTTGGGGTACCTCTGTCTTGGTCT
GTTCGCTTGTCGCCGTGCGCTCCCCTCCTCTGGCTCTCCATCGGGGATCCCACCGGCCTACGCCCATCGCCCGCAACTGC
AGGGCAAGGCGCTGGTGGAGCTAGAGGTGCAAACTGCTGAGGGAGCGGGCAAGGTGATCTTGGAGATTCACGGGGAGGAG
GCGCCCCTCACGGCTGGCCAGTTTGTGGATTTGGTGCAGCGGGGCTTTTACAACGGTCTCACCTTCCATCGAGTGGAGAA
AGATCCCCAACCTTTTGTGGTGCAAGGAGGGGATCCGCGGGGAGATGGCACCGGTGGCGCTACCGAGCCGGGCAGCAACC
GCCTGCGCACCATCCCTTTGGAGATTCAGGTGCGTGGGGAGCCTCACCCCCGCTACAACACCTTGATTGAGGATCCCATC
GCCCTGAGCAAGCTGGCCTTGCCCCATCGCTTGGGCGCGGTGGCCATGGCCCGTTCTAGCCCGCTGGATTCGGCCTCTTC
CCAGTTTTACATCGCCCTCTCTGCTCTGCCGATCCTGGATGGGCGCTATGCGGTGTTCGGCTATGTCACCAGTGGCATGG
AGTGGGTGGAGCGCCTGCAGGTGGGGGATGTGATCCGCTCGGCGCGGGTGCTGGAAGGAGCGGACTTGCTGCAGGTTCCC
GGATCTCCAGATTCAACTGCAAACTAG

Upstream 100 bases:

>100_bases
GCAATTGGGGTTGTCGCAACGGCTCTAGATATCTCTCTTGACATCTGGAGAGGGATCCCTGTGGAAAGTTGGATCAAATC
GAAAAAGGGAGAAGGGGCAG

Downstream 100 bases:

>100_bases
GGACCTCGGCGGCTTATGATGGGCTGCAGCCAGGATTTGCTTGCTTGGCTGCTTTTTCCGCCTTCATTCTGGCCTTTTGC
CTGGGGAGAAGAGATTTTCG

Product: peptidyl-prolyl cis-trans isomerase, cyclophilin-type

Products: NA

Alternate protein names: PPIase sll0227; Rotamase sll0227 [H]

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MQFTKLGRMSRCRVGLGLALGYLCLGLFACRRALPSSGSPSGIPPAYAHRPQLQGKALVELEVQTAEGAGKVILEIHGEE
APLTAGQFVDLVQRGFYNGLTFHRVEKDPQPFVVQGGDPRGDGTGGATEPGSNRLRTIPLEIQVRGEPHPRYNTLIEDPI
ALSKLALPHRLGAVAMARSSPLDSASSQFYIALSALPILDGRYAVFGYVTSGMEWVERLQVGDVIRSARVLEGADLLQVP
GSPDSTAN

Sequences:

>Translated_248_residues
MQFTKLGRMSRCRVGLGLALGYLCLGLFACRRALPSSGSPSGIPPAYAHRPQLQGKALVELEVQTAEGAGKVILEIHGEE
APLTAGQFVDLVQRGFYNGLTFHRVEKDPQPFVVQGGDPRGDGTGGATEPGSNRLRTIPLEIQVRGEPHPRYNTLIEDPI
ALSKLALPHRLGAVAMARSSPLDSASSQFYIALSALPILDGRYAVFGYVTSGMEWVERLQVGDVIRSARVLEGADLLQVP
GSPDSTAN
>Mature_248_residues
MQFTKLGRMSRCRVGLGLALGYLCLGLFACRRALPSSGSPSGIPPAYAHRPQLQGKALVELEVQTAEGAGKVILEIHGEE
APLTAGQFVDLVQRGFYNGLTFHRVEKDPQPFVVQGGDPRGDGTGGATEPGSNRLRTIPLEIQVRGEPHPRYNTLIEDPI
ALSKLALPHRLGAVAMARSSPLDSASSQFYIALSALPILDGRYAVFGYVTSGMEWVERLQVGDVIRSARVLEGADLLQVP
GSPDSTAN

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI7706339, Length=169, Percent_Identity=31.9526627218935, Blast_Score=88, Evalue=8e-18,
Organism=Homo sapiens, GI4505991, Length=205, Percent_Identity=31.7073170731707, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI4758950, Length=175, Percent_Identity=34.2857142857143, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI64276486, Length=165, Percent_Identity=30.9090909090909, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1789763, Length=156, Percent_Identity=33.974358974359, Blast_Score=74, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17506311, Length=187, Percent_Identity=32.620320855615, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17539496, Length=150, Percent_Identity=32, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71997782, Length=169, Percent_Identity=30.1775147928994, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI21357249, Length=164, Percent_Identity=31.7073170731707, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 26542; Mature: 26542

Theoretical pI: Translated: 7.56; Mature: 7.56

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQFTKLGRMSRCRVGLGLALGYLCLGLFACRRALPSSGSPSGIPPAYAHRPQLQGKALVE
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEE
LEVQTAEGAGKVILEIHGEEAPLTAGQFVDLVQRGFYNGLTFHRVEKDPQPFVVQGGDPR
EEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCEEEEEECCCCCCEEEECCCCC
GDGTGGATEPGSNRLRTIPLEIQVRGEPHPRYNTLIEDPIALSKLALPHRLGAVAMARSS
CCCCCCCCCCCCCCEEEEEEEEEECCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHCCC
PLDSASSQFYIALSALPILDGRYAVFGYVTSGMEWVERLQVGDVIRSARVLEGADLLQVP
CCCCCCCEEEEEEEECEECCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECC
GSPDSTAN
CCCCCCCC
>Mature Secondary Structure
MQFTKLGRMSRCRVGLGLALGYLCLGLFACRRALPSSGSPSGIPPAYAHRPQLQGKALVE
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEE
LEVQTAEGAGKVILEIHGEEAPLTAGQFVDLVQRGFYNGLTFHRVEKDPQPFVVQGGDPR
EEEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCEEEEEECCCCCCEEEECCCCC
GDGTGGATEPGSNRLRTIPLEIQVRGEPHPRYNTLIEDPIALSKLALPHRLGAVAMARSS
CCCCCCCCCCCCCCEEEEEEEEEECCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHCCC
PLDSASSQFYIALSALPILDGRYAVFGYVTSGMEWVERLQVGDVIRSARVLEGADLLQVP
CCCCCCCEEEEEEEECEECCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECC
GSPDSTAN
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]