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The map label for this gene is htpG

Identifier: 86360854

GI number: 86360854

Start: 129436

End: 131328

Strand: Direct

Name: htpG

Synonym: RHE_PF00122

Alternate gene names: 86360854

Gene position: 129436-131328 (Clockwise)

Preceding gene: 86360851

Following gene: 86360855

Centisome position: 20.15

GC content: 58.27

Gene sequence:

>1893_bases
ATGACGACAACTGTCGAACAGACCGCTGAAAGCCACGTCTTTGAGGCCGATGTTGCCCGCCTTTTGCATATGATGGTCCA
CTCCGTTTATTCGGACAAGGGCGTTTTCCTGCGCGAATTGATCTCGAATGGCGCCGATGCCTGCGAGAAGCTGCGCTATG
AGGCGATCGAGACGCCTTCGCTACTGGCAGCCGATGCCGAGAGCCGCATCATGCTGCGGCTTGACGAAGAGAGCCGGCAG
CTTGTCGTGGAGGACAACGGCATCGGGATGCGGCGTGACGAGATGATTGAGGCGCTCGGCACGATTGCGAGGTCGGGGAC
GCGGGCGTTCATGGAGCGTATTGCAGAGAACAAGGCCGCCGAAGGCGCACAATTCATCGGACAGTTCGGCGTCGGCTTCT
ATTCCTGCTTTATGGTCGCCGAGCATGTCGATGTGATTTCCCGTCGCGCCGGCTCAGAAGAGGCGTGGAAATGGTCCTCG
GACGGGAAGGGAAGCTATAGTGTCGAGGCAGCAAACCTCGTCGAAGCGCCAGCCCGCGGCACGCGCATCGTCCTGCATCT
GATGGAGGATGCCAAGACATACACCTCAAGGTGGACCGTCGAACGAATCGTCAAAGAACAATCCGGTCATGTCCCGGTCG
CGATCCGCATTGTGGACAAACCTGGTGGCGAGCCGGTCCAGATAACGGACGGGACTGCGCTGTGGACCAAATCGAAGAGC
GAAGTCAGCAAGGAAGACTATACCGACTTCTACCGCGGCCTATCTGGGCAATACGACGAACCGGCGCTCACTGTGCACTT
TCGTGCCGAGGGGCGGCACGAATACACAGCCCTGGCGTTTGTACCGGGAACGCAGCCGTTCGACATGTTTGATCCGGAAC
GCAAAGGAAGGATGAAGCTTTACGTCAAGCGGGTCTTCATCACCGACGATGCGGAACTGATGCCCAGATATCTGCGCTTC
GTTCGAGGGCTGATCGATACGGCTGACCTGCCGCTCAACGTGTCTCGCGAGATGATCCAGGAGAGCCCCATCCTGGCGGC
AATCCGCAAGGGTGTCACCAATAGGGTTATCACAGCGATCGAGAAACTGGCTGACGGCGAGTCGGAGACCTATCTCACGT
TCTGGAAGAATTTCGGACCCGTCTTGAAGGAGGGCATCTACGAGGATTACGAGCGGCGCGCACAATTGATGGCGCTTGCA
CGATTTCACACGTCGGCATCGCCGGAAGGGCACCGTTCACTTGCCGAATACGTCAAAGACGCCAAAGAAGGCCAGGACGC
CATCTACTATCTTGCGGGTGGCAGTCTGGACCAGTTGAAGGCGTCGCCACAGCTCGAAGGTTTCCGCGCGCGAGGCATCG
AAGTGCTGCTGCTGACCGACTCAGTCGACAGCTTCTGGGTGGTGAACGCGCCGGAATTCGAAGGGAAGGCGTTCAAATCG
ATCACGCAGGGAACTGCGGATCTGGCGCAGTTTCCAAGGCTCGACAATCAAACGCCACCGGAACAGGACAGCGCCGGTTT
GGCGACATTTATTGGCTTCGCAAGAGAAAAACTGGCCGGTCAAGTCGCCGATGTTCGGGCATCCGACCGCTTGACGGAGA
GCGCGGTCTGCCTGGTTGCGCCGGAGGACGGCTATGACAGGCAGATGGAAAAGATCCTGCAAAACGCAGGTCGTCTCCAG
GGAGCCACCAAACCGATCCTCGAAATCAACTTGGCACATCCCGTGATTAAAGCCATCGCGGCCGTCGAGGACGACGCGTC
TTATCAAGAGGACGCAACGTTCCTGTTGCTCGATCAAGCGCGAATTCTCGATGGCGAACGGCCACAAGATCCCCGAAAAT
TCGCGCAACGGCTGGCGAGGGTTTTCGAGAGGTCAGTGCGGTCGGAAGGTTAG

Upstream 100 bases:

>100_bases
TATATTTCGGCCGCGGCCAGCTGTTTTCGGATCTTGAATTTTGAGCCTGGTTTCGCCAATTGATCGGCGCAAATTGCATT
TCTTTGGAGAATCCGAGCAC

Downstream 100 bases:

>100_bases
CCTGTTCACGCATTGCTTACCGCTCGACTGGCGGTCTCGCTGCTCAAACCCGCTCGGCTCCATGTCAGGAGCCGAGCCTT
CCCGGCCCCCATGGCCAAAG

Product: heat shock protein 90

Products: NA

Alternate protein names: Heat shock protein htpG; High temperature protein G

Number of amino acids: Translated: 630; Mature: 629

Protein sequence:

>630_residues
MTTTVEQTAESHVFEADVARLLHMMVHSVYSDKGVFLRELISNGADACEKLRYEAIETPSLLAADAESRIMLRLDEESRQ
LVVEDNGIGMRRDEMIEALGTIARSGTRAFMERIAENKAAEGAQFIGQFGVGFYSCFMVAEHVDVISRRAGSEEAWKWSS
DGKGSYSVEAANLVEAPARGTRIVLHLMEDAKTYTSRWTVERIVKEQSGHVPVAIRIVDKPGGEPVQITDGTALWTKSKS
EVSKEDYTDFYRGLSGQYDEPALTVHFRAEGRHEYTALAFVPGTQPFDMFDPERKGRMKLYVKRVFITDDAELMPRYLRF
VRGLIDTADLPLNVSREMIQESPILAAIRKGVTNRVITAIEKLADGESETYLTFWKNFGPVLKEGIYEDYERRAQLMALA
RFHTSASPEGHRSLAEYVKDAKEGQDAIYYLAGGSLDQLKASPQLEGFRARGIEVLLLTDSVDSFWVVNAPEFEGKAFKS
ITQGTADLAQFPRLDNQTPPEQDSAGLATFIGFAREKLAGQVADVRASDRLTESAVCLVAPEDGYDRQMEKILQNAGRLQ
GATKPILEINLAHPVIKAIAAVEDDASYQEDATFLLLDQARILDGERPQDPRKFAQRLARVFERSVRSEG

Sequences:

>Translated_630_residues
MTTTVEQTAESHVFEADVARLLHMMVHSVYSDKGVFLRELISNGADACEKLRYEAIETPSLLAADAESRIMLRLDEESRQ
LVVEDNGIGMRRDEMIEALGTIARSGTRAFMERIAENKAAEGAQFIGQFGVGFYSCFMVAEHVDVISRRAGSEEAWKWSS
DGKGSYSVEAANLVEAPARGTRIVLHLMEDAKTYTSRWTVERIVKEQSGHVPVAIRIVDKPGGEPVQITDGTALWTKSKS
EVSKEDYTDFYRGLSGQYDEPALTVHFRAEGRHEYTALAFVPGTQPFDMFDPERKGRMKLYVKRVFITDDAELMPRYLRF
VRGLIDTADLPLNVSREMIQESPILAAIRKGVTNRVITAIEKLADGESETYLTFWKNFGPVLKEGIYEDYERRAQLMALA
RFHTSASPEGHRSLAEYVKDAKEGQDAIYYLAGGSLDQLKASPQLEGFRARGIEVLLLTDSVDSFWVVNAPEFEGKAFKS
ITQGTADLAQFPRLDNQTPPEQDSAGLATFIGFAREKLAGQVADVRASDRLTESAVCLVAPEDGYDRQMEKILQNAGRLQ
GATKPILEINLAHPVIKAIAAVEDDASYQEDATFLLLDQARILDGERPQDPRKFAQRLARVFERSVRSEG
>Mature_629_residues
TTTVEQTAESHVFEADVARLLHMMVHSVYSDKGVFLRELISNGADACEKLRYEAIETPSLLAADAESRIMLRLDEESRQL
VVEDNGIGMRRDEMIEALGTIARSGTRAFMERIAENKAAEGAQFIGQFGVGFYSCFMVAEHVDVISRRAGSEEAWKWSSD
GKGSYSVEAANLVEAPARGTRIVLHLMEDAKTYTSRWTVERIVKEQSGHVPVAIRIVDKPGGEPVQITDGTALWTKSKSE
VSKEDYTDFYRGLSGQYDEPALTVHFRAEGRHEYTALAFVPGTQPFDMFDPERKGRMKLYVKRVFITDDAELMPRYLRFV
RGLIDTADLPLNVSREMIQESPILAAIRKGVTNRVITAIEKLADGESETYLTFWKNFGPVLKEGIYEDYERRAQLMALAR
FHTSASPEGHRSLAEYVKDAKEGQDAIYYLAGGSLDQLKASPQLEGFRARGIEVLLLTDSVDSFWVVNAPEFEGKAFKSI
TQGTADLAQFPRLDNQTPPEQDSAGLATFIGFAREKLAGQVADVRASDRLTESAVCLVAPEDGYDRQMEKILQNAGRLQG
ATKPILEINLAHPVIKAIAAVEDDASYQEDATFLLLDQARILDGERPQDPRKFAQRLARVFERSVRSEG

Specific function: Molecular chaperone. Has ATPase activity

COG id: COG0326

COG function: function code O; Molecular chaperone, HSP90 family

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heat shock protein 90 family

Homologues:

Organism=Homo sapiens, GI155722983, Length=591, Percent_Identity=31.1336717428088, Blast_Score=303, Evalue=4e-82,
Organism=Homo sapiens, GI154146191, Length=402, Percent_Identity=34.3283582089552, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI4507677, Length=417, Percent_Identity=33.5731414868106, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI20149594, Length=408, Percent_Identity=34.0686274509804, Blast_Score=239, Evalue=4e-63,
Organism=Homo sapiens, GI153792590, Length=408, Percent_Identity=33.578431372549, Blast_Score=239, Evalue=7e-63,
Organism=Escherichia coli, GI1786679, Length=626, Percent_Identity=42.332268370607, Blast_Score=483, Evalue=1e-137,
Organism=Caenorhabditis elegans, GI17559162, Length=670, Percent_Identity=33.8805970149254, Blast_Score=383, Evalue=1e-106,
Organism=Caenorhabditis elegans, GI17542208, Length=676, Percent_Identity=32.8402366863905, Blast_Score=340, Evalue=1e-93,
Organism=Caenorhabditis elegans, GI115535205, Length=593, Percent_Identity=30.8600337268128, Blast_Score=276, Evalue=2e-74,
Organism=Caenorhabditis elegans, GI115535167, Length=427, Percent_Identity=33.9578454332553, Blast_Score=241, Evalue=8e-64,
Organism=Saccharomyces cerevisiae, GI6323840, Length=672, Percent_Identity=32.4404761904762, Blast_Score=369, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6325016, Length=677, Percent_Identity=32.2008862629247, Blast_Score=367, Evalue=1e-102,
Organism=Drosophila melanogaster, GI17647529, Length=684, Percent_Identity=32.8947368421053, Blast_Score=392, Evalue=1e-109,
Organism=Drosophila melanogaster, GI21357739, Length=687, Percent_Identity=30.8588064046579, Blast_Score=333, Evalue=2e-91,
Organism=Drosophila melanogaster, GI24586016, Length=647, Percent_Identity=32.1483771251932, Blast_Score=313, Evalue=2e-85,

Paralogues:

None

Copy number: 640 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 2419 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): HTPG_RHIEC (Q2JZH2)

Other databases:

- EMBL:   CP000138
- RefSeq:   YP_472741.1
- HSSP:   P07900
- ProteinModelPortal:   Q2JZH2
- STRING:   Q2JZH2
- GeneID:   3896287
- GenomeReviews:   CP000138_GR
- KEGG:   ret:RHE_PF00122
- eggNOG:   COG0326
- HOGENOM:   HBG631012
- OMA:   AIYYITA
- PhylomeDB:   Q2JZH2
- ProtClustDB:   PRK05218
- GO:   GO:0005737
- HAMAP:   MF_00505
- InterPro:   IPR003594
- InterPro:   IPR001404
- InterPro:   IPR020575
- InterPro:   IPR020568
- Gene3D:   G3DSA:3.30.565.10
- PANTHER:   PTHR11528
- PIRSF:   PIRSF002583
- PRINTS:   PR00775
- SMART:   SM00387

Pfam domain/function: PF02518 HATPase_c; PF00183 HSP90; SSF55874 ATP_bd_ATPase; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: NA

Molecular weight: Translated: 70275; Mature: 70144

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS00298 HSP90

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTTVEQTAESHVFEADVARLLHMMVHSVYSDKGVFLRELISNGADACEKLRYEAIETPS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHCCCCC
LLAADAESRIMLRLDEESRQLVVEDNGIGMRRDEMIEALGTIARSGTRAFMERIAENKAA
HHHCCCCCEEEEEECCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
EGAQFIGQFGVGFYSCFMVAEHVDVISRRAGSEEAWKWSSDGKGSYSVEAANLVEAPARG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEHHHHHHCCCCC
TRIVLHLMEDAKTYTSRWTVERIVKEQSGHVPVAIRIVDKPGGEPVQITDGTALWTKSKS
CEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCEEEEECCCEEEECCHH
EVSKEDYTDFYRGLSGQYDEPALTVHFRAEGRHEYTALAFVPGTQPFDMFDPERKGRMKL
HHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCEEEEEEECCCCCCCCCCCCCCCCEEE
YVKRVFITDDAELMPRYLRFVRGLIDTADLPLNVSREMIQESPILAAIRKGVTNRVITAI
EEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCHHHHHHHHCHHHHHHHHH
EKLADGESETYLTFWKNFGPVLKEGIYEDYERRAQLMALARFHTSASPEGHRSLAEYVKD
HHHHCCCCCEEEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
AKEGQDAIYYLAGGSLDQLKASPQLEGFRARGIEVLLLTDSVDSFWVVNAPEFEGKAFKS
HCCCCCEEEEEECCCHHHHCCCCCCCCHHCCCEEEEEEECCCCCEEEEECCCCCCHHHHH
ITQGTADLAQFPRLDNQTPPEQDSAGLATFIGFAREKLAGQVADVRASDRLTESAVCLVA
HHHCHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEE
PEDGYDRQMEKILQNAGRLQGATKPILEINLAHPVIKAIAAVEDDASYQEDATFLLLDQA
CCCCHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHCCCCCCCCCCEEEEEECH
RILDGERPQDPRKFAQRLARVFERSVRSEG
HHCCCCCCCCHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TTTVEQTAESHVFEADVARLLHMMVHSVYSDKGVFLRELISNGADACEKLRYEAIETPS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHCCCCC
LLAADAESRIMLRLDEESRQLVVEDNGIGMRRDEMIEALGTIARSGTRAFMERIAENKAA
HHHCCCCCEEEEEECCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
EGAQFIGQFGVGFYSCFMVAEHVDVISRRAGSEEAWKWSSDGKGSYSVEAANLVEAPARG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEHHHHHHCCCCC
TRIVLHLMEDAKTYTSRWTVERIVKEQSGHVPVAIRIVDKPGGEPVQITDGTALWTKSKS
CEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCEEEEECCCEEEECCHH
EVSKEDYTDFYRGLSGQYDEPALTVHFRAEGRHEYTALAFVPGTQPFDMFDPERKGRMKL
HHHHHHHHHHHHCCCCCCCCCEEEEEEEECCCCCEEEEEEECCCCCCCCCCCCCCCCEEE
YVKRVFITDDAELMPRYLRFVRGLIDTADLPLNVSREMIQESPILAAIRKGVTNRVITAI
EEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCHHHHHHHHCHHHHHHHHH
EKLADGESETYLTFWKNFGPVLKEGIYEDYERRAQLMALARFHTSASPEGHRSLAEYVKD
HHHHCCCCCEEEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
AKEGQDAIYYLAGGSLDQLKASPQLEGFRARGIEVLLLTDSVDSFWVVNAPEFEGKAFKS
HCCCCCEEEEEECCCHHHHCCCCCCCCHHCCCEEEEEEECCCCCEEEEECCCCCCHHHHH
ITQGTADLAQFPRLDNQTPPEQDSAGLATFIGFAREKLAGQVADVRASDRLTESAVCLVA
HHHCHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEE
PEDGYDRQMEKILQNAGRLQGATKPILEINLAHPVIKAIAAVEDDASYQEDATFLLLDQA
CCCCHHHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHCCCCCCCCCCEEEEEECH
RILDGERPQDPRKFAQRLARVFERSVRSEG
HHCCCCCCCCHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA