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The map label for this gene is idnD [H]

Identifier: 86360804

GI number: 86360804

Start: 71035

End: 72069

Strand: Direct

Name: idnD [H]

Synonym: RHE_PF00071

Alternate gene names: 86360804

Gene position: 71035-72069 (Clockwise)

Preceding gene: 86360803

Following gene: 86360805

Centisome position: 11.06

GC content: 65.51

Gene sequence:

>1035_bases
ATGCGAACACGTCTGGCACGGCTTTACCAAAAGGGCGATCTCAGGATCGAGGCCGACACCGTTGCGCCCCCCGGTCCGGG
CCAGGTGCTGCTGAAAATGGCGGCCGCTGGCATCTGCGGCTCCGACCTGCATTATTATCAGGACGGCGGCTTCGGACCGA
TCCGGGTGCGCGAGCCGATCATCCCCGGCCACGAGGCATCGGGAATCGTGGAGAGGGTGGGGGAAGGGACAGATCTGAAA
CCCGGGACGCTTGTGGCGATCAACCCCAGCCAGCCCTGCGGCCAATGCGAATATTGCGGGAAGGGACTGCCGATCCACTG
CCTCGACATGCGCTTCATGGGGAGCGCGATGCGCCTGCCGCATGAGCAGGGCATGTTCCGGGAATGGCTGGTGGTGCCGG
CCAGGCAGTGCTTCGAAGTGGGAGCGGCAACGACGGCCGCGGAAGCGGCGTGCAGCGAGCCCTTGGCCGTTTGCCTGCAC
GCGGCATCGCGTGCGGGAGAGATCTCGGGCAAGCGTGTCCTCGTCACAGGCGCTGGCCCGATCGGCTGCCTGATGGTTGC
CGCCGCCCACCATCACGGCGCGGCGGAGATCATCGTGACCGATCTGGCCGATGCGGCGCTGGCGAGAGCCGAGGCGATGG
GTGCGAACCGGACGATCAATGTGTCTCGGGAGGCTGCGGCGCTTGCCGAATTCGAGACCGGAAAGGGCTATTTCGATCTC
GTCTTCGAATGCTCGGCCGCCGCACCCGCCATCCGCAGCGCCATTGCCGCCATCAGGCCGCGTGGCACGATCGTGCAGGT
CGGCGTCACGGGAGAGATCCCGGTCCCGCTCAATGCCATCGTCGGCAAGGAGCTCCATATCCACGGCACGCAGCGTTTCC
ACGAGGAATTCGCTGCCGCCGTCGAGCTGATCTCAAGTCGCGAGATCGACGTGCGGCCAATCATCAGTCACAGCCTGCCT
CTCGAAGAGGCTGACGCCGCTTTCATCCTTGCCGGCGACCGTACGGCTGCCTGCAAGGTGCAGCTGACCTTATAG

Upstream 100 bases:

>100_bases
TTGGTGCCGCTCTTCCTGGCATTGATCCTGATCACCTTCATTCCCGCCGTATCGCTCTGGCTGCCGCAGCAACTCGGACT
GTTGAGATAGGATGGCCATG

Downstream 100 bases:

>100_bases
AGCACGGACGTTTTCGCGGGCGACAAAAAGGGCAGCACTCGGCGCCCCTCAGCTTATTGATCCTATCGGCGATTCTGCGG
TCTATGGTCGCTCGTGGCGG

Product: zinc-dependent alcohol dehydrogenase protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 344; Mature: 344

Protein sequence:

>344_residues
MRTRLARLYQKGDLRIEADTVAPPGPGQVLLKMAAAGICGSDLHYYQDGGFGPIRVREPIIPGHEASGIVERVGEGTDLK
PGTLVAINPSQPCGQCEYCGKGLPIHCLDMRFMGSAMRLPHEQGMFREWLVVPARQCFEVGAATTAAEAACSEPLAVCLH
AASRAGEISGKRVLVTGAGPIGCLMVAAAHHHGAAEIIVTDLADAALARAEAMGANRTINVSREAAALAEFETGKGYFDL
VFECSAAAPAIRSAIAAIRPRGTIVQVGVTGEIPVPLNAIVGKELHIHGTQRFHEEFAAAVELISSREIDVRPIISHSLP
LEEADAAFILAGDRTAACKVQLTL

Sequences:

>Translated_344_residues
MRTRLARLYQKGDLRIEADTVAPPGPGQVLLKMAAAGICGSDLHYYQDGGFGPIRVREPIIPGHEASGIVERVGEGTDLK
PGTLVAINPSQPCGQCEYCGKGLPIHCLDMRFMGSAMRLPHEQGMFREWLVVPARQCFEVGAATTAAEAACSEPLAVCLH
AASRAGEISGKRVLVTGAGPIGCLMVAAAHHHGAAEIIVTDLADAALARAEAMGANRTINVSREAAALAEFETGKGYFDL
VFECSAAAPAIRSAIAAIRPRGTIVQVGVTGEIPVPLNAIVGKELHIHGTQRFHEEFAAAVELISSREIDVRPIISHSLP
LEEADAAFILAGDRTAACKVQLTL
>Mature_344_residues
MRTRLARLYQKGDLRIEADTVAPPGPGQVLLKMAAAGICGSDLHYYQDGGFGPIRVREPIIPGHEASGIVERVGEGTDLK
PGTLVAINPSQPCGQCEYCGKGLPIHCLDMRFMGSAMRLPHEQGMFREWLVVPARQCFEVGAATTAAEAACSEPLAVCLH
AASRAGEISGKRVLVTGAGPIGCLMVAAAHHHGAAEIIVTDLADAALARAEAMGANRTINVSREAAALAEFETGKGYFDL
VFECSAAAPAIRSAIAAIRPRGTIVQVGVTGEIPVPLNAIVGKELHIHGTQRFHEEFAAAVELISSREIDVRPIISHSLP
LEEADAAFILAGDRTAACKVQLTL

Specific function: Catalyzes the NADH/NADPH-dependent oxidation of L- idonate to 5-ketogluconate (5KG) [H]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=323, Percent_Identity=36.8421052631579, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI4501933, Length=368, Percent_Identity=28.5326086956522, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI34577061, Length=368, Percent_Identity=27.7173913043478, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI4501929, Length=368, Percent_Identity=27.9891304347826, Blast_Score=92, Evalue=8e-19,
Organism=Homo sapiens, GI71743840, Length=366, Percent_Identity=25.9562841530055, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI262073058, Length=378, Percent_Identity=25.6613756613757, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI156523966, Length=378, Percent_Identity=25.3968253968254, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI4501939, Length=359, Percent_Identity=24.5125348189415, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI71565154, Length=363, Percent_Identity=26.4462809917355, Blast_Score=82, Evalue=5e-16,
Organism=Escherichia coli, GI1790718, Length=316, Percent_Identity=40.5063291139241, Blast_Score=250, Evalue=1e-67,
Organism=Escherichia coli, GI1788073, Length=333, Percent_Identity=32.7327327327327, Blast_Score=152, Evalue=2e-38,
Organism=Escherichia coli, GI1787863, Length=340, Percent_Identity=31.1764705882353, Blast_Score=139, Evalue=4e-34,
Organism=Escherichia coli, GI1790045, Length=310, Percent_Identity=30.3225806451613, Blast_Score=131, Evalue=6e-32,
Organism=Escherichia coli, GI1788407, Length=310, Percent_Identity=30, Blast_Score=122, Evalue=3e-29,
Organism=Escherichia coli, GI1788075, Length=339, Percent_Identity=30.3834808259587, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI87082125, Length=352, Percent_Identity=29.2613636363636, Blast_Score=101, Evalue=8e-23,
Organism=Escherichia coli, GI226510992, Length=319, Percent_Identity=30.0940438871473, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI87081918, Length=298, Percent_Identity=30.8724832214765, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1786552, Length=367, Percent_Identity=29.1553133514986, Blast_Score=78, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17562876, Length=329, Percent_Identity=38.2978723404255, Blast_Score=211, Evalue=6e-55,
Organism=Caenorhabditis elegans, GI17562878, Length=329, Percent_Identity=36.4741641337386, Blast_Score=190, Evalue=8e-49,
Organism=Caenorhabditis elegans, GI25146526, Length=357, Percent_Identity=26.890756302521, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI71997431, Length=359, Percent_Identity=26.7409470752089, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71988145, Length=310, Percent_Identity=27.4193548387097, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322619, Length=332, Percent_Identity=34.3373493975904, Blast_Score=171, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6319955, Length=332, Percent_Identity=34.3373493975904, Blast_Score=171, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6323099, Length=311, Percent_Identity=33.4405144694534, Blast_Score=159, Evalue=8e-40,
Organism=Saccharomyces cerevisiae, GI6319257, Length=381, Percent_Identity=27.5590551181102, Blast_Score=112, Evalue=6e-26,
Organism=Saccharomyces cerevisiae, GI6319258, Length=308, Percent_Identity=28.8961038961039, Blast_Score=107, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6323729, Length=284, Percent_Identity=27.112676056338, Blast_Score=86, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6319621, Length=263, Percent_Identity=28.8973384030418, Blast_Score=82, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6320033, Length=348, Percent_Identity=24.7126436781609, Blast_Score=72, Evalue=9e-14,
Organism=Saccharomyces cerevisiae, GI6324486, Length=263, Percent_Identity=25.0950570342205, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323961, Length=275, Percent_Identity=24.3636363636364, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17137530, Length=323, Percent_Identity=35.9133126934984, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI17737897, Length=322, Percent_Identity=35.4037267080745, Blast_Score=174, Evalue=6e-44,
Organism=Drosophila melanogaster, GI17737895, Length=354, Percent_Identity=27.9661016949153, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI221457811, Length=317, Percent_Identity=25.2365930599369, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI45550770, Length=317, Percent_Identity=25.2365930599369, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI45551930, Length=317, Percent_Identity=25.2365930599369, Blast_Score=78, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.264 [H]

Molecular weight: Translated: 36248; Mature: 36248

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTRLARLYQKGDLRIEADTVAPPGPGQVLLKMAAAGICGSDLHYYQDGGFGPIRVREPI
CCCHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHCCCCCCCCEEEECCCCCCEEEECCC
IPGHEASGIVERVGEGTDLKPGTLVAINPSQPCGQCEYCGKGLPIHCLDMRFMGSAMRLP
CCCCCHHHHHHHHCCCCCCCCCEEEEECCCCCCCCHHHCCCCCCEEEECHHHHHHHHCCC
HEQGMFREWLVVPARQCFEVGAATTAAEAACSEPLAVCLHAASRAGEISGKRVLVTGAGP
CCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHCCCCCCCCEEEEECCCH
IGCLMVAAAHHHGAAEIIVTDLADAALARAEAMGANRTINVSREAAALAEFETGKGYFDL
HHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHCCCCCEEEE
VFECSAAAPAIRSAIAAIRPRGTIVQVGVTGEIPVPLNAIVGKELHIHGTQRFHEEFAAA
EEECCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHCCEEEECCHHHHHHHHHHH
VELISSREIDVRPIISHSLPLEEADAAFILAGDRTAACKVQLTL
HHHHHCCCCCEEEHHCCCCCCCCCCEEEEEECCCCEEEEEEEEC
>Mature Secondary Structure
MRTRLARLYQKGDLRIEADTVAPPGPGQVLLKMAAAGICGSDLHYYQDGGFGPIRVREPI
CCCHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHCCCCCCCCEEEECCCCCCEEEECCC
IPGHEASGIVERVGEGTDLKPGTLVAINPSQPCGQCEYCGKGLPIHCLDMRFMGSAMRLP
CCCCCHHHHHHHHCCCCCCCCCEEEEECCCCCCCCHHHCCCCCCEEEECHHHHHHHHCCC
HEQGMFREWLVVPARQCFEVGAATTAAEAACSEPLAVCLHAASRAGEISGKRVLVTGAGP
CCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHCCCCCCCCEEEEECCCH
IGCLMVAAAHHHGAAEIIVTDLADAALARAEAMGANRTINVSREAAALAEFETGKGYFDL
HHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHCCCCCEEEE
VFECSAAAPAIRSAIAAIRPRGTIVQVGVTGEIPVPLNAIVGKELHIHGTQRFHEEFAAA
EEECCCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHCCEEEECCHHHHHHHHHHH
VELISSREIDVRPIISHSLPLEEADAAFILAGDRTAACKVQLTL
HHHHHCCCCCEEEHHCCCCCCCCCCEEEEEECCCCEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7610040; 9278503; 9658018 [H]