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The map label for this gene is panC

Identifier: 86360735

GI number: 86360735

Start: 709

End: 1602

Strand: Direct

Name: panC

Synonym: RHE_PF00001

Alternate gene names: 86360735

Gene position: 709-1602 (Clockwise)

Preceding gene: NA

Following gene: 86360736

Centisome position: 0.11

GC content: 62.86

Gene sequence:

>894_bases
ATGCGGGTTTTCTCGAGCATCGATGAGCTGCGCCACACGCTCGATGCGCTCAAACGCCAGGGGCGCAATGTCGGCCTCGT
GCCGACGATGGGGTATCTTCATGCCGGTCATATGGAGCTCGTCGCGCGCGCTCGGGCCGAAAACGACATCGTCGTCGTCT
CCATTTTCGTCAACCCGTTGCAGTTCGGCCCGGCCGAAGACCTCAGCAAATACCCGCGCGATCTGGAACGGGATGCCGCC
ATGCTCAAACAGGCCGGCGTAAATTTCCTCTTCGCCCCCGGCGTCGGGGACATGTATCCGCGCCCCATGAAAACCGTCGT
CGACATTCCCGATCTCGGCCGCGAGCTGGAAGGCGCGGTTCGCCCCGGGCATTTCGCCGGCGTTGCCACCGTCGTCTCCA
AGCTATTCAACATCGTGCAGCCGCAGACCGCTTACTTCGGAGAGAAGGACTACCAGCAGGTCGTCATCATTAAGCGCATG
GTGGAGGATCTCGCCGTGCCGGTGCGGGTGATATCGGTGCCGACCGTCAGGGATGCAGACGGCCTGGCATTGTCGTCGCG
CAATGTCTATCTCAGTCTGGAGGAGCGGCGCGCGGCGGTGATCGTCCCGCAGACACTCGACGAGGCGGAACGTCTGATTG
GCGATGGCCTCACGGATGCCAAGACATTGGAAGCCAAGCTCACGGAATTTCTCGGACGCGAGCCTCTGGCGAGGCCCGAG
GTCGTCGCCGTCAGGGATGCCACGACGCTTGAGCCGGTCACCTCAATCGGCGGGTCGGTCGTCGTGGCGCTCTTTGTCCG
GGTCGGCTCGACGCGCCTTCTCGATAACCGGGTGATCGGCGACAACAGAACGATCGGCGGGCGAAACCAGCCGGGAAAGG
GAGTGACGAAATGA

Upstream 100 bases:

>100_bases
TCTATTCAATCAATTTTATCGCCGATTATGCATTGACCTCCAGCATCGATTACACTTCTTATCCGCGCCCAAGATCAATG
CCGGCCGCGGGGGAGGATAT

Downstream 100 bases:

>100_bases
GCGCCATCGGATCGCAGAAGCGCCTGACGCCGCCCCGCATCTCAGCCATGAAGGGCGGCAAACCGATTGTCTGCCTGACC
GCCTACACCACGCCGATGGC

Product: pantoate--beta-alanine ligase

Products: NA

Alternate protein names: PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MRVFSSIDELRHTLDALKRQGRNVGLVPTMGYLHAGHMELVARARAENDIVVVSIFVNPLQFGPAEDLSKYPRDLERDAA
MLKQAGVNFLFAPGVGDMYPRPMKTVVDIPDLGRELEGAVRPGHFAGVATVVSKLFNIVQPQTAYFGEKDYQQVVIIKRM
VEDLAVPVRVISVPTVRDADGLALSSRNVYLSLEERRAAVIVPQTLDEAERLIGDGLTDAKTLEAKLTEFLGREPLARPE
VVAVRDATTLEPVTSIGGSVVVALFVRVGSTRLLDNRVIGDNRTIGGRNQPGKGVTK

Sequences:

>Translated_297_residues
MRVFSSIDELRHTLDALKRQGRNVGLVPTMGYLHAGHMELVARARAENDIVVVSIFVNPLQFGPAEDLSKYPRDLERDAA
MLKQAGVNFLFAPGVGDMYPRPMKTVVDIPDLGRELEGAVRPGHFAGVATVVSKLFNIVQPQTAYFGEKDYQQVVIIKRM
VEDLAVPVRVISVPTVRDADGLALSSRNVYLSLEERRAAVIVPQTLDEAERLIGDGLTDAKTLEAKLTEFLGREPLARPE
VVAVRDATTLEPVTSIGGSVVVALFVRVGSTRLLDNRVIGDNRTIGGRNQPGKGVTK
>Mature_297_residues
MRVFSSIDELRHTLDALKRQGRNVGLVPTMGYLHAGHMELVARARAENDIVVVSIFVNPLQFGPAEDLSKYPRDLERDAA
MLKQAGVNFLFAPGVGDMYPRPMKTVVDIPDLGRELEGAVRPGHFAGVATVVSKLFNIVQPQTAYFGEKDYQQVVIIKRM
VEDLAVPVRVISVPTVRDADGLALSSRNVYLSLEERRAAVIVPQTLDEAERLIGDGLTDAKTLEAKLTEFLGREPLARPE
VVAVRDATTLEPVTSIGGSVVVALFVRVGSTRLLDNRVIGDNRTIGGRNQPGKGVTK

Specific function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate

COG id: COG0414

COG function: function code H; Panthothenate synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pantothenate synthetase family

Homologues:

Organism=Escherichia coli, GI1786325, Length=284, Percent_Identity=43.3098591549296, Blast_Score=229, Evalue=1e-61,
Organism=Saccharomyces cerevisiae, GI6322046, Length=224, Percent_Identity=43.75, Blast_Score=179, Evalue=4e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANC_RHIEC (Q2JZU1)

Other databases:

- EMBL:   CP000138
- RefSeq:   YP_472622.1
- ProteinModelPortal:   Q2JZU1
- SMR:   Q2JZU1
- STRING:   Q2JZU1
- GeneID:   3896082
- GenomeReviews:   CP000138_GR
- KEGG:   ret:RHE_PF00001
- eggNOG:   COG0414
- HOGENOM:   HBG428839
- OMA:   YRAYFGQ
- PhylomeDB:   Q2JZU1
- ProtClustDB:   PRK00380
- GO:   GO:0005737
- HAMAP:   MF_00158
- InterPro:   IPR004821
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00125
- TIGRFAMs:   TIGR00018

Pfam domain/function: PF02569 Pantoate_ligase

EC number: =6.3.2.1

Molecular weight: Translated: 32418; Mature: 32418

Theoretical pI: Translated: 7.82; Mature: 7.82

Prosite motif: NA

Important sites: ACT_SITE 37-37 BINDING 61-61 BINDING 61-61 BINDING 153-153 BINDING 176-176

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVFSSIDELRHTLDALKRQGRNVGLVPTMGYLHAGHMELVARARAENDIVVVSIFVNPL
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCHHHHHHHHCCCCCEEEEEEEECCC
QFGPAEDLSKYPRDLERDAAMLKQAGVNFLFAPGVGDMYPRPMKTVVDIPDLGRELEGAV
CCCCHHHHHHCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHCCCHHHHHHHHCCC
RPGHFAGVATVVSKLFNIVQPQTAYFGEKDYQQVVIIKRMVEDLAVPVRVISVPTVRDAD
CCCHHHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCC
GLALSSRNVYLSLEERRAAVIVPQTLDEAERLIGDGLTDAKTLEAKLTEFLGREPLARPE
CCEEECCCEEEEEECCCEEEEECHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCC
VVAVRDATTLEPVTSIGGSVVVALFVRVGSTRLLDNRVIGDNRTIGGRNQPGKGVTK
EEEEECCCCHHHHHHCCHHHHHHHHHHHCCCHHHCCEECCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRVFSSIDELRHTLDALKRQGRNVGLVPTMGYLHAGHMELVARARAENDIVVVSIFVNPL
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCHHHHHHHHCCCCCEEEEEEEECCC
QFGPAEDLSKYPRDLERDAAMLKQAGVNFLFAPGVGDMYPRPMKTVVDIPDLGRELEGAV
CCCCHHHHHHCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHCCCHHHHHHHHCCC
RPGHFAGVATVVSKLFNIVQPQTAYFGEKDYQQVVIIKRMVEDLAVPVRVISVPTVRDAD
CCCHHHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCC
GLALSSRNVYLSLEERRAAVIVPQTLDEAERLIGDGLTDAKTLEAKLTEFLGREPLARPE
CCEEECCCEEEEEECCCEEEEECHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCC
VVAVRDATTLEPVTSIGGSVVVALFVRVGSTRLLDNRVIGDNRTIGGRNQPGKGVTK
EEEEECCCCHHHHHHCCHHHHHHHHHHHCCCHHHCCEECCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA