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The map label for this gene is tolC [C]

Identifier: 85860680

GI number: 85860680

Start: 2855796

End: 2857244

Strand: Direct

Name: tolC [C]

Synonym: SYN_00239

Alternate gene names: 85860680

Gene position: 2855796-2857244 (Clockwise)

Preceding gene: 85860679

Following gene: 85860681

Centisome position: 89.82

GC content: 51.69

Gene sequence:

>1449_bases
ATGGCAACACCCCACGGGCAGGACTGTATTACGATCAATAAAACGATCCTGGAGAGCTGTATGCAATCTTTATTTTGGAG
AGATAAGTATTGGAAAAAGATCTCAATTGTTCTCATGTTTCTTATTCTTATGCTCCTGACCTGCAGCAGCGTCCTGGCAG
AGTCGGGGCAATGGCAAAACGCAGGTGATGTCAGGATTTTTACTCTTTCCGATATTATCCACCACGCAATGATTAACAGT
CCGACCATTAAACAGGCAGAAAGCAATGTGGCCGTGGAACAGGCTAACTTAAAGGCTGCAAAATCCGAGAGATTTCCGAA
AATCGAGTTGGGCGGGGGGGGCGCCCGGTATCACTACCCCACTCCCGTTACACCGATAAGCGGCTCACCTCTGGCGGGAG
TGCCATTTCCCGAATTCAGTGAGACCATTTACGATGTCGGTGCTTTTCTTCACCTACCCCTCTATAAAGGTGGGAGACTG
GTTCGCAATGTAGAACTGTCAGAATTGCGAGGGGCTGCTGCCGCCGATCTGCTGGTGGCCAAACGCCAGGATCTTATCTA
CAACCTCACGAGTGTTTACTATAAGATTCTCCAACTCAACTCCTTTATGCAATCGACAGAAGCACAGGTCAGGGGATTGG
AGACGCATCAGCGCCAGGTTGAGGATTTTTTCAAGGCGGGAAAGGTGGCGCAGGTGGAGCTCTTGAAAGCGCAAGTCGAG
GTGGCAAAAGCCAGGGAAAACTTCCTCTTGGCGGAAAACAGCCTGAAGACGACTTACGAGCTATTGCGAATGCTCATGGG
GATGGAAGATCCGGGACAGGAGTTTCGGATCGCCGGAGAGCCAGGTTACAGGAAGATCGATTACTCGTTGGAACAGGCCC
TCGCTGAGGCGTTGAAGAGAAGACCGGAGTATCTGTCCGTGTTGAAGACAATGCAGGCCGGAGAGGAGCGCGTTGAAATA
GCGAAAGCCCGGAGGCTTCCCTACGTATACCTGGCTGGCCAGTACGTTGAGACGACGGGCACCTCTGTCGACCTTAAAGA
AAACTGGAACGCCGCACTGCGGCTTTCTCTTCCTCTTTTTGACGGAGGCCTCATCACCGCCGAAATCGACCGCGAGAAGG
CTGAACTCGAAAAAGTGAAACAGAACGAGCGATTCCTGCGACTCGAGATCAACCAGGAGGTCAAAGAGACGTTCTTGAGT
CTCGAAAACGCTGAAAAACGCATGGAAGTAGCCTCGAAGGCGATGGAATCGGCAAAGGAAAATCTGCGAGTTGAGGAACT
GAAGTACAGAAAGGGTGCCAGTACCACCACCAATGTGGTTGACGCCCAGACGAATCTCGTACTGGTCGAGACGGGATATT
ACCAAGCCCTTTATGACCGGGATATTGCAATTGCCGGAGTGCGCAGGGCGGTCGGAGAAGACCTTTCCGGGGAGGAACAG
TCGAAATGA

Upstream 100 bases:

>100_bases
CCTCTAACCTCCGCCATGAGCATCCAAAATGACTCCCCGGAACGTCTTGTCTTTCTCGTCATCAAAACCCCCCATCCGGA
TACCGTGAGAAAGACTTGAG

Downstream 100 bases:

>100_bases
AAACGAAGCGGTTGATCATTGTAGCCCTGCTGGTTGTCGCACTTCTTGTTATCATCGTCTGGTCGAAGGGCAAAGATCGG
CGGGAAGAAGGAGCCATGAA

Product: type I secretion outer membrane protein

Products: NA

Alternate protein names: Outer Membrane Protein; LC Family Type I Secretion Outer Membrane Protein; RND Efflux System Outer Membrane Lipoprotein; Type I Secretion Outer Membrane Protein lC; RND Efflux System Outer Membrane Lipoprotein NodT Family; Type I Secretion Outer Membrane Protein lC Family; Type I Secretion Outer Membrane Protein; Outer Membrane Protein lC; RND Family Outer Membrane Efflux Protein; RND Efflux System Outer Membrane Lipoprotein NodT; Outer Membrane Efflux Family Protein; Outer Membrane Macrolide Efflux Protein; Acriflavin Resistance Protein; Outer Membrane Efflux Protein Domain-Containing Protein; RND Efflux System; Outer Membrane Protein-Like; Outer Membrane Lipoprotein; Alkaline Protease Secretion Protein; RND Family Efflux Pump Outer Membrane Protein; Outer Membrane Efflux Protein Family; RND Family Efflux Pump Inner Membrane Protein; Type I Secretion Outer Membrane Protein lc Family; Outer Membrane Drug Efflux Protein; Acriflavin Resistance Family Protein; Outer Membrane Chanel Lipoprotein; Tranporter Outer Membrane Factor Family; RND Efflux Transporter Outer Membrane Protein; Metal Ion Efflux Outer Membrane Protein Family Protein; Outer Membrane Protein CyaE; Outer Membrane Export Factor; Cation Efflux System Protein CzcC; LC-Like Outer Membrane Protein Channel; Heavy Metal Efflux System Outer Membrane Lipoprotein

Number of amino acids: Translated: 482; Mature: 481

Protein sequence:

>482_residues
MATPHGQDCITINKTILESCMQSLFWRDKYWKKISIVLMFLILMLLTCSSVLAESGQWQNAGDVRIFTLSDIIHHAMINS
PTIKQAESNVAVEQANLKAAKSERFPKIELGGGGARYHYPTPVTPISGSPLAGVPFPEFSETIYDVGAFLHLPLYKGGRL
VRNVELSELRGAAAADLLVAKRQDLIYNLTSVYYKILQLNSFMQSTEAQVRGLETHQRQVEDFFKAGKVAQVELLKAQVE
VAKARENFLLAENSLKTTYELLRMLMGMEDPGQEFRIAGEPGYRKIDYSLEQALAEALKRRPEYLSVLKTMQAGEERVEI
AKARRLPYVYLAGQYVETTGTSVDLKENWNAALRLSLPLFDGGLITAEIDREKAELEKVKQNERFLRLEINQEVKETFLS
LENAEKRMEVASKAMESAKENLRVEELKYRKGASTTTNVVDAQTNLVLVETGYYQALYDRDIAIAGVRRAVGEDLSGEEQ
SK

Sequences:

>Translated_482_residues
MATPHGQDCITINKTILESCMQSLFWRDKYWKKISIVLMFLILMLLTCSSVLAESGQWQNAGDVRIFTLSDIIHHAMINS
PTIKQAESNVAVEQANLKAAKSERFPKIELGGGGARYHYPTPVTPISGSPLAGVPFPEFSETIYDVGAFLHLPLYKGGRL
VRNVELSELRGAAAADLLVAKRQDLIYNLTSVYYKILQLNSFMQSTEAQVRGLETHQRQVEDFFKAGKVAQVELLKAQVE
VAKARENFLLAENSLKTTYELLRMLMGMEDPGQEFRIAGEPGYRKIDYSLEQALAEALKRRPEYLSVLKTMQAGEERVEI
AKARRLPYVYLAGQYVETTGTSVDLKENWNAALRLSLPLFDGGLITAEIDREKAELEKVKQNERFLRLEINQEVKETFLS
LENAEKRMEVASKAMESAKENLRVEELKYRKGASTTTNVVDAQTNLVLVETGYYQALYDRDIAIAGVRRAVGEDLSGEEQ
SK
>Mature_481_residues
ATPHGQDCITINKTILESCMQSLFWRDKYWKKISIVLMFLILMLLTCSSVLAESGQWQNAGDVRIFTLSDIIHHAMINSP
TIKQAESNVAVEQANLKAAKSERFPKIELGGGGARYHYPTPVTPISGSPLAGVPFPEFSETIYDVGAFLHLPLYKGGRLV
RNVELSELRGAAAADLLVAKRQDLIYNLTSVYYKILQLNSFMQSTEAQVRGLETHQRQVEDFFKAGKVAQVELLKAQVEV
AKARENFLLAENSLKTTYELLRMLMGMEDPGQEFRIAGEPGYRKIDYSLEQALAEALKRRPEYLSVLKTMQAGEERVEIA
KARRLPYVYLAGQYVETTGTSVDLKENWNAALRLSLPLFDGGLITAEIDREKAELEKVKQNERFLRLEINQEVKETFLSL
ENAEKRMEVASKAMESAKENLRVEELKYRKGASTTTNVVDAQTNLVLVETGYYQALYDRDIAIAGVRRAVGEDLSGEEQS
K

Specific function: Required For Proper Expression Of Outer Membrane Protein Genes Such As Ompf, Nmpc, Protein 2, Hemolysin, Colicin V, Or Colicin E1. May Be Specialized For Signal Sequence Independent, Extracellular Secretion In Gram-Negative Bacteria. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Outer Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI87082199, Length=424, Percent_Identity=21.4622641509434, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: 120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 54220; Mature: 54089

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATPHGQDCITINKTILESCMQSLFWRDKYWKKISIVLMFLILMLLTCSSVLAESGQWQN
CCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
AGDVRIFTLSDIIHHAMINSPTIKQAESNVAVEQANLKAAKSERFPKIELGGGGARYHYP
CCCEEEEEHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCC
TPVTPISGSPLAGVPFPEFSETIYDVGAFLHLPLYKGGRLVRNVELSELRGAAAADLLVA
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEECCHHHHCCHHHHHHHHH
KRQDLIYNLTSVYYKILQLNSFMQSTEAQVRGLETHQRQVEDFFKAGKVAQVELLKAQVE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
VAKARENFLLAENSLKTTYELLRMLMGMEDPGQEFRIAGEPGYRKIDYSLEQALAEALKR
HHHHHHCEEEECCCHHHHHHHHHHHHCCCCCCCCEEECCCCCCEEHHHHHHHHHHHHHHC
RPEYLSVLKTMQAGEERVEIAKARRLPYVYLAGQYVETTGTSVDLKENWNAALRLSLPLF
CHHHHHHHHHHHCCHHHHHHHHHHCCCEEEEECCEEECCCCEEEECCCCCEEEEEEEEEE
DGGLITAEIDREKAELEKVKQNERFLRLEINQEVKETFLSLENAEKRMEVASKAMESAKE
CCCEEEEECCHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NLRVEELKYRKGASTTTNVVDAQTNLVLVETGYYQALYDRDIAIAGVRRAVGEDLSGEEQ
CCCHHHHHHHCCCCCCCCEEECCCCEEEEECCCHHHHHCCCHHHHHHHHHHCCCCCCCCC
SK
CC
>Mature Secondary Structure 
ATPHGQDCITINKTILESCMQSLFWRDKYWKKISIVLMFLILMLLTCSSVLAESGQWQN
CCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
AGDVRIFTLSDIIHHAMINSPTIKQAESNVAVEQANLKAAKSERFPKIELGGGGARYHYP
CCCEEEEEHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCC
TPVTPISGSPLAGVPFPEFSETIYDVGAFLHLPLYKGGRLVRNVELSELRGAAAADLLVA
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEECCHHHHCCHHHHHHHHH
KRQDLIYNLTSVYYKILQLNSFMQSTEAQVRGLETHQRQVEDFFKAGKVAQVELLKAQVE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
VAKARENFLLAENSLKTTYELLRMLMGMEDPGQEFRIAGEPGYRKIDYSLEQALAEALKR
HHHHHHCEEEECCCHHHHHHHHHHHHCCCCCCCCEEECCCCCCEEHHHHHHHHHHHHHHC
RPEYLSVLKTMQAGEERVEIAKARRLPYVYLAGQYVETTGTSVDLKENWNAALRLSLPLF
CHHHHHHHHHHHCCHHHHHHHHHHCCCEEEEECCEEECCCCEEEECCCCCEEEEEEEEEE
DGGLITAEIDREKAELEKVKQNERFLRLEINQEVKETFLSLENAEKRMEVASKAMESAKE
CCCEEEEECCHHHHHHHHHHCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NLRVEELKYRKGASTTTNVVDAQTNLVLVETGYYQALYDRDIAIAGVRRAVGEDLSGEEQ
CCCHHHHHHHCCCCCCCCEEECCCCEEEEECCCHHHHHCCCHHHHHHHHHHCCCCCCCCC
SK
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA