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The map label for this gene is csd [H]

Identifier: 85860632

GI number: 85860632

Start: 2798632

End: 2799807

Strand: Direct

Name: csd [H]

Synonym: SYN_01071

Alternate gene names: 85860632

Gene position: 2798632-2799807 (Clockwise)

Preceding gene: 85860630

Following gene: 85860633

Centisome position: 88.03

GC content: 59.35

Gene sequence:

>1176_bases
ATGCATTCAAACAACGTCATCTATTTCGATAATGCCGCCACATCCTGGCCCAAACCGGAGGAAACCCTCCAGGCCATGGA
GCACTACCTTCGCCATGTCGGCGGAAACCCGGGCCGGTCCGGACACAGGCATTCCCTGGACGCGGCGCGGATTGTCATGA
ATGCGCGGGAAGCCGTTGCCGAACTTTTCGGAATACAGGACGCTTTGAATGTGGCTTTCACAAAAAATGCCACAGAAGCG
CTGAACCTGGCAACCCGGGGACTTCTCCATCCCGGCGATCATGTCATCACCTCCAGCATGGAGCACAATTCAGTCATGCG
GCCGCTCCGGGCCCTGGAAAAGGAAGGGCTGGAACTGACCGTCATTCCCTGTTCATCCTCGGGCGAGCTGGATCCGGCTG
ATCTTCTGCCGGCCATCCGGCGCAATACGCGCGCCGTTTATCTGACTGCCGCCTCCAACGTGACGGGAACGCTCATGCCC
CTGAAGGAGGTCGGCATGCTTACCCGGGAAAAGGGTTTGATCTTCTGTGTAGATGCCGCACAGGCCGGGGGGTCCTTCCC
GCTCGATGTAACGGAACTGGGCATCGATCTGCTTGCCTTTACAGGGCATAAAGCGCTTTACGGCCCTCAGGGCACGGGAG
GACTGTATATCAGGGAAGGGCTGGAAAAGGACATCCGCCCGCTGATGATGGGAGGAACAGGCAGCCGGTCCGAGTTTGAG
GAACAGCCCGATTTCCTGCCCGATAAATTTGAAGCGGGCACACCCAATACAGTCGGTCTGGCCGGACTGGAAGCCGGAGT
TCGCTTCGTTCTTCGCCGGGGCGTGGCATCGATTCGAGCTCAGGAACAGGAACTCGCGGGACACTTGATGAATGGACTCA
GGACCGTTCCGGGGCTCACCCTGTATGGGCCGGAGATCCCGTCACGAAAAATCGCCGTCGTCTCCTTCACGGTCGAAGGA
CTGTCTCCCGCGGAAATTGCCATGGCTCTTGACGAGCAGGATATGATCATGTCCCGTCCCGGATTGCACTGCGCACCGTC
GGCCCATAAAACTCTCGGCACATTTCCCGTGGGAACCACCCGATTCAGTCTCGGGGCCTTCAATACGGCCGAGCAGGTGC
AAACCGCCGTGAAAGCCGTCGCCCGTCTCACAGCGACGGCGCGCCGGAAGGGTTAG

Upstream 100 bases:

>100_bases
GCAGGTTCAATATTTTACAGGGCATAAAAAAAGCCCCCTTGATCATCCGGAATAACAAACATCCCGTTACTTTCGGAAAG
CGGTTTCAGGAAAGGACTCA

Downstream 100 bases:

>100_bases
CCCGCGCGGGGCAGTATTTCGAGGATCACGTTCCTGCCGGTAAGCTGAATTTTCATCATTTCAGCTCATGTCAACGCCTT
TTACAGAACGCAGCAAAGGA

Product: cysteine desulfurase / selenocysteine lyase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MHSNNVIYFDNAATSWPKPEETLQAMEHYLRHVGGNPGRSGHRHSLDAARIVMNAREAVAELFGIQDALNVAFTKNATEA
LNLATRGLLHPGDHVITSSMEHNSVMRPLRALEKEGLELTVIPCSSSGELDPADLLPAIRRNTRAVYLTAASNVTGTLMP
LKEVGMLTREKGLIFCVDAAQAGGSFPLDVTELGIDLLAFTGHKALYGPQGTGGLYIREGLEKDIRPLMMGGTGSRSEFE
EQPDFLPDKFEAGTPNTVGLAGLEAGVRFVLRRGVASIRAQEQELAGHLMNGLRTVPGLTLYGPEIPSRKIAVVSFTVEG
LSPAEIAMALDEQDMIMSRPGLHCAPSAHKTLGTFPVGTTRFSLGAFNTAEQVQTAVKAVARLTATARRKG

Sequences:

>Translated_391_residues
MHSNNVIYFDNAATSWPKPEETLQAMEHYLRHVGGNPGRSGHRHSLDAARIVMNAREAVAELFGIQDALNVAFTKNATEA
LNLATRGLLHPGDHVITSSMEHNSVMRPLRALEKEGLELTVIPCSSSGELDPADLLPAIRRNTRAVYLTAASNVTGTLMP
LKEVGMLTREKGLIFCVDAAQAGGSFPLDVTELGIDLLAFTGHKALYGPQGTGGLYIREGLEKDIRPLMMGGTGSRSEFE
EQPDFLPDKFEAGTPNTVGLAGLEAGVRFVLRRGVASIRAQEQELAGHLMNGLRTVPGLTLYGPEIPSRKIAVVSFTVEG
LSPAEIAMALDEQDMIMSRPGLHCAPSAHKTLGTFPVGTTRFSLGAFNTAEQVQTAVKAVARLTATARRKG
>Mature_391_residues
MHSNNVIYFDNAATSWPKPEETLQAMEHYLRHVGGNPGRSGHRHSLDAARIVMNAREAVAELFGIQDALNVAFTKNATEA
LNLATRGLLHPGDHVITSSMEHNSVMRPLRALEKEGLELTVIPCSSSGELDPADLLPAIRRNTRAVYLTAASNVTGTLMP
LKEVGMLTREKGLIFCVDAAQAGGSFPLDVTELGIDLLAFTGHKALYGPQGTGGLYIREGLEKDIRPLMMGGTGSRSEFE
EQPDFLPDKFEAGTPNTVGLAGLEAGVRFVLRRGVASIRAQEQELAGHLMNGLRTVPGLTLYGPEIPSRKIAVVSFTVEG
LSPAEIAMALDEQDMIMSRPGLHCAPSAHKTLGTFPVGTTRFSLGAFNTAEQVQTAVKAVARLTATARRKG

Specific function: Cysteine Desulfurases Mobilize The Sulfur From L- Cysteine To Yield L-Alanine, An Essential Step In Sulfur Metabolism For Biosynthesis Of A Variety Of Sulfur-Containing Biomolecules. Component Of The Suf Operon, Which Is Activated And Required Under Speci

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=387, Percent_Identity=30.749354005168, Blast_Score=145, Evalue=9e-35,
Organism=Homo sapiens, GI156713448, Length=298, Percent_Identity=32.8859060402685, Blast_Score=112, Evalue=5e-25,
Organism=Escherichia coli, GI1787970, Length=386, Percent_Identity=33.9378238341969, Blast_Score=176, Evalue=2e-45,
Organism=Escherichia coli, GI48994898, Length=393, Percent_Identity=31.2977099236641, Blast_Score=155, Evalue=3e-39,
Organism=Escherichia coli, GI1789175, Length=386, Percent_Identity=31.8652849740933, Blast_Score=155, Evalue=6e-39,
Organism=Caenorhabditis elegans, GI25143064, Length=402, Percent_Identity=31.8407960199005, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI193211090, Length=389, Percent_Identity=24.6786632390745, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17533177, Length=193, Percent_Identity=33.160621761658, Blast_Score=81, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6319831, Length=389, Percent_Identity=31.3624678663239, Blast_Score=156, Evalue=6e-39,
Organism=Drosophila melanogaster, GI20129463, Length=234, Percent_Identity=37.6068376068376, Blast_Score=148, Evalue=6e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 41943; Mature: 41943

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHSNNVIYFDNAATSWPKPEETLQAMEHYLRHVGGNPGRSGHRHSLDAARIVMNAREAVA
CCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHH
ELFGIQDALNVAFTKNATEALNLATRGLLHPGDHVITSSMEHNSVMRPLRALEKEGLELT
HHHHHHHHHHEEECCCHHHHHHHHHHCCCCCCCHHEECCHHHHHHHHHHHHHHHCCCEEE
VIPCSSSGELDPADLLPAIRRNTRAVYLTAASNVTGTLMPLKEVGMLTREKGLIFCVDAA
EEECCCCCCCCHHHHHHHHHCCCEEEEEEECCCCCEEECCHHHHHHHCCCCCEEEEEECC
QAGGSFPLDVTELGIDLLAFTGHKALYGPQGTGGLYIREGLEKDIRPLMMGGTGSRSEFE
CCCCCCCCCHHHHCHHHEEECCCCEEECCCCCCCHHHHHHHHHHCCCEEECCCCCCHHHH
EQPDFLPDKFEAGTPNTVGLAGLEAGVRFVLRRGVASIRAQEQELAGHLMNGLRTVPGLT
HCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
LYGPEIPSRKIAVVSFTVEGLSPAEIAMALDEQDMIMSRPGLHCAPSAHKTLGTFPVGTT
EECCCCCCCEEEEEEEEECCCCHHHHHHHCCCHHHHHCCCCCCCCCCCHHHCCCCCCCCC
RFSLGAFNTAEQVQTAVKAVARLTATARRKG
EEECCCCCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MHSNNVIYFDNAATSWPKPEETLQAMEHYLRHVGGNPGRSGHRHSLDAARIVMNAREAVA
CCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHH
ELFGIQDALNVAFTKNATEALNLATRGLLHPGDHVITSSMEHNSVMRPLRALEKEGLELT
HHHHHHHHHHEEECCCHHHHHHHHHHCCCCCCCHHEECCHHHHHHHHHHHHHHHCCCEEE
VIPCSSSGELDPADLLPAIRRNTRAVYLTAASNVTGTLMPLKEVGMLTREKGLIFCVDAA
EEECCCCCCCCHHHHHHHHHCCCEEEEEEECCCCCEEECCHHHHHHHCCCCCEEEEEECC
QAGGSFPLDVTELGIDLLAFTGHKALYGPQGTGGLYIREGLEKDIRPLMMGGTGSRSEFE
CCCCCCCCCHHHHCHHHEEECCCCEEECCCCCCCHHHHHHHHHHCCCEEECCCCCCHHHH
EQPDFLPDKFEAGTPNTVGLAGLEAGVRFVLRRGVASIRAQEQELAGHLMNGLRTVPGLT
HCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCE
LYGPEIPSRKIAVVSFTVEGLSPAEIAMALDEQDMIMSRPGLHCAPSAHKTLGTFPVGTT
EECCCCCCCEEEEEEEEECCCCHHHHHHHCCCHHHHHCCCCCCCCCCCHHHCCCCCCCCC
RFSLGAFNTAEQVQTAVKAVARLTATARRKG
EEECCCCCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]