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The map label for this gene is cobB1 [H]

Identifier: 85860043

GI number: 85860043

Start: 2255597

End: 2256370

Strand: Direct

Name: cobB1 [H]

Synonym: SYN_00042

Alternate gene names: 85860043

Gene position: 2255597-2256370 (Clockwise)

Preceding gene: 85860041

Following gene: 85860044

Centisome position: 70.95

GC content: 54.13

Gene sequence:

>774_bases
ATGGAAAAACGGATCGAACTTATCGCTCAGTGGATTGCTGAAGCGAAGACTGTCGTCATTTTTACGGGAGCGGGACTCAG
CACGGAATCGGGTATTCCTGATTTTCGCAGTCCTGGAGGAGTCTGGGACAAGTACAATCCCGAAGATTTTTATTTCGACA
ATTTTCTCGCCTCGGAAATTTCCCGCTGGAAATACTGGCAGATGGCGACGGAGATGTATGAACCGATGAAGAAAGCTCAG
CCCAATGCCGCCCATAACGCCATCGCCGAACTGGAAAGAATGGGCAGGCTGGACTGCGTGATTACCCAGAACATCGACAA
CCTGCATGTCCGGGCCGGCAATTCCCCTGAGAAGGTCATTGAACTTCATGGAACGGCCATGTCCGTTTCCTGCCTGAACT
GCCGGCAAAAATTCGACAGGGACAGGGTGCAGGAACGGTTGAAAGAAGAAATGAAAGTCCCCTATTGCGACAATTGCGGC
GGTCCCCTGAAACCGGATACCATATCCTTCGGCCAGGCCATGCCGGTCAGGGAAACCCAGGAGGCCTATGAGCGGTCCTC
CGCCTGCGATCTGTTCATTGTCATCGGTTCTTCCCTCGTCGTGCAGCCTGCAGCGTCCATGCCGGTTACGGCGAGGAGAA
ACGGCGCCAAGCTGGTCATCATCAACCGCGACCCTACGCCCTGCGATGATATGGCCGATATCGTTCTCCATGAGCAGGCG
GGCGCGGTGATGACGTCTTTGATGCACTGCGTTAAAAAGATAACGGACCGATAG

Upstream 100 bases:

>100_bases
GATCGTGGCAGAATATCCGGAGCTTGATCTGAGCTTTTGCAGTCATGGACGGGGATTGCAGCTCCTGAGTTCATCCTGAA
ACGCAGGAAGGAGAATATTT

Downstream 100 bases:

>100_bases
AGTCCTTTGAAAAAGAGGAAGGTCGTTTTGGAAAATTCCCGCATTGAGAATCGTTTTATTGAACTGGTGAATGTTCTTCG
CCGCCTCCGTTCGCCGGATG

Product: sir2 family protein

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog 1 [H]

Number of amino acids: Translated: 257; Mature: 257

Protein sequence:

>257_residues
MEKRIELIAQWIAEAKTVVIFTGAGLSTESGIPDFRSPGGVWDKYNPEDFYFDNFLASEISRWKYWQMATEMYEPMKKAQ
PNAAHNAIAELERMGRLDCVITQNIDNLHVRAGNSPEKVIELHGTAMSVSCLNCRQKFDRDRVQERLKEEMKVPYCDNCG
GPLKPDTISFGQAMPVRETQEAYERSSACDLFIVIGSSLVVQPAASMPVTARRNGAKLVIINRDPTPCDDMADIVLHEQA
GAVMTSLMHCVKKITDR

Sequences:

>Translated_257_residues
MEKRIELIAQWIAEAKTVVIFTGAGLSTESGIPDFRSPGGVWDKYNPEDFYFDNFLASEISRWKYWQMATEMYEPMKKAQ
PNAAHNAIAELERMGRLDCVITQNIDNLHVRAGNSPEKVIELHGTAMSVSCLNCRQKFDRDRVQERLKEEMKVPYCDNCG
GPLKPDTISFGQAMPVRETQEAYERSSACDLFIVIGSSLVVQPAASMPVTARRNGAKLVIINRDPTPCDDMADIVLHEQA
GAVMTSLMHCVKKITDR
>Mature_257_residues
MEKRIELIAQWIAEAKTVVIFTGAGLSTESGIPDFRSPGGVWDKYNPEDFYFDNFLASEISRWKYWQMATEMYEPMKKAQ
PNAAHNAIAELERMGRLDCVITQNIDNLHVRAGNSPEKVIELHGTAMSVSCLNCRQKFDRDRVQERLKEEMKVPYCDNCG
GPLKPDTISFGQAMPVRETQEAYERSSACDLFIVIGSSLVVQPAASMPVTARRNGAKLVIINRDPTPCDDMADIVLHEQA
GAVMTSLMHCVKKITDR

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI300797577, Length=256, Percent_Identity=33.203125, Blast_Score=148, Evalue=6e-36,
Organism=Homo sapiens, GI6912662, Length=275, Percent_Identity=31.2727272727273, Blast_Score=142, Evalue=3e-34,
Organism=Homo sapiens, GI300797597, Length=248, Percent_Identity=31.4516129032258, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI300795542, Length=256, Percent_Identity=32.03125, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI6912664, Length=264, Percent_Identity=31.0606060606061, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI13787215, Length=244, Percent_Identity=32.7868852459016, Blast_Score=125, Evalue=5e-29,
Organism=Homo sapiens, GI6912660, Length=221, Percent_Identity=33.9366515837104, Blast_Score=115, Evalue=5e-26,
Organism=Homo sapiens, GI63054862, Length=215, Percent_Identity=33.953488372093, Blast_Score=112, Evalue=2e-25,
Organism=Homo sapiens, GI13775602, Length=235, Percent_Identity=32.7659574468085, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI13775600, Length=235, Percent_Identity=32.7659574468085, Blast_Score=108, Evalue=4e-24,
Organism=Homo sapiens, GI7657575, Length=236, Percent_Identity=32.2033898305085, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI300797705, Length=214, Percent_Identity=32.2429906542056, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI7706712, Length=267, Percent_Identity=28.4644194756554, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI215982798, Length=168, Percent_Identity=33.9285714285714, Blast_Score=82, Evalue=4e-16,
Organism=Escherichia coli, GI308199517, Length=218, Percent_Identity=37.1559633027523, Blast_Score=112, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17567771, Length=276, Percent_Identity=29.3478260869565, Blast_Score=134, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI71990482, Length=276, Percent_Identity=29.3478260869565, Blast_Score=132, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI71990487, Length=278, Percent_Identity=29.136690647482, Blast_Score=127, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI17541892, Length=218, Percent_Identity=33.4862385321101, Blast_Score=118, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17505510, Length=246, Percent_Identity=24.7967479674797, Blast_Score=87, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6320163, Length=282, Percent_Identity=29.0780141843972, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6324504, Length=282, Percent_Identity=29.4326241134752, Blast_Score=112, Evalue=5e-26,
Organism=Saccharomyces cerevisiae, GI6325242, Length=213, Percent_Identity=30.5164319248826, Blast_Score=92, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6324599, Length=276, Percent_Identity=23.1884057971014, Blast_Score=76, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6320397, Length=239, Percent_Identity=25.1046025104602, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI28571445, Length=275, Percent_Identity=30.9090909090909, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI24648389, Length=219, Percent_Identity=35.1598173515982, Blast_Score=119, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24645650, Length=252, Percent_Identity=28.1746031746032, Blast_Score=110, Evalue=8e-25,
Organism=Drosophila melanogaster, GI17137536, Length=249, Percent_Identity=29.3172690763052, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24650933, Length=264, Percent_Identity=29.1666666666667, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI28571443, Length=220, Percent_Identity=29.5454545454545, Blast_Score=96, Evalue=3e-20,
Organism=Drosophila melanogaster, GI28571441, Length=220, Percent_Identity=29.5454545454545, Blast_Score=96, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 28847; Mature: 28847

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
7.8 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
7.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKRIELIAQWIAEAKTVVIFTGAGLSTESGIPDFRSPGGVWDKYNPEDFYFDNFLASEI
CCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
SRWKYWQMATEMYEPMKKAQPNAAHNAIAELERMGRLDCVITQNIDNLHVRAGNSPEKVI
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEECCCCCEEEECCCCHHHHH
ELHGTAMSVSCLNCRQKFDRDRVQERLKEEMKVPYCDNCGGPLKPDTISFGQAMPVRETQ
EECCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHH
EAYERSSACDLFIVIGSSLVVQPAASMPVTARRNGAKLVIINRDPTPCDDMADIVLHEQA
HHHHHCCCCEEEEEECCCCEECCCCCCCEEECCCCCEEEEECCCCCCHHHHHHHHHHHHH
GAVMTSLMHCVKKITDR
HHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEKRIELIAQWIAEAKTVVIFTGAGLSTESGIPDFRSPGGVWDKYNPEDFYFDNFLASEI
CCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHH
SRWKYWQMATEMYEPMKKAQPNAAHNAIAELERMGRLDCVITQNIDNLHVRAGNSPEKVI
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEECCCCCEEEECCCCHHHHH
ELHGTAMSVSCLNCRQKFDRDRVQERLKEEMKVPYCDNCGGPLKPDTISFGQAMPVRETQ
EECCCEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHH
EAYERSSACDLFIVIGSSLVVQPAASMPVTARRNGAKLVIINRDPTPCDDMADIVLHEQA
HHHHHCCCCEEEEEECCCCEECCCCCCCEEECCCCCEEEEECCCCCCHHHHHHHHHHHHH
GAVMTSLMHCVKKITDR
HHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]