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The map label for this gene is trxA [H]

Identifier: 85860040

GI number: 85860040

Start: 2252580

End: 2252912

Strand: Direct

Name: trxA [H]

Synonym: SYN_00045

Alternate gene names: 85860040

Gene position: 2252580-2252912 (Clockwise)

Preceding gene: 85860037

Following gene: 85860041

Centisome position: 70.85

GC content: 52.85

Gene sequence:

>333_bases
ATGAGTTCACAGGAATCCCTGCTTCACGTCACCGATGCCAATTTTGAAGAGGAAATCATTAAATCGGACAAGCCCGCTCT
CGTTGATTTCTGGGCAACATGGTGCGGCCCCTGCCGGGCCATCGGTCCGCTGGTGGAGGGACTTGCTGAAACCTACAAGG
GCAGGGTCAAGATATCAAAACTGAATGTGGACGAAAATCCGAAAACTGCCGCAGACTTCGGGGTGCGCAGCATCCCTACG
CTGATTCTCTTCAAGGATGGCAAGGTGATGGATACCCTGGTCGGGGTCGTCTCAAAGGAGCGGCTGGAAACGTTCGTCAA
TCAAAGTCTCTAA

Upstream 100 bases:

>100_bases
TATCCCCTTTTTATGATTCTCAAAATGCGATTGACATCTTTCAGGAAGATATGATATAGATATCACGAATCAATAAAACT
AAAAAGAGGAGGGCCTGCTC

Downstream 100 bases:

>100_bases
ATCGCCGACAACTAATACCTCATGAAATACAGAACACTTTGCGTCCGTTCCCTTATTGTTTTCTGCGCGGCCAGTCTACT
TCTCTCACTACTGACCGGCT

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 110; Mature: 109

Protein sequence:

>110_residues
MSSQESLLHVTDANFEEEIIKSDKPALVDFWATWCGPCRAIGPLVEGLAETYKGRVKISKLNVDENPKTAADFGVRSIPT
LILFKDGKVMDTLVGVVSKERLETFVNQSL

Sequences:

>Translated_110_residues
MSSQESLLHVTDANFEEEIIKSDKPALVDFWATWCGPCRAIGPLVEGLAETYKGRVKISKLNVDENPKTAADFGVRSIPT
LILFKDGKVMDTLVGVVSKERLETFVNQSL
>Mature_109_residues
SSQESLLHVTDANFEEEIIKSDKPALVDFWATWCGPCRAIGPLVEGLAETYKGRVKISKLNVDENPKTAADFGVRSIPTL
ILFKDGKVMDTLVGVVSKERLETFVNQSL

Specific function: Component of the thioredoxin-thioredoxin reductase system. Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=95, Percent_Identity=33.6842105263158, Blast_Score=87, Evalue=4e-18,
Organism=Homo sapiens, GI50592994, Length=86, Percent_Identity=38.3720930232558, Blast_Score=66, Evalue=8e-12,
Organism=Homo sapiens, GI21361657, Length=84, Percent_Identity=38.0952380952381, Blast_Score=65, Evalue=1e-11,
Organism=Homo sapiens, GI5031973, Length=87, Percent_Identity=33.3333333333333, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI87082331, Length=106, Percent_Identity=46.2264150943396, Blast_Score=124, Evalue=1e-30,
Organism=Escherichia coli, GI1788936, Length=94, Percent_Identity=41.4893617021277, Blast_Score=98, Evalue=1e-22,
Organism=Escherichia coli, GI87081747, Length=109, Percent_Identity=30.2752293577982, Blast_Score=69, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI212646193, Length=97, Percent_Identity=39.1752577319588, Blast_Score=91, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71980565, Length=100, Percent_Identity=38, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71980562, Length=89, Percent_Identity=40.4494382022472, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71998175, Length=86, Percent_Identity=41.8604651162791, Blast_Score=72, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17509965, Length=90, Percent_Identity=36.6666666666667, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17556044, Length=78, Percent_Identity=37.1794871794872, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17510299, Length=85, Percent_Identity=40, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17554386, Length=91, Percent_Identity=35.1648351648352, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17549970, Length=81, Percent_Identity=34.5679012345679, Blast_Score=62, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6321648, Length=83, Percent_Identity=42.1686746987952, Blast_Score=74, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6323072, Length=76, Percent_Identity=46.0526315789474, Blast_Score=74, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6319925, Length=94, Percent_Identity=35.1063829787234, Blast_Score=71, Evalue=3e-14,
Organism=Drosophila melanogaster, GI28573567, Length=100, Percent_Identity=36, Blast_Score=96, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24639826, Length=80, Percent_Identity=42.5, Blast_Score=82, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24664269, Length=95, Percent_Identity=37.8947368421053, Blast_Score=75, Evalue=9e-15,
Organism=Drosophila melanogaster, GI19921434, Length=88, Percent_Identity=35.2272727272727, Blast_Score=70, Evalue=2e-13,
Organism=Drosophila melanogaster, GI21358065, Length=93, Percent_Identity=31.1827956989247, Blast_Score=69, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24639068, Length=93, Percent_Identity=30.1075268817204, Blast_Score=69, Evalue=6e-13,
Organism=Drosophila melanogaster, GI17648013, Length=89, Percent_Identity=33.7078651685393, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24583090, Length=89, Percent_Identity=33.7078651685393, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 12155; Mature: 12024

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSQESLLHVTDANFEEEIIKSDKPALVDFWATWCGPCRAIGPLVEGLAETYKGRVKISK
CCCCCCEEEECCCCHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEEE
LNVDENPKTAADFGVRSIPTLILFKDGKVMDTLVGVVSKERLETFVNQSL
ECCCCCCCHHHHCCHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SSQESLLHVTDANFEEEIIKSDKPALVDFWATWCGPCRAIGPLVEGLAETYKGRVKISK
CCCCCEEEECCCCHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEEE
LNVDENPKTAADFGVRSIPTLILFKDGKVMDTLVGVVSKERLETFVNQSL
ECCCCCCCHHHHCCHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100 [H]